Author Archives: teepundora

Vampire Bats Inspiring New Treatments

Close up shot of a Vampire Bat
Source

As Halloween happened just last week, I wanted to write about one last spooky creature, vampire bats! While some vampire bats can cause disturbance to humans by attacking their livestock, researchers have discovered that vampire bats may actually be able to provide something useful in return.

Stroke: Journal of the American Heart Association published an article written by Liberatore et al.. The article discusses an enzyme found in the vampire bat’s saliva which can help stroke patients. According to research, when a vampire bat feeds, their saliva contains an enzyme called desmoteplase and other anticoagulants that stops blood from clotting. This allows the blood to flow continuously so the bat can feed easily and quickly.

How can this help us?

What happens during an Isochemic Stroke
Source

When a person experiences a stroke, it is because blood flow to a part of the brain is stopped. If the brain does not receive any blood, it cannot get any oxygen which will then lead to brain cell damage. The specific type of strokes that researchers are hoping to utilize desmoteplase for are known as ischemic strokes. Desmoteplase  can be used to dissolve the blood clot at the blocked artery allowing blood flow to resume.

Currently, the approved FDA-approved drug for treating blood clots contains tissue plasminogen activator (tPA).  However, tPA can cause injury to the brain by damaging or killing nerve cells or by restricting blood flow. After countless experiments by Liberatore and Reddrop, results show that desmoteplase does not promote these injuries.

Which developmental stage is desmoteplase in?

Desmoteplase is being tested as two trials, DIAS-3 and DIAS-4 in phase III. They are determining if desmoteplase is a safe treatment for patients with acute ischaemic strokes by issuing the drug within 3-9 hours after experiencing stroke symptoms.  So far, 400 participants per trial are being tested with doses of 90 μg/kg. Final collection results are expected to be taken in December 2012 for DIAS-3 and December 2013 for DIAS-4.  More information can be read upon in these two links:

Hopefully, the results from these two trials will advance the field of stroke treatment and verify desmoteplase as safe for usage in the near future. Lastly, this is a video that briefly talks about the process of modifying desmoteplase to the updated version of the drug.

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Note: The last portion of the clip talks about having the results by 2011, however this has been changed as seen by the data from the two links above.

Post by: Tiffany Ho

Honey in Colours of the Rainbow?

Halloween is around the corner and candy factories are in full blast. This is great news for the candy business but for a town in France, the bees are creating honey that can match any colour of candy out there.

The unnatural shades of honey compared to the original appearance.
Source: http://www.reuters.com/article/slideshow/idUSBRE8930MQ20121005#a=1

In the town of Ribeauville, beekeepers found that the bees were making honey in shades of blue and green. Although the honey still tastes normal, beekeepers are unable to sell the honey due to their unnatural shade.  They noticed in August that the bees were bringing back colourful substances that were the cause of the honey being different colours.   After some investigation, they discovered a company called Agrivalor that owns a biogas plant 4 km away from the town. This company had been processing waste from a Mars plant which created colourful M&M candies. It turns out that they were leaving the waste in open containers which then allowed the bees to take the residues back to their hive.

Anatomy of a Bee, note where the “honey stomach” is located.                      Source: http://www.bees-online.com/beexray.gif

Bees begin their honey process by gathering nectar from flowers and storing them in a separate stomach that’s considered to be the “nectar backpack” or honey stomach. Since the biogas plant left the waste in the open, this was the easiest sugar source for the bees to gather instead of taking nectar from flowers.

This turn of events troubles the beekeepers as they are unable to profit from honey sales which were already suffering from a decline of the bee population.  This decline may be attributable to a couple of factors like habitation loss, pesticides or the colony collapse disorder. Just in the United States, an average of 33% of bee colonies has been lost during the winter months these past years according to the USDA.

The improper disposal of waste has already affected many businesses and the lives of the town residents. Taking shortcuts and using quick fix procedures may help a company in a short run but it may have serious ramifications in the future. Bees are one of the essential organisms that help the world flourish and plants to grow. With bee populations on the decline, they do not need any more human mistakes to add to the growing list of factors affecting their livelihood.

Blog post submitted by: Tiffany Ho

 

A Step Towards Finding Stuart Little?

Unfortunately, scientists have not discovered a rodent that can talk and dresses up as a human. However, they have discovered that rats can experience humanistic emotions and exhibit human characteristics.

The test rat in the process of freeing the imprisoned rat.
Source: http://www.cbc.ca/news/offbeat/story/2011/12/09/rats-empathy-chicago.html

Inbal Ben-Ami Bartal et al. at the University of Chicago have found that rats have the ability to show empathy towards other rats. The research team’s experiment was designed to test whether a rat would open a cage to free another comrade inside. The results showed that the tested rat would free their distressed companion when it hears its calls, regardless of rewards. In order to further test this empathetic behaviour, the researchers performed trials where they placed chocolate in another container nearby to see if the test rat will head to the food instead of the imprisoned rodent. Surprisingly, instead of the anticipated results, the test rat chose to free the restrained rat. Furthermore, instead of hoarding the chocolate, the test rat went as far as to share it with the other.  As such, not only have rats shown empathy in this experiment, they also appear to retain a pro-social behavior towards other rats which is reminiscent of behavior recognized in our culture.

Source: http://rosieheffernan.com/MISC-1

Another finding that exhibits human characteristics found in rats was conducted by Jaak Panksepp, a neuroscientist at Washington State University. He discovered that when tickled, rats emit chirps that are akin to laughter heard through Bat Detectors, a device that can bring high frequencies to our auditory range. These 50 kHz chirps were found to be related to positive affective state in rats (Burgdorf 2011) and can also be heard when the rodents play and chase each other.

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So why should people care whether rats can show empathy or laugh when tickled? These discoveries allow scientists to understand how the brain of specific animal works and its subsequent effect on behavior. Although these studies are focused on rats, the same experimental research may be applicable to other animals as well. This may in turn resolve some of the mysteries of the animal kingdom, from the process that fuels their keen instincts to the impulse that drives certain behaviours.

If further discoveries are made, perhaps we may one day see a genuine Stuart Little that can communicate with us. On the other hand, we might find a duo Pinky and the Brain  and stop them from taking over the world.

Blog post submitted by: Tiffany Ho

References:

Burgdorf, Jeffrey, Jaak Panksepp, and Joseph R. Moskal. “Frequency-Modulated 50 kHz Ultrasonic Vocalizations: A Tool for Uncovering the Molecular Substrates of Positive Affect.” Neuroscience and biobehavioral reviews 35.9 (2011): 1831-6. Print.