~ Actual reference scenario ~
1. A physician wants to find clinical trials written from 2003-2006 that demonstrate paxil’s efficacy for post-partum depression (PPD). Problem is the physician need articles that discuss the risks in prescribing paxil for breast-feeding women.
2. What is the clinical question? In patients taking paxil for post-partum depression (PPD), are there clinical trials from 2003 to 2006 discussing whether breast milk poses risk to baby?”
3. Important keywords for this search? Paxil is trade name; (paroxetine); SSRI is class; post-partum depression (PPD) see also: ante-natal and post-natal depression; adverse effects; risks; risk assessment; risk factors; clinical trials; infant; mother.
4. Research paxil and post-partum depression. See concepts to understand basics. See CPS; MeSH database, MedlinePlus (Drugs): Dorland’s Dictionary entry; Wikipedia has entry on Paxil and Merck; see eMedicine. Paxil is a brand name of GlaxoSmithLine. Paroxetine hydrochloride [drug name]. Drug class: selective serotonin reuptake inhibitor (SSRIs) treats depression and anxiety disorders. Admin’d orally.
5. Index terms: MeSH & keywords: Various combinations of “Paroxetine”[MeSH] AND “Depression, Postpartum” [MeSH] AND “risk assessment” [MeSH] “breast feeding”[MeSH] OR “milk, human”[MeSH] OR “lactation”[MeSH]. Keywords can be used to increase retrieval if results look unhelpful or irrelevant. Limits: 2003-2006, Humans, English, Clinical Trial. Clinical queries.
6. Databases consulted, to start: PubMed.gov; Google Scholar; Scirus. I like Scirus as a free alternative to EMBASE – see the range of results.
Documented search:
PUBMED SEARCH
This search requires a thorough review of research in PubMed. In order, I mapped the terms from above:
1. paxil maps to Paroxetine[MeSH] 2377 results vs. 1325 results as [MAJR]
2. post-partum depression maps to Depression, Postpartum[MeSH]
3. AND’ing the MeSH sets = 10 results, added to clipboard
4. Given the few results, I did a keyword search for “postpartum” AND “depression” and (“Paxil” OR “paroxetine”) = 21 references
5. When I OR’d the 10 results and the 21 results = 21 references, same citations
6. When limited to “ENGLISH”, I got 19. And LIMIT to clinical trial:
J Clin Psychiatry. 2004 Sep;65(9):1236-41. The use of paroxetine and cognitive-behavioral therapy in postpartum depression and anxiety: a randomized controlled trial.Misri S, Reebye P, Corral M, Milis L.
7.These references may be useful, but I still wanted to pursue other articles because these dealt with PPD and paxil, and not risks to the baby when mother is breastfeeding. Therefore, I used keyword variations to get these articles:
a) Berle JO, Steen VM, Aamo TO, Breilid H, Zahlsen K, Spigset O. Breastfeeding during maternal antidepressant treatment with serotonin reuptake inhibitors: infant exposure, clinical symptoms, and cytochrome p450 genotypes.J Clin Psychiatry. 2004 Sep;65(9):1228-34. PMID: 15367050 [PubMed – indexed for MEDLINE]
b) Merlob P, Stahl B, Sulkes J. Paroxetine during breast-feeding: infant weight gain and maternal adherence to counsel.Eur J Pediatr. 2004 Mar;163(3):135-9. Epub 2004 Jan 24. PMID: 14745552 [PubMed – indexed for MEDLINE]
c) Hendrick V, Fukuchi A, Altshuler L, Widawski M, Wertheimer A, Brunhuber MV. Use of sertraline, paroxetine and fluvoxamine by nursing women. Br J Psychiatry. 2001 Aug;179:163-6. PMID: 11483479 [PubMed – indexed for MEDLINE]
8) GOOGLE SCHOLAR
Using terms from above, I searched:
http://scholar.google.com/scholar?q=postpartum+depression+++paxil+OR+paroxetine+%22breast+feeding%22&;hl=en&lr=&c2coff=1&as_subj=med&scoring=r&as_ylo=2001
CINAHL is not as useful as Google scholar here as its focus is nursing whereas GS crawls peer-reviewed medical research, websites and open access journals. I should check PsycINFO and LactMed, time permitting.