{"id":33,"date":"2015-02-01T11:49:49","date_gmt":"2015-02-01T18:49:49","guid":{"rendered":"https:\/\/blogs.ubc.ca\/ryanyenn\/?p=33"},"modified":"2015-02-13T03:24:55","modified_gmt":"2015-02-13T10:24:55","slug":"draft-question","status":"publish","type":"post","link":"https:\/\/blogs.ubc.ca\/ryanyenn\/final-project\/draft-question\/","title":{"rendered":"Draft Question"},"content":{"rendered":"<div>It has been observed by Lee <i>et al.<\/i>(2013) that preconception consumption of ethanol by male mice results in skull malformation. Knezovich &amp; Ramsay (2012) found that transgenerational toxic effects are due to epigenetic mutations in sperm DNA caused by alcohol. Laufer <i>et al. <\/i>(2013) found three imprinting control regions (ICRs), <i>Sfmbt2, Snrpn-Ube3a, Dlk-Dio3<\/i>,\u00a0that are differentially methylated when the fetus is exposed to alcohol. These three ICRs are related to the development of the brain (Laufer and Singh, 2012).<\/div>\n<div><\/div>\n<div>My question is are these 3 imprinted regions differentially methylated in the sperm when the mice is fed ethanol compared to a no ethanol diet regime and then passed on to their offsprings to produce abnormal phenotypes such as skull malformations observed by Lee <i>et al. <\/i>(2013)?<\/div>\n<div><\/div>\n<div>Pam&#8217;s Feedback:<\/div>\n<div><\/div>\n<div><em>Hi Ryan,<\/em><\/p>\n<p><em>your question is excellent! One thing to consider:\u00a0 Knezovich &amp; Ramsay<\/em><br \/>\n<em>mention two loci that were differentially methylated in the progeny of<\/em><br \/>\n<em>males exposed to alcohol (but were not differentially methylated in the<\/em><br \/>\n<em>sperm of the fathers).<\/em><br \/>\n<em>You will want to take into consideration that something similar might also<\/em><br \/>\n<em>be the case for your three selected loci.<\/em><\/p>\n<p><em>Proceed with your question, it&#8217;s a good one!<\/em><\/p>\n<p><em>Cheers<\/em><\/p>\n<p><em><span class=\"il\">Pam<\/span><\/em><\/div>\n","protected":false},"excerpt":{"rendered":"<p>It has been observed by Lee et al.(2013) that preconception consumption of ethanol by male mice results in skull malformation. Knezovich &amp; Ramsay (2012) found that transgenerational toxic effects are due to epigenetic mutations in sperm DNA caused by alcohol. Laufer et al. (2013) found three imprinting control regions (ICRs), Sfmbt2, Snrpn-Ube3a, Dlk-Dio3,\u00a0that are differentially [&hellip;]<\/p>\n","protected":false},"author":28747,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[12778],"tags":[],"class_list":["post-33","post","type-post","status-publish","format-standard","hentry","category-final-project"],"_links":{"self":[{"href":"https:\/\/blogs.ubc.ca\/ryanyenn\/wp-json\/wp\/v2\/posts\/33","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.ubc.ca\/ryanyenn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.ubc.ca\/ryanyenn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.ubc.ca\/ryanyenn\/wp-json\/wp\/v2\/users\/28747"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.ubc.ca\/ryanyenn\/wp-json\/wp\/v2\/comments?post=33"}],"version-history":[{"count":1,"href":"https:\/\/blogs.ubc.ca\/ryanyenn\/wp-json\/wp\/v2\/posts\/33\/revisions"}],"predecessor-version":[{"id":34,"href":"https:\/\/blogs.ubc.ca\/ryanyenn\/wp-json\/wp\/v2\/posts\/33\/revisions\/34"}],"wp:attachment":[{"href":"https:\/\/blogs.ubc.ca\/ryanyenn\/wp-json\/wp\/v2\/media?parent=33"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.ubc.ca\/ryanyenn\/wp-json\/wp\/v2\/categories?post=33"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.ubc.ca\/ryanyenn\/wp-json\/wp\/v2\/tags?post=33"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}