Why Your Body Didn’t Fight that Cold

Have you ever found yourself sitting a little too close to a sniffling and sneezing stranger, and wondered if they’re contagiously sick or suffering due to allergies?

Fortunately, recent research supports that someone can be exposed to the common cold, and not get sick. This happens when your respiratory system is “free” to react to the germs in the air before they make you sick, and not fighting other stress from the environment.

Disease Transmission Through Sneezing - Photo from Wikimedia Commons

Disease Transmission Through Sneezing – Photo from Wikimedia Commons

Millions of common colds per year are caused by the rhinovirus. According to researchers, 2 million cases develop into respiratory illness, leading to hospitalization. In a recently published study in Cell Reports, Ellen F. Foxman and her team of scientists used two different airway epithelial cells between the nose and the lungs, nasal and lung cells respectively, to observe their responses to rhinovirus exposure and oxidative stress exposure.

Human Rhinovirus – photo from Flickr

Human Rhinovirus – Photo from Flickr

The outer layer cells of the airway normally provides the body protection from detrimental substances in the air. The study focused on the protective response of these cells further and found that exposure to oxidative stress increases the cell susceptibility to rhinovirus infection. This balance describes the natural compromise between taking viral versus oxidative airway damage. Furthermore, the study singled out smokers as the patient group most susceptible to rhinovirus infection, as smoking causes oxidative stress.

The researchers look forward to finding ways to protect against oxidative stress to better defend against rhinovirus infection.

While the common cold doesn’t sound dangerous, getting sick can lead to complications. These complications add to my long list of reasons to not smoke.

-Alyssa

Chinese Herbs: Are They Effective in Treating Cancers and Type II Diabetes?

The short answer, is no.

There is no evidence that Traditional Chinese medicine (TCM) treats individuals with cancer and diabetes alone. However, studies have shown that when integrated with current treatments, herbal medicine therapy in fact increases the survival rates of patients.

Chinese Medicine Shop by Bomb Bao. Flikr Image.

In a 2014 study led by Dr. Lee, roughly 700 individuals diagnosed with stage 4 metastatic breast cancer participated between 2001-2010.  Significant results over the 10-year period proved that supplementary TCM therapy helped to improve the survival rate of breast cancer patients as lower death rates of 12% were observed.

Chinese herbal medicines such as Pu Gong Ying and Ban Zhi Lian were prescribed as supplements to Taxane, a class of drugs used for breast cancer treatment.  These herbs were experimentally found to prevent uncontrolled cell growth and increase frequencies of tumour cell-mediated apoptosis that would otherwise lead to tumour formation and cancer.

Dr. Lee’s study also indicated that among the TCMs used, some assisted to diminish side-effects from breast cancer treatments.

Another study in 2016 investigated if Chinese medicine therapy reduced complications caused by Type II diabetes.  The researchers found that although patients who took antidiabetic medicines such as metformin and insulin did not lower their dosage intakes after introducing TCM treatments, their risk of vascular side-effects greatly improved.  But just how great?

Insulin by 2C2KPhotography. Flikr Image.

An astonishing 33% decrease in risk of stroke was observed in Type II diabetic individuals who regularly used Chinese medicinal herbs.  The study was conducted between 2000 and 2011, during which the most common herbs prescribed to Type II diabetic individuals were danshen and da huang.

Dan shen, also known as red sage, is extensively popular in Asian countries such as Taiwan as a traditional Chinese herb.  Not only is it known to reduce risks of hypertension, a long-term condition of high blood pressure, but it also promotes better blood flow.  Together, this significantly helps in decreasing the chances of stroke in diabetic individuals.

So red sage won’t help us fight diabetes, but it certainly helps to prevent cardiovascular diseases that are associated with it.  For a perfectly healthy individual, traditional Chinese medicine is probably a great supplement to take – that is, if you’re willing to tolerate the medicine’s bitter taste.

Is BPA-Free Safe for Me?

I often find myself gravitating towards products that have labels such as “organic”, “cruelty-free”, “free-range”, etc. stuck to their packaging. It’s comforting to know I am opting for a product that is beneficial to either my health, the environment, or both. That’s why when I’m faced with the option to purchase a water bottle that is BPA-free, versus one that is not, 10 times out of 10 I buy the former. For years now I believed this choice was protecting me from the harmful effects of bisphenol A, a chemical known to disrupt reproduction in mice. Much to my surprise, this belief was shattered by a recent article in Current Biology that revealed that the replacement bisphenols are potentially just as harmful.

BPA-free plastic water bottles – photo from Pixabay

Patricia Hunt, a biologist at Washington State University who first discovered the damaging effects of BPA 20 years ago, has uncovered data that mirrors those findings. This new study shows that BPS, a replacement bisphenol, is causing abnormalities in the eggs and sperm of mice. Essentially, BPA-free plastics could still be causing the same adverse effects in humans that led us to ban BPA so many years ago.

The findings were uncovered much in the same way as the BPA discovery decades ago. While conducting unrelated research, Hunt noticed changes in the data collected from her lab mice. Specifically, she found abnormalities in their eggs and low sperm counts. “Given our previous experience with BPA leaching from polycarbonate cages and water bottles,” states Hunt, “damaged materials were an obvious suspect”.

Upon analysis of the plastic cages that the mice were being kept in, Hunt and her team discovered that the inner surfaces to which the mice were being exposed had traces of BPS. The compound, which has replaced BPA in many household items, was being released from the plastic from everyday wear and tear. Notice the similarities between the two chemicals in the images below.

Chemical structure of BPA – photo from Wikimedia Commons

Chemical structure of BPS – photo from Wikimedia Commons

To further investigate the issue, Hunt designed experimental studies in which mice were exposed to several replacement bisphenols. The effects were observed by looking at the number of DNA points where chromosomes had been reshuffled, known as MLH1 foci. This data was telling as MLH1 foci is indicative of the degree of abnormality. Females who were found to have high numbers of MLH1 foci were producing abnormal eggs. On the other hand, males who had low numbers experienced an increase in cell death during sperm creation.

The thought that plastic, a material that we use daily, could be affecting our reproductive health is extremely concerning. The results from Hunt’s most recent studies are remarkably similar to those seen years ago with BPA and raise the question if bisphenols as a class should be eliminated. I hope an alternative replacement in plastics will soon be discovered so that we can still enjoy the diverse benefits of this material.

Trimming the Fat: Is the Canadian Ban on Trans Fats Justified?

Canadian Minister of Health, Genitte Petitpas Taylor, announced one year ago that Canada would be banning the addition of trans fats in food, and that ban came in effect today. Officials predicted the ban would prevent 12000 deaths from heart disease over the next 20 years.

Heart disease is no laughing matter. According to the Canadian Ministry of Health, “About 1 in 12 (or 2.4 million) Canadian adults age 20 and over live with diagnosed heart disease” and “Every hour, about 12 Canadian adults age 20 and over with diagnosed heart disease die”. So, what can we do to beat heart disease? Exercising, drinking and smoking in moderation, and eating a healthy diet are what any doctor will suggest. When it comes to eating a healthy diet, trans fats are public enemy number 1, but why is that?

Heart plaque – Courtesy Wikipedia Commons

Trans fats contain cholesterol that is carried in the body by proteins. The most common are low-density lipoprotein (LDL) and high-density lipoprotein (HDL). These two lipoproteins bind to cholesterol to make it soluble in water so that it can move around our body. Unfortunately, LDL is also responsible for the plaques in our heart and arteries that contribute to heart disease. Knowing this, it’s a no-brainer to reduce the amount of LDL cholesterol we eat. Trans fats have a high proportion of LDL to HDL cholesterol relative to other fats, so avoiding them is the obvious choice. If you’re worried that your favourite treats will soon be off the shelf, there’s no need to worry.

Krispy Kreme Bacon Cheddar Cheeseburger – Courtesy Clay Caviness of Flicker

Canada has joined a global initiative to reduce trans fats in food, alongside the United States of America and the European Union, and we’re a little late to the party. While our heel-dragging isn’t great for our health, we can at least rest easy knowing that food manufacturers in the USA and the EU have already had time to remove trans fats from their products, so we can keep buying them in Canada without interruption. While some alternatives to trans fats are a little more expensive, we can at least pay with our wallets rather than our health. I’ll raise a doughnut to that.

Antioxidants for Post-Workout Recovery: Do They Actually Work?

If you’re anything like me, you genuinely enjoy exercise but loathe the aftermath, and by aftermath, I mean soreness. Luckily, there are post-workout supplements to the rescue, right? Wrong. There is research on how antioxidant supplements that claim speedy muscle recovery and pain relief aren’t really beneficial for athletes, at all. As your average gym-enthusiast, this was a surprise to me as well. I paid good money for my antioxidant supplements, so why aren’t they working? Let’s break it down.

Intense exercise can induce oxidative stress, a condition that over-produces reactive and damaging chemicals in the body while the defensive line of natural antioxidants decrease. Additionally, delayed onset muscle soreness (DOMS) kicks in due to the inflammation of overworked muscles. So, it only makes sense that you would need to simply replenish your antioxidant levels, right?

Delayed Onset Muscle Soreness (aka DOMS)” by Zouhir Kharmaz. Image from Flickr.

 

Well, an interesting study published in The Cochrane Database of Systematic Reviews (CDSR) in 2017 offered insight on how athletes intaking more antioxidants than the daily required amount isn’t necessarily beneficial for speedy recovery or pain relief after strenuous exercise.

Experimental evidence revealed that only a select few athletes felt a slight reduction of muscle soreness upon higher doses of antioxidants. Because of such small numbers, this result unlikely equates to a meaningful difference.

The team compiled 50 similar experiments where athletes exposed to varying types of exercises resulting in muscle soreness were given either a placebo pill

“Antioxidant Supplements” by Mambo. Image from Flickr.

with no antioxidants, or an antioxidant supplement that contained a dosage higher than the daily recommended amount. Muscle soreness levels after 6, 24, 48, 72 and 96 hours, recovery and adverse effects were accessed.

Many scientists remain skeptical on the advantages as there are also reports discussing similar disappointing experimental results that leave room for uncertainty.  

So, does this mean that antioxidant supplements are useless? In this context, perhaps. The daily recommended amount of antioxidants is obtainable through a healthy, balanced diet, which will aid in post-workout recovery the same way as supplements intend to do, and for only a fraction of the cost. Personally, if my expensive post-workout supplements aren’t working miracles on my muscle soreness, I believe it’s time to switch to the healthy, cheaper alternative.

It’s easy to be swayed by cool labels, isn’t it?

Antioxidants” by Epickidstoys Smith. Image from Flickr.

 

  • Sonia Sharma

 

What type of exercises should I be doing to prevent Diabetes?

I frequently wonder about what type of exercise I should be doing to benefit my health, whether I should be doing cardio, strength training, or a combination of both. I am mainly concerned with my blood sugar levels. I have a family history of diabetes, so it is important for me to know how I can prevent myself from developing it. I have tried various exercises and felt an increase in my metabolism. However, I want to know which type of exercise can optimize my health by preventing diabetes.

Luckily, researchers from the University of Copenhagen are one step closer to understanding how different types of exercise affect our health by studying different hormones. In their article published in August 2018 in the JCI Insight Journal, they studied the endocrine hormone, FGF21, bile acids (BAs), and the growth hormone, FGF19, and discovered surprising effects of cardio and strength exercises on the production of FGF21.

Diabetes is a condition with abnormally high levels of blood sugar. Complications of diabetes can effect vision, kidney function, and nerve function. Many hormones are involved in the regulation of blood sugar, including FGF21 which is produced by the liver. It plays an important role in the endocrine system, mediating sugar intake. It could potentially be a future treatment against diabetes and obesity.

The research group studied the effects of cardio and strength exercises on ten healthy men. They were randomly divided into two groups and were asked to do either cardio or strength exercises for one hour once a week. They tested hormones at various times before and after exercise. They found that cardio exercises produced far more FGF21 than strength exercises, which showed no significant change in the production of FGF21.

Hiking
By: Cristopher Hinagpis

Seeing how different types of exercise affected the body was interesting. This research excited me because it showed that cardio exercises produced more FGF21, which would increase the mediation of my sugar intake. However, the results from the strength training tests shocked me because I thought strength training would also increase FGF21 production.

Associate professor, Dr. Christoffer Clemmensen explained the results’ importance further, saying: “Endurance training on a bicycle has such a marked effect on the metabolic hormone that we know ought to take a closer look at whether this regulation of FGF21 is directly related to the health-improving effects of cardio exercise. FGF21’s potential as a drug against diabetes, obesity and similar metabolic disorders is currently being tested, so the fact that we are able to increase the production ourselves through training is interesting.”

Common symptoms of Diabetes
From: Wikimedia Commons

This information reveals that exercise is important for our health. Exercise can affect our hormone production. Although strength training did not positively affect hormone production, cardio training positively affected the production of FGF21. With more production of FGF21, our sugar intake will be better mediated. Thus, doing more cardio exercises can lead to improved health and reduced risk of developing conditions such as diabetes.

Gale Ladua

CHEM 300 Course Blog

Welcome to the CHEM 300 course blog!

Here are few things to make note of before you get started with your posts. First of all, you should read the blogging resources page under the Create menu. This will help you out a lot if you are brand new to using WordPress. On this page, you will find video tutorials about writing posts on this blog, adding media to your posts, tagging, and categorizing. You will also find a link to the rubric we’ll use to grade your blog posts.

Next, check out the blogging guidelines. Here you will find the answer to the question: “What are we supposed to blog about?” You can also check out one of last term’s blogs for some additional inspiration.

There are a few important things to keep in mind when blogging. Please do not assume that just because something is online, it is OK for you to use it. For example, unless it is explicitly stated, an image on the internet cannot just be copied, saved, and used in your own post without permission to do so. We’ve provided you with a lot more detail about properly using online content, but if you have questions, let us know.

This blog also contains a lot of resources for you. For example, still under the Create menu, you will find a  list of suggested software to use for your projects. We’ve also collected some writing and presentation resources.  Basic audio/visual equipment can be borrowed from CHEM300. Contact the course coordinator for more info.

Under the Explore menu, you will find some sample podcasts and videos, links that may be of interest or assistance, a list of groups and associations related to communicating science as well as a list of local museums and science centres. The Explore menu also contains a library resources page, which you should definitely have a look at. Finally, there is a bookshelf that lists relevant books that are on reserve for you in Woodward Library.

Let us know if you have any questions about the blog or would like to see any other resources made available. Or, if you find something that you think would be useful to the rest of the class, tell us, and we can add it to the resources. Better yet — write a post about it!

Happy blogging!