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The placebo effect: Its not just ‘in your head’

What if you switched out real medication for a sugar pill? By W. Carter via Wikimedia Commons

Why does the placebo effect work? Photo courtesy of W. Carter via Wikimedia Commons

The placebo effect is an amazing thing. What is going on for patients to feel better when they’ve been given nothing but a sugar pill? Is it ‘all in their heads’ or are there real changes occurring in their bodies? The placebo effect is thought to be somewhat of a sham by many. Has your pain really been treated if you are given a sugar pill you believe to be a pain killer? What if you rate your pain as decreased? Some people would argue no, but lets take a closer look at what that means.

The placebo effect was first described by a Dr. Henry Beecher, who was treating soldiers in the field during World War II. After running out of morphine, Dr. Beecher administered shots of saline solution instead without telling the soldiers. To his surprise, nearly half of them reported their pain had decreased. What he was witnessing was actually what we now call the placebo effect. Even today though, there are still a lot of unknowns surrounding the subject.

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Dr. Henry Beecher. Photo courtesy of Mathew Brady via Wikimedia Commons

One explanation for the placebo effect could be the ‘subject -expectancy effect”. Simply put, you thought the pills would make you feel better, so you felt better after taking them. Another explanation is that those susceptible to the placebo effect have been conditioned to feel better when taking medication. Perhaps these theories do hold some truth but what is really amazing about the placebo effect is that studies have shown actual changes in brain chemistry after a placebo has been taken. Studies have shown that taking a placebo can actually lead to increases in dopamine levels in the brain, acting similarly to how the actual drug should work.

The structure of dopamine, which can increase in your brain after taking a placebo pill. Photo courtesy of Wainscott DB1, Little SP, Yin T, Tu Y, Rocco VP, He JX, Nelson DL.  via Wikimedia Commons

The structure of dopamine, which can increase in your brain after taking a placebo pill. Photo courtesy of Wainscott DB1, Little SP, Yin T, Tu Y, Rocco VP, He JX, Nelson DL. via Wikimedia Commons

Whatever the mechanism behind why the placebo effect works the way it does, if it does improve symptoms, isn’t that enough to label it as ‘real’ or ‘effective’?

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References:

http://www.health.harvard.edu/blog/the-placebo-effect-amazing-and-real-201511028544

http://science.howstuffworks.com/life/inside-the-mind/human-brain/placebo-effect.htm

http://www.brainfacts.org/sensing-thinking-behaving/mood/articles/2012/the-power-of-the-placebo/

Video

When Facebook friends ‘share’ questionable things

Everyone has at least one friend on Facebook who has ‘shared’ something questionable to your News Feed. Sometimes it’s a girl from high school sharing a link about how essential oils are the to cure cancer and sometimes its a distant relative posting an article making outlandish claims about a politician.

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Facebook is often a social media platform where misinformation is easily spread. Image courtesy of Wikimedia Commons.  

What always shocked me was just how little the people posting this content knew about the subject.  Recently, a Facebook friend shared a picture that caught my attention. It showed someone holding up an information sheet about the flu vaccine and it read,


Here are some things in the insert not on the store’s sheet:
1. The single dose vial contains mercury at ≤1mcg (This is called a “trace amount” by the industry.) (The multi-vial contains 25 mcg.)
2. People with egg allergies are contraindicated.
3. “Safety and effectiveness have not been established in pregnant women, nursing mothers and children under four. There are no adequate and well-controlled studies in pregnant women. This vaccine should be used during pregnancy only if clearly needed. It is not known whether fluvarin is excreted in human milk.”
4. “Fluvarin has not been evaluated for carcinogenic or mutagenic potential, or for impairment of fertility.”
5. “Antibody response is low in the geriatric population.”
6. “Serious reactions, including anaphylactic shock, have been observed.”
7. “There are no data to assess the concomitant administration of flu vaccine with other vaccines.”
8. “The vaccine has been associated with an increased frequency of Guillain-Barre syndrome.”
9. “In some studies, fluvarin protected up to 50% of subjects.”

 

Now obviously the woman who originally made this post chose those points because she thought they highlighted some ugly hidden facts about vaccines that “Big Pharma” wouldn’t like people to know. I’m not an expert in vaccines, but a few years of school and the little bit of common sense I have made a few of those points seem ridiculously obvious.

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A commonly discussed topic on Facebook is the efficacy and possible side effects of vaccines, too often without any scientific evidence referenced. Image courtesy of Centers for Disease Control and Prevention.

Unfortunately, many people don’t seem to care to fact check what they share and a lot of misinformation ends up being spread like wildfire. I wanted to see just how easy it would be to find out more about each of the points made in her post. Turns out, it was really easy. Much to my chagrin I must admit, I became a bit of a keyboard warrior.

Now I should point out that this post is by far one of the tamer ones I’ve seen get passed around. No one is claiming that our government is deliberately giving us cancer by infecting our water sources or that global warming is a conspiracy fabricated by the Chinese (yes I’m referring to Drumpf supporters). It’s not even outright stating vaccines are bad. It is however, trying to shine a negative light on vaccines without any scientific research to back it up.

So Facebook friends, PLEASE don’t believe everything you read, and DO fact check before spreading what could be falsehoods. Google is an amazing tool and the world wide web is at your fingertips, so you don’t have any excuses. In the meantime, please feel free to forward this video to any Facebook friends who insist on sharing anti-vaccine posts.

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Primates help advance HIV treatment

Rhesus macaque on which treatment testing was performed. https://www.sciencedaily.com/releases/2016/10/161013141053.htm

Rhesus macaque on which treatment testing was performed.
https://www.sciencedaily.com/releases/2016/10/161013141053.htm

An international research team based out of the German Primate Center has developed an effective treatment regime against the HIV-like Simian Immunodeficiency Virus (SIV) in rhesus macaques.

Human Immunodeficiency Virus (HIV)  affects more than 36 million people worldwide, it is a sexually transmitted disease which infects vital immune response cells, called helper T cells. By invading these cells, the virus forces the body to kill the helper T cells, thus weakening the host immune system. This environment is ideal for life-threatening infections and cancers to thrive in. Once the number of helper T cells in the blood is below a certain threshold, the patient is diagnosed with Acquired Immune Deficiency Syndrome. At this point the body is no longer able to sustain immunity and the patient succumbs to his infections or cancer. The most common cause of death among patients with AIDS is tuberculosis.

T helper cell count as compared to HIV and AIDS progression. https://en.wikipedia.org/wiki/HIV/AIDS

T helper cell count as compared to HIV and AIDS progression.
https://en.wikipedia.org/wiki/HIV/AIDS

 

There is not yet a cure for HIV and AIDS, but a combination of medications are used to fight the HIV infection. Patients are prescribed a regime of six drug classes which prevents the virus from multiplying in the patient’s body, allowing the immune system to recover and protect the patient from infections and cancers. This antiretroviral therapy (ART) controls the virus so that patients can live longer and healthier lives and reduces the risk of transmitting HIV to others.

HIV was originally transmitted as SIV when humans made contact with the blood of chimpanzees while hunting for bushmeat in Africa. In their natural hosts, chimpanzees, SIV is harmless even at high circulating levels, but if a rhesus macaque becomes infected, it will develop SIV, which has nearly identical characteristics as HIV.

In their study, the research team treated SIV-infected rhesus macaques with an antiretroviral drug regime similar to one a human patient would be prescribed if diagnosed with HIV. The macaques were also injected with Vedolizumab, a therapeutic drug used to treat inflammatory bowel diseases in humans such as Crohn’s disease, where the T helper cells also play a vital role.

After finishing the therapy, the macaques had almost no SI virus in their blood and near normal T helper cell levels. Scientists worldwide are testing to see whether a combination of antiretroviral therapy with Vedolizumab would have the same effect in humans infected with HIV.

By pushing the boundaries of effective HIV treatments, some of the adverse effects accompanied by administering continuous antiretroviral drugs such as chronic inflammation and accelerated aging can be reduced or eliminated.

Scarlett Liaifer