Author Archives: priya baichoo

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Is Your Gel Manicure Increasing Your Risk for Cancer?

Not long ago, I was a nail biter. It was a nasty nervous habit: I would do it in class, before a test and when I was bored. This summer I decided that it was actually time to stop and once I grew some semblance of nails I decided to get a gel manicure. Many people prefer gel polish over normal polish because its stronger, shinier and lasts two weeks without chipping. But there may be health risks associated with this polish that consumers are failing to consider.

Gel Nails-Px Here

Conventional nail polish is made of a single polymer, usually nitrocellulose, dissolved in a solvent like ethyl acetate.  When the nail polish is applied, the solvent evaporates, causing the nitrocellulose to form a film on the nail. Gel polish contains a monomer called methacrylate and radical initiators like benzyl peroxide.  Unlike normal polishes, gel polish must be applied and cured with ultraviolet light. The monomers and intiators mix under the UV light, causing the radical initiators gain energy and activate the polymerization process. This polymerization gives gel polish its characteristic hard and shiny look. This processes however, requires up to 8 minutes of exposure to UV rays which leads to the question, can gel manicures cause skin cancer?

Methacrylate-Wikimedia Commons

One study performed by the JAMA Dermatology group in 2014 tackled this question by testing the intensity of different salon UV lamps, evaluating the percentage of UV-A rays emitted. UV-A rays have a wavelength of 320-400nm and penetrates deeper into the skin, causing photoaging and contributing to all forms of skin cancer.The JAMA study randomly sampled seventeen UV-lights from actual salons, which caused them to notice large differences in the immersion of UV light across samples. They concluded that it would only take twelve visits to the salon for DNA damage to occur, increasing one’s risk for skin cancer. For regulars, one could reach this limit in almost 6 months. The study also noted that they standardized their measurements for 8 minutes of exposure per manicure, which may not be the case for many salons where they would rather over cure than under cure. Lastly, UV-A emitted from nail lamps are at least four times stronger than UV-A emitted from the sun which also puts customers more at risk.

Light Spectrum-Wikimedia Commons

In contrast, Paolo Boffetta, the director of cancer prevention at Mount Sinai Hospital in New York stated that being exposed to such a low dose of UV-A for such a short time period, on such a small scale is not something to worry about.  He argued that there is much more risk associated with going outside on a sunny day, especially since gel manicures only expose about 50-60% of the hand. Additionally, those over age 30 are less likely to be affected by the exposure because mitosis is happening less than in adolescence, thereby having less DNA damage accumulating over time.

Whether you believe that this exposure is enough to cause cancer or not, an easy way to protect yourself is to either wear fingerless gloves during the curing process or apply broad spectrum sunscreen. I personally believe that any direct exposure to UV light can put you more at risk for developing skin cancer, no matter how small the amount. Even though gel polish has helped me kick my habit of nail biting, I will definitely be taking a break from it soon!

-Priya

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The Link Between Weight and Puberty

In the 1700’s the average girl got her first period she was 16, 100 years later  girls got their first period at age 14.  Today, most girls start puberty at age 12.5, precocious puberty puts girls at risk for breast cancer, cardiovascular disease and type 2 diabetes later on in life. Additionally, girls who go through puberty earlier are more susceptible to low-self esteem and depression. The timing of puberty is determined by genetics but also mediated by nutritional and metabolic cues. Previous research has pointed to hormones in meat and chemicals in food as endocrine disruptors causing increased levels of estrogen earlier in development.

Estrogen Molecule-Wikimedia Commons

However, this October at Oregon’s Health and Science University, Alejandro Lomniczi explored the link between increased body weight and the early onset of puberty in female rats. The human genome has not changed drastically enough in the past 150 years to cause such a large change in the timing of puberty. Therefore, Lomniczi and his co-workers focused their research on epigenetics, a field of study that explores changes in gene expression rather than changes in the genetic code itself.

Overview of Puberty in Boys and Girls-Wikimedia Commons

In their study they raised overweight, average sized and lean female rats while searching for genes relating to the hypothalamus.  The hypothalamus is found on the lower part of the brain and controls reproductive development and hormone release. Lomniczi found a puberty activating gene within the hypothalamus called Kiss1 that interacts with Sirtuin 1, an enzyme that transmits body weight information to the brain. Sirtuin 1 binds to the promoter of the Kiss1 gene inhibiting transcription and delaying puberty.  In his study, Lomniczi found that overweight rats had less Sirtuin 1 in the hypothalamus which upregulated the Kiss1 gene causing female rats to go through puberty earlier than the lean and average weight rats. Average weight rats had higher levels of Sirtuin 1, delaying the expression of Kiss1 and the onset of puberty.

This epigenetic pathway makes sense evolutionarily, if the body senses extra fat and calories it believes that there is enough nutrient sources to support a baby, triggering reproductive maturation. Consequently, girls who are underweight or even anorexic experience delayed puberty or stop menstruating because of increased levels of Sirtuin 1.

With these established links between weight and precocious puberty the only thing parents can do to prevent this, is ensuring that children are receiving proper nutrition and daily exercise.  Puberty in itself is an emotional time for both boys and girls, going through the process even earlier than their peers can have detrimental effects on on mental health and self-esteem.

-Priya Baichoo

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Using Gut Enzymes to Transform Blood Type

In Canada, the average wait time to receive an organ transplant, like a kidney is almost five years. I have an uncle in Ontario who was diagnosed with kidney disease in 2008 and waited almost 8 years for a kidney transplant.  The delay in this procedure was mainly because he is O type blood, meaning that he could only receive a kidney from donors who also had O type blood. With a lack of organ donors and difficulties in blood type matching the wait for organ transplants could continue to increase.

This year, however, Steven Withers and his research group in the UBC Chemistry department have discovered gut enzymes that can transform any blood type into the universal donor, O type. Scientists have been researching methods to increase the number of blood matches since the 1980’s, especially with the growing population and increased frequency of natural disasters.  Almost half of Canada’s population has O type blood which can be received by all other blood types.  However, O type themselves can only receive blood transfusions from other O types which is exactly where the problem lies.

O Type Blood-Wikimedia Commons

Blood type is determined genetically by antigens, molecules made of protein and  sugars. In the case of blood typing, the antigens are specialized sugar structures attached to the surface of red blood cells. Different blood types have different antigens; for example, those with A type blood have the A type antigens, those with AB blood have both A and B antigens and O type has no antigens. For one to receive a blood transfusion, the blood type of the donor must match that of the acceptor or be O type.

ABO Blood Type-Wikimedia Commons

If the blood type does not match, the body’s immune system will fail to recognize the foreign antigens and attack the newly transfused blood cells which can be a life-threatening response. In emergencies, there is often not enough time to perform a blood test, therefore giving a patient O type blood is the safest and fastest method increasing the overall demand of O type. Converting any type of blood into O type is the key to saving more lives by making transfusions more accessible.

Withers strategy in transforming blood types to O type, was to find enzymes that consumed or cleaved sugars that were similar to the antigens present on red blood cells. To accomplish this he used metagenomics, a type of genetic analysis that samples DNA from millions of microorganisms finding similar environments to the desired enzyme. Withers eventually found enzymes housed in the mucosal lining of the gut that cleaved sugars similar to blood antigens. He cloned these enzymes assessing their efficiency and functionality on actual red blood cells, concluding that they were able to remove all antigens from the surface of the blood cells.

Previously, Withers and his research group isolated different enzymes that seemed to cleave the same sugars, but they were inefficient and inconsistent. Withers is now moving forward with the enzymes applying for patents and hopefully proceeding to clinical trials in the near future, they “hope that one day [they] can eventually render any type of donated blood, tissues or organs, safe for use by anyone regardless of their native blood type.”

While I  believe that this type of research is important, I also think a larger problem lies in the lack of people actually donating blood. In the United States alone, almost 38% of the population is eligible to give blood, but only about 10%  donate on a regular basis. In addition to Withers enzyme, more of the population needs to be aware of the importance of donating blood which I believe would increase the amount of overall donations a year.

-Priya Baichoo