Category Archives: Science Communication

Concussions: Impacts on the Brain

The brain is a complex organ, and while researchers have made great strides in understanding its function and mechanisms, we still know relatively little about the consequences of damage to the delicate structure.

The brain is suspended in the skull cavity, and sharp accelerations can sometimes cause collisions between the unyielding bone of the skull and soft tissue, bruising the surface and damaging important neural connections within. This is known as a concussion, an injury common in contact sports where blows to the head are frequent.

A concussion can be harmful to anyone, but could the impact be greater on a developing brain, like that of a teenager’s?

Dr. Naznin Virji-Babul

Dr. Naznin Virji-Babul, a physical therapist and neuroscientist at the University of British Columbia, set out to discover the true extent of brain damage on concussed adolescents.

“The common perception of people is that your brain stops developing when you’re 3-5 years old. That’s not exactly true… the frontal areas of your brain are still developing when you’re a teenager,” she says, adding that this frontal area is what collides with the skull when a concussion occurs. The frontal and temporal lobes are most vulnerable to injury, and damage to these areas is associated with impairments of regular function. The study that her team conducted at UBC used Magnetic Resonance Imaging to gauge the extent of damage to the brain.

The study was conducted using a group of teen athletes, some of whom had experienced a sports-related concussion within the past two months and others who had not  Each athlete underwent an MRI scan which measured the rates of diffusion of the fluids within the brain.

The results were surprising to the team, who had expected to find clear evidence of damage, and lower rates of diffusion in the concussed group compared to the uninjured group.

“But it was completely opposite to what we had expected, we thought we would find a decrease in [one of the tests] but we found an increase… It was like solving a puzzle trying to find out what was so different.”

Diffusion Tensor Imaging scan for a healthy brain(left) and concussed brain(right)

Dr. Virji formulated a theory as to why the changes were different than expected: the neural damage in the brain was subtle, not outright breaking but causing smaller tears in the neuron which collect fluids and cause edema. This could throw off a diffusion tensor image but still indicates damage present in the brain long after the actual injury occurred.

“I wasn’t expecting to find changes in the kids who have had a concussion two months prior, but we still did… Kids and adolescents take longer to recover.”

These findings call to question the established guidelines concerning returning concussed athletes to play and school, as all of the concussed athletes scanned in the study had returned to their sport. Luckily, thanks to the findings of Dr. Virji and her team, new light is being shed on the nature of concussions on a teenager’s developing brain. This will hopefully lead to safer practices regarding the athletes care both during the game, and after.

Celebrating Hockey without injury

This podcast covers further the nature of this resistance by the public towards concussions in adolescents, and how the established safety measures are not adequate enough to prevent brain injury.

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For more information, feel free to watch this video on the impact of Dr. Virji’s research.

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By: Ammar Vahanvaty, Derrick Lee and Ashley Dolman

 

How Sea Breezes Affect You!

The term sea breeze in itself seems rather simple. In fact, the every-day person probably believes that a sea breeze is, well, just a breeze – they are commonly overlooked. Yet they would be surprised to learn how much research actually goes into studying sea breezes that occur all over the world and the huge impacts that they can have on society as a whole.

Dr.Steyn from the University of British Columbia (UBC) has dedicated many years of his life to studying sea breezes and the different interactions they can have with the atmosphere. He has found that sea breezes and the winds associated with them are actually involved in the spreading of pollution all around the world.

Image showing energy plant releasing pollution into the air. Image by flickr user thewritingzone

How might this affect the general public? Well, our governments spend millions of taxpayer dollars to implement pollution reduction programs in their countries but fail to realize that much of the pollution that they are trying to cleanup actually comes from other regions of the world through wind circulation.

Furthermore, the growing shortage of fossil fuels has become a major problem in our society. Researchers estimate that the petrochemical supply will run out in about 50 years. We are fortunate to have researchers like Dr.Steyn, who are investigating
the occurrence and frequency of sea breezes, and are collecting a vast body of knowledge that could be used to substitute many forms of unsustainable energy.

In the video below, Dr.Steyn explains how sea breezes form, how they can actually help pollution spread, and how sea breezes data can be used for energy production.

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As you saw, sea breezes can be a major contributor to the way in which pollution is circulated around the world and can greatly influence where and how we build wind energy farms in the future.

The story doesn’t end there. Not only is collecting data and understanding sea breeze important for pollution and energy, it also influences the way we live our daily lives. It is surprising how great of an impact sea breeze can have on society and how less people know about them. From the way we travel, to the way that we spend our free time, sea breezes are everywhere.

 Sea breezes can have a significant impact on the way that planes land at airports and how surfers spend their time in the water. These two everyday examples are influenced by the direction of the sea breeze. Sea breezes are very regular in that they are onshore by day and are offshore by night. During the day, the land heats up more than the ocean because it has a lower heat capacity.

Image showing how sea breezes blow during the day and night. Image from Mr.Bent’s Educational Blog

This creates a low-pressure system near the land and causes the sea breeze to blow towards the shore. On the other hand, the complete opposite occurs during the night, when the land cools and creates a high-pressure system. This results in the sea breeze blowing towards the water. Surfers call this type of breeze an offshore wind, which is highly desired as it hollows out the wave, allowing for a more radical surf experience.

The podcast below gives a more in-depth explanation of how sea breezes affect people’s day-to-day lives.

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Hopefully, you’re convinced that the sea breeze is not just any breeze; it is a very important atmospheric phenomenon that may influence your lifestyle more than you care to know. They are not to be overlooked – they help planes land, circulate pollution but still, as we found when interviewing UBC students on their opinion about sea breezes, most people only pay attention to sea breeze when it “affects what [they] wear when it’s cold out.”

A special thanks to Dr.Steyn for the Interview.

By: Gagandeep, Grattin, Ki Won, and Dragana.

The Promised Future of Prosthetics: Robotic Limbs

It must feel great to be able to feel a friend’s hand after seven years. Researchers at the University of Pittsburgh School of Medicine and UPMC have enabled a 30-year-old paralysed man to be able to move his robotic arm by means of electrodes placed in his brain. The tested patient has been paralysed for seven years after a motorcycle accident. “It feels like I’m robocop” says Tim Hemmes, the spinal patient. Researchers used the newly developed brain-computer interference (BCI) technology to make Tim he has hand again. The data released from Tim’s thoughts are then interpreted by an IBM designed processor. The analysed data are then put into command language for the robotic limb. “When Tim reached out to high-five me with the robotic arm, we knew this technology had the potential to help people who cannot move their own arms achieve greater independence,” said Dr. Wang, when watching a memorable scene in 2011.

Today, different types of bionics are being made. There exists bionic lenses, bionic arms and bionic legs. However, the accuracy of these devices are not perfect yet but the clinical cases are showing a promising future in this field.

Tim Hemmes’s case

How does it work?!

In order for patience to feel comfortable using the prosthetic limb, the designed limb’s weight should match the actual limb’s weight. This prevents researchers from producing gigantic robots. The next step in making a robotic limb is building an appropriate BCI which matches the right part of the brain. In order to do so, researchers use functional magnetic resonance imaging (fMRI) to find the right place for the conductors. Conductors take data orders from your brain and analyse those data using bio-computational algorithms to transform data into machine language. The robots then do the job for the patient.

 

The robots used should have the same functionality as the actual limb since it is believed the brain of the patient can only command in a certain manner. That certain manner matches with what the patient did with his/her actual limb and our brains are not trained for anything beyond what our limbs can do.

Below is a Ted talk showing the clinical accomplishments of robotic limbs:

Although it is very early to comment on this technology but it is pretty evident that soon this technology will become a solution for amputated limbs. Many different researched are also being conducted on robotic lenses but not a lot of successful cases have been reported yet.

References:

1. Di Pino G, Porcaro C, Tombini M, et al. A neurally-interfaced hand prosthesis tuned inter-hemispheric communication. Restorative Neurol Neurosci. 2012;30(5):407-418.

2. Di Pino G, Porcaro C, Tombini M, et al. A neurally-interfaced hand prosthesis tuned inter-hemispheric communication. Restorative Neurol Neurosci. 2012;30(5):407-418.

3. Guymer R. The challenge and the promise of the bionic eye. the bionic vision australia project. Clin Exp Ophthalmol. 2012;40:123-124.

4. Li Hu, Yang Jian-yu, Su Peng-cheng, Wang Wan-shan. Computer aided modeling and pore distribution of bionic porous bone structure. J Cent South Univ. 2012;19(12):3492-3499.

5. Mironov V, Boland T, Trusk T, Forgacs G, Markwald RR. Organ printing: Computer-aided jet-based 3D tissue engineering. Trends Biotechnol. 2003;21(4):157-161.

Insulin – Spreading The Cure

Prior to the discovery of insulin, diabetes often resulted in fatalities. The disease is considered much less serious now that extractable insulin is well-established as an effective treatment for diabetes; however, it is important to analyze the historical methods in which the cure was globally implemented in case something similar occur. Imagine if a cure for cancer was discovered – I can picture the news making global headlines that very same day. But how would such groundbreaking news spread to the most isolated communities? Or would it at all? Who would have physical access to such a cure first? Using insulin as an example, I can deduce why it is too quickly assumed that such a cure would automatically reach everyone in the world with cancer.

Insulin As a Cure – Patients with type 1 diabetes can’t produce insulin by themselves, so insulin can be extracted from animals and injected into the patient to stabilize blood sugar levels (which if unstable could lead to toxic effects.) Insulin stops the catabolism of fat into energy by inhibiting the release of glucagon and removing excess glucose from the blood. The structure of insulin protein is shown below:

Insulin (click on images to view source)

The following is a short animated video about Insulin, Glucose and You:

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Discovery

Insulin was extracted from the pancreas by Frederick Banting and Charles Best in 1921 at the University of Toronto. They tested the anti-diabetic qualities of the pancreatic extract on a dog before their first human test subject, a 14 year-old boy, in 1922 – the results were “spectacular.” The two went around the diabetic ward of the Toronto General Hospital injecting comatose and dying children. “Before injecting their last comatose patients, the first started to awaken from their comas.”

 

How did the discovery spread globally?

Banting and his laboratory director John MacLeod received the Nobel Prize in Physiology or Medicine for the discovery in 1923 and both immediately shared credit (and prize money) with other individuals involved including Best. This news made headlines all over the world.

A historical newspaper clipping during the time of the discovery of insulin.

Banting and Best made the patent available without charge and didn’t try to control the commercial production of insulin. This played a huge role in the rapid spread of insulin as a cure. Also, prior to insulin, a strict diet was the best way to increase life-expectancy of diabetics (American Diabetes Association 2012). Insulin surely allows diabetics a less restrictive lifestyle (another reason for the increased demand); unfortunately the dietary freedom has caused the percentage of the US population diagnosed with diabetes to increase since 1980 (Polonsky 2012).

There is very little analysis of the physical spread of insulin at its time of discovery. It was such a major discovery that improved and saved the lives of many, yet how it became this way has been taken for granted, all we remember is that it happened. It is popular belief that the cure was in such a high demand and was so dramatically effective that it would find its own way around the globe. I argue that this isn’t exactly the case  – many poorer countries in Africa still suffer fatalities from diabetes today because they lack access to insulin (Cohen 2011).

Grattin Cox