Category Archives: Outreach Project

HIV Can’t Hide From Math

Despite the amazing advancements of modern medicine, detecting early stages of Human Immunodeficiency Virus (HIV) is still proving difficult.

Source: https://commons.wikimedia.org/wiki/File:Anti-hiv-medications

At the end of 2014, almost 76,000 Canadians had been diagnosed with HIV, up by almost 10% since 2011. Even more alarming is that 21% of the infected individuals weren’t even aware they had HIV. These numbers are an illustration of the medical industry’s struggle with understanding HIV.

While many researchers have studied HIV from a biological perspective, Dr. Daniel Coombs and a team of biological mathematicians at the University of British Columbia took on the issue from a different angle—by using math.

“We took a modelling approach because we couldn’t think of how you could study this experimentally”
– Dr. Daniel Coombs

According to Dr. Coombs, the study of HIV is crucial to our society, stating that “the reason people work on HIV in such detail is because it’s not curable.” Commonly, we would associate the study of infection and disease with biological research, however, there are times when the answers we need simply cannot be provided by a pure biologist. For example, scientists understand that after exposure to HIV, there is a period of time where no HIV tests can detect this infection (known as ‘eclipse period’); however, what biological scientists haven’t been able to confidently determine is the exact length of this eclipse period. That’s where Dr. Coombs and his team come in. They are using mathematical modelling in an attempt to calculate this.

https://www.youtube.com/watch?v=rnHEcUyrazk&feature=youtu.be

The length of this eclipse period is shown to be quite variable, but lasts an average of about 8-10 days. However, according to Coombs’ research, the chance of obtaining a false negative HIV test (test says there’s no infection, but there actually is) is still 5% at three weeks after exposure. In some cases, if the infection is tested too early, a false negative could be obtained and falsely convince a patient that they do not have HIV. This could lead to the patient ignoring the virus, and the virus secretly progressing without any treatment to combat it.

Source: http://www.freestockphotos.biz/stockphoto/17099

To avoid such a dangerous situation, those who believe they have been exposed to HIV should know what measures to take when getting tested. We explore the importance of proper HIV testing, along with insights from Dr. Coombs:

The quest to understand HIV has been difficult and unending, but Dr. Coombs and his research team have shown us how useful of a tool math can be. By providing us with one more piece to the puzzle, the eclipse period length, Coombs and his team have provided valuable insight into proper HIV patient care and HIV testing. Just like Dr. Coombs says, “there’s so much we don’t know and I think there’s so many places where mathematics can come in and make an impact on biology.”

Written by: Silvana Jakupovic, Grace Tang, Howard Bai, and Patrick Geeraert

Tooth Replacement Patterns in Leopard Geckos

Source: Dr. Theresa Grieco, UBC

As the most important component of eating, teeth are organs that are vital to a wide variety of species, including mammals, reptiles, and insects. Odontogenesis, which is the process of tooth replacement, is something that occurs in humans only once in a lifetime, yet this process varies between organisms. Reptiles, specifically geckos, shed and replace their teeth once a month, which is something that is not commonly known by the general public. It is this characteristic of a gecko that make them the ideal research animal for studying tooth replacement.  The leopard gecko, and its unique features, are discussed in the podcast below, with the help of researcher Dr. Theresa Grieco.

University of British Columbia’s Dr. Theresa Grieco conducted a research study  on odontogensis in leopard geckos, a relatively uncommon study animal. From the study, the main finding was that odontogensis is a process that is predetermined in the embryo, and continues naturally in an adult. The video below describes Dr. Grieco’s study, and its applications to the research community.

Dr. Grieco’s study has contributed a significant amount of information to the field of odontogenesis. The results of this study, which have laid down a foundation for future research, will eventually have valuable interpretations in humans.

In terms of future research, Dr. Grieco plans to perform surgeries that have yet to be  done by researchers, as there are many unanswered questions surrounding tooth replacement. As stated by Dr. Grieco, what the tooth replacement “cycle is actually made up of is still what we are trying to figure out.” From this, researchers can determine the importance that each step holds in the cycle of odontogenesis in geckos.

Source: Dr. Theresa Grieco, UBC

However, more importantly, this research has the potential to enhance understanding of human tooth, and organ regeneration. As mentioned in the study, “there is going to be a bridge at some point” between the findings on geckos, and human teeth. Specifically, Dr. Grieco states that her study serves as a basis to determine whether morphological clues and common tooth patterns (similar to those found in geckos) will be found in humans, and if these can be used to discover a way for humans to re-grow their teeth too.

This aspect of science research is minor, but has many implications and benefits, and as Dr. Grieco states, “I don’t think I’m learning everything about life, but I’m definitely helping.”

Lighting Our Future.

Thomas Edison submitted his patent for the light bulb in October 1878. He is widely known as the inventor of the light bulb but this is not entirely correct. There were over 20 ‘inventors’ of the light bulb dating back to 1802, far before Edison. So why does Edison get credit? He was the first one to make a commercially viable lightbulb. His lightbulb was longer lasting, as he removed the air from from the bulb so the filament wouldn’t burn up. It was much more energy efficient than the gas burning lamps used at the time, and it was relatively easy to manufacture. Finally, his bulb produced far less heat than the aforementioned gas lamps.  These qualities are still the benchmarks of lighting technology today. If a new technology wants to replace the old, it has to improve on some or all of these aspects.

Incandescent, Fluorescent and LED bulbs
Source: Google Free to share

Over the years we have seen three main generations of lighting technology; incandescent lamps, compact fluorescent tubes and most recently light emitting diodes or LEDs. While Edison’s incandescent bulbs were a huge step forward from gas lighting, they still only convert 5-10% of electrical energy to light while the rest is lost as heat. Compact fluorescent tubes are much more energy efficient, able to convert 75-85% of energy to light while lasting 10-15 times longer. Because of this, they are commonly used in large buildings, hospitals and office spaces. LED technology surpasses all of its predecessors, converting around 90% of energy to light and lasting 10 times longer than fluorescent bulbs.

Source: Science Direct

One major roadblock preventing LEDs from taking over the lighting industry is their high manufacturing cost. Many experts hope that one day, this obstacle can be overcome with OLED (organic light emitting diode) technology. OLEDs differ from conventional LEDs as they use organic, or carbon containing molecules as a light source.  

OLEDs have the advantage of being thin and flexible allowing them to be made into nearly any shape. They also produce a much wider range of colours, which has made them ideal for display screens. The newest generation of iPhones and LG TVs are being made with OLED technology.

The video below explains the light source in OLEDs.

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LED has been given a while to mature as a technology, while OLED is relatively new and has a lot of room for improvement. Today’s OLED lights are less efficient than LED lights (25-50 lumens per watt vs 90-100 lumens per watt), but are still far superior to incandescent bulbs. Blue OLEDs also don’t last quite as long because fluorine is used in the molecule, making it quite unstable. Manufacturing OLEDs currently can cost an order of magnitude more than LEDs. Despite carbon’s abundance, many of the colours involve trace amounts of rare metals, such as iridium.  

Christopher Brown is a chemist at the University of British Columbia. He joined us in the podcast below to discuss how he thinks this cost can be reduced, and the future of lighting technology.