I only have one image of our model, but we did come together to write the links:
Elements that are strong/weak:
- The arrows in our diagram are all supported by evidence form the articles assigned in class, with a few outside readings as well. These are all strong connections as far as we know.
- Including that Egfr sequence is found to be never methylated (Kucharski et al., https://www.nature.com/articles/srep14070)
- The exception to the above statement in our diagram is the connection of 10HDA to the upregulation of egfr.
- We do not know that egfr is upregulated by 10HDA.
- One of 10HDA’s primary functions is as a HDACi (histone de-acetylase inhibitor)
- It could theoretically act on any of the pathways listed in the diagram to carry out its effect on honeybee phenotype, but we hypothesized that it is likely through egfr based on the phenotypic effects and the known properties of 10HDA.
- This could be tested in future research to provide evidence to support this hypothesis
- Question: Does 10HDA function as an HDACi in the egfr pathway in queen differention?