{"id":393,"date":"2019-02-14T10:24:12","date_gmt":"2019-02-14T17:24:12","guid":{"rendered":"https:\/\/blogs.ubc.ca\/ksryan\/?p=393"},"modified":"2019-02-14T10:36:02","modified_gmt":"2019-02-14T17:36:02","slug":"a-two-enzyme-pathway-links-l-arginine-to-nitric-oxide-in-n-nitroso-biosynthesis","status":"publish","type":"post","link":"https:\/\/blogs.ubc.ca\/ksryan\/2019\/02\/14\/a-two-enzyme-pathway-links-l-arginine-to-nitric-oxide-in-n-nitroso-biosynthesis\/","title":{"rendered":"A Two-Enzyme Pathway Links L-Arg to Nitric Oxide in N-Nitroso Biosynthesis"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-390 alignleft\" src=\"https:\/\/blogs.ubc.ca\/ksryan\/files\/2019\/02\/TOC-300x162.jpeg\" alt=\"\" width=\"322\" height=\"174\" srcset=\"https:\/\/blogs.ubc.ca\/ksryan\/files\/2019\/02\/TOC-300x162.jpeg 300w, https:\/\/blogs.ubc.ca\/ksryan\/files\/2019\/02\/TOC.jpeg 460w\" sizes=\"auto, (max-width: 322px) 100vw, 322px\" \/>N-nitroso compounds are carcinogenic molecules previously thought to be made only through non-enzymatic routes. We investigated how the N-nitroso natural product streptozocin is constructed, and we revealed a new two-enzyme pathway that links L-arginine to production of nitric oxide. Congratulations to Hai-Yan and coauthors for their recent publication in\u00a0<a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.8b13049\"><em>JACS<\/em><\/a>!<\/p>\n","protected":false},"excerpt":{"rendered":"<p>N-nitroso compounds are carcinogenic molecules previously thought to be made only through non-enzymatic routes. We investigated how the N-nitroso natural product streptozocin is constructed, and we revealed a new two-enzyme pathway that links L-arginine to production of nitric oxide. Congratulations to Hai-Yan and coauthors for their recent publication in\u00a0JACS!<\/p>\n","protected":false},"author":46186,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-393","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/blogs.ubc.ca\/ksryan\/wp-json\/wp\/v2\/posts\/393","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.ubc.ca\/ksryan\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.ubc.ca\/ksryan\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.ubc.ca\/ksryan\/wp-json\/wp\/v2\/users\/46186"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.ubc.ca\/ksryan\/wp-json\/wp\/v2\/comments?post=393"}],"version-history":[{"count":5,"href":"https:\/\/blogs.ubc.ca\/ksryan\/wp-json\/wp\/v2\/posts\/393\/revisions"}],"predecessor-version":[{"id":398,"href":"https:\/\/blogs.ubc.ca\/ksryan\/wp-json\/wp\/v2\/posts\/393\/revisions\/398"}],"wp:attachment":[{"href":"https:\/\/blogs.ubc.ca\/ksryan\/wp-json\/wp\/v2\/media?parent=393"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.ubc.ca\/ksryan\/wp-json\/wp\/v2\/categories?post=393"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.ubc.ca\/ksryan\/wp-json\/wp\/v2\/tags?post=393"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}