Monthly Archives: March 2020

Enhancing Car Components – Car Bonnets Fabricated Using a Short-Carbon-Fiber-Reinforced Polypropylene Composite

In the automotive industry, the integration of composite materials into the fabrication of certain car components has become increasingly popular. Particularly in the case of forming lighter components. Car manufacturers have been developing novel and innovative materials in the pursuit of weight reduction, where they have achieved it using short-fibre reinforced polymer (SFRP) composites.

Mansory Carbon Fiber Bonnet                                  Source: Mansory Copyright: 2020 Mansory Design & Holding GmbH

As the name suggests, SFRPs are composite materials with short length fibers that are discontinuous. This composite is easy to synthesize and has excellent mechanical properties, making it quite an interesting, yet practical, material. Furthermore, incorporating carbon short fibers is advantageous, as it is light, corrosion-resistant and quite cheap.

With the backing from the Standard and Industrial Research Institute of Malaysia (SIRIM) and Ministry of Science, Technology, and Innovation (MOSTI) in Malaysia, Rezaei et al. were able to formulate and characterize short-carbon-fiber-reinforced polypropylene (SCF/PP) composites, with the intention of replacing the more traditional steel bonnet.

To synthesize the SCF/PP, the researchers used Titanpro SM950 Polypropylene Copolymer as their matrix and Composite OracleTM, Torayca T700S 12 K acted as their reinforcing carbon fiber. They were then able to prepare 5 composite samples of varying carbon fiber sizes by blending the short carbon fiber and polypropylene. Pellets of the material were then formed and subsequently pressed. This technique is a common method used to generate carbon-fiber-reinforced-thermoplastics. Density tests and Thermogravimetric analysis (TGA) were two techniques used to characterise the material. These properties are important factors that need to be considered when making a bonnet.

From the density test data, it is evident that the composite density increased with increasing fiber content used. This was expected since the density of CF (1.80 g/cm3) is greater than the PP (0.89 g/cm3). However, the composite density decreased with the increase in the CF length. The graph below illustrates this trend for 7% CF content.

Figure 1. Effect of CF size on the density of SCF/PP composites

One proposed explanation is that there is a reduction in the voids and vacuoles, which allows the composite to pack more tightly. However, they also suspect that there is a better distribution of short fibres embedded within the PP framework, which is likely to reduce the number of voids.

The TGA data is important as it is often used in the determination of the end use. From the data, it is evident that the introduction of CF fibers to the PP matrix, improved composites ability to withstand degradation. Furthermore, heat was used to begin the degradation processes and the overall structure was either ruptured or split. The graph below depicts the degradation of the samples with 7% fiber content.

Figure 2. TGA curves of composites with 7% fiber content

As more CF is added to the PP matrix, the heat absorption capacity of CF is higher than that of PP and thus the composite will withstand degradation. Furthermore, the data suggests that as the lengths of fibers increased, the fibers in the composites absorbed more heat.

These two properties and the relative ease of forming SCF/PP composites demonstrate the efficacy and effectiveness of the material in the fabrication of a bonnet.

Calculating Decay Rates for Double-Proton Emission

Double-proton emission has motivated great interests in nuclear and radiochemistry due to its extremely rare occurrence. This decay mode first appeared only as a prediction from theories on nucleon pairing; it involves the simultaneous emission of two protons in proton-very-rich nuclei, where competing single-proton emission is quantum-mechanically forbidden. Since 2002, double proton-emission was observed in experiments, but they still lacked a coherent and accurate theoretical framework.

Double-Proton Emission (made with blender/photoshop)

The group of researchers led by M. Goncalves have recently calculated the decay rate for double-proton emission, filling the missing theoretical gap. The rate of decay is fundamental to the quantification of nuclear reactions; theoretical decay rates from this research will provide the basis for future double-proton reaction designs.

Nucleons are massive and inert to physical conditions, thus nuclear reactions are only quantified statistically using special relativity and quantum mechanics. To tackle this, the researchers used the effective liquid drop model, widely used in alpha decay and cold fission calculations. This model assumes that nucleons interact with each other like particles in a droplet of water.

Liquid Drop Model
(Source:People’s University, Bhopal)

From known values of mass excess, coulomb’s barrier, and dimensional parameters, the researchers calculated the double-proton emission half-life for nuclides mass below 70u. The log of half-life is then plotted against parameter q, derived from the decay energy of each nuclide.

The available experimental double-proton emission half-lives for 16Ne, 19Mg, 45Fe, 48Ni, 54Zn and 67Kr are then plotted on the graph. The experimental values matched closely with the theoretical calculations, except 16Ne; a possible explanation for the deviation may be its mass number away from nuclear magic numbers.

When not using a log variable, the differences between experimental and

theoretical values seem significant. Nevertheless, in the field of nuclear science, this scale of difference is already near-perfection; even the best models such as SEME shows a deviation above 4-times for nuclear binding energy calculations.

Is the World Set to Run Out of Cobalt?

Cobalt is an important part of most batteries, and our global supply is running low. The demand of cobalt in the next 10 years is expected to increase by roughly 300%, and a team of researchers from the Massachusetts Institute of Technology decided to investigate exactly how much of a problem this increased demand could be.

Lithium-ion batteries, such as the ones found in electric cars and most smart phones, require a cathode for the battery to operate, and cobalt is the most common choice due to having a high energy density compared to its competitors. The study focuses on the amount of cobalt we are mining and processing now compared to how much we will need by 2030. By their estimates, the world may require 450 k tonnes per year in cobalt.

Values interpolated from research data. Source: Fu et al.

The researchers employed a methodology of analyzing market trends in the sales of electric cars, which account for roughly 60% of all cobalt use. To determine the amounts of cobalt production, they surveyed mining companies to determine the amount of cobalt being produced in cobalt mines, and as a by-product in non-cobalt mines. With these values as their main metrics, they made projections for the next decade with the hopes of seeing if, and when, our cobalt might run short.

 

The methodology is not perfect, however; it is a forecast and not a guaranteed trend. Thus, the data presented is largely extrapolated and estimated from general trends. But the goal of the paper was not to draw exact conclusion. Their goal was to investigate how sustainable this resource is in the short term.

 

The main take-away from their paper are that end-of-life reclamation of cobalt-reliant materials is going to start being more and more necessary. So even with all of our new technologies, the message of sustainability stays the same: Reduce, Reuse, Recycle!

Griffin Bare

Revolution of Orthopedic Surgery – Bioactive Glass Composite Pore-forming Strategy

The use of adhesives to replace traditional invasive internal fixation tools (such as steel plates and nails) will revolutionize orthopedic surgery. The ideal bone cement should be able to immediately fix the fracture site, while providing a space and microenvironment suitable for bone cell growth and promoting fracture healing.

Cyanoacrylate (commonly known as universal glue) is currently the only medical glue with excellent instant adhesive strength and biocompatibility, but its polymerization product is non-degradable and cannot support the growth of new bone tissue through the adhesive layer, which hinders Because of bone healing, it cannot yet be used as a bone cement.

Recently, with the support of the Ministry of Science and Technology, the National Natural Science Foundation of China, and the Chinese Academy of Sciences, Qiu Dong’s group at the has proposed a bioactive glass composite pore-forming strategy to help cyanoacrylate bonding Agents are used for internal fixation of fractures to promote fracture healing. Bioactive glass has excellent osteoconductivity, osteoinduction, and can promote the regeneration of bone tissue.

To prove that the bioactive pore‐forming adhesive is not only strong and instant bonded but also facilitates cell ingrowth and displays excellent bioactivity, they conducted bone‐fracture healing experiments. In the experiment, the bioactive pore‐forming adhesive (PSC1/PEG4/OCA5) was compared with commercial adhesive (OCA) and pore‐forming adhesive (PEG5/OCA5) by applying all to a circular bone piece which was fixed within freshly formed cranial fractures in a group of mice.

Figure 1. The scheme of a mouse cranial fracture with the craniotomy location (Source)

The stability of the circular bone piece and bone healing effect were evaluated at 12 weeks post‐operation. The ratio of bone volume (BV) within the circular gap over the total volume (TV) within the circular gap was quantified as shown in the figure 2 below. After 12 weeks, BV/TV of the PSC1/PEG4/OCA5 group was 0.76 ± 0.06, which was significantly higher than that of the PEG5/OCA5 group (0.47 ± 0.10), the OCA group (0.40 ± 0.06), and the group with no adhesive treatment (0.26 ± 0.05). These findings supported that the adhesive with pores for bone ingrowth was crucial for new bone formation.

Figure 2. quantitative analysis of new bone formation (Source)

ARS (Alizarin Red S) can detect calcium which is a characteristic evidence to bone‐like structures. As shown in Figure 3, the Ca content in the bioactive pore‐forming adhesive (OD = 0.084 ± 0.008) was around two-fold higher than those in the merely pore‐forming adhesive (OD = 0.046 ± 0.004) and CA adhesive (OD = 0.041 ± 0.001). As a result, these findings were consistent with the statement that the PSC BG can promote osteogenic differentiation that is of importance for bone regeneration.

Figure 3. The optical density of eluents from ARS‐stained adhesives (Source)

The bioactive bone cement has good clinical transformation prospects and can provide new ideas and methods for clinical fracture treatment. At the same time, the above-mentioned composite pore-forming strategy can also be used for substances other than bioactive glass to increase matrix materials and functions. Material compatibility.

 

-Xinyue Yang

Posted on Mar.2nd, 2020

Deep Brain Stimulation on Patients with Parkinson Disease

Deep Brain Stimulation (DBS) is a form of neurological stimulation and is used as a form of treatment for those suffering from Parkinson’s Diesease (PD). PD is a neurodegenerative brain disorder which hinders dopaminergic neurons, resulting in impaired mobility. DBS involves a surgical process of implanting a small battery operated device and a electrodes into the brain.

Figure 1 – Deep Brain Stimulation Retrieved from – GAPS

This study published in August 2006 highlights the efficacy of DBS. 156 patients were randomly paired (78 pairs) and were subjected to different treatments. One was subjected to treatment from pharmaceuticals and the other underwent DBS. To test the efficacy of DBS, the patients’ quality of life was assessed using the Parkinson’s Disease Questionaire (PDQ-39). Additionally, numerous symptoms associated with PD were measured using the Unified Parkinson’s Disease Rating Scale, part III (UPDRS-III).

Efficacy of DBS

Out of the 78 pairs of patients, the patient who underwent DBS in 50 of the pairs saw an improvement in their PDQ-39 and UPDRS-III scores compared to their partner who was only provided with pharmaceutical drugs.

Figure 2 – How DBS and Pharmaceuticals affected the PDQ-39 and UPDRS-III scores in patients immediately after treatment. In 50 of the 78 pairs, those who underwent DBS showed improvement in their scores compared to their partners who took medication. Data from Deuschl et al.

Furthermore, the patients were assessed again in six months. Those who underwent DBS saw a 25% increase (a lower score) to their PDQ-39 score, while there we no significant changes to those who took medication.

Figure 3 – PDQ-39 Scores immediately after treatment (baseline), and 6 months after treatment. Error Bars represent standard deviation. Data adapted from Table 3 of Deuschl et al.

Benefit of DBS Compared to Medication on Treating Depression

There are additional benefits of DBS on other aspects of PD. This study published in March of 2005 highlights how DBS is able to treat depression, which is a symptom associated with PD. Patients who were treated by DBS noted a decrease in depression-like symptoms 1 month after treatment, and up to 1 year. In contrast, medication can only treat depression in the short-term.

Figure 4 – A visual interpretation of depression Retrieved from – ConsumerReport

So why is DBS better than Prescription Medication?

The results of both studies indicate that DBS is capable to treating PD with a higher efficacy compared to medication. Additionally, medication is kept constant and can be used to treat one specific issue. In contrast, the strength of DBS can be altered (stronger/weaker pulses) to treat different symptoms that may arise. Consequently, DBS results in long-term benefits, while medication is only able to provide short-term benefits.

-Jackson Kuan

Re-wiring Your Brain For Sugar Craving

Have you ever wondered why we have desires for sweet food but not bitter food? Dr. Li Wang and other scientists at Columbia University have discovered that mammalian brains for tasting can be re-patterned or erased by performing a series of experiments on mice. This study has significance for future studies in eating disorders and weight management.

The taste sensory system 

Mammalians have a developed sensory system for identifying tastes and associating tastes with mechanisms of reward and aversion. This sensory system has two main parts: the tongue and the brain. There are many sensory neurons in our tongues. These sensory neurons, the detectors of the five basic tastes (sweet, sour, salty, bitter and umami), signal our brains and turn on the amygdala of the brains responsible for identifying and interpreting tastes. Dr. Li Wang and her team have confirmed that neurons in the sweet-responsive cortex project to a different area compared to those in the bitter-responsive cortex. The strong segregation of neuron projection transmits desirable, or aversive taste signals, as shown in Figures 1 and 2. Therefore, we cannot stop eating sweets since our amygdala associate sweets with appetitive, desirable signals.

Figure 1. b and c show the active bitter taste cortex and active sweet taste cortex respectively. Source: “Nature Journal”

 

Figure 2. Licks per second (Licks rate) of mice upon photostimulation of the sweet and bitter cortexes. Adapted from “Nature Journal

Rewiring the brain on taste

Dr. Wang and her team rewound the brain of mice on taste by using a drug to silence the neurons in the sweet-responsive cortex and the bitter-responsive cortex, respectively. The team used licks per second to quantify and verify the appetitive and aversive responses of the mice upon photo-stimulating the sweet and bitter cortexes independently. The team found out that by silencing the neurons in the sweet cortex, the lick rate decreased, according to Figure3. This showed that the mice could not recognize sweet when the neurons were silenced by the drug. This confirmed that the taste specific neurons are essential to recognize tastes.

Figure 3 also showed another interesting phenomenon that the team made the animals think they were tasting sweet, even when the animal was drinking water. In Figure3, without the presence of the sweet neuron silencer, the lick rate of the mice with their sweet cortex stimulated was two times higher compared to the mice without the stimulation. The increase in the lick rate in Figure 3. showed that neurons in the amygdala control an animal’s sensory perception of taste.

Figure 3. Photostimulated sweet cortex in the presence or absence of sweet neuron inhibitor. Adapted from “Nature Journal”

The finding that animals’ brains can be manipulated and rewound to change the perceptions of taste has implications in future studies in weight management and eating disorders. By using small drugs to target these taste-specific neurons, we may say no for eating more and more sweets.

Reference

Li Wang. The coding of valence and identity in the mammalian taste system. Nature Journal, 2018; 558, 127-131. DOI: https://www.nature.com/articles/s41586-018-0165-4

Pricia

2020-03-02

 

Don’t Let Stress Get The Best of You

You may have heard of the saying, “diamonds are made under pressure”, especially from people working last-minute to meet deadlines. However, a study found that the stress accompanying our seemingly never-ending tasks actually decreases our ability to produce high-quality work, or to perform well on exams.

The study showed that upon chronic stress, neurons shrink in the hippocampus, which is the region in the brain that controls our memory; this equates to a weaker memory. Furthermore, neurons end up growing in the amygdala, which is the region in the brain that reinforces our fears; this translates to an increase in anxiety levels.

Figure 1. Chronic stress promotes the growth of neurons in the amygdala (a), and leads to the shrinkage of neurons in the hippocampus (b). Created by Athena Wang. Adapted from Davidson and McEwen (2012).

Therefore, instead of studying a week before exams when stress levels are the highest, you should space out your studying throughout the semester to retain as much information as possible while also being more calm.

ACUTE VS. CHRONIC STRESS

A bit of stress can be good for us; acute stress triggers our fight-or-flight response, and helps us overcome short-term stressors. However, chronic stress weakens our immune system, and leads to even more troubles, such as mental health and cardiovascular problems. Therefore, stress should be dealt with before it escalates.

WAYS TO RELIEVE STRESS

Good time-management skills are important, so that you don’t end up with a plethora of assignments due at the same time. Designate and follow the allotted times for your tasks, and hopefully having a better control over your time will decrease stress.

Another way is to practice mindfulness. This type of meditation makes you embrace your current situation and not dwell on unnecessary worries, which then allows you to feel less stressed. Lastly, incorporate enjoyable activities in your schedule to improve your mood and help you relax.

The next time you’re feeling stressed out, don’t let it get the best of you. Take a deep breath, and remember that you’ve got this!

Any additional tips? I would love to hear your thoughts in the comments below.

-Athena Wang

Enhancing Safety Gloves

Safety gloves do not protect you from every chemical or dangerous substance. The glove deteriorates and makes it easier for chemicals to penetrate through and onto the skin. One way to tackle this problem is by implementing a self-healing material, which can be used for rubber gloves.

Researchers at the Central Institute for Labour Protection in Poland tested  polyamide, cotton–polyamide, and cotton fabrics, onto methyl vinyl silicone rubber containing inorganic silsesquioxane, which are used for rubber gloves. Its resistance to chemical substances, abrasions, and punctures were analyzed. Using SEM, the surface is observed for any damages or self-healing behaviour for each rubber material containing each type of fabric.

A cross-section of a rubber material with textile reinforcements (Source:

A test to determine the resistance of chemical substance with methyl vinyl silicone rubber with silsesquioxanes, and one coated with cotton was carried by using 2-propanol. This studied the breakthrough time of the 2-propanol through the 2 different materials at various conditioning times. The idea is to simulate the effectiveness of the self-healing mechanism.

Permeation times of 2-propanol into 2 different materials (Adapted: )

The data shows an increase in permeation time when coated with cotton, and when conditioned at 70 degrees Celsius for 24, 48, 72 hours. This means coating the material with textile reinforcements increases the resistance of chemical substances from penetrating. A similar trend was obtained when testing different textile compositions through puncture and abrasion tests.

The result concludes the effectiveness of the textile reinforcement in the self-healing process, qualitatively and quantitatively. This study brought improvements to lessen the stress chemists have on the quality of their own safety gloves. Safety gloves should never be a safety concern.

-Wilson Wong