{"id":133,"date":"2021-04-20T11:46:00","date_gmt":"2021-04-20T18:46:00","guid":{"rendered":"https:\/\/blogs.ubc.ca\/mbimcures\/?page_id=133"},"modified":"2021-07-08T09:55:19","modified_gmt":"2021-07-08T16:55:19","slug":"bac-phys","status":"publish","type":"page","link":"https:\/\/blogs.ubc.ca\/mbimcures\/for-educators\/ongoing-projects\/bac-phys\/","title":{"rendered":"Bacterial Physiology CURE"},"content":{"rendered":"<p>The bacterial physiology CURE is our longest-standing course model that involves student teams pursuing novel wet lab investigations on <em>Escherichia coli<\/em>.\u00a0 This model was published <a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmicb.2020.589025\/full\">here<\/a>.<\/p>\n<p>Two ongoing research projects are summarized and mapped chronologically below. Each node represents one student publication in <a href=\"https:\/\/jemi.microbiology.ubc.ca\/\">UJEMI<\/a>. This represents a very small portion of <a href=\"https:\/\/jemi.microbiology.ubc.ca\/\">UJEMI<\/a> publications to date. This is a small representation of the myriad of student-derived projects or CUREs in our program.<\/p>\n<figure id=\"attachment_39\" aria-describedby=\"caption-attachment-39\" style=\"width: 529px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-39\" src=\"https:\/\/blogs.ubc.ca\/mbimcures\/files\/2021\/04\/Fig2_Revised-248x300.jpg\" alt=\"\" width=\"529\" height=\"641\" srcset=\"https:\/\/blogs.ubc.ca\/mbimcures\/files\/2021\/04\/Fig2_Revised-248x300.jpg 248w, https:\/\/blogs.ubc.ca\/mbimcures\/files\/2021\/04\/Fig2_Revised-845x1024.jpg 845w, https:\/\/blogs.ubc.ca\/mbimcures\/files\/2021\/04\/Fig2_Revised-768x931.jpg 768w, https:\/\/blogs.ubc.ca\/mbimcures\/files\/2021\/04\/Fig2_Revised-1268x1536.jpg 1268w, https:\/\/blogs.ubc.ca\/mbimcures\/files\/2021\/04\/Fig2_Revised-1690x2048.jpg 1690w\" sizes=\"auto, (max-width: 529px) 100vw, 529px\" \/><figcaption id=\"caption-attachment-39\" class=\"wp-caption-text\">UJEMI Case studies demonstrate how each CURE build on each other over time. A. Left: Working model of proteins involved in the secretion of capsule in E. coli strain K30 (reprinted with permission). Gene products discussed include Wza (red), Wzb (green), Wzc (blue). Capsule subunits are shown in small blue and black circles. Auxiliary secretion machinery subunits (Wzx, Wzy) are not discussed in the text. Right: Plasmid map, PI2-MBP fusion protein domain architecture, and primary amino acid sequence of PI2 (reprinted with permission). Cysteine residues are shown in bold font. B. Chronology of ongoing CURE-based research projects published in UJEMI investigating the capsule on antibiotic resistance (left, blue\/red project nodes) and the expression and purification of protease inhibitor 2 (PI2) (right, purple\/red project nodes). Projects sharing similar research aims are depicted as the same shape project node. The red project nodes represent research articles describing key advancements in each project.<\/figcaption><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>The bacterial physiology CURE is our longest-standing course model that involves student teams pursuing novel wet lab investigations on Escherichia coli.\u00a0 This model was published here. Two ongoing research projects are summarized and mapped chronologically below. Each node represents one student publication in UJEMI. This represents a very small portion of UJEMI publications to date. &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/blogs.ubc.ca\/mbimcures\/for-educators\/ongoing-projects\/bac-phys\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Bacterial Physiology CURE&#8221;<\/span><\/a><\/p>\n","protected":false},"author":39432,"featured_media":0,"parent":2,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-133","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/blogs.ubc.ca\/mbimcures\/wp-json\/wp\/v2\/pages\/133","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.ubc.ca\/mbimcures\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/blogs.ubc.ca\/mbimcures\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.ubc.ca\/mbimcures\/wp-json\/wp\/v2\/users\/39432"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.ubc.ca\/mbimcures\/wp-json\/wp\/v2\/comments?post=133"}],"version-history":[{"count":12,"href":"https:\/\/blogs.ubc.ca\/mbimcures\/wp-json\/wp\/v2\/pages\/133\/revisions"}],"predecessor-version":[{"id":249,"href":"https:\/\/blogs.ubc.ca\/mbimcures\/wp-json\/wp\/v2\/pages\/133\/revisions\/249"}],"up":[{"embeddable":true,"href":"https:\/\/blogs.ubc.ca\/mbimcures\/wp-json\/wp\/v2\/pages\/2"}],"wp:attachment":[{"href":"https:\/\/blogs.ubc.ca\/mbimcures\/wp-json\/wp\/v2\/media?parent=133"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}