Category Archives: Biological Chemistry

Eczema Patients May Be Vulnerable to Developing Allergic Diseases

In many cases, babies with eczema also go on to develop food allergies, asthma and hay fever. Dr. Donald Leung, the head of Pediatric Allergy & Clinical Immunology at National Jewish Health suggests it may not be a coincidence.

In this study published on February 2019 by National Jewish Health, it was found that the cracks caused by eczema weaken the skin barrier, allowing allergens to penetrate the skin and cause a sequence of allergic diseases. This process is known as the “atopic march”. Food particles introduced through the skin instead of the digestive system is much more likely to trigger an allergic response that leads to food allergy. The atopic march often sets off a chain of allergic diseases that develop over several years, sometimes resulting in hay fever and asthma.

The skin serves as the first line of defense by keeping external allergens and microbes out and keeping moisture in. Dr. Leung has shown in his study that patients with eczema lack important proteins and lipids in the outer layers of their skin. As result of this defect, water is able to escape from the skin and dry it out, resulting in cracking that allergens and microbes are able to enter.

Body Moisturizer

 

In order to remedy dry cracked skin, experts suggest performing a “soak and seal”. This involves thoroughly moisturizing the skin in a warm bath, then immediately applying moisturizing ointment in order to trap the moisture.

“Restoring the skin barrier as soon as eczema develops is the best way to stop the atopic march in its tracks and prevent allergic diseases from developing.” said Dr. Leung.

A baby’s skin is particularly susceptible to drying out due to exposure to the dry outside world as opposed to the watery environment of the womb. Studies suggest regular treatment with skin moisturizers can reduce an infant’s chances of developing eczema and subsequently other diseases in the atopic march.

 

Engineered bacteria is capable of feeding through atmospheric CO2

A study led by a team of researchers from the Weizmann Institute of Science in Israel has confirmed a recently developed fully autotrophic E.coli strain whose generated biomass is solely derived from a greenhouse gas.

E. coli bacteria cells. Source: Livescience

CO2 accumulates in our atmosphere and it is commonly used by plants to generate sugars for their sustainable growth.This promising strain could be used as a renewable food source and energy storage.

Hacking Metabolism

An originally heterotrophic bacterium was successfully converted into an autotrophic organism. Scientists rewired their core metabolic pathway, introduced heterologous (non-native) genes and Formate as an accessible electron donor, providing such organism with the required enzymatic machinery to effectively convert inorganic carbon into biomass under physiological conditions. Furthermore, the carbon source of nearly all biomass produced was confirmed to atmospheric CO2 with isotopic labeling techniques.

Summary of photosynthetic pathway from an engineered bacterium cell. Source: Cell

Photosynthesis is a process common to plants and some microorganisms, and it is the first step in the food chain. Evolutionarily speaking, this transformation is considered a major accomplishment since these two metabolic pathways are very distinct. Autotrophs and heterotrophs diverged millions of years ago, although some organisms with both metabolic routes are known to exist.

Summary of transformation. Source: technologyandus.com

 

Next Steps

Regulation of CO2 in our atmosphere has become one of the most important challenges in today’s era.  We are constantly looking for sustainable ways of producing food, fuel and biochemicals, and this study presents a new yet promising approach to reduced carbon emitting food sources with a broad spectrum of fields in which this technology can be applied.

There is great diversity in the compounds that can be synthesized through this process and its deep understanding may have a large impact in the future of a new carbon neutral world.

This finding also denotes the flexibility of metabolic processes to support life as mentioned by the authors:

– “This rapid trophic mode transformation showcases the outstanding plasticity of metabolism and demonstrates the power of the framework described here for designing and implementing the rewiring of cellular metabolism.”

-Aron Engelhard

The Polymer, PLA: it will be degraded, but our future is not degraded

Did you know that less than 11% of plastics are recycled in Canada since 1950? Many plastics, such as water bottles, bags, and takeaway coffee cups, are buried in landfills and are disposed into the ocean. Over a long period of exposure to air, sunlight, and moisture, they eventually become invisible. Are they degradable? We may be able to use the word “degradation”, but they do not disappear at all. The invisible ones exist as microplastics, thereby polluting our ecosystem.

 

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Video: plastics in the ocean

To resolve the further pollution, chemists have made an effort to develop biodegradable polymers that can be applied to produce commercial plastics. In modern polymer chemistry, considerable attention has been paid to polylactic acid, so-called PLA. Polylactic acid is produced from lactide which is derived from renewable resources such as corn and potato starch.

Figure 2. Chemical structures of lactide (monomer) and polylactic acid (polymer)  . ROP stands for ring-opening polymerization (a type of polymerization). DOI:10.1021/acs.accounts.7b00447

Unlike petroleum-based polymers used in plastics, for example, polyethylene (PE), polyethylene terephthalate (PET), and polypropylene (PP), PLA has biodegradability and biocompatibility. The enriched oxygen atoms in PLA and its structural flexibility make it undergo hydrolytic and enzymatic degradations, regenerating monomers and oligomers. The degraded substances are further broken down to water and carbon dioxide, precluding the formation of micro plastics. Therefore, PLA is a great candidate to substitute for plastics derived from petroleum sources

Although there are general issues to resolve in the economical perspective, the environmentally friendly outcomes and industrial applications have made PLA more attractive research area. PLA certainly has the potential to save our future!

-Young Cho

These Ingredients in Sunscreen Might Promote Breast Cancer

Breast cancer is the most diagnosed cancer with an estimated diagnosis of 331,530 women and 2670 men this year in the US alone. Cancer is a incredibly dangerous illness, caused by the unfiltered division of cells in the body. It is predicted that this year 41,760 women and 500 men will die of breast cancer in the US. Research by the University of Massachusetts Amherst published on January 15 2020 found that benzophenone-3 (BP-3) and propylparaben (PP) can increase the chances of breast cancer.

Because of this, the estimations may now have to take into consideration the dangers of common everyday items that include the chemicals BP-3 and PP. BP-3 is commonly found in sunscreen as it helps to block harmful UV light that may cause damage to the skin. PP is a chemical widely used in the cosmetics industry and can be found in items such as makeup, hair products and moisturisers.

Previous research into the effects of BP-3 had shown that only extremely high concentrations could promote cancer growth. Since these concentrations were far beyond the normal levels of exposure to women, there was no cause for concern. However, this new research shows that cells containing oestrogen receptors, important for regulating gene activity, require only a fraction of the cancer promoting concentration of BP-3 to cause damage to the DNA of the cell. “There may be a risk at lower levels than we would have previously understood,” says professor of Veterinary & animal Sciences at the University of Massachusetts Amherst, science director of Pioneer Valley Institute, and co-director of Rays of Hope Centre for Breast Cancer Research, Dr. Joseph Jerry.

The study shows that DNA damage only occurs in cells containing oestrogen receptors, and that all other cells show no adverse effects.

It might be time to take a look at the ingredients in your everyday items!

 

– Chantell Jansz