HIV Can’t Hide From Math

Despite the amazing advancements of modern medicine, detecting early stages of Human Immunodeficiency Virus (HIV) is still proving difficult.

Source: https://commons.wikimedia.org/wiki/File:Anti-hiv-medications

At the end of 2014, almost 76,000 Canadians had been diagnosed with HIV, up by almost 10% since 2011. Even more alarming is that 21% of the infected individuals weren’t even aware they had HIV. These numbers are an illustration of the medical industry’s struggle with understanding HIV.

While many researchers have studied HIV from a biological perspective, Dr. Daniel Coombs and a team of biological mathematicians at the University of British Columbia took on the issue from a different angle—by using math.

“We took a modelling approach because we couldn’t think of how you could study this experimentally”
– Dr. Daniel Coombs

According to Dr. Coombs, the study of HIV is crucial to our society, stating that “the reason people work on HIV in such detail is because it’s not curable.” Commonly, we would associate the study of infection and disease with biological research, however, there are times when the answers we need simply cannot be provided by a pure biologist. For example, scientists understand that after exposure to HIV, there is a period of time where no HIV tests can detect this infection (known as ‘eclipse period’); however, what biological scientists haven’t been able to confidently determine is the exact length of this eclipse period. That’s where Dr. Coombs and his team come in. They are using mathematical modelling in an attempt to calculate this.

https://www.youtube.com/watch?v=rnHEcUyrazk&feature=youtu.be

The length of this eclipse period is shown to be quite variable, but lasts an average of about 8-10 days. However, according to Coombs’ research, the chance of obtaining a false negative HIV test (test says there’s no infection, but there actually is) is still 5% at three weeks after exposure. In some cases, if the infection is tested too early, a false negative could be obtained and falsely convince a patient that they do not have HIV. This could lead to the patient ignoring the virus, and the virus secretly progressing without any treatment to combat it.

Source: http://www.freestockphotos.biz/stockphoto/17099

To avoid such a dangerous situation, those who believe they have been exposed to HIV should know what measures to take when getting tested. We explore the importance of proper HIV testing, along with insights from Dr. Coombs:

The quest to understand HIV has been difficult and unending, but Dr. Coombs and his research team have shown us how useful of a tool math can be. By providing us with one more piece to the puzzle, the eclipse period length, Coombs and his team have provided valuable insight into proper HIV patient care and HIV testing. Just like Dr. Coombs says, “there’s so much we don’t know and I think there’s so many places where mathematics can come in and make an impact on biology.”

Written by: Silvana Jakupovic, Grace Tang, Howard Bai, and Patrick Geeraert

Tooth Replacement Patterns in Leopard Geckos

Source: Dr. Theresa Grieco, UBC

As the most important component of eating, teeth are organs that are vital to a wide variety of species, including mammals, reptiles, and insects. Odontogenesis, which is the process of tooth replacement, is something that occurs in humans only once in a lifetime, yet this process varies between organisms. Reptiles, specifically geckos, shed and replace their teeth once a month, which is something that is not commonly known by the general public. It is this characteristic of a gecko that make them the ideal research animal for studying tooth replacement.  The leopard gecko, and its unique features, are discussed in the podcast below, with the help of researcher Dr. Theresa Grieco.

University of British Columbia’s Dr. Theresa Grieco conducted a research study  on odontogensis in leopard geckos, a relatively uncommon study animal. From the study, the main finding was that odontogensis is a process that is predetermined in the embryo, and continues naturally in an adult. The video below describes Dr. Grieco’s study, and its applications to the research community.

Dr. Grieco’s study has contributed a significant amount of information to the field of odontogenesis. The results of this study, which have laid down a foundation for future research, will eventually have valuable interpretations in humans.

In terms of future research, Dr. Grieco plans to perform surgeries that have yet to be  done by researchers, as there are many unanswered questions surrounding tooth replacement. As stated by Dr. Grieco, what the tooth replacement “cycle is actually made up of is still what we are trying to figure out.” From this, researchers can determine the importance that each step holds in the cycle of odontogenesis in geckos.

Source: Dr. Theresa Grieco, UBC

However, more importantly, this research has the potential to enhance understanding of human tooth, and organ regeneration. As mentioned in the study, “there is going to be a bridge at some point” between the findings on geckos, and human teeth. Specifically, Dr. Grieco states that her study serves as a basis to determine whether morphological clues and common tooth patterns (similar to those found in geckos) will be found in humans, and if these can be used to discover a way for humans to re-grow their teeth too.

This aspect of science research is minor, but has many implications and benefits, and as Dr. Grieco states, “I don’t think I’m learning everything about life, but I’m definitely helping.”

Lighting Our Future.

Thomas Edison submitted his patent for the light bulb in October 1878. He is widely known as the inventor of the light bulb but this is not entirely correct. There were over 20 ‘inventors’ of the light bulb dating back to 1802, far before Edison. So why does Edison get credit? He was the first one to make a commercially viable lightbulb. His lightbulb was longer lasting, as he removed the air from from the bulb so the filament wouldn’t burn up. It was much more energy efficient than the gas burning lamps used at the time, and it was relatively easy to manufacture. Finally, his bulb produced far less heat than the aforementioned gas lamps.  These qualities are still the benchmarks of lighting technology today. If a new technology wants to replace the old, it has to improve on some or all of these aspects.

Incandescent, Fluorescent and LED bulbs
Source: Google Free to share

Over the years we have seen three main generations of lighting technology; incandescent lamps, compact fluorescent tubes and most recently light emitting diodes or LEDs. While Edison’s incandescent bulbs were a huge step forward from gas lighting, they still only convert 5-10% of electrical energy to light while the rest is lost as heat. Compact fluorescent tubes are much more energy efficient, able to convert 75-85% of energy to light while lasting 10-15 times longer. Because of this, they are commonly used in large buildings, hospitals and office spaces. LED technology surpasses all of its predecessors, converting around 90% of energy to light and lasting 10 times longer than fluorescent bulbs.

Source: Science Direct

One major roadblock preventing LEDs from taking over the lighting industry is their high manufacturing cost. Many experts hope that one day, this obstacle can be overcome with OLED (organic light emitting diode) technology. OLEDs differ from conventional LEDs as they use organic, or carbon containing molecules as a light source.  

OLEDs have the advantage of being thin and flexible allowing them to be made into nearly any shape. They also produce a much wider range of colours, which has made them ideal for display screens. The newest generation of iPhones and LG TVs are being made with OLED technology.

The video below explains the light source in OLEDs.

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LED has been given a while to mature as a technology, while OLED is relatively new and has a lot of room for improvement. Today’s OLED lights are less efficient than LED lights (25-50 lumens per watt vs 90-100 lumens per watt), but are still far superior to incandescent bulbs. Blue OLEDs also don’t last quite as long because fluorine is used in the molecule, making it quite unstable. Manufacturing OLEDs currently can cost an order of magnitude more than LEDs. Despite carbon’s abundance, many of the colours involve trace amounts of rare metals, such as iridium.  

Christopher Brown is a chemist at the University of British Columbia. He joined us in the podcast below to discuss how he thinks this cost can be reduced, and the future of lighting technology.

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Why Should We Start to Drink Green Tea?

Health issues are a topic that everybody is interested in. People find healthy foods because they have irregular eating habits and living habits. Organic foods, vegetables, less meat consumptions, fresh fruits, supplements like vitamin D are major substances that most people are pursuing.

Amongst those various health-related foods, one of the most I love to have is green tea because of its huge benefits other than anything.

source: nokchawon

Green tea is the most well-known and popular beverage in the world. Even people living in non- tea culture conturies enjoy green tea for its health benefits.  The origin of green tea started in China and it is widely accepted that the first green tea appeared in history was in 2723 BC. Then green tea spread to East Asia and Britain, and then to the rest of the world.

source: teasenz

Then why is green tea so loved? What makes it so beneficial to our health?

Green tea has a variety of antioxidants and nutrients. Catechin and caffeine are well-known among them. These antioxidants and nutrients work in multiple beneficial ways in our body.

Here are few benefits of drinking green tea

 

1) Protect the heart health:

Having green tea prevent many risk factors for heart disease such as stroke, lowering blood pressure, and reducing cholesterol levels. Even after suffering from heart disease, green tea helps the recovery of heart cells.

2) Protect vision:

One of major nutrients in green tea is called catechins; a type of antioxidants. Because catechins are strong antioxidatns, they help to protect the eyes  from oxidation stress and also vision loss. Therefore, it would benefit to people who are surrounded by electronic devices.

3) Improve bone health:

Because bone is a living tisuue, it has certain balance between formation and resorption. As humans get old, this balance gets weaker too. Regular consumption of green tea helps to increase bone formation (mineralization) and weaken the cells that resorb it, so the balance of formation and resorption is maintained in normal.

4) Improve brain function:

Regular consumption of green tea every day could help to improve memory. According to the reseach done by University of Newcastle, green tea inhibits certain enzymes in the brain which cause memory loss. In addition, it is shown that green tea is also effective to prevent Alzheimer’s disease. Green tea inhibits the enzyme in the brain which breaks down neurotransmitter (it transmits signals across brain nerve cells).

5) Prevent cancers:

According to the research in the Nature, regular consumption of green tea help preven cancers in humans by inhibition of enzyme that causes growth of cancers; typically stomach, breast, and prostate cancer.

 

source: ochaandco

Too much dosage of any foods or drinks always induce troubles as well as green tea. However, moderate intake of green tea regularly will change our lifestyle and health in highly beneficial ways. This is not hassle as much as visiting physicians and not hard as much as doing exercise everyday. This simple living habits can greatly change our health.

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The Effects of Soft Drinks

Recently, there has been increasing interest in the effect of soft drink on the life quality. By the research, the consumption of  has become a obvious and controversial health issue. Many people regard soft drinks as a major contributor to obesity , especially in children. So the aim of this blog were to review the available literature to determine whether soft drink consumption is related to increase in body weight, destruction of nutrients, and increase Prevalence of  diseases.

Soft-drinks

In 1942, the American Medical Association mentioned soft drinks specifically in a strong recommendation to limit intake of added sugar. Until 2000, the annual US production of carbonated soft drinks was increased from 90 8-oz to 600 8-oz per person. Interestingly, by the research of Koning L , People who take soft drinks 1 to 2 cans a day or more, have a 26% greater risk of developing type 2 diabetes than people who rarely have such drinks. And Dr. Frank Hu, which is the professor of Nutrition and Epidemiology at Harvard School of Public Health, indicate that there is significantly evidence show that decreasing sugar beverage intake will reduce the risk of obesity and related diseases. Also, for most of soft drinks, the added colors and preservatives have even worse effects than high sugar content. The bright color of the soft drinks looks pleasing but its effects are sensational: 4-methylimidazole, which is a compound found in the brown food coloring may caused lung, liver, and thyroid cancer in mice.

NO MORE SOFT DRINKS

Above available studies show a strong relation between soft drink consumption and increased health risk. This finding alone suggests that we should reduce the soft drink consumption. So what could we drink instead of soft drinks? The plain old H2O would be perfect to replace soft drinks; Or if you can’t give up on that fizz, the soda water or sparkling water will satisfy you.