Category Archives: Uncategorized

Could the new Cyclosporin be in our own bodies?

Audio clip: Adobe Flash Player (version 9 or above) is required to play this audio clip. Download the latest version here. You also need to have JavaScript enabled in your browser.

 

The Immune system Simplified (Nobel Media)

YouTube Preview Image

Recent research at the BC children’s hospital in Vancouver, Canada has unearthed one of the mysteries of an immune cell that may play a key role in combating auto-immune diseases.

"A Regulatory T Cell" Image Source: http://www.iayork.com/Images/2008/12-8-08/BioLegendTReg.png

The cell in question is the regulatory T cell (Treg), a regulatory cell responsible for the management of immune responses. While largely unstudied, this cell has been found to prevent disease and illness brought on by the body’s own immune system. Tregs monitor our immune systems and counter-balance the constant assault against the cells within our bodies both malignant and benign. In a sense, they’re the whistle blowers of the body police.

While the job of Tregs is to control and reduce immune response, they can also be used to quell a person’s runaway immune system and subdue the illnesses our immune systems can sometimes create.

Audio clip: Adobe Flash Player (version 9 or above) is required to play this audio clip. Download the latest version here. You also need to have JavaScript enabled in your browser.

While Treg therapy may seem futuristically out of reach or too good to be true, preliminary trials so far demonstrated promising results in human and mouse models. Anti-immune therapies using Tregs have been so effective and versatile that they not only treat the inflammation in Crohn’s Disease but tissue rejection in organ transplants. At times, this cell is  even capable of giving the body life long tolerance to the transplanted foreign organs.

Audio clip: Adobe Flash Player (version 9 or above) is required to play this audio clip. Download the latest version here. You also need to have JavaScript enabled in your browser.

"Simplified Illustration of the Inflammatory Response" Image Source: http://www.rkm.com.au/immunology/immune-images/IMMUNE-inflammation-R-600.jpg

Despite these triumphs, Treg therapies still have a long way to go. The recent discovery found by the BC researchers shed light on interactions of Tregs with Neutrophils, immune cells involved in the generic first response of immune systems. While Tregs are meant to suppress immune responses, they seem to attract neutrophils in vast quantities which are highly inflammatory in nature. Until more is known about the relationships and functions of Tregs, researchers may run the risk of accidentally triggering an immune response when trying to reduce it. Another possible risk to consider is that Treg therapy may increase our risk of cancer by suppressing the cells responsible for keeping it in check.

Audio clip: Adobe Flash Player (version 9 or above) is required to play this audio clip. Download the latest version here. You also need to have JavaScript enabled in your browser.

Despite these risks it is obvious that Treg therapies have an untapped potential with almost limitless application to illnesses associated with an overactive immune system. Our bodies’ tolerance of Tregs and their adaptive and responsive nature make them not only ideal in that they act like living cyclosporine, but they have been tweaked and perfected to be the ideal  immune suppressant for over millennia, before we ever got sick.

 

 

 

Why do we have acne?

Acne is a technically a type of human skin disease. This includes whiteheads, blackheads and inflamed area of skin.

Why do we have acne?

The formation of acne is mainly because the pore of the skin is clogged. Each pore contains a sebaceous gland and this gland makes sebum which is oil that lubricates our hair and skin. A sebaceous gland usually functions normally and produces right amount of sebum in the pore. However, since teenager’s body starts to develop, hormones stimulate the sebaceous gland to make more sebum. When there is too much oil inside the pore, it will be clogged. Bacteria called Propionibacterium acnes can be easily trapped inside the pore. Swelling and redness symbolizes the start of acne.


 I am no longer a teen.

We are not teens but why do we still have acne? Acne is also triggered by hormonal changes due to stress, menstrual periods and pregnancy (Palmer 2010). Acne certainly affects people of all ages.

What should we do if we have acne?

There are three things that we should do. We should clean our skin gently, try not to touch our skin, and see a dermatologist if acne becomes worse. Dermatologists suggest that we should not pop or squeeze acne, although it is very tempting to do (Palmer 2010). Popping acne increases a chance of making it worse (MedlinePlus 2011). This irritation of the skin may cause permanent acne scars which are harder to get rid of (AcneNet 2010).

This video tells us why it is bad to pop acne in detail.

Popping-Pimples.htm

Palmer,A. 2010. Diagosing Acne. http://acne.about.com/od/diagnosisofacne/a/diagnosis.htm (accessed 3/21/2012)

MedlinePlus. 2011. Acne. http://www.nlm.nih.gov/medlineplus/acne.html (accessed 3/21/2012)

AcneNet. 2010. What causes Acne? http://www.skincarephysicians.com/acnenet/acne.html (accessed 3/21/2012)

Wikipedia. 2012. Propionibacterium acnes. http://en.wikipedia.org/wiki/Propionibacterium_acnes (accessed 3/21/2012)

Wikipedia. 2012. Sebaceous gland. http://en.wikipedia.org/wiki/Sebacious_gland (accessed 3/21/2012)

Video:

http://video.about.com/acne/Popping-Pimples.htm

Picture:

http://www.nlm.nih.gov/medlineplus/images/acne.jpg

http://www.nlm.nih.gov/medlineplus/ency/images/ency/fullsize/19666.jpg

 

When Your Genes Trick You

Our body is governed by our genes. Our genes specify what type of proteins should be produced by our cells, and proteins are responsible for almost everything in our body. Each protein has three dimensional shape; proteins’ shape indicate their job in the body.

DNA has the information to to make proteins, and proteins are responsible for almost everything in our body ( from : http://www.flyfishingdevon.co.uk/salmon/year3/psy339evaluation-evolutionary-psychology/evaluation-evolutionary-psychology.htm )

In this blog I would like to talk about a genetic condition, called Thalassemia which so many  people in the world have it and simply are not aware of it. In people with Thalassemia, the shape of their hemoglobin protein in some of  their red blood cells is different because in their body the genes that have the information for hemoglobin production have been altered. Therefore, since shape of a protein specifies its functionality, hemoglobin becomes inefficient in transferring oxygen.(http://www.cdc.gov/Features/Thalassemia/)

shape some of the red blood cells in people with Thalassemia is oval or sickle shape( from :http://www.islamicboard.com/health-science/134270536-medical-student-review-2.html )

Thalassemia has two version of minor and major. Thalassemia minor in most cases does show significant signs or symptoms, that is why so many people may have it and are not aware of it. However people with major Thalassemia require advanced medical care and mostly they do not live very long.( http://www.medicinenet.com/beta_thalassemia/article.htm )

According to Dr. Greenberg this condition is often mistaken by iron deficiency in the nutrition. The reason is that  hemoglobin in people with Thalassemia is not capable of utilizing enough iron because of its faulty protein structure, as a result, their  blood tests show lower amount of iron compared to normal range. Misdiagnosis of Thalassemia and consumption of iron pills in fact accumulates in the liver because the iron is not being utilized by hemoglobin and causes damage to people who have Thalassemia and not iron deficiency. link to his article is here >>http://www.utoronto.ca/kids/Thalassemia.htm

Epidemiology and History: Thalassemia is common in discrete regions of the world where malaria was prevalent, such as Asia, Africa, middle-east, and parts of Europe. It is interesting to note that people with such condition could survive malaria at a higher rate than people who did not have Thalassemia. Therefore Thalassemia condition caused a selective survival advantage for carriers(Wikipedia :http://en.wikipedia.org/wiki/Thalassemia ).

Hence, if you are from the countries that Thalassemia is common or your background is from countries mentioned above and your family doctor diagnosed you with either iron deficiency or “anemia” make sure you ask for a genetic test and make sure you do not have Thalassemia.

According to Wikipedia “This genetic disorder is autosomal recessive trait, meaning a person needs to inherit two copies of the gene from each parent for the trait to be expressed. Therefore both parents have to be carriers of a recessive trait in order for a child to express that trait. If both parents are carriers, there is a 25% chance with each child to show the recessive trait”. This is important for people who are carriers of Thalassemia and plan to have kids and become pregnant to make sure their partner is not a carrier.

Here is a link which you can share with your friends to make them awareYouTube Preview Image

 

Let’s Play Some Mario!!!

Do not think Mario games are easy because it is old and many kids are playing it. Mario is actually difficult. You think other people have no problem playing it? You are wrong.

NP-hard (non-deterministic polynomial-time hard) means problems that are at least as hard as the hardest problems in NP. Mario and and many games such as Zelda, Pokemon, and  are considerred as NP-hard. It meas it can be very hard for a player. Here are some examples of Pokemon and Zelda problems.

According to Jacob Aron. Each game can be transformed into a logical puzzle called Boolean satisfiability problem. It is used to determine if variables of a given Boolean  formula can be assigned in such a way as to make the formula evaluate to TRUE. For the games, elements suchs as enemies and mushrooms are assigned as variables in formulas to deteremine if they allow a game level to complete and produce true or make a game level impossible and produce false. In the result, games like Super Mario Bro. are proven to be NP-hard.

Mario games are also NP-complete. Many difficult problems can be classified into the NP-complete catogory. For examples, Salesman and knapsack problems are NP-complete; they require of finding the shortest route between series of points, and  how to allocate resources.

Here is just an example of very hard Mario game. (video contains coarse language. Viewer discreption is advised)

YouTube Preview Image

It is not common to run into Goomba or not be able to jump over the bottomless pit. Since Mario is proven to be a very hard game, dont feel bad to see “GAME OVER” many times.

Reference

1. NewScientist. Jacob Aron. Mario is hard, and that’s mathematically official. [Accessed March 14, 2012. ]

2. Kotaku.  Luke Plunkett. Science Proves Old Video Games Were Super Hard. [Accessed March 14, 2012. ]

2. Wikipedia. [Accessed March 14, 2012. ]

 

How Forgetting Might Become the Norm

Memory is a strange thing.

The more we learn the more we seem to forget, quite literally, and in so doing we help ourselves learn even more.

A strange proposal then would be whether it possible to forget the baggage we don’t like, keep those we do, and maybe throw in some fun stuff that never happened. It all sounds crazy, but this world is a crazy place.

YouTube Preview Image

To start with how, let’s look at how memories are formed. In the brain, chemicals and proteins are released that help neurons pass electric potentials between themselves, and this helps the neurons make new ion channels with each other. It’s like making phone lines of memory between brain cells. The creation of these circuits is called Consolidation and until recently was thought to be concrete.

That “recently” happened when a young graduate named Karim Nader discovered that when memories are remembered or “Reconsolidated” they can be wiped out if the chemicals aren’t there to make the connection.

It turns out that when you remember something, a few things happen. Similar memories that would compete with that memory can be mixed in or weakened/eliminated by the prefrontal cortex and the memory itself is literally rebuilt.

"Seems Like a Good Idea" Image:Eternal Sunshine of the Spotless Mind

Because of this, every time you remember something it gets a little altered in the process, and if the chemicals are blocked, the reconsolidating memory becomes wiped.

“This is crazy and awesome, but too crazy for me, can I make bad, painful memories better without this?” Yes you can. Because memories are associated with different emotions or perceptions, they’re located in different places. Negative ones are found in the amygdala, though they can be removed and relocated elsewhere. How? Think about the memory in a happier setting when you’re immune to feeling blue, it will remain in your mind but won’t have the same emotionally negative effects. This is why ecstasy is one of the most effective PTSD treatments ever.

"Pacman, eating pills to invoke trippy colours and devour your ghosts" Image:Pacman

“How can I make this more fun?” PLAY TETRIS. Playing Tetris within 4-6 hours of trauma significantly reduces the associated trauma with a painful memory. Yes folks, drugs and videogames are the answer, Pacman had it right.

“This is cool, can I be programmed with happy thoughts?” Yes you can. It turns out we’re really good at remembering things that never happened. Dr. Elizabeth Loftus has demonstrated that 1/3 of subjects can be tricked into thinking false memories are their own, even with only one exposure to it. This is why people can be convinced they met Bugs bunny at Disneyland.

“Nice, can I have this memory wipe as a pill please?” Not yet, but a scientist named Dr.Sacktor has found the primary and defining chemical involved in (re)consolidation. It’s called PKMzeta, a form of protein Kinase C. It’s needed to maintain memories, and inhibiting it while remembering something leads to a swift and selective wipe of that something.

“Do you think I can get a prescription?” You may in the future if you have chronic neuropathic pain. It likely will have the same effect on the spine as the brain, and it might even help people with addictions.

All in all this is fabulous news. Though it can be a lot to take in, whether it makes you fear an Orwellian mind control police or you’re just excited to become a mind-tweaking psychonaut, it likely won’t matter as you’ll probably forget you thought about it anyway.

"A Sea of Potential" Image from: http://thetechnologicalcitizen.com/?p=2471

Is Daylight Saving time change a good idea?

Sleep deprivation. Picture courtesy of Yoni Freedhoff

We have all just experienced the agonizing pain of waking up 1 hour early on a monday morning. According to a recent study, daylight saving time change might not necessarily be beneficial to your health.

It has been found the “Monday and Tuesday after moving the clocks ahead  one hour in March is associated with a 10 percent increase in the risk of having a heart-attack,” says UAB Associate Professior Martin Young, Ph.D., in the Division of Cardiovascular Disease. Furthermore, the risk is decreased in October by 10 percent.

Need more sleep? Courtesy of Omnigraphics Inc.

 

This study also indicated heart-attack tends to peak on Monday when most people get up earlier to go to work. Why this is happening is not exactly known however, Yougn proposes “Sleep deperivation, the body’s circadian clock and immune responses all can come into play when considering reasons that changing the time by an hour can be detrimental to someone’s health.”

How does these three factors affect the risk of  heart-attack?

Sleep deprivation has been a well studied topic, it has been found “individuals who are sleep-deprived weigh more and are at an increased risk of developing diabetes or heart disease,” furthermore sleep depriviation alter infalmmatory response, which can contribute to a heart attack.

According to Young, “every cell in the body has its own clock that allows it to anticipate when someting is going to happen and prepare for it,” but when cell clocks are anticipating another hour to sleep that they won’t get, the negative impact of the stress worses”

Lastly, in the case of immune function, because “immune cells have a clock, and the immune response depends on the time of day, and acute time change can be detrimental to the immunte system response”

This study may sound scary, however our body’s clock eventually synchs with the environment.

But do not worry!

Professor Young have a few tips for this problem!

-waking up 30 minutes earlier on Saturaday and Sunday to prepare for the early start on monday

-do more exercise

References

References

  1. Circadian rhythm sleep disorder.  http://www.sciencedaily.com/articles/c/circadian_rhythm_sleep_disorder.htm (accessed 03/12, 2012).
  2. Circadian rhythm. http://www.sciencedaily.com/articles/c/circadian_rhythm.htm  (accessed 03/12, 2012).
  3. Jet lag. http://www.sciencedaily.com/articles/j/jet_lag.htm (accessed 03/12, 2012).
  4. Sleep deprivation. http://www.sciencedaily.com/articles/j/jet_lag.htm (accessed 03/12, 2012).

Bill Nye is Good.

Hello fellow students of Science 300 and valued readers of science.

My name is Bruce Wayne and when I grow up, I want to be like Bill Nye. Well that’s what I would say if I was younger and was not a multimillionaire entrepreneur, but that’s not really the point.

Picture of Bill Nye during the 90's, Image by Ace Online Schools

For those who grew up in the 90’s like myself, Bill Nye is a very familiar name. For those who are unfamiliar with Mr. Nye, he is a science educator that became popular in the 90’s for his science television show Bill Nye the Science Guy which ran from 1993 to 1998. It was an education show for preteens with good humour and pop culture references. What was different about his show was that Nye made science fun and enjoyable, but also relate-able as well, something that most education shows seem to miss out on. Each episode focused on a number of different topics such as the Earth’s crust, sound, blood circulation. The theme song was also incredibly catchy. There have been many times in high school where I have chanted “Bill Bill Bill!” under my breath while writing science exams. It was that catchy. For those lucky enough to grow up in the 90’s, Bill Nye was the reason to why science was cool and why wearing a bowtie was cool as well.

Bill Nye the Science Guy

Bill Nye the Science Guy, Image provided by Escapist Magazine

So why am I writing about Mr. Nye? Well being in a course that teaches how to communicate science to the population, I thought it would be perfect to write about the my childhood figure who taught me the wonders of science. Communicating science right?

I truly admire Mr. Nye’s ability to clearly communicate science to the general public in a way that everyone can understand. Not only that, Bill Nye is also incredibly talented in presenting science to multiple age groups and audiences. In fact, he has created a few shows such as Bill Nye the Science Guy and his more recent, The Eyes of Nye that dealt with more politically relevant topics such as global warming, genetically modified food, and antibiotics.

In the following clip, Bill Nye explains the dangers stemming from explosion of a nuclear plant in Japan that happened in last year March. For someone like myself who is not very well versed in nuclear physics, I found I could follow much of what Nye was trying to explain pretty easily. What helped a great deal as the fact that Nye talked clearly and slowly. He explained using comparisons and even took time to explain background science essential to understanding further concepts such as explaining what “aftershocks” and what that has to do with the “epicentre”. He also did not use exclusive jargon, but used words the general public would apprehend. It’s a pretty valuable thing to be able to speak in front of thousands and make most of the people understand science in a casual and intelligent way.

 

YouTube Preview Image

YouTube clip provided by FoxNewsInsider

 

Taking this course and learning about how to communicate science reminded me of times when I was younger the Saturday afternoons of watching Bill Nye the Science Guy. It’s cool to think that right now I am learning the skills to perhaps someday create my own show about science on a local cable network.

Cool right?

I’d probably call my show “Bruce Wayne the Scienceman”.