Category Archives: Science Communication

How America’s Scientist Failed to Communicate Science

Right now communicating science to the general public is more important than ever, and we are failing. With less than 50% of Americans saying they would receive a vaccine for COVID-19 if it were approved today shows the eroding trust that the public has for their once highly esteemed scientist.

 

Where did we go wrong? Perhaps we can trace this back to the article published in 1998 by the Lancet linking autism and vaccines. However, in the January before COVID-19  a poll found that only 10% of Americans believed that vaccines caused autism. This cannot explain the nearly 50% of Americans who fear a potential COVID-19 vaccine just 4 months later. I believe the seeds of mistrust were sown during this pandemic. The line of communication between scientist and the public, once pristine, has been scarred by misinformation and rushed conclusions.

Perhaps the most notable slip up was the controversy surrounding masks.  While commonplace (and in many cases mandatory) now it was not until April 3rd,3 months into the pandemic, that the CDC began recommending the general public to wear a mask. This was in direct conflict with their earlier statements that only healthcare workers needed masks. The rush of the pandemic has upended the scientific process. Scientist rushed conclusions that could not be properly verified before being shared with the public. The public demanded answers from a process that can take years, in a matter of weeks. By caving in to public demand, the CDC and World Health Organization were inevitably set up for failure as the virus progressed and more data was collected leading to contradicting statements. This trial and error is an important part of the scientific method, but it is rarely shared with the public in real time as viable information. So tweets from the U.S surgeon general like this only serve to fuel distrust when compared with tweets he makes a few months later. I do not fault scientist for changing their opinion as new data becomes available, but I do fault (some) scientist for stating their answers with the same confidence as answers that result from years of work and scrutiny from peers.

 

As the race to find a vaccine has taken off, so has the search for a treatment. Scientist have been under enormous pressure to find treatments for COVID-19 that can reduce mortality and infection rate. This has created haste in the scientific method and has allowed some treatments to receive emergency authorization from the FDA such as remdesivir. Even these emergency authorizations are accompanied by randomized, double blind, placebo-controlled clinical trials that make sure these treatments are safe. These studies involved hundreds of patients of varying backgrounds and age groups. None of these sound scientific methods for testing were present in the study of Hydroxychloroquine that led to its eventual emergency authorization.  The original study that sparked interest in Hydroxychloroquine involved only 32 patients. 26 were treated with Hydroxychloroquine and 16 were not. The researchers concluded that despite their small sample size “our survey shows that hydroxychloroquine treatment is significantly associated with viral load reduction/disappearance in COVID-19“. Despite its merger sample size and lack of randomization, the study was enough to propel Hydroxchloroquine past the normally rigorous FDA approval process. Later studies conducted on Hydroxychloroquine would questions it effectiveness as a treatment for COVID-19 and thus the scientific process was able to correct itself and the FDA revoked the use of Hydroxychloroquine as treatment for COVID-19. However, the damage was done. The public once again lost its trust in doctors. This opened the door to rumours and conspiracy theories to dominate the publics view. Social media has only exacerbated this spread of misinformation. This allowed the spread of a rumour that drinking bleach could cure you of COVID-19 which led to 4% of respondents of a CDC survey saying that they had drunk or gargled bleach.

 

This graph published by American Journal of Tropical Medicine and Hygiene. shows the number of rumours, conspiracy theories, and stigma surrounding COVID-19 starting from January 21 and continuing until April 5th.  We can see a steady increase starting in February and hitting its peak in march. Its worth noting that Hydroxychloroquine was approved in February and began to receive doubt in March from the media and scientist alike for its unproven effectiveness. This coincides with the spike we see in rumours happening in late February and continuing into March. This possible correlation cannot be overlooked as we continue to learn more about how to treat COVID-19. The spread of misinformation can be as damaging to the public as the virus itself.

 

By allowing leniency in the airtight scientific method, we have opened the flood gates to all types of information being thrust onto the pedestal once reserved for conclusion from the scientific method. Your uncles facebook post about the healing power of Clorox bleach carry as much weight as the cutting edge research on COVID-19.  “Todays Propaganda has become tomorrows truth“. Scientist have lost credibility with the public. This is not the first time this has happened, but it may be the most damaging.

The Use of Recreational Drug MDMA in PTSD Treatment

When you think of MDMA, otherwise known as ecstasy, you imagine most users using this drug would be most people using it at a club to party. However, scientists have recently used MDMA to assist in treating PTSD, and the results thus far are shocking.

What is MDMA?

MDMA is a drug that alters the mood and perception, where energy, pleasure, emotional warmth and sensory perception of the user are enhanced. To do so, MDMA enhances the release of neurotransmitters like serotonin, dopamine and norepinephrine. The most notable neurotransmitter is serotonin. Serotonin is a neurotransmitter that plays an important role in mood regulation and sleep. When MDMA binds to the synapse of nerve cells, it blocks the reuptake of serotonin, creating excess levels of serotonin present in the synaptic cleft. This is what is believed to cause the mood-elevating effects that people experience.

MDMA is found normally in the form of pressed pills. Source: Wikimedia Commons

PTSD and its effects on the human body 

PTSD is usually associated with dramatic flashbacks following a month after a traumatic event. Additionally, it can also be emotional numbness and avoidance of things that are reminders of the trauma. Most people also suffer from increased arousal, where they are very easily irritated and angered. However, these symptoms could take up to many months or years to appear following the trauma. These symptoms, if left untreated, could lead to an increase in suicidal thoughts and behaviours.”. War veterans, who usually suffer some degree of PTSD, are known to have a higher suicide rate compared to regular Canadian citizens. As well, more than 46% of adolescent girls who had been sexually abused attempted suicide at one point in their lives. 

 

Veteran Suicide Rates compared to Civilian Suicide Rates
Source: reddit.com/r/dataisbeautiful by /u/datashown

 

Decrease in PTSD symptoms after MDMA treatment

In a study done with MDMA and its effect on PTSD, it saw over 68% of its participants no longer meet the standards of PTSD diagnosis over the course of a year. As well, almost all patients saw their symptoms reduced. The treatment of MDMA was done by administering 75-125 mg of the drug during psychotherapy sessions in two/three 8 hour long sessions monthly, with regular psychotherapy sessions that occur between the monthly sessions. 

People with PTSD often have a hyperactive amygdala, their part of the brain that regulates fear and anger. When aroused, it causes them to feel stressed and undergo “fight or flight” responses. This is why traditional psychotherapy is difficult because discussion surrounding sensitive topics could trigger it. Additionally, since MDMA regulates the amygdala, this allows for the open discussion of sensitive topics, without triggering the patients “flight or fight” response. 

MDMA may improve PTSD symptoms with psychotherapy.
Source: Clearvue Health

The following Ted Talk by Brad Burge furthers the details of why MDMA can be used to treat PTSD

YouTube Preview Image

 

So why is this important?

PTSD affects 7-8 out of 100 people throughout their lives, so it is important there is a clear treatment path. As well, it opens up the possibility for MDMA to be researched into other forms of mental health issues, such as depression and anxiety.

– Martin Au-yeung

Mental Health: The Undiscussed Impacts of the COVID-19 Pandemic

The mental health consequences of COVID-19 receive less attention than the epidemiology, transmission patterns, and management of the virus. Policy makers have implemented several important measures to help mitigate the spread of the virus, but have provided less consideration to the mental health effects on individuals. 

Image: Engin AkyurCC0 

Do you find yourself stressed and anxious as a result of the COVID-19 pandemic?

If so, you are not alone: 

Researchers from the Centre for Addiction and Mental Health and the research technology company Delvinia conducted a national survey with over 4000 respondents ages 18 and older, that revealed that 19% of Canadians experienced moderate to severe anxiety as a result of the COVID-19 pandemic. With 18.7% reporting that they felt depressed, and 27.2% reporting that they engaged in binge-drinking. 

The results were fairly consistent between men and women, with women experiencing slightly higher percentages overall. 

Anxiety levels are shown to decrease with age as the majority of respondents experiencing moderate-severe anxiety were in the 18-39 age group. The percentage of respondents that reported feeling depressed and lonely follow the same trend, with individuals in the 18-39 age group having the highest percentage, followed by the 40-59, and 60+ age groups.

38.8% of individuals who felt depressed reported feeling very worried about finances and 34% lost their jobs or are no longer working due to the pandemic.

It is clear that the COVID-19 pandemic affects not only physical health, but mental health as well. The rapid direct contact transmission of COVID-19 resulted in the enforcement of lockdowns to stop the spread of the disease. Social distancing, isolation, and the closure of educational institutes, workplaces, and entertainment venues urged people to stay in their homes to stop the transmission of the virus. These restrictive measures have undoubtedly affected the mental health of individuals in Canada.

In addition, the closing of businesses due to COVID-19 has led to financial stress for business owners and employees. The worry associated with having decreased or no income leads to and may aggravate symptoms of depression.

The COVID‐19 pandemic has had and will continue to have an impact on society. It is important to understand that mitigation measures are necessary to combat the virus, all while recognizing the mental health effects. However, there are ways to better your mental health during these difficult times.

MENTAL HEALTH TIPS:

  • Self-care is very important at this time. Reach out to your social supports, try to get enough sleep, eat healthy, & exercise. Do the things you would normally do to support your health but use caution and follow health and safety guidelines.
  • Seek information from reliable news sources only. Limit checking in on the latest news to short, defined periods. 
  • Take the recommended precautions as outlined by Health Canada and other credible health agencies: continue washing your hands, covering your mouth during coughs & sneezes, etc.
  • Consider reaching out to mental health resources. Or, call 8-1-1 any time of the day for help navigating the mental health system

Image: by kike vega CC0

 

– Sarah Ghoul

Excess carbon dioxide: How can we combat this problem, and why is it problematic for marine organisms?

Did you know that excess carbon dioxide poses a significant problem for marine life? Although CO2 is naturally occurring and acts as an important heat-trapping gas in moderate amounts, human activities have pumped lots of excess CO2 into the atmosphere.

Exhaust fumes from an industrial plant, which includes carbon dioxide (as well as other chemicals). Photo by Damian Bakarcic.

Too much carbon dioxide not only contributes to more extreme weather and global warming, but it also made oceans 30% more acidic since the beginning of the Industrial Revolution.

Today, CO2 makes up 84% of all greenhouse gases from human activity, with around 40 billion tons being produced per year.

Numerous climate scientists, such as climatologist Dr. James Hansen, state that to avoid the impacts of climate change, the levels need to be reduced to at maximum 350 ppm. However, CO2 levels have already exceeded 400 ppm in 2019.

Across the world, many different marine species, such as barnacles, experience the chemical effects of lowered pH levels. This comes in the form of problems with shell formation/ adhesion and lower survival rates, as demonstrated in a laboratory study by the Northeast Coastal Acidification Network.

Ocean acidification has an especially adverse impact for animals that are sensitive to changes in carbonate chemistry. For example, shellfish use carbonate in the ocean to make their protective shell structures. With a low pH, calcium carbonate is in short supply because it will react with acidic solutions.

An infographic depicting the chemistry behind ocean acidification, and why it is harmful for marine life. Source: Climate Commission (RIP)

One remedy involves catalysis. This uses catalysts to convert CO2 into useful goods – fertilizers and plastics. Doing so would convert the polluting waste product into useful molecules, and simultaneously lessen our need to use fossil fuels to generate such products.

A way this can be achieved is with an electrolysis cell, which employs electrical energy to run a non-spontaneous redox (i.e. oxidation-reduction) reaction. A non-spontaneous redox reaction occurs only when an external voltage is applied, whereas a spontaneous one would generate a voltage itself.

On the electrode surface, the CO2 is reduced – meaning the addition of hydrogen, the removal of oxygen, or both (oxidation is the opposite: lose hydrogen/ gain oxygen). Depending on the number of electrons transferred, many different molecules could be produced. The products form in the electrolyte, and move to a separation system.

Catalysis involving carbon dioxide and hydrogen, with a Cu/ZnO catalyst. CO2 is reduced, producing methanol and carbon monoxide. Source: a drawing by myself.

Any unreacted CO2 and the electrolyte are recycled. Tin is a metallic catalyst used to make formic acid via catalysis. More complex molecules can be formed as well, such as the ethanol found in hand sanitizers.

In conclusion, too much carbon dioxide is a significant threat to marine life, and catalysis is one solution that scientists are investigating to recycle CO2. Are there other potential solutions for excess CO2 that you know of?

– Jacqueline (Wai Ting) Chan