Category Archives: Popular Science

Eczema Patients May Be Vulnerable to Developing Allergic Diseases

In many cases, babies with eczema also go on to develop food allergies, asthma and hay fever. Dr. Donald Leung, the head of Pediatric Allergy & Clinical Immunology at National Jewish Health suggests it may not be a coincidence.

In this study published on February 2019 by National Jewish Health, it was found that the cracks caused by eczema weaken the skin barrier, allowing allergens to penetrate the skin and cause a sequence of allergic diseases. This process is known as the “atopic march”. Food particles introduced through the skin instead of the digestive system is much more likely to trigger an allergic response that leads to food allergy. The atopic march often sets off a chain of allergic diseases that develop over several years, sometimes resulting in hay fever and asthma.

The skin serves as the first line of defense by keeping external allergens and microbes out and keeping moisture in. Dr. Leung has shown in his study that patients with eczema lack important proteins and lipids in the outer layers of their skin. As result of this defect, water is able to escape from the skin and dry it out, resulting in cracking that allergens and microbes are able to enter.

Body Moisturizer

 

In order to remedy dry cracked skin, experts suggest performing a “soak and seal”. This involves thoroughly moisturizing the skin in a warm bath, then immediately applying moisturizing ointment in order to trap the moisture.

“Restoring the skin barrier as soon as eczema develops is the best way to stop the atopic march in its tracks and prevent allergic diseases from developing.” said Dr. Leung.

A baby’s skin is particularly susceptible to drying out due to exposure to the dry outside world as opposed to the watery environment of the womb. Studies suggest regular treatment with skin moisturizers can reduce an infant’s chances of developing eczema and subsequently other diseases in the atopic march.

 

You will never know, what happens in an organic chemistry lab.

“Organic synthesis”, seems like a mysterious area to many people outside of a chemistry degree. In many amateurs’ eyes, in an organic chemistry lab, some “wizards” are using “magic power” to create incredible things. However, organic chemistry is very “touchable”, not only many things that we are using are synthesized by chemists, but also some chemists in labs are synthesizing funny things which can add fun to our life.

In April 2003, an article published by Dr. James Tour at Rice University described the procedure of synthesis a “NanoKid”, as well as “NanoProfessionals” based on the NanoKid.

Synthesis and Modifications of the NanoKid

A NanoKid is formed of two parts: an upper body and a lower body. The upper and lower bodies were synthesized in the first several steps, and the last step involved the coupling of the top and bottom portions. This was accomplished by using a Pd/Cu-catalyst through a Sonogashira Reaction.

Synthesis of a NanoKid (Copyright: The Journal of Organic Chemistry)

After Dr. Tour’s team synthesized the NanoKid successfully, he changed the “head” of the NanoKid to make NanoProfessionals, such as NanoChef, NanoAthlete and NanoScholar. Furthermore, by hydrogenating the triple bond on the “waist” to a single bond, and coupling the “hand” of NanoKids, the research team got NanoBalletDancers and NanoKid-Polymer respectively.

Electron cloud-based space-filling model of NanoProfessionals (Copyright: James M. Tour)

Other relevant synthesis projects

Other than NanoKids, the research group of Dr. Tour constructed NanoCars by carbon-based molecules and won the first prize in the NanoCar Race in 2017.

Three models of possible conformations of NanoCars under the scanning tunneling microscopy (STM) (Copyright: Organic Letters)

Summary of the NanoCar Race results. (Copyright: Nature)

Recently, many organic chemists use carbon atoms as building blocks to build molecules with unusual names. Such as “Broken Windowpane” which has a molecular formula of C8H12 and looks like a broken window, “Housane” which looks like a house and “Churchane” which looks like a church.

Is it a waste of taxpayers’ money?

Chemists have already synthesized the NanoKid, NanoCar and Broken Windowpane, and in the future, chemists might build more interesting Nano-things. These research outcomes are very delighted, but some people might ask: Is it a waste of money? What is the meaning of these chemicals?
To synthesize a Broken Windowpane, chemists need to overcome an extraordinary intramolecular tension, to give birth to a NanoKid, researchers had to design and control the reaction accurately. “Beyond the molecular-sized domain, there is no conceivable entity upon which to tailor architectures that could have programmed cohesive interactions between the individual building blocks. It is at this size region that synthetic chemists have been inherently captivated; however, their fascination is rarely shared by the layperson.” Dr. Tour said. The Broken Windowpane might be adapted for more fantastic molecules, and the NanoCar might be used to deliver targeted drugs to a certain part of the body one day in the future. These molecules show that chemists can make whatever they want, and how magic chemistry is.

These Ingredients in Sunscreen Might Promote Breast Cancer

Breast cancer is the most diagnosed cancer with an estimated diagnosis of 331,530 women and 2670 men this year in the US alone. Cancer is a incredibly dangerous illness, caused by the unfiltered division of cells in the body. It is predicted that this year 41,760 women and 500 men will die of breast cancer in the US. Research by the University of Massachusetts Amherst published on January 15 2020 found that benzophenone-3 (BP-3) and propylparaben (PP) can increase the chances of breast cancer.

Because of this, the estimations may now have to take into consideration the dangers of common everyday items that include the chemicals BP-3 and PP. BP-3 is commonly found in sunscreen as it helps to block harmful UV light that may cause damage to the skin. PP is a chemical widely used in the cosmetics industry and can be found in items such as makeup, hair products and moisturisers.

Previous research into the effects of BP-3 had shown that only extremely high concentrations could promote cancer growth. Since these concentrations were far beyond the normal levels of exposure to women, there was no cause for concern. However, this new research shows that cells containing oestrogen receptors, important for regulating gene activity, require only a fraction of the cancer promoting concentration of BP-3 to cause damage to the DNA of the cell. “There may be a risk at lower levels than we would have previously understood,” says professor of Veterinary & animal Sciences at the University of Massachusetts Amherst, science director of Pioneer Valley Institute, and co-director of Rays of Hope Centre for Breast Cancer Research, Dr. Joseph Jerry.

The study shows that DNA damage only occurs in cells containing oestrogen receptors, and that all other cells show no adverse effects.

It might be time to take a look at the ingredients in your everyday items!

 

– Chantell Jansz