Author Archives: dylan chambers

Does an Obesity Gene Exist?

Genes play a big role in determining how a person looks including our eye color, hair color, and height, but can your genes also determine your waistline? As of now, 61% of Canadians are overweight or obese and that number is even higher in America, with 66% of its citizens overweight or obese.  While these numbers can be attributed to a more sedentary lifestyle and poor diet, genetics has been shown to be a factor. A study in 1986 found that adopted children’s BMI more closely matched their biological parents than adoptive parents. While environmental factors play a huge role in a person’s weight, the importance of genetics cannot be understated.

One of the first genes to be linked to obesity was the melanocortin-4-receptor gene (MC4R). In 1998 a study found that mutations in MC4R would lead to early-onset obesity in children. However, this mutation is extremely rare, affecting less than 5% of those suffering from obesity leading researchers to search for more common genetic variations. Starting in 2002 scientists began to perform genome-wide association studies (GWAS). Instead of looking at genomes of a few hundred people, scientists could now look at entire DNA sequences of hundreds of thousands of people in order to find links between certain genes and illness.  A GWAS in 2007 led to the discovery that variations in the fat mass and obesity (FTO) gene were associated with higher BMI’s. These variations were much more common with 43% of the population carrying this “risky” allele of the FTO gene.  The study found that individuals with certain variations of this gene were 1.67 times as likely to be obese. Despite this, the FTO gene itself only raised BMI .4 kg/m^2 an amount much too small to lead to the increase in BMI observed (3 kg/M^2). This is why the majority of obesity in the population is caused by many genes, not just one. Since 2006 GWAS has led to the discovery of more than 50 genes associated with obesity.

The discovery of these genes not only can tell us who is predisposed to becoming obese, but who is also more likely to suffer from metabolic diseases associated with obesity like heart disease, stroke, and type 2 diabetes. This video from the University of Michigan explains some of the surprises that came from studying genes related to obesity and how we can use this information to benefit people.

YouTube Preview Image

 

 

However, just discovering these genes isn’t enough. In order to treat these variations, we have to better understand the mechanism of these genes. Recent studies have revealed that variations of the FTO can cause alterations in satiety that people feel, but the exact mechanism of these effects are still largely unknown. For now, proper exercise and nutrition can counter the effects of most of these “fat” genes. In the future, people may be able to find the best way to prevent weight gain based on their genetic makeup. Only time will tell if future discoveries can reverse this obesity epidemic.

 

By Dylan Chambers

Failure to Communicate

Introduction 

Right now communicating science to the general public is more important than ever, and we are failing. Less than 50% of Americans say they would receive a vaccine for COVID-19. This shows the eroding trust that the public has for their once highly esteemed scientist. This is the result of breakdowns in the scientific method that have led to conflicting information being shared with the public.

Mask  Wearing

Perhaps the most notable slip up was the controversy surrounding masks.  While recommended now, it was not until April 3rd, three months into the pandemic, that the CDC began recommending the general public to wear a mask. This was in direct conflict with their earlier statements that only healthcare workers needed masks.  Scientists rushed conclusions that could not be properly verified before being shared with the public. The public demanded answers from a process that can take years, in a matter of weeks. By caving in to public demand, the CDC and World Health Organization were inevitably set up for failure as the pandemic progressed and more data was collected leading to new developments. Tweets from the U.S surgeon general like this

Tweet by Surgeon General Feb 29

only serve to fuel distrust when compared with tweets he makes a few months later.

Tweet by Surgeon General June 14

 

I do not fault scientists for changing their opinion as new data became available, but I do fault (some) scientists for stating their answers with confidence when the proper research and review had not been conducted.

 

Treatment

Image: flickr

Scientists have been under enormous pressure to find treatments for COVID-19 that can reduce mortality and infection rate. This has created haste in the scientific method and has allowed some treatments to receive emergency authorization from the FDA such as remdesivir. Even these emergency authorizations are accompanied by randomized, double-blind, placebo-controlled clinical trials that assure treatments are safe. These methods for testing were not present in the study of Hydroxychloroquine that led to its eventual emergency authorization.  The original study involved only 26 patients treated with Hydroxychloroquine that were compared to 16 untreated patients at a different hospital. Later studies conducted on Hydroxychloroquine would question its effectiveness as a treatment for COVID-19 and thus the scientific process was able to correct itself and the FDA revoked the use of Hydroxychloroquine. However, the public once again lost its trust in doctors. This opened the door to rumors and conspiracy theories to dominate the public view. In a pandemic where time is everything the spread of misinformation costs lives

By allowing leniency in the scientific method, we have opened the flood gates to all types of information being thrust onto the pedestal once reserved for the conclusion from the scientific method. Your uncle’s Facebook post about the healing power of Clorox bleach carries as much weight as the cutting edge research on COVID-19. Scientists have lost credibility with the public. This is not the first time this has happened, but it may be the most damaging.

 

Dylan Chambers

How America’s Scientist Failed to Communicate Science

Right now communicating science to the general public is more important than ever, and we are failing. With less than 50% of Americans saying they would receive a vaccine for COVID-19 if it were approved today shows the eroding trust that the public has for their once highly esteemed scientist.

 

Where did we go wrong? Perhaps we can trace this back to the article published in 1998 by the Lancet linking autism and vaccines. However, in the January before COVID-19  a poll found that only 10% of Americans believed that vaccines caused autism. This cannot explain the nearly 50% of Americans who fear a potential COVID-19 vaccine just 4 months later. I believe the seeds of mistrust were sown during this pandemic. The line of communication between scientist and the public, once pristine, has been scarred by misinformation and rushed conclusions.

Perhaps the most notable slip up was the controversy surrounding masks.  While commonplace (and in many cases mandatory) now it was not until April 3rd,3 months into the pandemic, that the CDC began recommending the general public to wear a mask. This was in direct conflict with their earlier statements that only healthcare workers needed masks. The rush of the pandemic has upended the scientific process. Scientist rushed conclusions that could not be properly verified before being shared with the public. The public demanded answers from a process that can take years, in a matter of weeks. By caving in to public demand, the CDC and World Health Organization were inevitably set up for failure as the virus progressed and more data was collected leading to contradicting statements. This trial and error is an important part of the scientific method, but it is rarely shared with the public in real time as viable information. So tweets from the U.S surgeon general like this only serve to fuel distrust when compared with tweets he makes a few months later. I do not fault scientist for changing their opinion as new data becomes available, but I do fault (some) scientist for stating their answers with the same confidence as answers that result from years of work and scrutiny from peers.

 

As the race to find a vaccine has taken off, so has the search for a treatment. Scientist have been under enormous pressure to find treatments for COVID-19 that can reduce mortality and infection rate. This has created haste in the scientific method and has allowed some treatments to receive emergency authorization from the FDA such as remdesivir. Even these emergency authorizations are accompanied by randomized, double blind, placebo-controlled clinical trials that make sure these treatments are safe. These studies involved hundreds of patients of varying backgrounds and age groups. None of these sound scientific methods for testing were present in the study of Hydroxychloroquine that led to its eventual emergency authorization.  The original study that sparked interest in Hydroxychloroquine involved only 32 patients. 26 were treated with Hydroxychloroquine and 16 were not. The researchers concluded that despite their small sample size “our survey shows that hydroxychloroquine treatment is significantly associated with viral load reduction/disappearance in COVID-19“. Despite its merger sample size and lack of randomization, the study was enough to propel Hydroxchloroquine past the normally rigorous FDA approval process. Later studies conducted on Hydroxychloroquine would questions it effectiveness as a treatment for COVID-19 and thus the scientific process was able to correct itself and the FDA revoked the use of Hydroxychloroquine as treatment for COVID-19. However, the damage was done. The public once again lost its trust in doctors. This opened the door to rumours and conspiracy theories to dominate the publics view. Social media has only exacerbated this spread of misinformation. This allowed the spread of a rumour that drinking bleach could cure you of COVID-19 which led to 4% of respondents of a CDC survey saying that they had drunk or gargled bleach.

 

This graph published by American Journal of Tropical Medicine and Hygiene. shows the number of rumours, conspiracy theories, and stigma surrounding COVID-19 starting from January 21 and continuing until April 5th.  We can see a steady increase starting in February and hitting its peak in march. Its worth noting that Hydroxychloroquine was approved in February and began to receive doubt in March from the media and scientist alike for its unproven effectiveness. This coincides with the spike we see in rumours happening in late February and continuing into March. This possible correlation cannot be overlooked as we continue to learn more about how to treat COVID-19. The spread of misinformation can be as damaging to the public as the virus itself.

 

By allowing leniency in the airtight scientific method, we have opened the flood gates to all types of information being thrust onto the pedestal once reserved for conclusion from the scientific method. Your uncles facebook post about the healing power of Clorox bleach carry as much weight as the cutting edge research on COVID-19.  “Todays Propaganda has become tomorrows truth“. Scientist have lost credibility with the public. This is not the first time this has happened, but it may be the most damaging.