Category Archives: Science in the News

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Spontaneous and Contagious Yawning

In any given day, there is at least one instance where we yawn. This may be a “spontaneous yawn” or something called a “contagious yawn“. The difference between the two is that a “contagious yawn” is a reaction to someone else’s yawn. … Continue reading

The Harmful Sun: Evidence for Post-Exposure Damage

 

Woman applying sunscreen on to her face for maximum protection against the UV-radiation

Woman applying sunscreen on to her face for maximum protection against the UV-radiation of the Sun. Source:Flickr commons. Image by earthlydelights

It is common knowledge that the ultra-violet (UV) radiation from the Sun has the ability to cause skin-cancer. For this reason, many of us make sure to apply sunscreen before we depart for the beach on a sunny day. But is the sunscreen doing it’s job? Is it effective in preventing skin-cancer?

Sunscreen can come in the form of a spray or a creme and is vital for protection from the Sun’s harmful rays. As described in this article, sunscreen functions to protect your skin by absorbing the UV rays, acting as the first-line of defence. The article also mentions that no matter how high the protective power of the sunscreen, not all of the UV-rays will be absorbed and some will ultimately reach the layers of the skin.

As per this BBC article, as these UV-rays make it past the sunscreen, they are absorbed by a component of the skin called melanin. Similar to how sunscreen is the first layer of defence, melanin is the second layer of defence against the sun’s rays. Again, melanin does not absorb all of the UV-rays and some pass through to the deeper layers of the skin. This article says that once the UV-rays penetrate the melanin, they can cause disruption at the DNA-level which may cause skin-cancers.  This is not the whole story, however.

The video by Kevin Boyd through Ted-Ed explains why sunscreen is necessary to prevent skin-cancers:

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According to a new study out of Yale University, scientists have discovered that the Sun’s UV rays have the ability to do damage for more than three hours after exposure. The study found that once the melanin absorbs the UV-rays, it initiates a series of chemical reactions in the skin that produces heat. This heat, it was discovered, is what ultimately damages the DNA, hours after initial exposure to the sun.This is a huge breakthrough as it was not previously known what happens to the UV-rays after being absorbed by melanin.

Yes, the sunscreen that is on the market now still protects against UV rays, however, it does not protect against the post-exposure damage that occurs. So no, the present form of sunscreen is not as effective as it should be. The real-life implication of this study is that now scientists can produce an ‘evening-after’ sunscreen that can be applied after exposure, protecting your DNA from the heat and ultimately preventing cancers.

Finally, a quick note for all those that don’t feel the need for any sunscreen; not only are you putting yourself at risk for cancer when you are in the sun but also for up to four hours later,even if you are indoors. Until this new type of sunscreen is developed, I think it’s essential that we allow for as little UV-rays to get to our melanin as possible. So, lather up!

A sign that reminds everyone to 'use plenty of sunscreen' to protect themselves from the harmful rays of the Sun

A sign that reminds everyone to ‘use plenty of sunscreen’ to protect themselves from the harmful rays of the Sun.  Source: Flickr commons. Image by Alex Liivet

 

 

Three-Parent Babies

Last month, the United Kingdom voted to legalize “three-parent babies.” They are the first country to allow this procedure and within a year, the first of these babies will be born.

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Mitchondrial replacement can prevent mitchondrial disease from being passed on to future generations
Photo courtesy of Flickr

These babies will have three parents in an attempt to eradicate mitochondrial disease. In short, this disease is caused by mutations in the mitochondrial DNA which in turn leads to insufficient energy for the cell’s survival. The death of cells causes the organs to fail ultimately leading to death. This illness is passed through the mother to her children. There are three traditional choices for mothers with this disease that hope to have children. They can adopt a child, use a donor egg, or become pregnant and at 11 weeks have the fetus tested for mitochondrial disease. At that point, they can choose to terminate the pregnancy. However, there is new hope on the horizon for prospective mothers in the United Kingdom that have this disease. The government recently legalized a method of three-person in-vitro fertilization, mitochondrial donation.

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There are two methods of mitochondrial DNA replacment, maternal spindle transfer and pronuclear transfer.
Photo courtesy of Flickr

There are two different methods of mitochondrial donation. The first is named maternal spindle transfer where the repair is completed before fertilization. An egg is taken from both the mother and the donor and both the nuclei are removed. Next, the mother’s nucleus is kept and inserted into the donor’s egg while the donor’s nucleus is destroyed. Then, the donor egg containing the mothers nucleus and healthy mitochondria is fertilized with the father’s sperm. Finally, the egg is implanted back into the mother.

The other method of fertilization is named pronuclear transfer. In this procedure, the repair is done after fertilization. First, an egg is taken from both the mother and the donor. Then, they are fertilized with the father’s sperm. Before the eggs have a chance to replicate, the chromosomes from each egg are taken out. Next, the donor ones are thrown out and the donor egg is filled with the mother’s chromosomes. Finally, the egg is implanted in the mother.

There are many ethical concerns attached to this issue causing countries including Canada to hold back on legalizing this procedure. In Canada, this specifically has to do with the fear of opening the doors to designer babies. Not only are designer babies horrifically dystopian and Brave New World-esque, it may also decrease the natural variability of the human race, something that is required for the race to survive and adapt. However, changing a baby’s mitochondrial DNA is a far cry from creating designer babies. The procedure has no effect on their hair or eye colour and it isn’t enhancing them in any way. In fact, the change affects less than 1% of the baby’s total genome.

Other ethical concerns include “germline” genetic engineering, the fact that one of the embryos are destroyed in the pronuclear transfer and that we are unsure of this procedure’s effects on humans. Even with these concerns, this procedure is worth it if we can eradicate a painful disease affecting millions.

Check out this video by Elliot M. that sums up mitochondrial replacement:

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– Siana Lai

Boosting Your Immune System with a Dose of Personality

Personalities and their effects on biological systems have become an increasingly popular focus of research over the last few years; the target of these studies is often related to the degree in which our personalities can regulate many aspects of our life, such as our wellbeing. A video from the Youtube series ASAPScience (see below) provides an example of the link between personality and biology. The video specifically discusses a relationship between personality and sleep habits (whether you’re a night owl or a morning person) and how the latter reveal your personality traits.

The science behind our personality is simple. It can be defined as a collection of characteristics or qualities that form an organism’s unique character. These specific traits that all combine to form a unique personality can affect different aspects of our life, such as our performance in school and the friendships we have. The question is, does personality really have an impact on our health?

Previous studies have linked personality and its role in the risk of developing health problems. More recently, research has shown that personality traits can be a factor in how well a body can fight a disease. Published in the journal Psychoneuroendocrinology, a study conducted by Kavita Vadhara and colleagues at The University of Nottingham has shown that some traits part of the ‘Big Five’ group, which are five primary dimensions of personality common to all humans, can play a role in the way the defence system of the body works. This system is also known as our immune system.

The 'Big Five' Model shows the five primary dimensions of personality. Big Five Source: Wikipedia Commons

The ‘Big Five’ Model shows the five primary dimensions of personality.
Big Five Source: Wikipedia Commons

The team of researchers asked 121 students to complete a questionnaire based on their personality. This questionnaire measured their degree of the ‘Big Five’ personality traits. Specifically, they looked how extroverted the participants were (energetic, talkative), their neuroticism (how anxious or moody) and their conscientiousness (how organized or thoughtful). In addition to the questionnaire, they also took a blood sample from each participant. This allowed the analysis of a number of genes that are involved in an inflammatory immune response, which is a response initiated by our immune system that helps the body fight infection and speed up the recovery from injury. Using microarray technology to determine which genes are active, the team of researchers were able to make a correlation between personality traits and the active genes required for an immune response.

The above instrument is used in microarray technology to identify active genes. Microarray Source: Wikipedia Commons

The above instrument is used in microarray technology to identify active genes.
Microarray Source: Wikipedia Commons

Results showed that participants who scored higher for extroversion in the questionnaire had an increased expression of pro-inflammatory genes (genes capable of promoting inflammation). However, participants who demonstrated a higher degree of conscientiousness subsequently had a decreased expression of pro-inflammatory gene expression. In other words, individuals with a more social behavior appear to have a greater ability to deal with infection and injury, whereas participants who were more cautious could not effectively handle the infections. The third trait mentioned, neuroticism, did not show an association with gene expression.

Before you celebrate that your outgoing disposition means you’re better at fighting illness, I think an important question that should be asked is, what is influencing what? Could it be the opposite cause-and-effect relationship, where our immune system influences our behaviour? Whatever the cause of the above results, the study conducted by Vadhara and colleagues provides further support to the dynamic relationship between health and personality.

Check out this video by Kurz Gesaft explaining how the immune system works:

 

Thanks for reading!

Samantha Mee

Tattoo removal might be easier than you think

Do you have a tattoo that you regret getting? Maybe your tattoo is not appropriate for your future career or you made a spontaneous decision to get one. For whatever reason, one in six people who have tattoos hate them so much that they want them surgically removed.

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Woman has to get tattoo removed due to her job because the U.S. Marine Corps does not authorize any hand tattoos. Source: Slick-o-bot Wikimedia Commons

Luckily, surgery may not be needed because Alec Falkenham, a Ph.D. student from Dalhousie University, is developing a tattoo removal cream as a painless alternative. This topical cream promises to eventually make any tattoo fade away.

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Using a tattoo needle. Source: James Gray-King Flickr

To make a tattoo, tattoo needles are used to go through the epidermis, the outer layer of the skin, and send dyes into the dermis, the deepest layer of the skin, causing an inflammatory response. This would then signal the immune system to send a type of cell called macrophages to the wounded site. As a result, the macrophages eat up the dye and show up as the desired colour which is visible through the skin. In order to remove the tattoo, Falkenham’s cream allows new macrophages to consume the macrophages with dye and then migrate to the lymph node, essentially removing all of the tattoo’s dye.

Below is a video by TED-Ed which goes into further detail of the science behind tattoos:

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This tattoo removal cream would challenge current methods such as surgery or laser removal. Surgery requires the excision of the skin containing the tattoo and then stitching it back together, and laser removal uses a highly concentrated light to break the dyes apart so that the immune system can clear them away.

An article states that surgery is better for smaller tattoos but would still leave a scar, while laser removal is a long and painful procedure, and does not promise full removal of the tattoo. Moreover, the price of surgery could range from $500-$1000 and laser removal could be $200-$350 per session with a suggested 4-5 sessions. Alternatively, the tattoo removal cream would not cause any pain or scarring, and it would cost 4.5 cents per square centimetre for each treatment.

Falkenham’s cream has the potential to be a popular choice for many people regretting their tattoos because it would be a cheaper and painless alternative. It could even promote more people to get tattoos knowing they could remove them with a simple cream. The idea of this cream is enticing, but some things still need be known such as the amount of applications in order to see a noticeable change, whether the cream permanently removes the tattoo or just fades most of it, or the side effects while using the cream. Although Falkenham’s cream is still in its research stages, it would be interesting to see the results of his tests and if successful, a finalized product for commercial use.

-Ian Villamin