Email: hyhe@chem.ubc.ca
B.Sc. in Applied Chemistry, Tianjin University
Ph.D. in Biochemistry, Shanghai Institute of Organic Chemistry
Research Interests: Biosynthesis, Biocatalysis, and Crystallography
Current position: Assistant Professor, Chinese Academy of Medical Sciences and the Peking Union Medical College, Beijing
Representative Publications:
He, H.-Y., Niikura, H., Du, Y.-L., Ryan, K.S. Biosynthetic routes to nitrogen-nitrogen bonds. In press, Chem. Soc. Rev., DOI: 10.1039/C7CS00458C.
He HY, Ryan KS (2021) Glycine-derived nitronates bifurcate to O-methylation or denitrification in bacteria. Nat. Chem. DOI: 10.1038/s41557-021-00656-8.
He HY, Henderson AC, Du YL, Ryan KS (2019) A two-enzyme pathway links L-arginine to nitric oxide in N-nitroso biosynthesis. J Am Chem Soc. 141(9):4026-4033.
Du YL, He HY, Higgins MA, Ryan KS (2017) A heme-dependent enzyme forms the nitrogen-nitrogen bond in piperazate. Nat Chem Biol. 13(8):836-8.
Du YL, Singh R, Alkhalaf LM, Kuatsjah E, He HY, Eltis LD, Ryan KS. (2016) A pyridoxal phosphate-dependent enzyme that oxidizes an unactivated carbon-carbon bond. Nat Chem Biol. 12(3):194-9.
He HY, Yuan H, Tang MC, Tang GL (2014) An unusual dehydratase acting on glycerate and a ketoreductase stereoselectively reducing alpha-ketone in polyketide starter unit biosynthesis. Angew Chem Int Ed Engl. 53(42):11315-9.
He HY, Tang MC, Zhang F, Tang GL (2014) Cis-double bond formation by thioesterase and transfer to ketosynthase in FR901464 biosynthesis. J Am Chem Soc. 136(12):4488-91.
He H-Y, Pan H-X, Wu L-F, Zhang B-B, Chai H-B, Liu W, Tang G-L (2012). Quartromicin Biosynthesis: Two Alternative Polyketide Chains Produced by One Polyketide Synthase Assembly Line. Chem. Biol. 19, 1313–1323.