Author Archives: bmaxwell

Hearing Regained

Have you lost your ear or part of it? Well, new research has come to light to help with that problem!  In a new study done by physicians at Weill Cornell Medical College and biomedical engineers at Cornell University, human ears can be developed to look and act just as real as the ones people are born with.

The research was conducted in hopes of developing alternatives to replacement ears, which are currently used to treat children who do not have ears or have deformed ones.  The most common use of the replacement ears is to treat children who are suffering from a congenital disorder known as microtia where there are problems in ear tissue development. This results in hearing loss which varies depending on the severity of the case.  The current replacement ears are of a Styrofoam base and the procedure children undergo to have them surgically attached usually comes with many challenges.  The surgery can be quite painful for children and sometimes the ears do not last, work proficiently or even look natural.  However, with this new study, another option will soon be available.

Child with microtia. Image provided by Wikimedia Commons.

The Cornell team of researchers has developed a bioengineering technique that allows them to produce very human like ears.  The process of making the ears for patients is actually quite a quick process and can be completed within a few weeks.  First, using a combination laser scanner as well as taking a panoramic photo of the patient’s ear, a 3D image is obtained.  Depending on the case, the physicians may use one of the “good” ears of a patient or it is a possibility they may construct one from scratch based on what a proper ear would look like.  Next, they turn the image of the ear into a “digitized solid ear” and a 3D printer is able to construct a mirror image mold of the ear to be.  Collagen is then injected into the mold, followed by the addition of approximately 250 million cartilage cells.  About 15 minutes after this mixture of collagen and cartilage has been injected, the ear is ready to be removed.  Lastly, the ear’s shape is perfected, and it is placed in a culture medium where it stays until the implantation.

Below is a video of Dr. Lawrence Bonassar, who was one of the key author’s describing the bioengineered ears his team has developed.

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Although human implantation is still a few years away, this research is life changing.  To think that a child’s hearing could be restored and that the bioengineered ears look so natural is truly a wonderful thing.

Brittany Maxwell

Are HIV Medications a Thing of the Past?

Being diagnosed with human immunodeficiency virus (HIV) is one of the most devastating things a person can hear.  This virus which breaks down a person’s immune system and eventually leads to acquired immune deficiency (AIDS) is still one of Earth’s incurable tragedies.  However, new research has come to light where gene therapy  may be used as an alternative to medications for patients with HIV.

HIV gains entry into the body by attaching to the surface proteins CCR5 and CXCR4 of a person’s immune cells, also known as T-cells.  The current medication treatment of HIV is called highly active antiretroviral therapy (HAART) which is a mixture of pharmaceutical drugs.  HAART acts to prevent the spread of HIV in the body.   However,  researchers at the Stanford University of Medicine have found a way to halt further HIV infection in the body without requiring patients to take medications.

A model of HIV that was on display at the Smithsonian Museum of Natural History in July of 2012. Image from Fickr user dctim1.

Many different gene therapy research approaches are being investigated, but Dr. Matthew Porteus and his team at Stanford made a unique adjustment to the other research.  The Stanford scientists utilized zinc finger nucleases in order to break open the CCR5 receptor protein’s DNA found on T-cells.  From there, they added three genes that are resistant to HIV in a process known as stacking.  Stacking the genes is what differs between the various teams of gene therapy research.  Faced with the resistant genes, HIV has less of a chance of entering the cell.  In order to test this, the scientists inserted either one, two or the three genes and then exposed the T-cells to HIV.  They found that the cells with the combination of the three genes were the most resistant.

Some people in the world actually have a resistance to HIV because of a mutation in their CCR5 receptors.  Thus, if this new gene therapy can mimic this resistance hopefully HIV will not be as daunting.  Below is a video displaying the research done at the University of Pennsylvania , which is similar to what is being done at the Stanford School of Medicine.  The video is from February of 2011.

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Although this research appears very promising, it is by no means perfect yet. There are certain problems that could arise including the cells not responding to the genes and breakages in the other areas possibly causing cancer or other problems.  This research is extremely new and still has a lot of work to be done before it is ready to be tested on the general public.

Brittany Maxwell

A Smile Does Not Always Cut It for a Good First Impression

Have you ever felt that you aren’t being trusted by someone who knows nothing about your character and who only briefly looked at you? If so, do not be too offended.  According to a new study done by Charles University in Prague, people with brown eyes appear more trustworthy compared to people with blue eyes.  However, it is not eye colour alone that causes people to develop an unwarranted assumption, face shape is also a key factor.

Photo from Flickr user nelu_bodean.

40 male and 40 female students with either blue or brown eyes were photographed and judged by 238 participants that rated their trustworthiness.  After the initial round, a second group consisting of 106 people was asked to judge the same 80 photos; however, the eyes of the blue students were recoloured to brown and the brown eyed students had their eyes recoloured to blue.  The point of this was to determine whether or not other facial characteristics were influencing the participants’ choices or if it was strictly eye colour.

It was determined that people with brown eyes have a more trustworthy appearance due to the facial qualities linked with having brown eyes.  Interestingly, this phenomenon is more significant in males rather than females.  According to the study, males with blue eyes more commonly have smaller eyes, eyebrows that are further apart and narrow mouths.  On the other hand, brown eyed men generally have the complete opposite with larger eyes, eyebrows that are closer together and wider mouths.  This less dominating and more childish appearance is associated with being more trustworthy.

Photo from Flickr user CarbonNYC.

Similar research conducted by Alexander Todorov and Nikolaas Oosterhof at Princeton University determined that people will make instant assumptions about others based on whether they appear strong or weak and whether they should be avoided or not.  Knowing this, the scientists utilized a computer software program that would display a broad spectrum consisting of 300 faces to participants who would decide how trustworthy, dominating and threatening the faces were.  With this information, more analysis and testing was done to understand what specific facial characteristics are the most important for making judgements about others.  The clip below demonstrates the changing facial features that make one appear more or less trusting.  The video gradually transitions through different faces with the least trustworthy in the middle and the most at the beginning and end.

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Therefore, if you find that you are being avoided for no reason and people are not immediately putting their faith in you don’t take it to heart.  Instead perhaps embrace the challenge and prove to people that their initial judgements are sometimes incredibly inaccurate.