Category Archives: chemistry in the news

Bacteriophages: A Possible Alternative to Antibiotics?

What would happen if we ran out of antibiotics to use against bacteria? Antibiotic resistance is known to be one of the major concerns among doctors and scientists around the world since, it’s our primary defense against bacterial infections. Without these antibiotics, it’d be virtually impossible to treat many types of diseases or even perform surgeries.

The quality of healthcare has significantly improved over the centuries as more people have access to treatment, medicine, and antibiotics. However, it has also increased the risk of wrong applications of drugs, allowing the bacteria to develop defense mechanisms to different types of antibiotics. In fact, there has been a dramatic increase in the number of scientific reports about different drugs resistance cases.

Antibiotic resistance occurs through process known as ‘Natural Selection’, where the bacteria has evolved and is no longer affected by the antibiotics. A stand-out candidate as an alternative for antibiotics is known as bacteriophages.

‘Alternative treatments are urgently required and we are investigating one such treatment – the use of bacteriophage.’

  • Robert Atterbury, Phage Biotechnology, University of Nottingham.                             
Resistance bacteria survived the treatment of antibiotics, thus able to reproduce and increase in numbers.

Resistance bacteria survived the treatment of antibiotics, thus able to reproduce and increase in numbers. <http://www.reactgroup.org/toolbox/mutation-and-selection/>. Photo credit: Uppsala University

‘Bacteriophage, or phage is a virus that infects bacteria, so these don’t infect human cells- they are specialised and only infect bacteria’

  • Brent Gilpin, Science Leader, Environmental Science Group, New Zealand.
Bacteriophage attached itself to the bacteria before releasing its DNA inside.

Bacteriophage attached itself to the bacteria before releasing its DNA inside. <http://www.news-medical.net/news/20151202/Bacteriophage-therapy-an-alternative-to-antibiotics-An-interview-Professor-Clokie.aspx>. Photo credit: News-Medical.net team

Bacteriophage or phage infects the bacterial cell by first recognizing the bacteria and then attaching itself to the bacteria’s surface (cell wall). After the phage has penetrated the cell wall, entering the bacteria, and it releases its DNA inside. This DNA merges itself with the bacterial DNA causing the bacteria to produce proteins for the phage. Other chain reactions occur which causes the bacteria cell to produce more phages and eventually bust out, causing the bacteria to die. – This process is shown in the following video:

‘Bacteriophage Life Cycle’

This method is currently being adopted by many industries including food protection against food-borne disease, and medical treatment for both animal and humans. Furthermore, there are many advantages in using phage therapy; for example the phages are target specific, thus only attacking bacteria with a certain structure. With the right phage, it’s harmless to humans and since, phage is found naturally throughout the environment, there are several types of phages that can be studied and used. In addition to this, phage can be genetically modified to reduce their side effects, harmful abilities, or any unnecessary features. With this, it’s possible that phages can be used as an efficient and effective treatment against bacteria.

I strongly believe that bacteriophage is a potential alternative for antibiotics due to its ability to target specific bacteria, its harmless nature to humans, and its ability to be genetically engineered. Moreover, it can also be used in many industries as a safety precaution, in medical treatments, or even scientific research.

 

Poramat Sucharit

Oxygen Water and Reasons to Avoid It

Have you heard of “oxygen water?”  This self-explanatory product that you may have passed by unsuspectingly at a grocery store or a gas station contains higher levels of oxygen than normal water.  The manufacturers of oxygen water such as GP8 oxygen water and OXiGEN all claim their products have many health benefits, one of them being an improvement in an athlete’s performance; but is this true?  In short it isn’t.

OGO Oxygen Water, courtesy of Flickr Commons

Oxygen is an essential ingredient needed to generate energy in the human body.  When vigorously exercising, athletes are always in short of oxygen; therefore, they breathe heavier and faster to get more oxygen in their lungs.  What if there was an alternate way of getting oxygen inside your body than breathing?  Oxygen water manufacturers say that their products will increase the blood oxygen level because there is an extra supply of oxygen in the body from drinking oxygen-rich water.  Unfortunately, this is no where near the truth.

With the popularity of oxygen water growing in both professional and amateur athletes, a few teams of scientist decided to challenge the science behind oxygen water.  Dr. Piantadosi tested whether consuming oxygen benefited athletic performance or not.  The study concluded that oxygen water did not improve any athletic abilities and Dr. Piantadosi stated: “oxygenated water fails both quantitative analysis and practical physiological tests of exercise performance and recovery.”

Radical Oxygen, courtesy of Wikimedia

Oxygen Radicals, courtesy of Wikimedia

Another study investigated the effects of oxygen water but approached the subject slightly different.  Schoenberg et al. (2006) were determined to figure out if oxygen water was more harmful than beneficial.  The team suspected that drinking oxygen-rich water will generate oxygen radicals and when tested, they were right.  Oxygen radicals, which are unstable form of oxygen that damage or even kill our cells, were higher than normal in the volunteers who drank oxygen water up to 30 minutes after consumption.  From these results, it is clear that oxygen water should be avoided.  Unlike the claims made by the manufacturers, they do not enhance physical endurance or athletic ability and they do more harm than good.

Techniques Preventing Cancer Metastasis in Development

When I was 8 years old, my friend’s mother was diagnosed with breast cancer. Several years later her aunt was also diagnosed with breast cancer. For my friend, developing cancer is not imminent, however the thought of developing cancer is a terrifying idea for her. There is no doubt that almost everyone knows someone in their life who has been diagnosed by cancer, whether it be a family member, a friend, or an acquaintance. In my opinion, to fight against cancer the only way is to entrust the development of cures to the scientific community.

Cancer is menacing disease caused via changes to genes that control the way cells function. In the 21st century cancer has been the most renowned disease. The mortality rate of this disease is no laughing matter as an estimated 1,685,210 patients will be diagnosed with cancer and of those, 595,690 will die during 2016 in the United States alone. While many researchers are feverishly looking for cancer cures that kills cancer, others have been investigating methods to halt cancer from spreading throughout a patient’s body. MIT’s Natalie Artzi, a research scientist at MIT’s Institute for Medical Engineering and Science (IMES), and Tel-Aviv University’s Noam Shomrom have developed a new technique that may help prevent cancer metastasis.

Cancer Metastasis

Cancer Metastasis, courtesy of Wikimedia Commons

Metastasis is the spread of malignant cells from one organ or part of the body to another. Artzi and Shomrom’s new gene therapy technique involves applying microRNAs to cancer tumours. MicroRNAs are cellular RNA fragments that prevents the production of a particular protein. In their research Artzi and Shomrom identified that the protein Palladin plays a key role in the metastasis of breast cancer cells. Their experiments led to the discovery that miR-96 and miR-182, types of microRNAs, decreased the expression of Palladin, thus hampering the cancer cells capabilities to spread.

microRNA

microRNA, courtesy of Andres Zapata https://vimeo.com/52646065

 

With this new gene therapy technique in development, many types of cancers can be halted so long as the correct microRNAs are applied to the cancer sites. I  feel that this research is an immense step towards defeating cancer. Artzi and Shomon’s technique coupled with already known cancer treatments, such as chemotherapy,  can effectively halt the metastasis of early-stage cancer tumours. Thus, potentially saving thousands of patients in the United states, and millions around the world. Nonetheless, cancer would likely never be extinct until a definitive cure is found. However as members of the scientific community, we must do our best in following Artzi and Shomon’s footsetps by developing new techniques and treatments in hopes of saving the lives of people we know.

– Nelson Yu

A Solution for Climate Change?

CO2 concentrations over the last 400,000 years

A graph showing the rise and fall of CO2 concentration in the atmosphere, recorded over thousands of years. The magnified area indicates the dramatic increase of CO2 concentration during the Industrial Revolution. (c) Robert A. Rohde, used under Creative Commons Attribution-Share Alike 3.0 Unported

There is no doubt that climate change is real, dangerous, and occurring at an alarming rate that is unprecedented in the past 1,300 years. A major of the cause of this change is due to carbon dioxide gas, the product of burning fossil fuels for energy to run our cars, factories, for the production of electricity, and more. Carbon dioxide, one of many greenhouse gas, naturally acts as sort of a “blanket”, absorbing and emitting infrared radiation from the earth, causing the atmosphere to warm up, which known as the greenhouse effect.

A diagram illustrating the greenhouse effect.

A diagram illustrating the greenhouse effect. (c) US EPA used under public domain

Initiatives to reduce carbon dioxide emissions have already been implemented in our everyday lives, for example a simple thing like biking or taking public transit can reduce the amount of carbon dioxide emitted by automobiles. However, new carbon dioxide emissions data shows that our  efforts are not paying off. Every year, it is estimated that 38 billion tons of unnecessary carbon dioxide is released into the atmosphere. Even as you read this article 2.4 million pounds of this greenhouse gas is released into the atmosphere per second!

It seems that our efforts to reduce carbon dioxide emissions have failed and each year we can see a steady increase in emissions. Our economic and societal infrastructure has made us incredibly dependent on burni

Simple illustration of the conversion of CO2 into CO using silicon. (c) Chenxi Qian, used under Creative Commons Attribution 4.0 International License.

ng fossil fuels for energy. Perhaps the real solution lies in taking the excess carbon dioxide gas and converting it back into usable energy.

Recently, scientists from the University of Toronto believe to have discovered a method of converting carbon dioxide gas into energy-rich fuel. Professor Geoffrey Ozin and his team have developed a method using silicon, naturally found in sand, to efficiently and selectively convert gaseous carbon dioxide to carbon monoxide without any harmful emissions. Carbon monoxide can then be converted into hydrocarbon fuels such as petrol through a series of chemical reactions known as the Fischer-Tropsch process.

“A chemistry solution to climate change requires a material that is a highly active and selective catalyst to enable the conversion of CO₂ to fuel. It also needs to be made of elements that are low cost, non-toxic and readily available,” said Dr. Ozin.

Right now they are working on ways to increase the activity, enhance the scale, and boost the rate of production. Hopefully in the near future, there will be even more research dedicated to converting other greenhouse gases, not just carbon dioxide, into reusable energy, and then maybe we will be able to resolve the issues that have been caused by the detrimental amounts of greenhouse gases in our atmosphere.

– Charlie Wei

Buyer Beware: What You Should Know About Organic Food Products

There has been a lot of hype and excitement over organic foods and the health benefits associated with “going organic” these past few years. However, one particular experience recently has made me question whether or not the whole “organic movement” is well portrayed to the public or if it is just overrated in general.

One day while at work, a customer comes up to me and asks if we carried frozen organic hamburgers. My initial thought was “Huh, do they even sell such a thing in general?”. But because I have not seen any types of organic frozen hamburgers for sale at any point I have worked or shopped at my workplace, I kindly told her that we, unfortunately, do not carry such a product and that was the end of that conversation. Or at least I thought so. This customer proceeds to ask why we do not carry organic frozen hamburgers and that we should carry it because organic products are, according to her, “healthier and will help you live a longer life”. First of all, that statement is pretty contradictory to me. If one wants to be healthy and eat healthier, frozen hamburgers wouldn’t be on my list of healthy foods to eat. Secondly, how can one conclude that eating organic “will help you live a longer life”? But due to the time restrictions and the ridiculousness of the conversation, I did not ask how one would reach such a conclusion and kindly told the customer that I would make a suggestion to my manager when convenient and that was the end of the conversation (for real this time).

Since then, I have been read a few online articles on organic foods to further educate myself about organic food products and there was one particular article titled “The Dirty Truth About ‘Organic’ Produce” by Henry Miller(5) I found to be very interesting as it summarized my opinions about organic foods in general. Keep in mind I call it an opinion because there is still extensive research and studies made on the difference between organic and conventional food products. This article argues that the idea of organic food products may be misinterpreted by the public and that there may even be further risks when compared to conventional food products.

It seems as if the public classifies organic foods as being “pesticide-free”, but that is not the case. The term “organic” allows for an arbitrarily defined set of principles and techniques to implement the use “natural” pesticides and approved chemical pesticides. In other words, although conventional food products implement the use of synthetic chemical pesticides, organic food products also implement the use of pesticides that pose the same health risks because “organic” pesticides do not just disappear(5). Qualitatively, when comparing the toxic effects of synthetic pesticides to organic pesticides, a research has shown that the exposure to synthetic pesticides are negligible when introduced in small doses such as that in the residues of conventional food products and are only significant when exposed in large doses such as to those working in agriculture(3).

Although some experiments and studies have shown that organic foods contain higher levels of antioxidant and metabolites(2), their actual benefits, if there exists any at all, is unknown and required more scientific investigation(5). Moreover, even with higher levels of antioxidant and metabolites, it is important to note that one trade-off with organic food products is that organic food products are more likely subject to contamination than conventional food products from external sources(4,5). How often do you hear stories on social media about a woman finding a spider inside her organic apple or organic food products being recalled due to E. Coli or Salmonella contamination?

Furthermore, organic farming methods are not as beneficial to the economy compared to conventional farming methods. The cost of processing organic food products which includes providing fertility, weed control, pest control, and disease control combined with the overall reduced yield compared to conventional farming methods is neither efficient nor reliable to the agricultural industry(6). This is also evident because if organic farming methods were more reliable and efficient, one would simply observe a massive upscale movement from conventional farming methods to organic farming methods, but that is not the case(5).

chem-300-blog-image

Figure 1: Willingness of Consumers to Pay for Organic Products (1).

In conclusion, organic food products tend to be overrated and do not live up to their standards because of misinterpretations by the public, the potential for increased health risks, and the overall cost-benefit factor in comparison to conventional food products. So next time when shopping, think about whether you really want to pay a few extra dollars for the organic food product- something that is probably only good for bragging to your neighbors about.

Andrew Siu

Chem 300 109

References

  1. Batte, M. et al. Putting their money where their mouths are: Consumer willingness to pay for multi-ingredient, processed organic food product 2007, 2, 145.
  2. Brandt, K., Molgard, J.P. Organic agriculture: does it enhance or reduce the nutritional value of plant foods? 2001, 9, 924.
  3. Holzman, D. PESTICIDES. Organic Food Conclusions Don’t Tell the Whole Story 2012, 12, A458.
  4. Grob, K. et al. Food Contamination with Organic Materials in Perspective: Packing Materials as the Largest and Least Controlled Source? A View Focusing on the European Situation 2007, 1, 529.
  5. Miller, H. The Dirty Truth About ‘Organic’ Produce 2015, 1, 1.
  6. Richards, T. The Economics of the Organic Food Sysytem: Discussion 2011, 2, 322.

Rio’s Emerald Pools: A Scientific Whodunit

This summer, when I tuned in to the Rio de Janeiro Olympic games and saw cloudy green waters in the diving pools, I barely batted an eye. I thought this was merely a media stunt. The Brazilian authorities had harmlessly dyed the waters green because it fit with the country’s theme. They have a green flag, they have incredible natural greenery and so on. I soon learned that this was no dye. The waters had, seemingly spontaneously, turned green overnight.

The games’ organizers pointed the finger at an unnamed stadium worker who apparently poured copious amounts of hydrogen peroxide into the pool. Possibly this was an attempt to “super-sterilize” the pool, akin to using peroxide on a skinned knee? However, like most swimming pools, this one had already been treated with chlorine. More specifically, sodium hypochlorite (NaOCl). When NaOCl is combined with water it forms hypochlorous acid, a potent antimicrobial agent. Adding hydrogen peroxide to the mix would have reacted with the chlorine-containing NaOCl in the pool, producing NaCl, O2 and water. As NaOCl is added to kill microbes such as algae, its absence allowed them to proliferate and fill the pool.

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source: BBC sports

According to a recent article  in the C&En News, this response has been refuted by chemists and biologists alike. It seems impossible (or, in science terms: highly improbable) that the algae could reproduce so quickly to muddy the pool overnight. Some scientists believe it was a chemical reaction resulting from the addition of copper-containing antiseptic chemicals in improper quantities. In the presence of chlorine, copper forms a green complex. This theory even accounts for the smell reported by athletes: hydrogen sulfide, which is a by-product of this reaction.

Solutions

Which solution is THE solution?                                  Image Courtesy: Leiem, Wikimedia Commons

As the Newscripts article reports, we will never know the true solution to this chemistry mystery. All pool water, and potential analytic samples, has long gone down the drain. Nevertheless, chemists will always remember the time when their discipline had its moment in the hot Brazilian sun.

– Megan Wolf

Waste not, want not!

Value Chain Management International published a report stating that food waste costs Canada $31 billion a year. The report found food waste accumulating in restaurants, retail stores, domestic homes, restaurants, hotels, food processing factories, farms, and many more. Unfortunately the report says the amount of food wasted can actually increase the cost of food by 10 percent or more! Peers, I don’t know about you, but as a full time student, passionate eater, and no-time employee, I am not interested in forking up any percent more money to feed my persistent stomach, or else my face will look just like this baby.

uhoh

Image Credits: Elizabeth Delisi elizabethdelisi.blogspot.com

Luckily for us, Huaichen Zhang et al. at the Eindhoven University of Technology in the Netherlands, are developing a possible method to use sugar alcohols to store solar, and wind energy. The study uses naturally occurring xylitol and erythritol (molecular structures shown below). Both of which are often used as natural sweeteners. They investigated nanoscale heat transfer (NHT) across carbon structures dissolved in these compounds. The researchers used several sizes of carbon nanotubes (cylindrical forms of carbon depicted in the image below) submerged in the sugar alcohols, and employed various analytical techniques, and computer simulations, to observe the movements of the molecules and quantify the thermal conductance across them.

Structure of Xylitol. Image Credits: Century Stone Dental http://www.centurystonedental.com/blog/health-benefits-of-xylitol/

Structure of Erythritol. Image Credits: Wikipedia https://en.wikipedia.org/wiki/Erythritol

Structure of Erythritol. Image Credits: Wikipedia https://en.wikipedia.org/wiki/Erythritol

Carbon Nanotube. Image Credits: Gaia Technologies http://www.gaia3d.co.uk/3d-models/3d-chemistry/carbon-nanotube/Nanotube

Carbon Nanotube. Image Credits: Gaia Technologies http://www.gaia3d.co.uk/3d-models/3d-chemistry/carbon-nanotube/Nanotube

Most people are familiar with macroscale heat transfer: conduction, radiation, and convection. NHT on the other hand, is at a much smaller scale; it deals with heat transfer across atoms and molecules, as opposed to larger macroscopic objects. To put it into perspective, nano typically means 1 x 10-9.

NHT can be applied to modern technology. This includes improving the efficiency of energy conversion and storage. Alan McGaughey, a professor at Carnegie University, studies NHT, and thermal conductivity. He shows the importance of understanding heat transfer at the atomic level in order to advance technology and science. For example, further research of NHT could improve the energy conversion of light to electricity in LEDs.

YouTube Preview Image

In conclusion of the Netherlands study, they found that smaller diameters of the nanotubes led to less heat transfer within the mixture. However, higher density combinations of the mixtures led to more heat transfer!

If Zhang, et al. can investigate the use of carbon and sugar alcohols in NHT to improve thermal storage, there may be hope for the food waste problem. The sugars and materials found in food waste could potentially be the key to better thermal energy storage, and therefore it wouldn’t really be considered waste after all!

This research contributes to a stronger understanding of the conductivity of carbon nanotubes, significance of nanoscale heat transfer, possible applications of these understandings, and most importantly brings forward a way to use all of the waste our species is contributing to the world!

Hooray for science!

– Nicole Yipp

References:

  1. Huaichen Zhang, Camilo C. M. Rindt, David M. J. Smeulders, Silvia V. Nedea. Nanoscale Heat Transfer in Carbon Nanotubes – Sugar Alcohol Composite as Heat Storage Materials. The Journal of Physical Chemistry C, 2016; DOI:10.1021/acs.jpcc.6b05466
  1. Luo, T.; Chen, G. Physical Chemistry Chemical Physics 2013, 15 (10), 3389.
  2. Chen, G.; Borca-Tasciuc, D.; Yang, R. G. Encyclopedia of Nanoscience and Nanotechnology 2004, 7, 429–459
  1. American Chemical Society (ACS). “Food waste could store solar, wind energy.” ScienceDaily. www.sciencedaily.com/releases/2016/09/160915133240.htm (accessed October 3, 2016)