The bacterial physiology CURE is our longest-standing course model that involves student teams pursuing novel wet lab investigations on Escherichia coli. This model was published here.
Two ongoing research projects are summarized and mapped chronologically below. Each node represents one student publication in UJEMI. This represents a very small portion of UJEMI publications to date. This is a small representation of the myriad of student-derived projects or CUREs in our program.
UJEMI Case studies demonstrate how each CURE build on each other over time. A. Left: Working model of proteins involved in the secretion of capsule in E. coli strain K30 (reprinted with permission). Gene products discussed include Wza (red), Wzb (green), Wzc (blue). Capsule subunits are shown in small blue and black circles. Auxiliary secretion machinery subunits (Wzx, Wzy) are not discussed in the text. Right: Plasmid map, PI2-MBP fusion protein domain architecture, and primary amino acid sequence of PI2 (reprinted with permission). Cysteine residues are shown in bold font. B. Chronology of ongoing CURE-based research projects published in UJEMI investigating the capsule on antibiotic resistance (left, blue/red project nodes) and the expression and purification of protease inhibitor 2 (PI2) (right, purple/red project nodes). Projects sharing similar research aims are depicted as the same shape project node. The red project nodes represent research articles describing key advancements in each project.
