Tag Archives: Medical Research

Do you know someone with Alzheimer’s? 

Chances are you answered yes because Alzheimer’s is currently the sixth largest cause of death in the United States, and it continues to rise. Between 2000-2017, Alzheimer’s has increased by 145% and now affects about 5.8 million people in USA. Alzheimer’s is a degenerative brain disease that has no cure. It often starts with loss of memory and can lead to loss of communication and even death. Such individuals can require specialized care in later stages, which can put pressure on medical systems and family. Most people see symptoms after their 65thbirthday. It is generally accepted that amyloid plaques (protein fragments that get stuck in the brain) are somehow linked to Alzheimer’s, but the exact relationship is not known. A recent study from MIT suggests brain waves could be used to get rid of such plaques and help improve memory.

Gamma Way Treatments May Be Key to Fighting Alzheimer’s

Researchers at MIT, led by senior author Li-Huei Tsai, exposed a group of mice to gamma brain waves and stimulating sounds. The brain is made up of many types of neurons, which are specialized cells, that must communicate with each other. They do this through electrical signals, and if these signals cycle about 25-80 times per second they are labelled as gamma waves. Gamma waves are thought to play an important role in memory and cognition and previous research has shown they may play a role in reducing brain amyloids.

Courtesy: Pexels | Photo Credit: Pixabay | A researcher peers into a microscope.

The MIT researchers had previously performed similar experiments with only audio or only gamma ray stimulation. Both of these experiments had shown positive results for mice memory. The mice were better able to navigate mazes and identify objects. The decided to build on those previous projects by subjecting the mice to both types of treatments. The results were resoundingly positive and resulted in a “… very dramatic reduction of amyloid,” explained Dr. Tsai. Mice were once again better able to remember and navigate mazes and recognize objects. However, even though initial results are promising, more research needs to be done to determine whether this treatment is safe and effective for humans. Also, the mice stopped showing improvement if the treatments were stopped for a week, meaning treatment may have to be recurring to provide any benefit.

Caring for Those with Alzheimer’s Is Not Easy

Courtesy: Pexels | Photo Credit: Matthias Zomer | People with Alzheimer’s need specialized care and support.

Caring for people with Alzheimer’s is no small task. Not only does it require immense resources and specialized care, but it can also weigh on family members and caregivers. In 2018 alone, $277 billion US dollars were spent on Alzheimer’s care, and this number is expected to grow as the population ages. Currently, a number for prescription drugs exist to slow down the disease in its early stages but there is no definite treatment. This research could lead the way for one of the first treatments that could actually reverse the effects of this disease. About 95% of Alzheimer’s affects those above 65, which means younger generations may still be able to reap the rewards of continued research in this field.

-Sukhman Bhuller

Can Sharks Help Us Cure Cancer?

There are very few things in this world that are more terrifying to humans than sharks are. After all, with their intelligence, size, agility and ideal anatomical features, they really are the perfect predators. They have dominated the ocean for over 400 million years, instilling fear in other animals and humans alike. But what if these fierce hunters actually hold the key to surviving some of our deadliest diseases?

A great white shark in Dyer Island. Courtesy of Wikimedia Commons (Olga Ernst).
Source: https://commons.wikimedia.org/wiki/File:Great_white_shark_Dyer_Island.jpg

Recently, scientists at the Save Our Seas Foundation Shark Research Center characterized the full genome of a great white shark, essentially the genetic blueprint that maps the structure and function of the animal. Their studies revealed that sharks are just as resilient on the inside as they look on the outside.

Their research, published in the Proceedings of the National Academy of Sciences of the United States, found that sharks can repair and alter their DNA, the material in our bodies that carry genetic information, in order to fight diseases and heal wounds efficiently as they age. Their built-in resistance to DNA damage increases their genetic stability and health, which is how they are able to thrive for millions of years.

A 3D-model of DNA strands.
Courtesy of Flickr Commons (Helen Carmody).
Source: https://flic.kr/p/R8JhxZ

Healing progression of a lemon shark over a three year period. Courtesy of YouTube (Ramon Llaneza Technical Diving). Source: https://www.youtube.com/watch?v=-lrn5AHipp8. 

Our cells, the building blocks of our body, along with our DNA, which provide the layout for the cells to function, breakdown as we age. This damage, termed genomic instability, is what makes humans so vulnerable to serious age-related diseases like cancer.

By studying the shark genome, the scientists hope to understand the mechanisms behind how these animals are able to preserve its stability, information that may potentially help us fight cancer and other serious human diseases. It may also help improve current flesh-healing treatments.

There is still so much to learn from sharks, both from a biomedical perspective and from an environmental perspective. Hopefully, this newfound research will heighten our appreciation for these evolutionary superheroes instead of feeling the need kill them.

– Justine Law