Category Archives: Synthesis

Human Augmentation: Salvation or Destruction?

With the emergence of technologies such as gene therapy, neural implants and brain-computer interfaces; one can only imagine, how far can we push the human body?

DNA. Courtesy of Wikimedia Commons

According to a report done by The National Intelligence Council, exoskeletons offer improved functionality over human limbs; allowing workers to carry increased loads without physical burden. Future neural implants could possibly link human brains to computers leading to enhanced “superhuman” abilities (think permanent photographic memory!)

However, not everyone believes in augmentation…

A movement called Bioconservatism challenges the idea of radical technological advancement in the basis that it destroys human dignity. According to them, should these augmentations come to fruition, they bring a problem that could change human society forever. This quote shows a Bioconservative sharing his testimony:

“It undermines our self – conception as free, thoughtful, responsible beings, worthy of respect because we alone among the animals have minds and hearts that aim far higher than the mere perpetuation of our genes.” – Leon Kass

Anti-Transhumanism. Courtesy of Wikimedia Commons

The National Intelligence Council predicts that only the rich could purchase these augmentations due to their enormous costs. Which may create a divide between enhanced and non-enhanced individuals leading to a two-tiered society.

In fact, our daily lives would definitely change! Individuals with hearing or sight augmentations could invade our privacy and use our information for their own benefit. I guess annoying phone calls from telemarketers would stop (that’s great!), but instead they could just access your mind! (not so great!)

Our current technology prevents us from venturing further into human augmentation, as it cannot support these futuristic designs. For example, the battery life in exoskeletons doesn’t last long enough for practical use in work settings. Not to mention, malicious individuals could easily hack augmentations as this technology still remains in its infancy stage.

US Army Exoskeleton Prototype. Courtesy of Wikimedia Commons

While Bioconservatives disapprove of human augmentation, another movement called Transhumanism supports the change and believes that humans can evolve beyond our current physical and scientific limitations. A quote from a famous body artist states his opinion:

“The question is not whether a society will allow freedom to express yourself, but whether the human species will allow you to break the bonds of your genetic parameters” – Stelarc

Beyond philosophical ideas, the military sees human augmentation as the future of warfare. Researchers seek to develop retinal implants that offer night vision, neural implants that give improved cognitive ability (such as increased concentration) and augmented reality devices that enhance situational awareness of soldiers in battle.

In the future, we might see a real life Captain America or even an actual Terminator! (Excited?… maybe not)

In this day and age, if someone wants to change their physical appearance, services such as plastic surgery already exist. In my opinion, the individual should have the choice if they want to augment themselves.

I wouldn’t mind getting a bionic arm actually…

 

Why Graphene hasn’t Taken Over the World… Yet

Fourteen years ago, Nobel prize winners Andre Geim and Konstantin Novoselov created one of the strongest materials in the world using just some graphite and scotch tape. Graphene is one of the thinnest materials ever made, but is still hundreds of times stronger than steel. It is as pliable as rubber and an excellent electrical conductor. When news about graphene first came out, scientists proposed myriad uses of the material from creating electronics to developing new water purification technologies. But graphene hasn’t lived up to the hype it initially created. This raises an important question: Why is graphene not ubiquitous in today’s world?

A visual representation of the structure of graphene. Image Source: SketchPort by User magicalhobo (2014)

Graphene has a unique structure that gives it many desirable characteristics. It is composed of only a single layer of carbon atoms arranged in interlocking hexagons, much like chicken wire. Scientists from Northwestern University have exploited this property in an atypical application – Using graphene as a hair dye alternative. Graphene is mixed with chitosan, a sugar from crustacean shells, and applied onto the hair. Graphene wraps around the hair follicles and the chitosan glues it into place, allowing the dye to stay on even after 30 washes. The findings are significant because the treatment does not cause any hair damage, unlike typical hair dyes which use chemical reactions to change hair colour.

A vintage advertisement for a chemical hair dye proclaiming to preserve natural hair colour. Image Source: Flickr by User Classic Film (2015)

In a more radical application, graphene could be used to make artificial heart valves. Heart valves are attractive sites for clot formation after surgery. These clots can block blood vessels, eventually resulting in death. Patients thus need to take anticoagulant drugs for life to prevent such clots from forming. Instead, scientists from two U.S. universities suggest coating the heart valve itself with a catalyst that produces the needed anticoagulant. Graphene could be used as a durable scaffold for this catalyst, eliminating the need for a lifetime course of medication.

Visual representation of a blood clot. The thrombus/blood clot obstructs the flow of blood through the vessel. Image Source: Wikipedia by User Persian Poet Gal (2006)

However, graphene yet has to overcome many obstacles before it can be put to practical use. The biggest hurdle remains how we make graphene on a large scale. It is difficult to control the structure of graphene when it is manufactured as large sheets. This problem arises from the structure of the material itself – Because graphene is very thin, it is difficult to handle in large volumes. Even if this problem is solved, we must consider the overall cost of producing graphene. At present, graphene production requires the use of extreme reaction conditions such as high temperatures and low vacuum environments. Graphene is simply not cost effective for its proposed uses.

In the long run, it is also important to consider some of the health and environmental concerns of using graphene. These influences are difficult to predict for a material that is only starting to come into use, but several studies have already begun to focus on the potential toxicity of graphene. A study published in 2016 revealed that inhaling high doses of graphene oxide could result in lung damage in humans. The findings are particularly significant when considering the applications of graphene in products such as hair dyes. Accidentally inhaling or ingesting a hair dye could result in significant health concerns. It is then also important to investigate the effects of graphene on other flora and fauna. The results from such studies could influence how we dispose of graphene in the environment.

From my viewpoint, these predicaments are not unusual for many innovative technologies. The process of translating scientific discoveries from the lab bench-top into a commercially viable product is often difficult and suffers from a significant lag time. While it would be nice for these potential applications to materialize, we should act in a prudent manner. The long-term impacts of graphene on human health and the environment are important to consider before we start to use graphene more widely. My two cents would be to consider the problem one layer at a time.

Can We Manufacture “Magic” Rice to Treat HIV at Low Cost?

It appears that we can finally provide cheaper methods of HIV treatment to benefit patients in developing countries, where it is most needed. But is the world ready to accept this magic treatment?

In Rice Field – Photo by zcf428526 on Pixabay

In a study published on July 2018, Dr. Vamvaka and her team of scientists from various countries concluded that using rice grains to produce HIV-neutralizing agents is possible, at a cost much lower than current manufacturing methods allow.

Current methods use mammalian or microbial cells to produce proteins against the virus, however “these are expensive because the products must be extensively purified”, as the study points out. Additionally, the manufacturers must make several different proteins, to ensure treatment even if the virus mutates.

Plants seemingly offer a novel alternative. Cereal grains allow multiple proteins to be produced on the same grain and are safe to use as crude extract without extensive purification.

Sounds easy enough. But does it really work? The answer is yes.

After the study, researchers found that they could yield enough modified grains. The extracts from these grains also successfully neutralized the virus even at very low concentrations.

So, in theory, rice could be our new savior against a deadly virus. The researchers certainly think so. “This groundbreaking strategy is realistically the only way that microbicidal cocktails can be manufactured at a cost low enough for the developing world, where HIV prophylaxis is most in demand.”

But…

This is where things take a turn. Can we really propose that the world should suddenly rely on genetically modified organisms for treatments? As in the widely feared GMOs?

It won’t be easy.

March Against Monsanto Vancouver- by Rosalee Yagihara in Flickr. Monsanto, a company known for manufacturing GMO seeds, received a lot of backlash.

Let’s look at the results of a survey about the public opinion towards GMO’s.  CBC News states that in 2016, 62% of the respondents would prefer non-modified food. Why? Because they believe it is safer.

Forget about surveys. In Turkey, we have TV programs where people show up to claim any genetic process means playing God and is against religion. So, let me ask a simple question. If my country is like that, what is the possibility that other countries share similar opinions? I say it is very possible.

What is one glimmer of hope? The treatment from rice would be produced as medicine rather than a food item. People seem to be more accepting of modifications when the product is a drug.

In essence, yes, scientifically this is the most feasible method that is out there so far. Can we have people accept this treatment? It surely will be a struggle.

Nevertheless, it is a significant step towards combating HIV in the developing world, and I hope that we soon see the treatment in clinical trials.

Automated Chemical Synthesis Machine: Reaction Optimization Has Never Been Easier!

Researchers in Massachusetts Institute of technology have developed an automated machine that can perform several chemical reactions in a short time to determine the most efficient route for synthesizing complex organic molecules such as various drugs and artificially synthesized natural products such as proteins and vitamins.

Researchers in the field of organic synthesis, spend weeks or months trying to come up with a synthetic route for a new complex organic molecule such as a new drug. These routes often are not efficient, so they spend even more time, trying to optimize the route so that the target molecule can be synthesized with high yields in large scales in industry. This new system can test and optimize a new synthetic route in about a day.

Synthesis of useful but complex organic molecules is a time-consuming process. Image from Pixabay

According to Timothy F. Jamison, head of MIT’s Department of Chemistry, in an interview with MIT News“our goal was to create an easy to use system that would allow scientist to come up with the best conditions for making their molecules of interest”. This would allow chemists to have more time to come up with new ideas that can be easily and efficiently tested.

This machine uses a continuous flow systemco-designed by Jamison a few years ago. In this system, chemical reagents flow through a series of tubes and at different points, new chemicals are added to the reaction. So, the machine performs a multi-step synthetic process continuously without the need to manually transfer the products of a reaction to be used as the starting materials of the next reaction.

So, the chemist comes up with a new synthetic route for a desired molecule and programs the machine with the reaction conditions. Then the machine uses an optimization program to explore different conditions and determines the reaction conditions that result in the highest yield.

This new system can test and improve a synthetic route for a complex organic molecule like a pharmaceutical in a day. Image from shutterstock

In my opinion, innovations like this can easily and rapidly improve synthetic organic chemistry so many useful natural organic molecules can be efficiently synthetized in industry. This means more reasonable prices for many drugs and important supplements.

The researchers have patented this new technology and published the results of the research as a journal article in Science.

 

Can We Manufacture “Magic” Rice to Treat HIV at Low Cost?

It appears that we can finally provide cheaper methods of HIV treatment to benefit the patients on developing countries, where it is most needed.

In Rice Field: Photo by zcf428526 on Pixabay

In a study published on July 2018, Dr. Vamvaka and her team of scientists from various countries concluded that using rice grains to produce HIV-neutralizing agents is possible, at a cost much lower than current manufacturing methods allow.

The existing methods rely on mammalian or microbial cell systems to produce proteins against HIV, however “these are expensive because the products must be extensively purified”, as the study points out. Additionally, the manufacturers must make several different proteins, to ensure treatment even if the virus mutates.

Plants offer a novel alternative. Cereal grains allow multiple proteins to be produced on the same grain and are safe to use as crude extract without thorough purification methods.

To create the anti-HIV rice grains, the researchers used genetic information for three different commonly prescribed anti-HIV agents, GRFT, 2G12 and CV-N, to implant into the rice tissue. The resulting rice were then tested by ELISA assay, using HIV-1 pseudoviruses to analyze inhibitor binding activity. While they were able to produce feasible amount of successfully transformed grains, the extract of rice grown with transformed seeds showed sufficient anti-HIV activity.

When tested for any interactions in between, the three reagents extracted from rice didn’t show any adversity. Instead, they complemented each other such that small concentrations of GRFT neutralized more HIV-binding sites.

Neutralization of GRFT in different combinations of anti-HIV proteins in rice. Figure by Vamvaka et. al. in PNAS

The research team believes that anti-HIV rice is the main method that should be employed to combat HIV in the developing world: “This groundbreaking strategy is realistically the only way that microbicidal cocktails can be manufactured at a cost low enough for the developing world, where HIV prophylaxis is most in demand.”

With such a promising development, it appears that we will soon be able to grow HIV-fighting rice to help HIV patients all over the world.