Email: erhoffar@chem.ubc.ca
B.Sc. (Honours) in Biochemistry, University of Calgary, 2014
Ph.D. Candidate, Department of Chemistry, 2014 – 2021
NSERC Canada Graduate Scholarship-Master’s, 2015
NSERC Canada Postgraduate Scholarship Doctoral, 2017-2019
Current position: Research Scientist at Tersa Earth
Publications:
Hoffarth, E.R., Caddell Haatveit K, Kuatsjah, E., MacNeil, G.A., Garcia-Borràs M., Saroya, S., Walsby, C.J., Eltis, L.D., Houk, K.N. & Ryan, K.S.^ (2021) A shared mechanistic pathway for pyridoxal phosphate-dependent arginine oxidases. Proc. Natl. Acad. Sci. U. S. A. 118(40):e2012591118.
Hoffarth, E.R., Kong, S., He, H.-Y. & Ryan, K.S. (2021) An engineered biosynthetic-synthetic platform for production of halogenated indolmycin derivatives. Chem. Sci., 12(25): 8817-8821.
Hoffarth E., Rothchild, K.W. & Ryan K.S.^ (2020) Emergence of oxygen- and pyridoxal phosphate-dependent reactions. FEBS J. 287(7): 1403–1428.
Torres MA, Hoffarth E, Eugenio L, Savtchouk J, Chen X, Morris J, Facchini PJ, Ng KK. (2016) Structural and Functional Studies of Pavine N-Methyltransferase from Thalictrum flavum Reveal Novel Insights into Substrate Recognition and Catalytic Mechanism. Journal of Biological Chemistry 291(45):23403-23415.
Arias M, Hoffarth ER, Aramini J, Montelione GT, Vogel HJ. (2016) Recombinant expression, antimicrobial activity and mechanism of action of tritrpticin analogs containing fluoro-tryptophan residues. Biochimica et Biophysica Acta – Biomembranes. 1858(5):1012-1023.
Zamyatkin D, Rao C, Hoffarth E, Jurca G, Rho H, Parra F, Grochulski P, Ng KK (2014) Structure of a backtracked state reveals conformational changes similar to the state following nucleotide incorporation in human norovirus polymerase. Acta Crystallogr D Biol Crystallogr. 70: 3099-3109.