{"id":473,"date":"2019-07-12T09:00:03","date_gmt":"2019-07-12T16:00:03","guid":{"rendered":"https:\/\/blogs.ubc.ca\/ksryan\/?p=473"},"modified":"2019-07-12T09:48:11","modified_gmt":"2019-07-12T16:48:11","slug":"an-asymmetric-reductase-for-acyclic-imino-acids","status":"publish","type":"post","link":"https:\/\/blogs.ubc.ca\/ksryan\/2019\/07\/12\/an-asymmetric-reductase-for-acyclic-imino-acids\/","title":{"rendered":"An asymmetric reductase for acyclic imino acids"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-476 alignleft\" src=\"https:\/\/blogs.ubc.ca\/ksryan\/files\/2019\/07\/TOC-2-300x149.png\" alt=\"\" width=\"300\" height=\"149\" srcset=\"https:\/\/blogs.ubc.ca\/ksryan\/files\/2019\/07\/TOC-2-300x149.png 300w, https:\/\/blogs.ubc.ca\/ksryan\/files\/2019\/07\/TOC-2-768x382.png 768w, https:\/\/blogs.ubc.ca\/ksryan\/files\/2019\/07\/TOC-2-620x308.png 620w, https:\/\/blogs.ubc.ca\/ksryan\/files\/2019\/07\/TOC-2.png 945w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/>Acyclic imines are unstable in aqueous conditions, but acyclic imino acids can exhibit transient aqueous stability. Here we report the X-ray crystal structure and mechanism of Bsp5, an asymmetric acyclic imino acid reductase that intercepts acyclic imino acids produced by a partner oxidase and then converts them into D-amino acids. To read more, check out our recent paper in <a href=\"https:\/\/pubs.acs.org\/doi\/abs\/10.1021\/jacs.9b03307\">JACS<\/a>!<\/p>\n<p>Congratulations to <a href=\"https:\/\/blogs.ubc.ca\/ksryan\/people\/jin-guo\/\">Jin<\/a>, <a href=\"https:\/\/blogs.ubc.ca\/ksryan\/people\/melanie-higgins\/\">Mel<\/a>, and <a href=\"https:\/\/blogs.ubc.ca\/ksryan\/people\/phillip-daniel-ivad\/\">Phil<\/a> on this work!<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Acyclic imines are unstable in aqueous conditions, but acyclic imino acids can exhibit transient aqueous stability. Here we report the X-ray crystal structure and mechanism of Bsp5, an asymmetric acyclic imino acid reductase that intercepts acyclic imino acids produced by a partner oxidase and then converts them into D-amino acids. To read more, check out [&hellip;]<\/p>\n","protected":false},"author":46186,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-473","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/blogs.ubc.ca\/ksryan\/wp-json\/wp\/v2\/posts\/473","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.ubc.ca\/ksryan\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.ubc.ca\/ksryan\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.ubc.ca\/ksryan\/wp-json\/wp\/v2\/users\/46186"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.ubc.ca\/ksryan\/wp-json\/wp\/v2\/comments?post=473"}],"version-history":[{"count":5,"href":"https:\/\/blogs.ubc.ca\/ksryan\/wp-json\/wp\/v2\/posts\/473\/revisions"}],"predecessor-version":[{"id":481,"href":"https:\/\/blogs.ubc.ca\/ksryan\/wp-json\/wp\/v2\/posts\/473\/revisions\/481"}],"wp:attachment":[{"href":"https:\/\/blogs.ubc.ca\/ksryan\/wp-json\/wp\/v2\/media?parent=473"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.ubc.ca\/ksryan\/wp-json\/wp\/v2\/categories?post=473"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.ubc.ca\/ksryan\/wp-json\/wp\/v2\/tags?post=473"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}