Here is the link to my group’s Chiesa et al. (2012) assignment, with additional answers to questions that were not answered previously and modified answers to address comments: chiesa_assignment_2016
I chose the Chiesa et al. (2012) assignment as one of my top assignments because it demonstrated how I was able to draw from concepts that I learned in earlier sections of the course and used them to hypothesize mechanisms that contribute to disease phenotypes. More specifically, I recognized that epigenetic regulation strongly contributes to abnormal gene expression patterns associated with Beckwith-Wiedemann syndrome. In addition, I considered this assignment to be engaging because it involved a paper that studied humans. Many of the papers covered in this course used animal models, so it was nice to look at humans through a clinical study for a change.