Author Archives: Brandon Kato

Binge Drinking in the United States: The Growing Trend of Alcoholic Misuse

St. Patrick’s Day is a holiday most popular for sharing a glass of Guinness with friends. However, it is not commonly known that binge-drinking accounts for more than half of all alcohol related deaths in the United States annually.

Figure 1: Alcoholic beverages Source: Flickr

Binge drinking is defined as consuming more than five drinks in a two-hour span for men and consuming more than four drinks in a two-hour span for women was recently studied by the Center for Disease Control and Prevention. In this study, a drink can consist of a 12-ounce glass of beer, one 5-ounce glass of wine or one shot of hard liquor.

Figure 2: Guideline for what is classified as a “drink” Source: CDC

This study surveyed over 400,000 participants across the United States ages 18 and over about their drinking habits in the past 30 days. Some questions included the number of times participants drank, the amount of alcoholic beverages consumed and the most alcohol they consumed in one outing.

The results showed of the 17.5 billion reported drinks consumed, men were drinking four out of every five beverages. Men were also reported to consume twice the amount of alcohol compared to women.

They also found that adults over the age of 35 were consuming over half of all the reported drinks consumed.

Overall, one in six Americans were reported to have been binge drinking in the thirty day period surveyed. On average, the frequency was at least once a week with seven alcoholic beverages consumed.

It was reported that binge-drinking cost the United States $191 billion in health care expenditures, criminal justice costs and other related costs. With alcohol use disorder (AUD) on the rise each year, as reported by the National Epidemiologic Survey on Alcohol and Related Conditions, it is important to educate the public on the dangers of binge drinking and provide preventative measures through counselling.

As with anything in life, it is all in moderation.

-Brandon Kato

References:

1.http://www.ajpmonline.org/article/S0749-3797(17)30753-5/fulltext

2.https://jamanetwork.com/journals/jamapsychiatry/article-abstract/2647079?redirect=true

3. https://www.flickr.com/photos/pure-water/4236552628/in/photolist-7snruQ-e4ogE1-evWhFU-3gRJMK-68kLtR-grTep-9AF438-96tk3T-8ZEAW2-bo5LMu-8vxWjT-6Rtuu1-5qWhb1-UK6CHN-cHqfS-3PZkcE-8B6jac-sU67sc-8ZHBks-6vR66z-846qe6-9kbKUu-4wBBAW-kSzduM-a8ohb6-5BoCca-976jdc-5LkuxL-4fgkiE-a2TtfQ-788dqm-6cR178-8ZHF7L-6vVhMy-6kQonm-9h5TW3-nvUfYp-46TjW4-dmvwhX-7RzPV-72mANu-a82HkS-6vVhQ3-uTUH-8uWYuC-7WMFRM-aDKEo-5Bua2X-bysKZi-5By5Ro

4.https://www.cdc.gov/alcohol/fact-sheets/moderate-drinking.htm

 

Rise of the Anti-Vaccinations: The European Outbreak of the Measles Virus

With over 20,000 cases and 35 deaths, measles is on the rise again in Europe. Could the “anti-vax” movement be to blame?

Figure 1: Vaccine being drawn into a needle Source: Flickr

According to the World Health Organization’s (WHO) most recent report, after a record low of 5273 cases in 2016, there were four times as many cases of the measles virus in 2017.

Of the 53 countries in the region, 21 had reported large outbreaks. A classification of a large measles outbreak includes over 100 reported cases. Some countries on this list include Germany, Greece and the United Kingdom. The countries that top this list are Romania, Italy and Ukraine, all nearing or over 5000 reported cases.

Figure 1: List of all European countries that have large outbreaks of the measles virus Source: WHO Europe

So how could Europe go from a record low to a four-fold increase in only a year?

The WHO claims that this is because of the decrease in routine vaccinations, interrupted supply of vaccines and underperforming disease surveillance systems.

In the retracted 1998 publication from the Lancet, a medical journal from the United Kingdom, an article stated that there was a correlation between the measles vaccination and autism.

Although this statement was highly discredited, the anti-vaccination (anti-vax) movements in recent years have surged from these false claims. The influence from the opinion of the “anti-vax” movement has led to an overall loss of trust in vaccinations.

Figure 3: Bumper sticker promoting the views of the anti-vax movement Source: Flickr

Some countries, such as Italy, have had government intervention where legislation requires children to get vaccinated if they plan on attending state-run schools.

The French Health Ministry has also promised to enforce mandatory vaccinations for young children by early 2018.

Unsurprisingly, this decrease in vaccinations is the largest risk in spreading the measles. Any individuals unvaccinated, regardless of age, are at risk of catching and spreading the virus to others who are not protected.

For now, the WHO intends to increase vaccination rates in Europe by improving the supply chain of vaccines and informing the public with awareness campaigns.

-Brandon Kato

References:

Europe observes a 4-fold increase in measles cases in 2017 compared to previous year http://www.euro.who.int/en/media-centre/sections/press-releases/2018/europe-observes-a-4-fold-increase-in-measles-cases-in-2017-compared-to-previous-year (accessed Feb 25, 2018).

Wakefield, A. J. The Lancet. 1998351(9103), 637–641.

Italy makes 12 vaccinations compulsory for children http://www.bbc.com/news/world-europe-39983799 (accessed Feb 25, 2018).

8 nouveaux vaccins obligatoires pour les enfants de moins de 2 ans http://www.gouvernement.fr/argumentaire/8-nouveaux-vaccins-obligatoires-pour-les-enfants-de-moins-de-2-ans (accessed Feb 25, 2018).

SAAP-148: Could New Peptide Gel Be Turning Point in the Antibiotics Arms Race?

Drug-resistance in bacteria has become a top threat to global public health. With antibiotic developments becoming slower than the drug-resistance increases in bacteria, will humankind ever gain the advantage?

Figure 1: Timeline of Antibiotic Discovery Dates. As it currently stands, no new discoveries of antibiotics have been made since 1987                                                 Source: Review on Antimicrobial Resistance

Luckily, new research from the Leiden University Medical Center in the Netherlands may bring this war to its much-needed turning point. Researchers successfully created an antibiotic gel containing synthetic anti-microbial and anti-biofilm peptides, SAAP-148. The research proved it was effective against five different antibiotic-resistant bacteria strains.

Published on January 10th in Science Translational Medicine, SAAP-148 gel was first created then tested against the group of antibiotic-resistant ESKAPE pathogens, an acronym for Enterococcus faecium, S aureus, Klebsiella pneumoniae, Acinetobacter baumannii, P aeruginosa, and Enterobacter.

When the SAAP-148 gel was used multiple times for each bacterium, no drug-resistance was developed. Co-author Anna de Breij claims this is because of how fast the peptide kills the bacteria.

SAAP-148 is a modification of the bacteria-fighting peptide LL-37 that is found in the human body.  Researchers discovered its bacteria-killing capabilities better than all other derivatives they made. Compared to the other modifications, SAAP-148 was the most powerful when it was tested in conditions similar to the human body.

This research is deemed important as The Infectious Diseases Society of America stated that antibiotic development is urgently needed for the ESKAPE pathogens. This conclusion is reached because of cases caused by the said strains being frequently reported in healthcare environments.

Since bacteria are becoming more immune to the current antibiotics available, finding new treatment and remedies to this issue is crucial. With these results, there is an opportunity for discovering a new class and generation of antibiotics that can help fight even the most resistant of bacteria.

Researchers are now planning clinical trials for the SAAP-148 gel, hoping to treat patients suffering from skin infections. Along with the researchers, the company Madam Therapeutics is working to create an injectable SAAP-148 formulation to treat bacterial infections inside the body.

-Brandon Kato

Figure 2: World Map of Current Mortality Rates From Antibiotic Resisting Bacteria Source: Review on Antimicrobial Resistance

References:

Breij, A. D.; Riool, M.; Cordfunke, R. A.; Malanovic, N.; Boer, L. D.; Koning, R. I.; Ravensbergen, E.; Franken, M.; Heijde, T. V. D.; Boekema, B. K.; Kwakman, P. H. S.; Kamp, N.; Ghalbzouri, A. E.; Lohner, K.; Zaat, S. A. J.; Drijfhout, J. W.; Nibbering, P. H. Science Translational Medicine 2018, 10 (423).

Boucher, H. W.; Talbot, G. H.; Bradley, J. S.; Edwards, J. E.; Gilbert, D.; Rice, L. B.; Scheld, M.; Spellberg, B.; Bartlett, J. Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America. https://academic.oup.com/cid/article/48/1/1/288096 (accessed Feb 8, 2018).

About IDSA. http://www.idsociety.org/About_IDSA/ (accessed Feb 8, 2018).

Madam Therapeutics. http://www.madam-therapeutics.com/ (accessed Feb 8, 2018).

Infographics. https://amr-review.org/infographics.html (accessed Feb 8, 2018).