Looking at the Vista shell was somewhat familiar to me as last term my group in ETEC 510 built a course using Vista as the asynchronous and Adobe Connect as the synchronous form of communication. It is somewhat different than Moodle. Now having had experience with both I think it comes down to which one you feel more comfortable with. A lot of that comes with experience. I worked with Vista in a group. That was a great experience as I learned so much from everyone else who seemed to know a lot about it. With Moodle I worked independently, reading and spending a lot of time experimenting. There is an advantage to both ways of learning. Now that I have had experience with Moodle, I would say that it is more familiar than Vista for me in the creating of a course.
I like the areas to create in Vista. There seems to be more choices as to the activities. The set up is also great. I am more use to seeing it as our courses are built through Vista.
I spent some time exploring and setting up a file. I added a chat room, a discussion link, a Live Classroom and a Module. Either way both LMS offer a good shell for teachers to build online courses.