Coffee has been a really important component of human diet and has been known the acute effect that maybe harmful on human health. As we know, coffee also contains beneficial compounds such as antioxidants, though the net effect of coffee on human health is also uncertain.
Recently, there is an organization which is called “JACC” in Japan. They assessed to the association of coffee with the all-cause and total cancer mortality. They followed up 110792 subjects aged 40-79 at baseline by conducting a large-scale cohort, aand then grouped them into four categories according their daily coffee intake: consuming less than 1 cup, 1 cup, 2 or 3 cups, and 4 or more cups. They also adjusted the other factors which maybe associated with the cancer mortality and coffee consumption such as smoking status, drinking status, and sleep length. The linear trend in the risk of mortality was assessed by treating the number of cups of coffee intake per day as ordinal variable. Further analysis stratified by baseline age in addition to gender was also conducted.
After they followed up for 16 years, the results showed the mortality was decreasing with the increased coffee consumption in both men and women. However, in women there was a slight risk elevation at the highest coffee consumption level compared with the second level. The result of further analysis, with exclusion of those with past medical history or those died early, th erisk of cancer mortality did not show any association with coffee comsumption in men, but was slightly reduced with increasing coffee consumption in women. The results also indicated the women aged 40-59 at baseline showed a slightly non-significant decreasing trend with the increasing coffee intake. However, the women aged 60-79 showed the risk reduction was only at the 2nd and 3rd level.
Youwen Zhang
Oct 2nd, 2016
