{"id":23,"date":"2012-03-24T19:45:23","date_gmt":"2012-03-25T02:45:23","guid":{"rendered":"https:\/\/blogs.ubc.ca\/hsuanhui\/?page_id=23"},"modified":"2012-03-28T22:47:38","modified_gmt":"2012-03-29T05:47:38","slug":"so-why-mice","status":"publish","type":"page","link":"https:\/\/blogs.ubc.ca\/hsuanhui\/so-why-mice\/","title":{"rendered":"So Why Mice?"},"content":{"rendered":"<p>&nbsp;<\/p>\n<header>\n<h1>Common House Mice (Mus musculus):<\/h1>\n<h1>The most extensively used rodent species in research<\/h1>\n<p>&nbsp;<\/p>\n<\/header>\n<div>\n<h1>WHY ARE THEY THE CHOSEN ONES?<\/h1>\n<ul>\n<li>Physiological and genetic<em>\u00a0<\/em>similarities to humans<\/li>\n<li>Fully sequenced genome: can conveniently be analyzed and manipulated to induce diseases<\/li>\n<li>Natural ability to develop sicknesses that humans also battle:<br \/>\n&#8211; cancer<br \/>\n&#8211; atherosclerosis<br \/>\n&#8211; hypertension<br \/>\n&#8211; diabetes<br \/>\n&#8211; osteoporosis<\/li>\n<li>\n<h1>How they are involved in research<\/h1>\n<\/li>\n<\/ul>\n<ol>\n<li><em>Test subjects for the safety of novel medical procedures and drugs prior to clinical studies on humans<\/em><img decoding=\"async\" src=\"http:\/\/www.sxc.hu\/pic\/l\/l\/le\/leonardini\/1238683_60809452.jpg\" alt=\"\" \/><\/li>\n<li><em>In vivo production factories for biological reagents such as monoclonal antibodies and vaccines<\/em><img decoding=\"async\" src=\"http:\/\/www.sxc.hu\/pic\/l\/z\/ze\/zeathiel\/1028452_61302173.jpg\" alt=\"\" \/><\/li>\n<li><em>Guineas pigs for the toxicity and other negative effects of new chemical products<\/em> such as household cleaners and pesticides or biological relevant studies involving venoms and carcinogens<br \/>\n<img decoding=\"async\" src=\"http:\/\/www.adventuresincoupons.com\/wp-content\/uploads\/2012\/03\/windex_span.jpg\" alt=\"\" \/><\/li>\n<li><em>Models for human diseases and associated treatments<\/em>\n<p>&#8211; \u00a0<em><strong>Techniques:<\/strong><\/em>Insertion of new genes to a mouse\u2019s germ line via molecular techniques such as homologous recombination, knock-out (replace existing genes with altered versions), and knock-in (alter mouse gene in natural location) procedures combined with in vitro fertilization and ovary transplantation- Product: Transgenic mice- <strong><em>What is a transgenic mouse?<\/em><\/strong> Your own custom made genetically modified animal; they are then selectively inbred to produce strains that are prone to diseases such as cancer, diabetes, obesity, blindness, anxiety, aggressive behaviour, alcoholism, or drug addiction<\/p>\n<p><a href=\"https:\/\/blogs.ubc.ca\/hsuanhui\/files\/2012\/03\/SKC43-2.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-27\" title=\"Transgenic Mouse - SKC Strain\" src=\"https:\/\/blogs.ubc.ca\/hsuanhui\/files\/2012\/03\/SKC43-2-300x225.jpg\" alt=\"\" width=\"300\" height=\"225\" srcset=\"https:\/\/blogs.ubc.ca\/hsuanhui\/files\/2012\/03\/SKC43-2-300x225.jpg 300w, https:\/\/blogs.ubc.ca\/hsuanhui\/files\/2012\/03\/SKC43-2-1024x768.jpg 1024w, https:\/\/blogs.ubc.ca\/hsuanhui\/files\/2012\/03\/SKC43-2-400x300.jpg 400w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; Common House Mice (Mus musculus): The most extensively used rodent species in research &nbsp; WHY ARE THEY THE CHOSEN ONES? Physiological and genetic\u00a0similarities to humans Fully sequenced genome: can conveniently be analyzed and manipulated to induce diseases Natural ability &hellip; <a href=\"https:\/\/blogs.ubc.ca\/hsuanhui\/so-why-mice\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":12442,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"open","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-23","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/blogs.ubc.ca\/hsuanhui\/wp-json\/wp\/v2\/pages\/23","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.ubc.ca\/hsuanhui\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/blogs.ubc.ca\/hsuanhui\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.ubc.ca\/hsuanhui\/wp-json\/wp\/v2\/users\/12442"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.ubc.ca\/hsuanhui\/wp-json\/wp\/v2\/comments?post=23"}],"version-history":[{"count":4,"href":"https:\/\/blogs.ubc.ca\/hsuanhui\/wp-json\/wp\/v2\/pages\/23\/revisions"}],"predecessor-version":[{"id":26,"href":"https:\/\/blogs.ubc.ca\/hsuanhui\/wp-json\/wp\/v2\/pages\/23\/revisions\/26"}],"wp:attachment":[{"href":"https:\/\/blogs.ubc.ca\/hsuanhui\/wp-json\/wp\/v2\/media?parent=23"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}