One main question that I have after still reading “Structural and Functional Differences in the Long-noncoding RNA Hotair in Mouse and Human” by Schoderet and Duboule:
It is interesting to read that a depletion of Hotair cognate lincRNA in mouse has had no severe effect upon Hoxd gene activation, trump development, or limb morphogenesis. Especially since it is an area where Hotair is expressed. I’d be curious to know the answer to the question of whether these processes are being regulated directly, or indirectly, by another lincRNA instead of Hotair. And if that is the case, what the selective advantage was against Hotair in mouse.