{"id":2,"date":"2019-10-08T20:34:31","date_gmt":"2019-10-08T20:34:31","guid":{"rendered":"https:\/\/blogs.ubc.ca\/simchasrebnik\/?page_id=2"},"modified":"2021-08-09T10:21:53","modified_gmt":"2021-08-09T17:21:53","slug":"sample-page","status":"publish","type":"page","link":"https:\/\/blogs.ubc.ca\/simchasrebnik\/","title":{"rendered":"Home"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-5 alignleft\" src=\"https:\/\/blogs.ubc.ca\/simchasrebnik\/files\/2019\/10\/Simcha-247x300.png\" alt=\"\" width=\"237\" height=\"288\" srcset=\"https:\/\/blogs.ubc.ca\/simchasrebnik\/files\/2019\/10\/Simcha-247x300.png 247w, https:\/\/blogs.ubc.ca\/simchasrebnik\/files\/2019\/10\/Simcha.png 297w\" sizes=\"auto, (max-width: 237px) 100vw, 237px\" \/><\/p>\n<p><strong>Simcha Srebnik<\/strong><br \/>\nAssociate Professor, Chemical and Biological Engineering, UBC<\/p>\n<p>Member, Institute of Applied Mathematics<\/p>\n<p>PhD, University of California, Berkeley, 1998<br \/>\nBSc Chemical Engineering, University of Toledo, 1994<\/p>\n<p>Room: CHBE 419<br \/>\nTel: 604.827.4814<br \/>\nEmail: <a href=\"mailto:simcha.srebnik@ubc.ca\">simcha.srebnik@ubc.ca<\/a><\/p>\n<h1><strong><u>Research Openings<\/u><\/strong><\/h1>\n<p>Research in my group focuses on developing simple physical models to describe molecular behaviour.<\/p>\n<h3><strong><span style=\"color: #ff0000;\">!!!<\/span> <span style=\"color: #ff0000;\">An opening for a graduate student available to start thesis studies at UBC <u>IMMEDIATELY<\/u> on the following topic:\u00a0<\/span><span style=\"color: #339966;\"><em>The use of molecular dynamics simulation to identify structural and surface properties of a capillary that will prevent cavitation and maintain a stable liquid state of water<\/em><\/span><\/strong> <span style=\"color: #ff0000;\"><strong>!!!<\/strong><\/span><\/h3>\n<p>In addition, I am actively seeking undergraduate students for specific projects in the following two areas:<\/p>\n<h3><strong><span style=\"color: blue;\">I. Protein Structure and Folding<\/span><\/strong><\/h3>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-15 alignleft\" src=\"https:\/\/blogs.ubc.ca\/simchasrebnik\/files\/2019\/10\/Pic-4-249x300.png\" alt=\"\" width=\"249\" height=\"300\" srcset=\"https:\/\/blogs.ubc.ca\/simchasrebnik\/files\/2019\/10\/Pic-4-249x300.png 249w, https:\/\/blogs.ubc.ca\/simchasrebnik\/files\/2019\/10\/Pic-4.png 612w\" sizes=\"auto, (max-width: 249px) 100vw, 249px\" \/>Using data mining and deep learning algorithms, combined with simple physical models, we advance our understanding of protein structure, folding, aggregation, and misfolding dynamics. Amyloids are one example where misfolding of a protein secondary structure (usually involving a transition from helical to sheet structures) can propagate into m<span style=\"font-size: 1rem;\">alignant superstructures. A simple physical interpretation of the dihedral angles <\/span><span style=\"font-size: 1rem;\">representing alpha helical conformations in proteins allowed us to correlate amyloidal helices with their angular pitch, \u00a0q. We are currently developing dynamic models to <\/span><span style=\"font-size: 1rem;\">further our understanding of protein folding and misfolding.III<\/span><\/p>\n<ol>\n<li><strong><span style=\"color: #ff0000;\"><i>A position is open for an\u00a0<\/i><\/span><span style=\"text-decoration: underline; color: #ff0000;\">undergraduate<\/span><span style=\"color: #ff0000;\"><i> student to use statistical and machine learning techniques to analyze the\u00a0<\/i><span style=\"caret-color: #ff0000;\"><i>protein<\/i><\/span><i>\u00a0data\u00a0bank for structural descriptors of amyloidal polypeptide sequences.<\/i><\/span><\/strong><\/li>\n<li><strong style=\"font-size: 1rem;\"><span style=\"color: #ff0000;\"><i>A position is open for an <strong><span style=\"text-decoration: underline;\">undergraduate<\/span><\/strong><\/i><\/span><span style=\"color: #ff0000;\"><i>\u00a0student to develop a simple model for mechanisms of helix-to-beta sheet transition<\/i><\/span><\/strong><\/li>\n<\/ol>\n<h3><strong><span style=\"color: blue;\">II. Anion exchange membrane fuel cells (AEMFCs)<img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-14 alignright\" src=\"https:\/\/blogs.ubc.ca\/simchasrebnik\/files\/2019\/10\/Pic-3-291x300.png\" alt=\"\" width=\"291\" height=\"300\" srcset=\"https:\/\/blogs.ubc.ca\/simchasrebnik\/files\/2019\/10\/Pic-3-291x300.png 291w, https:\/\/blogs.ubc.ca\/simchasrebnik\/files\/2019\/10\/Pic-3-624x644.png 624w, https:\/\/blogs.ubc.ca\/simchasrebnik\/files\/2019\/10\/Pic-3.png 643w\" sizes=\"auto, (max-width: 291px) 100vw, 291px\" \/><\/span><\/strong><\/h3>\n<p>&nbsp;<\/p>\n<p>Rapid degradation of AEMFCs occurs due to the consumption\u00a0of water at the cathode. At critically low water levels, hydroxide anions react with the cationic functional groups in the anion exchange membrane (AEM), limiting the conductivity of the AEM. At critically low water levels, we found new hydrated structures of two hydroxide anions at close proximity, bridged by water molecules. These surprising structures are very stable and have high activity.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-13 alignleft\" style=\"font-size: 1rem;\" src=\"https:\/\/blogs.ubc.ca\/simchasrebnik\/files\/2019\/10\/Pic-2-300x171.png\" alt=\"\" width=\"300\" height=\"171\" srcset=\"https:\/\/blogs.ubc.ca\/simchasrebnik\/files\/2019\/10\/Pic-2-300x171.png 300w, https:\/\/blogs.ubc.ca\/simchasrebnik\/files\/2019\/10\/Pic-2-768x439.png 768w, https:\/\/blogs.ubc.ca\/simchasrebnik\/files\/2019\/10\/Pic-2-1024x585.png 1024w, https:\/\/blogs.ubc.ca\/simchasrebnik\/files\/2019\/10\/Pic-2-624x357.png 624w, https:\/\/blogs.ubc.ca\/simchasrebnik\/files\/2019\/10\/Pic-2.png 1325w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>&nbsp;<\/p>\n<p><strong><em><span style=\"color: red;\">A position is open for an <span style=\"text-decoration: underline;\">undergraduate<\/span> student to further our understanding of AEM behaviour using advanced molecular simulation techniques.<\/span><\/em><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Simcha Srebnik Associate Professor, Chemical and Biological Engineering, UBC Member, Institute of Applied Mathematics PhD, University of California, Berkeley, 1998 BSc Chemical Engineering, University of Toledo, 1994 Room: CHBE 419 Tel: 604.827.4814 Email: simcha.srebnik@ubc.ca Research Openings Research in my group focuses on developing simple physical models to describe molecular behaviour. !!! An opening for a [&hellip;]<\/p>\n","protected":false},"author":68466,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-2","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/blogs.ubc.ca\/simchasrebnik\/wp-json\/wp\/v2\/pages\/2","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.ubc.ca\/simchasrebnik\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/blogs.ubc.ca\/simchasrebnik\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.ubc.ca\/simchasrebnik\/wp-json\/wp\/v2\/users\/68466"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.ubc.ca\/simchasrebnik\/wp-json\/wp\/v2\/comments?post=2"}],"version-history":[{"count":9,"href":"https:\/\/blogs.ubc.ca\/simchasrebnik\/wp-json\/wp\/v2\/pages\/2\/revisions"}],"predecessor-version":[{"id":27,"href":"https:\/\/blogs.ubc.ca\/simchasrebnik\/wp-json\/wp\/v2\/pages\/2\/revisions\/27"}],"wp:attachment":[{"href":"https:\/\/blogs.ubc.ca\/simchasrebnik\/wp-json\/wp\/v2\/media?parent=2"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}