Category Archives: Science Communication

Cutting out the middleman

Fungal infection of the bone marrow. Image by euthman.

Nowadays, clinical transplantation is known to save many lives, but not without a catch. Patients have to go through immunosuppressive therapy if the MHC molecules on the graft, or transplanted tissue, do not match their own.

Our bodies are very picky and sensitive. For instance, we are okay with accepting skin grafts from ourselves – this is a type of autograft. However, if we were to be given a skin graft from someone unrelated, this arrangement is not long-lived. We let this allograft stick around for a bit, but ultimately kick it out after 10-13 days. We’ll remember it, too. Like a woman scorned, if this same offensive graft comes again, we boot it out even faster. The T cells living in our bodies as defenders do not take kindly to foreign tissue. Immune responses are mounted as a result, causing transplant rejection. Learn more about the immune response here:

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For clinical transplantation to be successful, people have relied on immunosuppressive drugs to inhibit the defensive mechanisms our cells carry out when we encounter foreign molecules. This is problematic because now people are more susceptible to cancer and infections. The issue with transplant rejection is that donor and recipient cells don’t like each other. What do we do when two people don’t get along? We force them to.

Scientists have recently tested a method for transplant recipients to accept mismatched donor organs. In this ongoing trial, patients are exposed to chemotherapy and radiation and injected with enriched donor stem cells, hoping to achieve what is called “chimeric tolerance”. The idea is to make two immune systems work in one body by destroying the host’s first.

This new approach is pretty questionable. Small sample size aside, it is not known whether the enriched cells really made an impact as the study is missing a control group (where patients would presumably undergo treatment without these cells). Furthermore, these cells were not described very clearly. Suppressing the immune system with chemotherapy and radiation is also unnecessarily harmful and risky. Will it be worth it in the end?

The lengths we will go to in order to cure disease (Image from xkcd.com - click to enlarge).

References:

1. Murphy, Kenneth P. Janeway’s Immunology (8th ed), p652-664.
2. Steenhuysen, Julie. Immune system tricked to accept donor organs: study. NewsDaily. Accessed March 14, 2012.
3. Garland Science. The Immune Response. Youtube video, accessed March 14, 2012.

How Forgetting Might Become the Norm

Memory is a strange thing.

The more we learn the more we seem to forget, quite literally, and in so doing we help ourselves learn even more.

A strange proposal then would be whether it possible to forget the baggage we don’t like, keep those we do, and maybe throw in some fun stuff that never happened. It all sounds crazy, but this world is a crazy place.

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To start with how, let’s look at how memories are formed. In the brain, chemicals and proteins are released that help neurons pass electric potentials between themselves, and this helps the neurons make new ion channels with each other. It’s like making phone lines of memory between brain cells. The creation of these circuits is called Consolidation and until recently was thought to be concrete.

That “recently” happened when a young graduate named Karim Nader discovered that when memories are remembered or “Reconsolidated” they can be wiped out if the chemicals aren’t there to make the connection.

It turns out that when you remember something, a few things happen. Similar memories that would compete with that memory can be mixed in or weakened/eliminated by the prefrontal cortex and the memory itself is literally rebuilt.

"Seems Like a Good Idea" Image:Eternal Sunshine of the Spotless Mind

Because of this, every time you remember something it gets a little altered in the process, and if the chemicals are blocked, the reconsolidating memory becomes wiped.

“This is crazy and awesome, but too crazy for me, can I make bad, painful memories better without this?” Yes you can. Because memories are associated with different emotions or perceptions, they’re located in different places. Negative ones are found in the amygdala, though they can be removed and relocated elsewhere. How? Think about the memory in a happier setting when you’re immune to feeling blue, it will remain in your mind but won’t have the same emotionally negative effects. This is why ecstasy is one of the most effective PTSD treatments ever.

"Pacman, eating pills to invoke trippy colours and devour your ghosts" Image:Pacman

“How can I make this more fun?” PLAY TETRIS. Playing Tetris within 4-6 hours of trauma significantly reduces the associated trauma with a painful memory. Yes folks, drugs and videogames are the answer, Pacman had it right.

“This is cool, can I be programmed with happy thoughts?” Yes you can. It turns out we’re really good at remembering things that never happened. Dr. Elizabeth Loftus has demonstrated that 1/3 of subjects can be tricked into thinking false memories are their own, even with only one exposure to it. This is why people can be convinced they met Bugs bunny at Disneyland.

“Nice, can I have this memory wipe as a pill please?” Not yet, but a scientist named Dr.Sacktor has found the primary and defining chemical involved in (re)consolidation. It’s called PKMzeta, a form of protein Kinase C. It’s needed to maintain memories, and inhibiting it while remembering something leads to a swift and selective wipe of that something.

“Do you think I can get a prescription?” You may in the future if you have chronic neuropathic pain. It likely will have the same effect on the spine as the brain, and it might even help people with addictions.

All in all this is fabulous news. Though it can be a lot to take in, whether it makes you fear an Orwellian mind control police or you’re just excited to become a mind-tweaking psychonaut, it likely won’t matter as you’ll probably forget you thought about it anyway.

"A Sea of Potential" Image from: http://thetechnologicalcitizen.com/?p=2471

Is Too Much Exercise Good For You ?

 

Benefits of exercising is not a new topic . Almost everybody (at least in north America) has heard once in their life time that in order to gain a stronger immune system you have to have a proper diet and consistent exercising habit. It is recommended by government of Canada to be involve in at least 30 minutes of moderate to vigorous activity exercising 5 days a week (http://www.healthyalberta.com/Documents/Choosewell-Logbook-2011.pdf).

it is important to have a balanced diet and consistent exercise pattern to achieve optimal health (http://www.justprnews.com/15416/colon-cleanser-for-a-healthy-body-and-mind/)

 

However it has been proven scientifically that long, vigorous exercising can suppress the immune system and in fact makes the body more vulnerable to infection.

One of the studies that supports this finding is the study that was published in journal Brain, Behavior, and Immunity, conducted by Murphy and his colleges which the link to the study is here http://www.ncbi.nlm.nih.gov/pubmed/18616997. They have divided mice into two groups. One rested and the other group ran on treadmill for three days until they were exhausted. Both groups were exposed to influenza virus; the group who were running had more severe symptoms of the illness

The second study (http://www.sciencedirect.com/science/article/pii/S088915910500067X) which its result agreed with the above experiment also published in journal Brain, Behavior, and Immunity, examined the influence of the virus on subjects who were already sick.  In this study one group of sick mice were allowed to rest while the second group ran leisurely  for 20 to 30 minutes , also there were a third group in this study which ran for two and half hours. Each group repeated the routine for three days. Their results were very interesting: 50 % of the sedentary mice dies , while only 12 % of the gently jogging mice passes away and 70 % of the third group could not survive the virus. Therefore what we can learn here is what my father always tells me:” do not overdue anything in your life,  and be reasonable in your decisions”

The reason for such finding is still unclear. Scientists believe that intense work out suppresses immune response for a period of time immediately after you have finished your workout. An associate professor of sport and exercise sciences at Loughborough University  says“the longer you exercise the longer the period of suppress immune system”

relationship between exercise intensity and risk of getting an infection (http://www.cps.ca/english/statements/hal/exerciseillness.htm)

At the end, I would like to emphasize that it does not mean that you should not exercise , in fact Jeffrey A. Woods, a professor of kinesiology and community health at the University of Illinois believes that “in general, moderate exercise, such as a leisurely jog or walk, may prop up your immune response and lessen the duration and severity of a mild infection”. Here is a video that lists the benefits of exercise :

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Hence, Exercise but DO NOT OVERDUE IT .

 

A Lovely Indecision

There’s hardly anything as conflicting as tastes, especially subconscious tastes that vary on a monthly cycle and alternate with circumstance. In honour of Valentine’s Day, we shall explore the theme of indecision in female mate selection, featuring the wonders of the pill.

To begin, attraction in females shifts between when she’s ovulating and not.

While in the fertile throws of follicle phase, females generally prefer a male with manly features and high testosterone levels, as well as a dissimilar Major Histocompatibility Complex (MHC). MHCs are linked to immunity, so humans naturally seek to diversify for maximum heterozygosity and variation. A fun fact, while fertile, girls in relationships are also known to develop a taste for dominant smelling men.

YouTube Preview Image (A little More on MHC)

Most of the time though, women are not in fertile mode, and in these circumstances tend to fall back on men who have a similar MHC to themselves. They also favour men who are less masculine and more nurturing and supportive, especially if they live in a healthy environment.

Based on these natural cycles, we can see how there might be some conflict of interest depending on what day it is.

"I don't know what I want!" Image:ehow.com

Sometimes, one doesn’t even need cycles to complicate things. While single, girls have an increased preference for MHC similar men, but then have dissimilar MHC preference when they’re already with someone. If that’s not enough, these changing preferences of MHC make a huge impact as scent is much more emphasized in importance with women rather than men. Occasionally, scent can even be at odds in importance with visuals though it varies on the population and culture.

That said, a person’s heterozygosity of their MHC can be sensed through the inspection of facial features. While females favour as much heterozygosity as possible, they seem to be attracted to those with similar MHC as well.

So, visuals conflict with olfactory cues? Awesome.

Now what about the pill? Surely this fabulous contraption of contraception must simplify things no? Well, sort of.

The Pill adds some consistency, whereby everyday is non-fertile day. It’s more or less a fake pregnancy that replaces the possibility of a real one, and this causes women to go into “find a nurturing, similar man phase.” It’s without any surprise then that women on the pill have a marked preference for MHC similar men that totally overrides any ambition for seeking a dissimilar partner.

Consistency? Fabulous! What’s the catch?

Women who find their man on the pill tend to have less sexual attraction to their partners as well as decreasing sexual satisfaction over time. They become very jealous at a rate proportional to estradiol intake, and also have an increased desire to cheat, meanwhile having much more severe “affective responses” to partner infidelity, and having an increased frequency of “mate retention behaviour.” And you put on a few :3

But don’t worry, there are some positives. Those that meet their partner on the pill have more satisfaction with their partner in non-sexual ways, have happier relationships with more emotional satisfaction, and have relationships that last 2 years longer on average.

So really no matter what, it’s a mess of matter of preference. Just have a preference for the mess that you prefer.

"Use Both Instead!" Image:ehow.com

SCIE 300 Scientific Investigation Project: The value of good taste

Rachel Lee, Bryant Rathbone, Colin Todd

PowerPoint slides (link)

References

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(4) Goldstein, R.; Almenberg, J.; Dreber, A.; Emerson, J. W.; Herschkowitsch, A.; Katz, J. Journal of Wine Economics 2008, 3, 1-9.

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(7) Kumar, N.; Scheer, L.; Kotler, P. European Management Journal 2000, 18, 129.

(8) Laoro, M.; Delahunty, C.; Cox, D. Food Research International , 44, 3235.

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(10) Lawless, H. Journal of Food Science 1984, 49, 120-123.

(11) Lehrer, J. The Subjectivity of Wine. http://scienceblogs.com/cortex/2007/11/the_subjectivity_of_wine.php (accessed 01/17, 2012).

(12) MacQueen, K. MacLeans 2011, .

(13) Mckinnon, M. The Globe and Mail 2011, .

(14) Morrot, G.; Brochet, F.; Dubourdieu, D. Brain and Language 2001, 79, 309-320.

(15) Solomon, G. American Journal of Psychology 1990, 105, 495-517.