During the DNA replication process, the DNA and proteins that form nucleosomes are disassembled and then reassembled exactly on the newly-replicated DNA. Histone chaperones are a broad class of proteins that deposit histones on the DNA, but which of these assist in the reassembly of chromatin in the newly-replicated DNA is unknown. Some proteins involved in DNA replication also have similar functions to these histone chaperones, which means that the replisome itself may mediate the replacement of histones after replication. My research question hopes to cover:
- Which proteins are responsible for the deposition of histones and reassembly of nucleosomes immediately following DNA replication?