{"id":14,"date":"2021-10-01T11:14:38","date_gmt":"2021-10-01T18:14:38","guid":{"rendered":"https:\/\/blogs.ubc.ca\/andislab\/?page_id=14"},"modified":"2026-06-03T16:00:31","modified_gmt":"2026-06-03T23:00:31","slug":"publications","status":"publish","type":"page","link":"https:\/\/blogs.ubc.ca\/andislab\/research\/publications\/","title":{"rendered":"Recent Publications"},"content":{"rendered":"<ul>\n<li><strong>Creed, E.C., Beckedorf, M., Yudin, S.C.Y., Deyholos, F.L.,<\/strong>\u00a0<strong>Klegeris, A.<\/strong> (2026). Extracellular matrix-derived matrikines as emerging modulators of neuroinflammation and central nervous system signaling. Rev. Neurosci. (in press; DOI: 10.1515\/revneuro-2026-0014)<\/li>\n<li><strong>Klegeris, A.<\/strong> (2026) Matrikines as emerging mediators in gut\u2013brain communication: Bridging gastrointestinal remodeling and CNS. Neural Regen. Res. 21 (in press; <span class=\"ej-journal-doi\">DOI:\u00a0<\/span>10.4103\/NRR.NRR-D-25-01199<a id=\"ej-article-indicators-ccl\" href=\"http:\/\/creativecommons.org\/licenses\/by\/4.0\" target=\"_blank\" rel=\"noopener\"><\/a>)<\/li>\n<li><strong>Yudin, S.C.Y.<\/strong>, Day, K., Scott, E.Y., <strong>Patel, M.N.,<\/strong> Islam, H., <strong>Klegeris, A.<\/strong> (2026) Extracellular succinate modulates neuroimmune responses in a murine microglial cell line. Biomolecules 6:407<\/li>\n<li><strong>Klegeris, A.\u00a0<\/strong>(2026) Extracellular matrix-derived matrikines: Circulating peptides as candidate mediators of lung-to-brain signaling. Int. J. Mol. Sci. 27:3339<\/li>\n<li><strong>Brooks, N.A.H., Riar, I.,<\/strong> <strong>Klegeris, A. <\/strong>(2026) Mitochondrial damage-associated molecular patterns (DAMPs): Neuroimmunomodulators in the central nervous system pathophysiology. Neural Regen. Res. 21:1322-38<\/li>\n<li><strong>Yang. S., Brooks. N.A.H., Da Silva, D.E.,<\/strong> <strong>Gibon, J., Islam, H., Klegeris, A. <\/strong>(2025) Extracellular ATP regulates phagocytic activity, mitochondrial respiration, and cytokine secretion of human astrocytic cells. Purinergic Signal. 21:485-98<\/li>\n<li><strong>Wiens, K., Riar. I., Greuel, B., Lindhout, I.,<\/strong> <strong>Klegeris, A. <\/strong>(2024) Psilocin, the psychoactive metabolite of psilocybin, modulates select neuroimmune functions of microglial cells in a 5-HT<sub>2<\/sub> receptor-dependent manner. Molecules 29:5084<\/li>\n<li><strong>Mohammad, Z.B., Yudin, S.C.Y., Goldberg, B.J., Serra, K.L., Klegeris, A.<\/strong> (2024) Exploring neuroglial signaling: diversity of molecules implicated in microglia-to-astrocyte neuroimmune communication. Rev. Neurosci. 36:91-117<\/li>\n<li><strong>Wiens, K., Wasti, N., Ulloa, O.O, Klegeris, A.<\/strong> (2024) Diversity of microglia-derived molecules with neurotrophic properties that support neurons in the central nervous system and other tissues. Molecules 29:5525<\/li>\n<li style=\"font-weight: 400;\"><strong>Da Silva, D.R., Richards, C.M., McRae, S.A., Riar, I., Yang, S., Zurfluh, N.E., Gibon, J., Klegeris, A.<\/strong> (2024) Extracellular mixed histones are neurotoxic and modulate select neuroimmune responses of glial cells. PLoS ONE 19:e0298748<\/li>\n<li style=\"font-weight: 400;\"><strong>McRae, S.A., Richards, C.M., Da Silva, D.R., Riar, I., Yang, S., Zurfluh, N.E., Gibon, J., Klegeris, A.<\/strong> (2024) Pro-neuroinflammatory and neurotoxic potential of extracellular histones H1 and H3. Neurosci. Res. 204:34-45<\/li>\n<li><strong>Greuel, B.K., Da Silva, D.E., Robert-Gostlin, V.N., Klegeris, A.<\/strong> (2024) Natural compounds oridonin and shikonin exhibit potentially beneficial regulatory effects on select functions of microglia. Brain Sci. 14:328<\/li>\n<li style=\"font-weight: 400;\"><strong>Kosari, M., Asgari Taei, A., Klegeris, A., Soleimani, S. Tavasol, A. Jazi K. Eyvani, K., Bahrami, A., Farrokhi, Z., Vosough, F., Rahmani Khajeh, F., Behzadi, S., Zamani, Z.<\/strong> (2024) The role of dysregulated neuroinflammatory molecular pathways in Parkinson disease: A systematic review. Caspian J. Neurol. Sci. 10:151-68<\/li>\n<li><strong>Ahmadi, F., Behzadi, S., Aghazadeh-Habashi, K., Eyvani, K., Fatehi, A., Alipour, M., Sodeifian, F., Khajeh, F.R., AzariBakhsh, A., Nazerian, A., Tavasol, A., Klegeris, A., McElhinney, A., Markazi-Moghaddam, N., Fathi, M., Hajiesmaeili, M., Nooraei, N. <\/strong>(2024) Dynamic changes in metabolites of the kynurenine pathway in Alzheimer\u2019s disease, and Huntington\u2019s disease: A systematic review of pre-clinical studies Caspian J. Neurol. Sci. 10:174-89<\/li>\n<li><strong>Yang, S., Simtchouk, S. Gibon, S. Klegeris, A.<\/strong> (2023) Regulation of the phagocytic activity of astrocytes by neuroimmune mediators endogenous to the central nervous system. PLoS ONE 18:e0289169<\/li>\n<li><strong>Bernath, A.K., Murray, T.E., Yang, S., Gibon, J., Klegeris, A.<\/strong> (2023) Microglia secrete distinct sets of potential neurotoxins in response to different stimuli. Brain Res. 1807:148315<\/li>\n<li><strong>Wenzel, T.J., Murray, T.E., Noyovitz, B., Narayana, K., Gray, T.E., Lee, J., Hee J., Simtchouk, S., Gibon, J., Alcorn, J., Mousseau, D.D., Zandberg, W. F., Klegeris, A.<\/strong> (2023) Cardiolipin released by microglia can act on neighboring glial cells to facilitate the uptake of amyloid-\u03b2 (1-42). Mol. Cell. Neurosci. 124:103804<\/li>\n<li><strong>Calou, I.B.F, Pereira Lopes, M,J., Mottin, M., Klegeris, A.<\/strong>,<strong> Tavares Neves, K.R., de Castro Brito, G.A., de Barros Viana, G.S.<\/strong> (2023) Protective effects of Auranofin on the 6-hydroxydopamine model of Parkinson&#8217;s disease in rats. World J. Biol. Pharm. Health Sci. 13:106\u201319<\/li>\n<li><strong>Richards, C., McRae, S., Ranger, A., Klegeris, A.<\/strong> (2022) Extracellular histones as damage-associated molecular patterns in neuroinflammatory responses. Rev. Neurosci. 34(5):533-558<\/li>\n<li><strong>Wenzel, T. J., Haskey, N., Kwong, E., Greuel, B. K., Gates, E. J., Gibson, D. L., Klegeris, A.<\/strong> (2022). Dietary fats modulate neuroinflammation in mucin 2 knock out mice model of spontaneous colitis. Biochim. Biophys. Acta Mol. Basis Dis. 1868:166336<\/li>\n<li><strong>Murray, T.E. Wenzel, T.J., Greuel, B.K. Simtchouk, S., Gibon, J., Klegeris, A.<\/strong> (2022) Extracellular cardiolipin modulates select immune functions of astrocytes in toll-like receptor (TLR) 4-dependent manner. Mediat. Inflamm. 2022:9946439<\/li>\n<li><strong>Bernath, A., Gates, E.J., Klegeris, A.<\/strong> (2022) Modifying the diet and gut microbiota to prevent and manage neurodegenerative diseases. Rev. Neurosci. 33:767-78<\/li>\n<li><strong>Bajwa, E., Klegeris, A.<\/strong> (2022) Neuroinflammation as the key mechanism linking hypertension with the increased risk of Alzheimer\u2019s disease. Neural Regen. Res. 17:2342-46<\/li>\n<li><strong>Murray, T.E., Richards, C.M., Robert-Gostlin, V.N., Bernath, A.K. Lindhout, I.A., Klegeris, A.<\/strong> (2022) Potential neurotoxic activity of diverse molecules released by astrocytes. Brain Res. Bullet. 189:80-101<\/li>\n<li><strong>Fathi, M., Vakili, K., Yaghoobpoor, S., Tavasol, A., Jazi, K., Mohamadkhani, A., Klegeris, A., McElhinney, A., Mafi, Z., Hajiesmaeili, M., Sayehmiri, F.<\/strong> (2022) Dynamic changes in kynurenine pathway metabolites in multiple sclerosis: A systematic review. Front. Immunol. 13:1013784<\/li>\n<li><strong>Fathi, M., Vakili, K., Yaghoobpoor, S., Tavasol, A., Jazi, K., Hajibeygi, R., Shool, S., Sodeifian, F., Klegeris, A., McElhinney, A., Tavirani, M.R., Sayehmiri, F.<\/strong> (2022) Dynamic changes in metabolites of the kynurenine pathway in Alzheimer\u2019s disease, Parkinson\u2019s disease, and Huntington\u2019s disease: A systematic Review and meta-analysis. Front. Immunol. 13:997240.<\/li>\n<li><strong>Fathi, M., Vakili, K., Yaghoobpoor, S., Qadirifard, M.S., Kosari, M., Naghsh, N., Asgari taei, A., Klegeris, A., Dehghani, M., Bahrami, A., Taheri, H., Mohamadkhani, A., Hajibeygi, R., Rezaei Tavirani, M., Sayehmiri, F.<\/strong> (2022) Pre-clinical studies identifying molecular pathways of neuroinflammation in Parkinson\u2019s disease: A systematic review. Front. Aging Neurosci. 14:855776<\/li>\n<li><strong>Wenzel, T.J., Ranger, A.L., McRae, S.A., Klegeris, A<\/strong>. (2021) Extracellular cardiolipin modulates microglial phagocytosis and cytokine secretion in a toll-like receptor (TLR) 4-dependent manner. J. Neuroimmunol. 353:577496<\/li>\n<li><strong>Klegeris A<\/strong>. (2021) Mixed-mode instruction using active learning in small teams improves generic problem-solving skills of university students. J. Furth. High. Educ. 45:871-85<\/li>\n<li><strong>Hashioka, S., Wu, Z., Klegeris A<\/strong>. (2021) Glia-driven neuroinflammation and systemic inflammation in Alzheimer&#8217;s disease. Curr. Neuropharmacol. 19:908-24<\/li>\n<li><strong>Lindhout, I.A., Murray, T.E., Richards, C.M., Klegeris, A<\/strong>. (2021) Potential neurotoxic activity of diverse molecules released by microglia. Neurochem. Int. 148:105117<\/li>\n<li><strong>Hashioka, S., McLarnon, J.G., Klegeris, A<\/strong>. (2021) Diversity and regulation of astrocyte neurotoxicity in Alzheimer&#8217;s disease. Curr. Alzheimer Res. 18:925-38<\/li>\n<li><strong>Klegeris A<\/strong>. (2021) Targeting neuroprotective functions of astrocytes in neuroimmune diseases. Expert Opin. Ther. Targets 25:237-41<\/li>\n<li><strong>Lowry, J.R., Marshall, N., Wenzel, T.J., Murray, T.E., Klegeris, A<\/strong>. (2020) The dietary fatty acids \u03b1-linolenic acid (ALA) and linoleic acid (LA) selectively inhibit microglial nitric oxide production. Mol. Cell. Neurosci. 109:103569<\/li>\n<li><strong>Wenzel, T.J., Kwong, E., Bajwa, E.,<\/strong> Klegeris, A. (2020) Resolution-associated molecular patterns (RAMPs) as endogenous regulators of glia-mediated neuroinflammation. CNS Neurol. Disord. Drug Targets. 19:483-494<\/li>\n<li><strong>Klegeris A.<\/strong>\u00a0(2020) Regulation of neuroimmune processes by damage- and resolution-associated molecular patterns Neural Regen. Res. 16:423-9<\/li>\n<li><strong>Wenzel, T.J., Gates, E.J., Ranger, A.L., Klegeris, A.<\/strong>\u00a0(2020) Short-chain fatty acids (SCFAs) alone or in combination regulate select immune functions of microglia-like cells Mol. Cell. Neurosci. 105:103493<\/li>\n<li><strong>Klegeris, A.<\/strong>\u00a0(2020) Microglial targets for effective therapies of Alzheimer\u2019s disease. Front. Drug Chem. Clin. Res. 3:1-4<\/li>\n<li><strong>Leitner, G., Wenzel, T.J., Marshall, N., Gates, E., Klegeris, A.<\/strong>\u00a0(2019) Targeting toll-like receptor 4 to modulate neuroinflammation in central nervous system disorders. Expert Opin. Ther. Targets. 23:865-82<\/li>\n<li><strong>Wenzel, T.J., Bajwa, E., Klegeris, A.\u00a0<\/strong>(2019) Cytochrome c can be released into extracellular space and modulate functions of human astrocytes in a toll-like receptor 4-dependent manner. Biochem. Biophys. Acta Gen. Subjects. 1863:129400<\/li>\n<li><strong>McKenzie, J.A.<\/strong>, Barghash, R.F., Alsaggaf, A.T., Kulkarni, O.,<strong>\u00a0Boudreau, K.<\/strong>, Menard, F., Neeland, E.G.,\u00a0<strong>Klegeris, A.\u00a0<\/strong>(2019) Synthesis and evaluation of novel pyrazole ethandiamide compounds as inhibitors of human THP-1 monocytic cell neurotoxicity. Cells 8:655<\/li>\n<li><strong>Klegeris, A.<\/strong>,\u00a0Dubois, P.J., Code, W.J., Bradshaw, H. (2019) Non-linear improvement in generic problem-solving skills of university students: a longitudinal study. High. Educ. Res. Dev. 38:1432\u201344<\/li>\n<li><strong>Bajwa, E., Pointer, C.B., Klegeris, A.<\/strong>\u00a0(2019) The role of mitochondrial damage-associated molecular patterns in chronic neuroinflammation. Mediators Inflamm. 2019:4050796<\/li>\n<li><strong>Alford, M.A.<\/strong>, Tian, Z., Menard, F.,\u00a0<strong>Klegeris, A.<\/strong>\u00a0(2019) Characterization of novel kainic acid analogs as inhibitors of select microglial functions. Eur. J. Pharmacol. 851:25-35<\/li>\n<li><strong>Pointer, C.B., Wenzel, T.J., Klegeris, A.<\/strong>\u00a0(2019) Extracellular cardiolipin regulates select immune functions of microglia and microglia-like cells. Brain Res. Bull. 146:153-63<\/li>\n<li><strong>Spielman, L.J.<\/strong>, Gibson, D.L.,\u00a0<strong>Klegeris, A.<\/strong>\u00a0(2018) Unhealthy gut, unhealthy brain: The role of the intestinal microbiota in neurodegenerative diseases. Neurochem. Int. 120:149-163<\/li>\n<li><strong>Schindler, S.M.<\/strong>, Frank, M.G., Annis, J.L., Maier, S.F.,\u00a0<strong>Klegeris, A.<\/strong>\u00a0(2018) Pattern recognition receptors mediate pro-inflammatory effects of extracellular mitochondrial transcription factor A (TFAM) Mol. Cell. Neurosci. 89:71-9<\/li>\n<li><strong>Lowry, J.R.<\/strong>,\u00a0<strong>Klegeris, A.<\/strong>\u00a0(2018) Emerging roles of microglial cathepsins in neurodegenerative disease. Brain Res. Bull. 139:144-56<\/li>\n<li><strong>Klegeris, A.\u00a0<\/strong>, Gustaffson, E., Hurren, H.,(2018) Generic problem-solving skills and academic ability of students as distinct skill sets revealed by an assessment panel and campus-wide testing. Compare J. Compar. Int. Edu. 48:674-85<\/li>\n<li><strong>Wenzel, T., Klegeris A.<\/strong>\u00a0(2018) Novel multi-target directed ligand-based strategies for reducing neuroinflammation in Alzheimer\u2019s disease. Life Sci. 207:314-22<\/li>\n<li><strong>McKenzie, J.A.<\/strong>,\u00a0<strong>Klegeris, A.<\/strong>\u00a0(2018) Modulation of microglial functions by methyl jasmonate. Neural Regen. Res. 13:1290-3<\/li>\n<li>Raievskyi, A.V., Sharifi, M., Pinchuk, V.,\u00a0<strong>Klegeris, A.<\/strong>\u00a0(2018) In silico design of novel gold-phosphate containing compounds as selective inhibitors of cathepsin B in neuroinflammation. Neuroimmunol. Neuroinflamm. 5:33<\/li>\n<li><strong>Slattery, W.T.<\/strong>,\u00a0<strong>Klegeris, A.<\/strong>(2018) Acetaminophen metabolites p-aminophenol and AM404 inhibit microglial activation. Neuroimmunol. Neuroinflamm. 5:11<\/li>\n<li><strong>Gouveia, A.<\/strong>,\u00a0<strong>Bajwa, E.<\/strong>,\u00a0<strong>Klegeris, A.<\/strong>\u00a0(2017) Extracellular cytochrome C as an intercellular signaling molecule regulating microglial functions. Biochim Biophys Acta. Subjects 1861:2274-2281.<\/li>\n<li><strong>Spielman, L.J.<\/strong>, Gibson, D.L.,\u00a0<strong>Klegeris, A.<\/strong>\u00a0(2017) Incretin hormones regulate microglia oxidative stress, survival and expression of trophic factors Eur. J. Cell. Biol. 96:240-53<\/li>\n<li><strong>Bahniwal, M.<\/strong>, Little, J.P.,\u00a0<strong>Klegeris, A.<\/strong>\u00a0(2017) High glucose enhances neurotoxicity and inflammatory cytokine secretion by stimulated human astrocytes. Curr. Alzheimer Res. 14:731-41<\/li>\n<li><strong>Spielman, L.J.<\/strong>, Estaki, M., Ghosh, S., Gibson, D.L.,\u00a0<strong>Klegeris, A.<\/strong>\u00a0(2017) The effects of voluntary wheel running on neuroinflammatory status: Role of monocyte chemoattractant protein-1. Mol. Cell. Neurosci. 79:93-102<\/li>\n<li><strong>Klegeris, A.,\u00a0<\/strong>Barclay McKeown S., Hurren, H.,\u00a0<strong>Spielman, L.J., Stuart, M.,<\/strong>\u00a0<strong>Bahniwal, M.<\/strong>\u00a0(2017) Dynamics of undergraduate student generic problem-solving skills captured by a campus-wide study. Higher Educ. 74:877\u201396<\/li>\n<li><strong>McKenzie, J.A., Spielman, L.J., Pointer, C.B., Lowry, J.R., Bajwa, E., Lee, C.W., Klegeris, A.<\/strong>\u00a0(2017) Neuroinflammation as a common mechanism associated with the modifiable risk factors for Alzheimer\u2019s and Parkinson\u2019s diseases. Curr. Aging Sci. 10:158-76<\/li>\n<li><strong>Pointer, C.B.<\/strong>,\u00a0<strong>Klegeris, A.<\/strong>\u00a0(2017) Cardiolipin in central nervous system physiology and pathology Cell. Mol. Neurobiol. 37:1161-72<\/li>\n<li>Hashioka, S., Suzuki, H., Nakajima, D., Miyaoka, T., Wake, R., Hayashida, M., Horiguchi, J.,\u00a0<strong>Klegeris, A.<\/strong>\u00a0(2016) Metabolomics analysis implies noninvolvement of the kynurenine pathway neurotoxins in the interferon-\u03b3-induced neurotoxicity of adult human astrocytes. Neuropsychiatry (London) 7:610\u20137<\/li>\n<li><strong>Bajwa, E., Pointer, C.B.<\/strong>,\u00a0<strong>Klegeris, A.<\/strong>\u00a0(2016) Modifiable risk factors of Alzheimer\u2019s disease and neuroinflammation: What are the links? Future Neurol. 11:237-44<\/li>\n<li><strong>Schindler, S.M., Bajwa, E.<\/strong>, Little, J.P.,\u00a0<strong>Klegeris, A.<\/strong>\u00a0(2016) Possible role of microparticles in neuroimmune signaling of microglial cells. Neuroimmunol. Neuroinflammation 3:232-42<\/li>\n<li><strong>Schindler, S.M.<\/strong>,\u00a0<strong>Klegeris, A.<\/strong>\u00a0(2016) Elucidating the link between the modifiable risk factors of Alzheimer&#8217;s disease and neuroinflammation. Neurodegener. Dis. Manag. 6:375-84<\/li>\n<li><strong>Spielman, L.J.,\u00a0<\/strong>Little, J.P.,\u00a0<strong>Klegeris, A.<\/strong>\u00a0(2016) Physical activity and exercise attenuate neuroinflammation in neurological diseases. Brain Res. Bullet. 125:19-29<\/li>\n<li><strong>Spielman, L.J.<\/strong>,\u00a0<strong>Bahniwal, M.<\/strong>, Little, J.P., Walker, D.G.,\u00a0<strong>Klegeris, A.<\/strong>\u00a0(2015) Insulin modulates in vitro secretion of cytokines and cytotoxins by human glial cells. Curr. Alzheimer Res. 12:684-693<\/li>\n<li><strong>Schindler, S.M., Spielman, L.J., Pointer, C., Bajwa, E., Slattery, W.T., McKenzie, J.,<\/strong>\u00a0<strong>Lowry, J.R., Klegeris, A.<\/strong>\u00a0(2015) An interplay between neuroinflammation and modifiable risk factors of Alzheimer\u2019s disease, Parkinson\u2019s disease and Amyotrophic lateral sclerosis. In &#8216;Neuroinflammation in Disease: Risk Factors, Management and Outcomes\u2019 Dawson, R.K. (Ed.), pp. 1-56, Nova Publishers, New York.<\/li>\n<li><strong>Madeira, J.M., Schindler, S.M.<\/strong>, Klegeris, A. (2015) A new look at auranofin, dextromethorphan and rosiglitazone for reduction of glia-mediated inflammation in neurodegenerative diseases Neural Regener. Res. 10:391-393<\/li>\n<li><strong>Villanueva E.B.,<\/strong>\u00a0Little, J.P.,\u00a0<strong>Klegeris A.<\/strong>\u00a0(2015) Therapeutic potential of cannabinoids in the treatment of neuroinflammation associated with Parkinson&#8217;s disease. Recent Adv. Med. Chem. 2:59-75<\/li>\n<li><strong>Schindler, S.M., Spielman, L.J., Bajwa, E., Slattery, W.T., Harris, D.B., Klegeris, A.<\/strong>\u00a0(2015) The diversity of microglial activators and their elicited responses: Implications for central nervous system functions. In \u2018Microglia: Physiology, Regulation and Health Implications\u2019 Giffard, E.R. (Ed.), pp.113-156, Nova Publishers, New York.<\/li>\n<li><strong>Spielman, L.J., Klegeris, A.<\/strong>\u00a0(2014) The role of insulin and incretins in neuroinflammation and neurodegeneration. Immunoendocrinology, 1:e391<\/li>\n<li><strong>Madeira, J.M., Bajwa, E., Stuart, M.J.,\u00a0<\/strong>Hashioka, S.,<strong>\u00a0Klegeris, A.\u00a0\u00a0<\/strong>(2014) Gold drug auranofin could reduce neuroinflammation by inhibiting microglia cytotoxic secretions and primed respiratory burst. J. Neuroimmunol. 276, 71-79<\/li>\n<li><strong>Schindler, S.M.<\/strong>, Little, J.P.,\u00a0<strong>Klegeris, A.<\/strong>\u00a0(2014) Mitochondrial transcription factor A (TFAM): A novel brain intercellular signaling molecule and microglial activator. Inflam. Cell Signal. 1:224-229<\/li>\n<li><strong>Spielman, L.J.<\/strong>, Little, J.P.,\u00a0<strong>Klegeris, A.<\/strong>\u00a0(2014) Inflammation and insulin\/IGF-1 resistance as the possible link between obesity and neurodegeneration. J. Neuroimmunol. 273:8-21<\/li>\n<li><strong>Little, J.P.<\/strong>, Simtchouk, S.,\u00a0<strong>Villanueva, E.M., Gill, N.E.<\/strong>, Walker, D.G., Wolthers, K.R.,\u00a0<strong>Klegeris, A.<\/strong>\u00a0(2014) Mitochondrial transcription factor A (Tfam) is a pro-inflammatory extracellular signaling molecule recognized by brain microglia. Mol. Cell. Neurosci. 60:88-96<\/li>\n<li><strong>Schindler, S.M.<\/strong>, Little, J.P.,\u00a0<strong>Klegeris, A.<\/strong>\u00a0(2014) Microparticles: A new perspective in central nervous system disorders. BMRI Neurosci. 2014: 756327<\/li>\n<li>Wan, Z., Mah, D., Simtchouk, S.,\u00a0<strong>Klegeris, A.<\/strong>, Little J.P. (2014) Globular adiponectin induces a pro-inflammatory response in human astrocytic cells. Biochem. Biophys. Res. Commun. 446:37-42<\/li>\n<li>Hashioka, S., Wang, Y.F.,\u00a0<strong>Little, J.P.<\/strong>, Choi, H.B.,\u00a0<strong>Klegeris, A.<\/strong>, McGeer, P.L., McLarnon, J.G. (2014) Purinergic responses of calcium-dependent signaling pathways in cultured adult human astrocytes. BMC Neurosci. 15:18<\/li>\n<li><strong>Madeira, J.M., Renschler, C.J., Mueller, B.,\u00a0<\/strong>Hashioka, S., Gibson, D.L.,\u00a0<strong>Klegeris, A.<\/strong>\u00a0 (2013) Novel protective properties of auranofin: inhibition of human astrocyte cytotoxic secretions and direct neuroprotection. Life Sci. 92:1072-80<\/li>\n<li><strong>Bahniwal, M., Little, J.P., Klegeris, A.<\/strong>\u00a0(2013) Regulation of glial metabolism and immune responses by insulin. In Glial Cells: Embryonic Development, Types\/Functions and Role in Disease. Kaur, C., Ling E.A. (Eds.) pp. 117-146, Nova Publishers, New York.<\/li>\n<li>Ryu, J.K.,\u00a0<strong>Little J.P., Klegeris, A.,<\/strong>\u00a0Jantaratnotai, N., McLarnon, J.G. (2013) Actions of the anti-angiogenic compound angiostatin in an animal model of Alzheimer\u2019s disease. Curr. Alzheimer Res. 10:252-260<\/li>\n<li><strong>Klegeris, A., Bahniwal, M.,<\/strong>\u00a0Hurren, H. (2013) Improvement in generic problem-solving abilities of students by use of tutor-less problem based learning in a large classroom setting. CBE Life Sci. Educ. 12:73-79<\/li>\n<li><strong>Madeira, J.M., Little, J.P., Klegeris, A.\u00a0<\/strong>(2012)<strong>\u00a0<\/strong>Microglia secretome: from neurotoxins to neurotrophins.\u00a0 In Microglia: Biology, Functions and Roles in Disease. Kaur, C., Ling, E.A. (Eds.) pp. 73-92, Nova Publishers, New York.<\/li>\n<li><strong>Madeira, J.M.<\/strong>, Gibson, D.L., Kean, W.F.,\u00a0<strong>Klegeris, A.<\/strong>\u00a0(2012) The biological activity of auranofin: implications for novel treatment of diseases. Inflammopharmacology 20:297-306<\/li>\n<li><strong>Villanueva, E.B., Little, J.P.,<\/strong>\u00a0Lambeau, G.,\u00a0<strong>Klegeris, A.<\/strong>\u00a0(2012) Secreted phospholipase A2 group IIA is a neurotoxin released by stimulated human glial cells. Mol. Cell. Neurosci. 49:430-438.<\/li>\n<li><strong>Little, J.P., Madeira, J.M., Klegeris, A.\u00a0<\/strong>(2012)<strong>\u00a0<\/strong>The saturated fatty acid palmitate induces human monocytic cell toxicity towards neuronal cells: exploring a possible link between obesity-related metabolic impairments and neuroinflammation. J. Alzheim. Dis. 30, Suppl. 2: S179-S183.<\/li>\n<li><strong>Madeira, J.M., Beloukhina, N., Boudreau, K., Boettcher, T. Gurley, L.,<\/strong>\u00a0Walker, D.G., McNeil, W.S.,\u00a0<strong>Klegeris, A.<\/strong>\u00a0(2012) Cobalt(II) beta-ketoaminato complexes as novel inhibitors of neuroinflammation.\u00a0 Eur. J. Pharmacol. 676: 81-88.<\/li>\n<li>Hashioka, S.,\u00a0<strong>Klegeris, A.<\/strong>, McGeer, P.L. (2012) The histone deacetylase inhibitor suberoylanilide hydroxamic acid attenuates human astrocyte neurotoxicity induced by interferon-gamma. J. Neuroinflam. 9:113<\/li>\n<li>Hashioka, S.,\u00a0<strong>Klegeris, A.<\/strong>, McGeer, P.L. (2012) Inhibition of human astrocyte and microglia neurotoxicity by calcium channel blockers. Neuropharmacology 63: 685-691 IF=4.8 A<\/li>\n<li><strong>Bahniwal, M., Villanueva, E.B. Klegeris A.<\/strong>\u00a0(2011) Moderate increase in temperature may exacerbate neuroinflammatory processes in the brain: human cell culture studies. J. Neuroimmunol. 233:65-72<\/li>\n<li><strong>Ionescu, V.A., Villanueva, E.B.,<\/strong>\u00a0Hashioka, S.\u00a0<strong>Bahniwal, M., Klegeris A.<\/strong>\u00a0(2011) Cultured adult porcine astrocytes and microglia cells express functional interferon-gamma receptors and exhibit toxicity towards SH-SY5Y cells. Brain Res. Bullet. 84:244-251<\/li>\n<li><strong>Little, J.P., Villanueva, E.B., Klegeris. A.<\/strong>\u00a0(2011) Therapeutic potential of cannabinoids in the treatment of neuroinflammation associated with Parkinson\u2019s disease. Mini Rev. Med. Chem. 11:582-590<\/li>\n<li><strong>Gurley, L., Beloukhina, N., Boudreau, K., Klegeris,A.,<\/strong>\u00a0McNeil, W.S. (2011) The synthesis and characterization of a series of cobalt(II) beta-ketoaminato complexes and their anticancer activity towards human tumor cell lines. J. Inorg. Biochem. 105:858-66<\/li>\n<li><strong>Klegeris A.,\u00a0<\/strong>Hurren H. (2011) Problem-based learning in large classrooms: assessing student perception and problem-solving skills. Adv. Physiol. Educ. 35:408-415<\/li>\n<li>Hashioka, S., McLarnon, J.G., Ryu, J.K., Youssef, A.M., Abd-El-Aziz, A.S., Neeland, E.G.,\u00a0<strong>Klegeris, A.<\/strong>\u00a0(2011) Pyrazole compound 2-MBAPA as a novel inhibitor of microglial activation and neurotoxicity in vitro and in vivo. J. Alzheim. Dis. 27:531-541<\/li>\n<li>Ghosh, S., Dai, C., Brown, K., Rajendiran, E., Makarenko, S., Baker, J., Ma, C., Halder, S., Montero, M.,\u00a0<strong>Ionescu, V.A., Klegeris, A.<\/strong>, Vallance, B.A., Gibson, D.L. (2011) Colonic microbiota alters host susceptibility to infectious colitis by modulating inflammation, redox status and ion transporter gene expression. Am. J. Physiol. Gastrointest. Liver Physiol., 301:G39-49<\/li>\n<li>Hashioka, S.,\u00a0<strong>Klegeris, A.,<\/strong>\u00a0Qing, H., McGeer, P.L. (2011) STAT3 inhibitors attenuate interferon-\u03b3-induced neurotoxicity and inflammatory molecule production by human astrocytes. Neurobiol. Disease, 41:299-307<\/li>\n<li>Hashioka, S.,\u00a0<strong>Klegeris, A.,<\/strong>\u00a0McGeer, P.L. (2011) Proton pump inhibitors reduce interferon-gamma-induced neurotoxicity and STAT3 phosphorylation of human astrocytes. Glia, 59: 833-840<\/li>\n<li>Youssef, A.M., Neeland, E.G.,\u00a0<strong>Villanueva, E.B.,\u00a0White M.S.,<\/strong>\u00a0El-Ashmawy, I.M., Patrick, B.,<strong>\u00a0Klegeris, A.,<\/strong>\u00a0Abd-El-Aziz, A.S. (2010) Synthesis and biological evaluation of novel pyrazole compounds. Bioorg. Med. Chem. 18:5685-5696<\/li>\n<li>Youssef, A.M.,\u00a0<strong>White, M.S.,\u00a0Villanueva, E.B.,<\/strong>\u00a0El-Ashmawy, I.M.,\u00a0<strong>Klegeris, A.<\/strong>\u00a0(2010) Synthesis and biological evaluation of novel pyrazolyl-2,4-thiazolidinediones as anti-inflammatory and neuroprotective agents Bioorg. Med. Chem. 18:2019-2028<\/li>\n<li>Hashioka, S.,\u00a0<strong>Klegeris, A.,<\/strong>\u00a0Qing, H., McGeer, P.L. (2011) STAT3 inhibitors attenuate interferon-gamma-induced neurotoxicity and inflammatory molecule production by human astrocytes. Neurobiol. Disease 41:299-307<\/li>\n<li>Hashioka, S.,\u00a0<strong>Klegeris, A.,<\/strong>\u00a0Yu, S., Schwab, C., McGeer, P.L. Differential expression of interferon-gamma receptor on human glial cells in vivo and in vitro. (in press, J. Neuroimmunol.)<\/li>\n<li>Schwab, C.,\u00a0<strong>Klegeris, A.<\/strong>, McGeer, P.L. (2010) Inflammation in transgenic mouse models of neurodegenerative disorders. Biochim. Biophys. Acta \u2013 Mol. Basis Dis. 1802:889\u2013902<\/li>\n<li>Hashioka, S.,\u00a0<strong>Klegeris, A.,<\/strong>\u00a0Schwab, C., McGeer, P.L. (2009) Interferon-gamma-dependent cytotoxic activation of human astocytes and astrocytoma cells. Neurobiol. Aging 30:1924-1935<\/li>\n<li>Shipley, P.R.,\u00a0<strong>Donnelly, C.C.A.,\u00a0<\/strong>Le, C.H.,\u00a0<strong>Bernauer, A.D.,\u00a0Klegeris, A.<\/strong>\u00a0(2009) Antitumor activity of asukamycin, a secondary metabolite from the actinomycete bacterium Streptomyces nodosus subspecies asukaensis. Int. J. Mol. Med. 24:711-715<\/li>\n<li>Hashioka, S.,\u00a0<strong>Klegeris, A.,<\/strong>\u00a0McGeer, P.L. (2009) Proton pump inhibitors exert anti-inflammatory effects and decrease human microglial and monocytic THP-1 cell neurotoxicity Exp. Neurol. 217:177-183<\/li>\n<li><strong>Klegeris, A.,<\/strong>\u00a0Pelech, S.L., Giasson, B.I., Maguire, J., Zhang, H., McGeer, E.G. and McGeer, P.L. (2008) a-Synuclein activates stress signaling protein kinases in THP-1 cells and microglia. Neurobiol. Aging 29:739\u2013752<\/li>\n<li><strong>Klegeris, A.,<\/strong>\u00a0Li, J., Bammler, T., Jin, J., Zhu, D., Kashima, D., Pan, S., Hashioka, S., Maguire, J., McGeer, P.L., Zhang, J. (2008) Prolyl endopeptidase is revealed following SILAC analysis to be a novel mediator of human microglial and THP-1 cell neurotoxicity. Glia 56:675\u2013685<\/li>\n<li>Hashioka,\u00a0S.,\u00a0<strong>Klegeris, A.,<\/strong>\u00a0Schwab, C., McGeer, P.L. Interferon-g-dependent cytotoxic activation of human astocytes and astrocytoma cells. Neurobiol. Aging (2008, in press, doi:10.1016\/j.neurobiolaging.2008.02.019)<\/li>\n<li>Hashioka, S., Miklossy, J., Schwab, C.,\u00a0<strong>Klegeris, A.,<\/strong>\u00a0McGeer, P.L. Adhesion of exogenous human microglia and THP-1 cells to amyloid plaques of post mortem Alzheimer disease brain. J. Alzheimers Dis. (2008)<\/li>\n<li><strong>Klegeris, A.,<\/strong>\u00a0McGeer, E.G., McGeer, P.L. (2007) Therapeutic approaches to inflammation in neurodegenerative disease. Curr. Opin. Neurol. 20:351-357<\/li>\n<li><strong>Klegeris, A.,<\/strong>\u00a0McGeer, P.L. (2007) Complement activation by islet amyloid polypeptide (IAPP) and alpha-synuclein 112. Biochem. Biophys. Res. Commun. 357:1096-1099<\/li>\n<li><strong>Klegeris, A.,<\/strong>\u00a0Choi, H.B., McLarnon, J.G., McGeer, P.L. (2007) Functional ryanodine receptors are expressed by human microglia and THP-1 cells: Their possible involvement in modulation of neurotoxicity. J. Neurosci. Res. 85:2207-2215<\/li>\n<li><strong>Klegeris, A.,<\/strong>\u00a0Schulzer, M., Harper, D.G. and McGeer, P.L. (2007) Increase in core body temperature of Alzheimer\u2019s disease patients as a possible indicator of chronic neuroinflammation: A meta-analysis. Gerontology 53: 7-1<\/li>\n<li>Hashioka, S.,\u00a0<strong>Klegeris, A.,<\/strong>\u00a0Kato, T., Monji, A., Sawada, M., McGeer, P.L., Kanba, S. (2007) Antidepressants inhibit interferon-gamma-induced microglial production of IL-6 and nitric oxide. Exp. Neurol. 206:33-42<\/li>\n<li><strong>Klegeris, A.,<\/strong>\u00a0Giasson, B.I., Zhang, H., Maguire, J., Pelech, S.L. and McGeer, P.L. (2006) Alpha-synuclein and its disease-causing mutants induce ICAM-1 and IL-6 in human astrocytes and astrocytoma cells FASEB J. 20: 2000-2008<\/li>\n<li>Miklossy, J., Arai, T. Guo, J.P.,\u00a0<strong>Klegeris, A.,<\/strong>\u00a0Yu, S., McGeer, E.G. and McGeer, P.L. (2006) LRRK2 expression in normal and pathologic human brain and in human cell lines J. Neuropathol. Exp. Neurol. 65: 953-963<\/li>\n<li>Shih, A.Y., Fernandes H.B., Choi, F.Y., Kozoriz, M.G., Liu, Y. Li, P., Cowan, C.M. and\u00a0<strong>Klegeris, A.<\/strong>\u00a0(2006) Policing the police: astrocytes modulate microglial activation [comment]. J. Neurosci. 26: 3887-3888<\/li>\n<li>Arai, T., Miklossy, J.,\u00a0<strong>Klegeris, A.,<\/strong>\u00a0Guo, J.P. and McGeer, P.L. (2006) Thrombin and prothrombin are expressed by neurons and glial cells and accumulate in neurofibrillary tangles in Alzheimer\u2019s disease brain. J. Neuropath. Exp. Neurol. 65:19-25<\/li>\n<li><strong>Klegeris, A.,<\/strong>\u00a0Bissonnette, C.J. and McGeer, P.L. (2005) Modulation of human microglia and THP-1 monocytic cell neurotoxicity by cytokines endogenous to the nervous system. Neurobiol. Aging 26: 673-682<\/li>\n<li><strong>Klegeris, A.<\/strong>\u00a0and McGeer, P.L. (2005) Chymotrypsin-like proteases contribute to human monocytic THP-1 cell as well as human microglial neurotoxicity. Glia 51: 56-64<\/li>\n<li><strong>Klegeris, A.<\/strong>\u00a0and McGeer, P.L. (2005) Non-steroidal anti-inflammatory drugs (NSAIDs) and other anti-inflammatory agents in the treatment of neurodegenerative disease. Curr. Alzheimer Res. 2: 355-365<\/li>\n<li><strong>Klegeris, A.,<\/strong>\u00a0Maguire, J. and McGeer, P.L. (2004) S- but not R-enantiomers of flurbiprofen and ibuprofen reduce human microglial and THP-1 cell neurotoxicity. J. Neuroimmunol. 152: 73-77<\/li>\n<li>Bissonnette, C.J.,\u00a0<strong>Klegeris, A.,<\/strong>\u00a0McGeer, P.L. and McGeer, E.G. (2004) Interleukin 1a and interleukin 6 protect neuronal SH-SY5Y cells from oxidative damage. Neurosci. Lett. 361: 40-43<\/li>\n<li><strong>Klegeris, A.,<\/strong>\u00a0Bissonnette, C.J. and McGeer, P.L. (2003) Reduction of human monocytic cell neurotoxicity and cytokine secretion by ligands of the cannabinoid type CB2 receptor. Br. J. Pharmacol. 139: 775-786<\/li>\n<li><strong>Klegeris, A.<\/strong>\u00a0and McGeer, P.L. (2003) Toxicity of human monocytic THP-1 cells and microglia toward SH-SY5Y neuroblastoma cells is reduced by inhibitors of 5-lipoxygenase and its activating protein FLAP. J. Leukoc. Biol. 73: 369-378<\/li>\n<li><strong>Klegeris, A.,<\/strong>\u00a0Singh, E.A. and McGeer, P.L. (2002) Effects of C reactive protein and pentosan polysulfate on human complement activation. Immunology 16: 381-388<\/li>\n<li><strong>Klegeris, A.,<\/strong>\u00a0Liutkevicius, E., Mikalauskiene, G., Duburs, G., McGeer, P.L. and Klusa, V. (2002) Anti-inflammatory effects of cerebrocrast in a model of rat paw edema and on human mononuclear phagocytes. Eur. J. Pharmacol. 441: 203-208<\/li>\n<li><strong>Klegeris, A.,<\/strong>\u00a0McGeer, E.G. and McGeer, P.L. (2000) Inhibitory action of 1 (2 chlorophenyl)-N-methyl-N-(1 methylpropyl)-3-isoquinolinecarboxamide (PK 11195) on some mononuclear phagocyte functions. Biochem. Pharmacol. 59: 1305-1314<\/li>\n<li><strong>Klegeris, A.<\/strong>\u00a0and McGeer, P.L. (2000) Interaction of various intracellular signaling mechanisms involved in mononuclear phagocyte toxicity toward neuronal cells. J. Leukoc. Biol. 67: 127-133<\/li>\n<li><strong>Klegeris, A.<\/strong>\u00a0and McGeer, P.L. (2000) R-( )-Deprenyl inhibits monocytic THP 1 cell neurotoxicity independently of monoamine oxidase inhibition. Exp. Neurol. 166: 458-464<\/li>\n<li><strong>Klegeris, A.,\u00a0<\/strong>Bissonnette, C.J., Dorovini-Zis, K. and McGeer, P.L. (2000) Expression of complement messenger RNAs by human endothelial cells. Brain Res. 871: 1-6<\/li>\n<li><strong>Klegeris, A.,<\/strong>\u00a0Walker, D.G. and McGeer, P.L. (1999) Toxicity of human THP 1 monocytic cells towards neuron-like cells is reduced by non-steroidal anti inflammatory drugs (NSAIDs). Neuropharmacology 38: 1017-1025.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Creed, E.C., Beckedorf, M., Yudin, S.C.Y., Deyholos, F.L.,\u00a0Klegeris, A. (2026). Extracellular matrix-derived matrikines as emerging modulators of neuroinflammation and central nervous system signaling. Rev. Neurosci. (in press; DOI: 10.1515\/revneuro-2026-0014) Klegeris, A. (2026) Matrikines as emerging mediators in gut\u2013brain communication: Bridging gastrointestinal remodeling and CNS. Neural Regen. Res. 21 (in press; DOI:\u00a010.4103\/NRR.NRR-D-25-01199) Yudin, S.C.Y., Day, K., &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/blogs.ubc.ca\/andislab\/research\/publications\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Recent Publications&#8221;<\/span><\/a><\/p>\n","protected":false},"author":87870,"featured_media":0,"parent":6,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-14","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/blogs.ubc.ca\/andislab\/wp-json\/wp\/v2\/pages\/14","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.ubc.ca\/andislab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/blogs.ubc.ca\/andislab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.ubc.ca\/andislab\/wp-json\/wp\/v2\/users\/87870"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.ubc.ca\/andislab\/wp-json\/wp\/v2\/comments?post=14"}],"version-history":[{"count":49,"href":"https:\/\/blogs.ubc.ca\/andislab\/wp-json\/wp\/v2\/pages\/14\/revisions"}],"predecessor-version":[{"id":591,"href":"https:\/\/blogs.ubc.ca\/andislab\/wp-json\/wp\/v2\/pages\/14\/revisions\/591"}],"up":[{"embeddable":true,"href":"https:\/\/blogs.ubc.ca\/andislab\/wp-json\/wp\/v2\/pages\/6"}],"wp:attachment":[{"href":"https:\/\/blogs.ubc.ca\/andislab\/wp-json\/wp\/v2\/media?parent=14"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}