Author Archives: Sahil Kanani

Why Graphene hasn’t Taken Over the World… Yet

Fourteen years ago, Nobel prize winners Andre Geim and Konstantin Novoselov created one of the strongest materials in the world using just some graphite and scotch tape. Graphene is one of the thinnest materials ever made, but is still hundreds of times stronger than steel. It is as pliable as rubber and an excellent electrical conductor. When news about graphene first came out, scientists proposed myriad uses of the material from creating electronics to developing new water purification technologies. But graphene hasn’t lived up to the hype it initially created. This raises an important question: Why is graphene not ubiquitous in today’s world?

A visual representation of the structure of graphene. Image Source: SketchPort by User magicalhobo (2014)

Graphene has a unique structure that gives it many desirable characteristics. It is composed of only a single layer of carbon atoms arranged in interlocking hexagons, much like chicken wire. Scientists from Northwestern University have exploited this property in an atypical application – Using graphene as a hair dye alternative. Graphene is mixed with chitosan, a sugar from crustacean shells, and applied onto the hair. Graphene wraps around the hair follicles and the chitosan glues it into place, allowing the dye to stay on even after 30 washes. The findings are significant because the treatment does not cause any hair damage, unlike typical hair dyes which use chemical reactions to change hair colour.

A vintage advertisement for a chemical hair dye proclaiming to preserve natural hair colour. Image Source: Flickr by User Classic Film (2015)

In a more radical application, graphene could be used to make artificial heart valves. Heart valves are attractive sites for clot formation after surgery. These clots can block blood vessels, eventually resulting in death. Patients thus need to take anticoagulant drugs for life to prevent such clots from forming. Instead, scientists from two U.S. universities suggest coating the heart valve itself with a catalyst that produces the needed anticoagulant. Graphene could be used as a durable scaffold for this catalyst, eliminating the need for a lifetime course of medication.

Visual representation of a blood clot. The thrombus/blood clot obstructs the flow of blood through the vessel. Image Source: Wikipedia by User Persian Poet Gal (2006)

However, graphene yet has to overcome many obstacles before it can be put to practical use. The biggest hurdle remains how we make graphene on a large scale. It is difficult to control the structure of graphene when it is manufactured as large sheets. This problem arises from the structure of the material itself – Because graphene is very thin, it is difficult to handle in large volumes. Even if this problem is solved, we must consider the overall cost of producing graphene. At present, graphene production requires the use of extreme reaction conditions such as high temperatures and low vacuum environments. Graphene is simply not cost effective for its proposed uses.

In the long run, it is also important to consider some of the health and environmental concerns of using graphene. These influences are difficult to predict for a material that is only starting to come into use, but several studies have already begun to focus on the potential toxicity of graphene. A study published in 2016 revealed that inhaling high doses of graphene oxide could result in lung damage in humans. The findings are particularly significant when considering the applications of graphene in products such as hair dyes. Accidentally inhaling or ingesting a hair dye could result in significant health concerns. It is then also important to investigate the effects of graphene on other flora and fauna. The results from such studies could influence how we dispose of graphene in the environment.

From my viewpoint, these predicaments are not unusual for many innovative technologies. The process of translating scientific discoveries from the lab bench-top into a commercially viable product is often difficult and suffers from a significant lag time. While it would be nice for these potential applications to materialize, we should act in a prudent manner. The long-term impacts of graphene on human health and the environment are important to consider before we start to use graphene more widely. My two cents would be to consider the problem one layer at a time.

Meat-ing a Rising Global Demand for Food

If the 20 largest meat and dairy companies in the world were a single country, they would have overtaken Germany to become Europe’s largest polluter in 2016 (GRAIN & IATP, 2018).

This statement probably makes you sad. But you’ll also get over it in the next few minutes because meat is tasty, and nothing else can fill its void in your life. Despite the damaging impacts of industrial livestock farming on the environment, the demand for farmed meat is unlikely to change without any effective meat substitutes.

But this reality is being challenged by a San Francisco-based start-up, JUST For All, developing lab-grown meat products. The movement is inspired by solving two of the meat industry’s biggest problems: the unethical treatment of animals and the poor efficiency of meat production.

The world’s first lab-cultured hamburger unveiled in 2013. Image Source: World Economic Forum – The Meat Revolution by Mark Post

The idea involves harvesting muscle tissue from an animal, followed by isolating special satellite cells from the sample. These cells can become skeletal muscle cells and so are allowed to multiply under controlled lab conditions. The cells eventually clump up into muscle fibers which can be processed into meat:

An overview of the process of producing meat in the lab – Figure by Brad Wierbowski (Image Source) (accessed 22nd October, 2018)

Raising animals for food requires many resources such as water, feed, and energy for animal upkeep. But you might think the same is true for many other industries in today’s age. The claim is justified, but the main problem concerns the resource efficiency of meat production i.e., how much meat we produce relative to the number of resources we invest.

The graph below is an example of the resource efficiency of animal feed in producing meat and dairy products. The efficiency is expressed as the percentage of energy in animal feed actually incorporated into an animal product. The energy conversion efficiency of most meat products is below 15%, with beef ranking last at 1.9%. This means that about 98% of the energy in the feed a cow eats is wasted. 

Graph illustrating percentage of energy in animal feed incorporated into final animal product. Figure by Sahil Kanani. Data Source: (Alexander et al., 2016)

I was personally skeptical about the notion of growing meat in a petri dish, but the benefits are significant. Most of the energy consumed by an animal is either wasted as heat or used in other metabolic processes asides from muscle production. Cell cultures eliminate most of these side processes, making more energy available for muscle fiber growth.

Furthermore, only a single sample of tissue needs to be harvested to make a large amount of meat: about 80,000 quarter-pounders according to start-up company Mosa Meat. Lab-grown meat effectively removes the need to raise animals from birth to harvest, reducing how much water and energy we use for meat production. 

But the road to cleaner meat is also not so straightforward. The lab-grown meat industry still needs to convince people that their products are safe to consume. Several start-ups have recently faced resistance from the US Cattlemen’s Association (USCA) who filed a petition on how lab-grown meat should be marketed. The lobby group has demanded that the term ‘meat’ only include products derived from raising or slaughtering animals. From my analysis, the petition aims to deter consumers from purchasing lab-grown meat due to the negative preconceptions associated with ‘artificially’ produced foods.

Overall, for clean meat to be well-assimilated, the industry must do a good job of educating the public about the safety of their products and highlighting the need for a more environmental-friendly meat substitute.

Is it also far too late in this blog to declare i’m vegetarian?

The Bowel Movement: A Revolution in Treating Gut Disease

If you have ever suffered from an upset stomach, your doctor might have prescribed you an antibiotic to help you feel better. But repeatedly using antibiotics can make us more susceptible to severe forms of disease that antibiotics cannot treat. One such disease is caused by the bacterium Clostridium difficile and is characterized by symptoms ranging from mild diarrhea to rupturing of the bowel in extreme cases. Luckily, the future for treating such conditions doesn’t seem to be a complete stink as scientists believe we might be able to use our own poop to combat diseases of the gut.

Clostridium difficile bacteria are tiny inhabitants of your gut wall. They are about a million times smaller than a baseball bat and can only be seen with a microscope. (Image Source)

Your own poop? Yes. Call it a trans-poo-sion to appear cool and hip like today’s millennials.

A study published in March 2015, by scientists from Italian universities, has shown that fecal transplants are more effective in treating diarrhea caused by Clostridium difficile than one of humankind’s most powerful antibiotics. The findings come at an important time when newly emerging strains of antibiotic-resistant bacteria pose a huge risk for human health and health-related government expenditure.

The problem with overusing antibiotics is that they negatively impact the community of micro-organisms living in your gut, collectively known as the microbiome. The microbiome is important in digesting our food, but is also part of the disease-fighting immune system. Common thought has made us believe that removing bugs from our bodies can help us improve our health, but removing some of these competitors may allow for more dangerous strains of bacteria such as C. difficile to flourish.

There are more than 10 times as many microbes inside and on our bodies than there are human cells – The gut microbe community is one of the most complex. (Image Source)

Fecal transplants could be used to restore a damaged microbiome and allow the body to fight off an infection. While I was initially skeptical about the idea, it now seems reasonable – If a damaged microbiome promotes disease, then why not replace the microbiome itself? According to the scientists, infusing a patient with feces from a healthy donor can help replenish useful communities of microorganisms that may have previously been wiped out by an antibiotic.

In their study, the scientists administered either a treatment of vancomycin, a powerful antibiotic, or a fecal transplant to 39 patients suffering from recurring C. difficile infections. The results were astounding: a whopping 90% of patients treated by fecal transplants recovered from the infection, compared to only 26% of the patients who received an antibiotic. 

The promise of fecal transplants for treating gut diseases has had far-reaching effects, with companies investigating ways of making the treatment more accessible. OpenBiome, a non-profit company based in Boston, currently freezes poop samples to a low enough temperature to be packed into ready-to-take capsules. However unconventional, I believe that re-defining traditional pharmaceuticals is important in the odyssey of treating disease – As disease-causing organisms become smarter and more powerful, our treatments need to become more sustainable asides from being just effective. 

In opposition, skeptics argue that the long-term safety issues of using feces to treat disease are still unknown. But with all new treatments comes a probation period to unravel some of its problems. At present, the case for poop transplants seems more substantiated than the case against.

In this spirit, it might be a good idea to start thinking about saving your poop for a rainy day.