- I learned more about chromatin architecture, and how cis-factors do not necessarily have to be close to each other in sequence, as long as they are in the same topologically-associated domain (TAD). Moreover, I also learned about different techniques that are used to study chromatin architecture and TADs (such as 3C and its derivatives), and I find all the progress being made in this field to be quite interesting.
- These fit nicely into my learning objective of how proteins can regulate genes, and moreover how one protein can regulate different genes. If genes are in the same TAD, they can be regulated by the same trans-acting factors as well, and boundary elements that barrier this TAD from others can prevent those trans-acting factors from acting on other genes instead.
- I think the most challenging part of the course so far has been learning what to directly conclude from experimental data, and how to analyze data. I am surprised by this as well as not too many of my other courses rely heavily on reading real papers, and instead focus on hypothetical data sets for experimental data.
Small Assignment: DocuLearn 2
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