Author Archives: calvin pan

The Future of Antarctica

In September 2019, the Amery Ice Shelf in Antarctica produced its biggest iceberg, which beat the record 50 years ago. The massive iceberg named D-28  covers an area of 1,636 sq km, which is slightly more than half of the Metro Vancouver area. It is about 210 m thick and contains 315 billion-tonne of ice.

Iceberg D-28 breaks away from the Amery Ice Shelf. Credit: ESA

 The cause of iceberg D-28 calving?

As a matter of fact, global warming, caused by greenhouse-gasses emission, has contributed to ice melting around the world. It is interesting to note that the calving of D-28 was a part of the normal cycle of ice shelves.

Firstly, glacier gradually moves toward the ocean by its own weight. As the glacier flow, the friction with the bedrock and surface melting thinning the ice sheets and form ice shelves, which are the arm of the ice sheet. Moreover, the warm circumpolar deep water flows in and melts the ice under the ice shelf that weakening its strength. Thus, the plane of ice starts splitting and shedding into icebergs.

Formation of icebergs. Credit: Calvin Pan

Climatic impacts of the iceberg

Melting icebergs influence both global sea levels and ocean salinity. If iceberg D-28 completely melted, researchers projected that sea volume would increase by 2.6 % compared to the volume of saltwater that was displaced. Annually, the global sea level is rising by about 3 mm, whereas the melting of D-28 only accounts for 0.049 mm of increase per year. As such, an individual iceberg would not dramatically raise the sea level. In considering the ocean salinity, indeed, the melted ice would dilute the salt concentration in the ocean and decline its salinity. This process usually occurs at lower latitudes when the iceberg melts. Nevertheless, at higher latitudes (eg, near where the iceberg breaks off), seawater is frozen by nearby icebergs, and its freezing process increases the salinity. The stabilizing influence on ocean salinity promotes the convection and circulation of oceanic currents.

Will climate change alter the Antarctic landscape?

Yes, climate change will accelerate the loss of Antarctic glaciers due to various reasons. For example, warmer sea, higher air temperatures, and higher sea levels fasten the natural cycle of ice shelves. Watch this short video made by Vox to understand the association between glaciers loss and climate change using the example of Thwaites Glacier, as well as possible consequences.

A study has proposed that reducing greenhouse-gas emissions could possibly mitigate the rate of change in Antarctica. Losing antarctic ice will not only raise the sea level but also threaten wildlife and food security because of more frequent extreme weather. Before dealing with an irreversible change in Antarctica, we must start thinking of how we can save the Antarctic ecosystem.

-Calvin Pan

Toward enzymatic blood conversion: A promising solution for blood shortage and transfusion incompatibility

What do you do when a patient requires blood transfusion, but the specific blood type is inadequate in the blood bank? Blood shortage has become a concern worldwide. According to American Red Cross, approximate 36,000 units of red blood cells (RBCs) are needed daily in the U.S, yet 13 million units are collected in a year, resulting in an average daily shortage of 400 units. And, this crisis usually expands during extraordinary situations. A recent example is the critical blood shortage during COVID-19 pandemic.

To solve the challenge, chemists have taken a step forward to examine the structure of RBCs and consider what if we convert all blood types to the universally accepted O blood. The importance of such research is that the barrier of blood transfusion between different types no longer exists. Hence, blood supply increases to ease the shortage.

What are blood types and transfusional barrier?

Image credit: InvictaHOG

There are four major blood types: A, B, AB, and O. Although blood might look the same and do the same job, such as carrying oxygen for respiration, transfusing incompatible blood type will trigger fatal immune responses. That is because of the additional sugar molecule, called antigen, attaching to the core sugar structure on a RBC. Type A blood has A antigens. Similarly, type B blood has B antigens. Moreover, type AB blood contains both A and B antigens. Importantly, type O has none of them.

Image credit: Marius Lixandru

Due to the presence of either A or B antigen, A-blood people cannot transfuse with type B; B-blood people cannot transfuse with type A. Consequently, AB-blood people cannot take either A or B but only with AB blood. Only O blood is the universally accepted type because it shares without being recognized as an outsider by our immune system.

Origin of enzymatic blood conversion

The first idea of blood-type conversion can be traced back to 1980s, Goldstein and his colleagues used an enzyme found in coffee beans and have shown success in the complete enzymatic removal of B antigen, generating non-antigen blood (O blood). However, the conversion requires large quantity of enzymes and output a trace amount of type O. As a result, the work done by Goldstein is not suitable for practical use. Similarly, other research uses an enzyme found in fungi to remove A antigen but its efficiency is still inadequate.

Improving enzyme activity using enzyme engineering

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Description: How enzymes found in gut bacteria change blood types for transfusion

Great improvement in enzyme activity is recently done by Kwan’s team who modify sugar hydrolase (GH98) with 170-times higher enzyme activity than that of the original hydrolase from human gut bacteria using enzyme engineering. It is inspiring because GH98 enzyme can remove both A and B antigens, whereas other enzymes used in past research only remove either A or B antigens. Their research broadens the specificity of the enzyme and makes the blood conversion more promising and practical for resolving blood shortage.

– Calvin Pan