Key scientific interests are summarized in Research Themes.
Updated October 31, 2024. For automated indexing services see Google Scholar, ORCID and PubMed.
Publications
Cover Issues
6. Todorovic, M.; Rivollier, P.; Wong, A. A. W. L.; Wang, Z.; Pryyma, A.; Nguyen, T. T.; Newell, K. C.; Froelich, J.; Perrin, D. M. Rationally Designed Amanitins Achieve Enhanced Cytotoxicity. J Med Chem 2022, 65 (15), 10357–10376. https://doi.org/10.1021/ACS.JMEDCHEM.1C02226.
3. Matinkhoo, K.; Wong, A. A. W. L.; Hambira, C. M.; Kato, B.; Wei, C.; Müller, C.; Hechler, T.; Braun, A.; Gallo, F.; Pahl, A.; Perrin, D. M. Design, Synthesis, and Biochemical Evaluation of Alpha-Amanitin Derivatives Containing Analogs of the Trans-Hydroxyproline Residue for Potential Use in Antibody-Drug Conjugates. Chemistry – A European Journal 2021, 27 (40), 10212. https://doi.org/10.1002/chem.202102062.
2024
14. A Novel 68Ga-Labeled 2-Azabicyclo[3.1.0]hexane-3-carbonitrile-based Fibroblast Activation Protein-targeted Tracer for Cancer Imaging with Positron Emission Tomography. Chen, C. C.; Wang, L.; Wong, A. A. W. L.; Lau, W. S.; Ng, P., Merkens, H.; Bénard, F.; Lin K.-S. J. Label. Compd. Radiopharm. 2024; submitted.
13. Bendre, S.; Merkens, H.; Kuo, H. T.; Ng, P.; Wong, A. A. W. L.; Lau, W. S.; Zhang, Z.; Kurkowska, S.; Chen, C. C.; Uribe, C. F.; Bénard F.; Lin, K. S. Development, preclinical evaluation and preliminary dosimetry profiling of SB03178, a first-of-its-kind benzo[h]quinoline-based fibroblast activation protein-α-targeted radiotheranostic for cancer imaging and therapy. Eur. J. Med. Chem. 2024; 268, 116238. https://doi.org/10.1016/j.ejmech.2024.116238.
12. Verena, A.; Merkens, H.; Chen, C. C.; Chapple, D. E.; Colpo, N.; Ng, P.; Wang, L.; Wong, A. A. W. L.; Bénard F.; Lin, K. S. Synthesis and Preclinical Evaluation of Two Novel 68Ga-labeled Bispecific PSMA/FAP-targeted tracers with 2-Nal-containing PSMA-targeted Pharmacophore and Pyridine-based FAP-targeted Pharmacophore. Molecules 2024; 29 (4), 800. https://doi.org/10.3390/molecules29040800.
2023
11. Kuo, H. T.; Zhang, Z.; Zhang, C.; Merkens, H.; Tan, R.; Wong, A. A. W. L.; Uribe, C. F., Bénard F.; Lin, K. S. Lys-urea-Aad, Lys-urea-Cmc and Lys-urea-Cms as potential pharmacophores for the design of PSMA-targeted radioligands to reduce off-target uptake in kidneys and salivary glands. Theranostics 2023; 13 (13), 4559-4573. https://doi.org/10.7150/thno.87663.
10. Bendre, S.; Zhang, Z.; Colpo, N.; Zeisler, J.; Wong, A. A. W. L.; Bénard, F.; Lin, K. S. Synthesis and Evaluation of 68Ga-Labeled (2S,4S)-4-Fluoropyrrolidine-2-Carbonitrile and (4R)-Thiazolidine-4-Carbonitrile Derivatives as Novel Fibroblast Activation Protein-Targeted PET Tracers for Cancer Imaging. Molecules 2023, 28 (8), 3481. https://doi.org/10.3390/MOLECULES28083481.
9. Bendre, S.; Kuo, H.-T.; Merkens, H.; Zhang, Z.; Wong, A. A. W. L.; Bénard, F.; Lin, K.-S. Synthesis and Preclinical Evaluation of Novel 68Ga-Labeled (R)-Pyrrolidin-2-yl-Boronic Acid-Based PET Tracers for Fibroblast Activation Protein-Targeted Cancer Imaging. Pharmaceuticals 2023, 16 (6), 798. https://doi.org/10.3390/PH16060798.
8. Verena, A.; Kuo, H. T.; Merkens, H.; Zeisler, J.; Bendre, S.; Wong, A. A. W. L.; Bénard, F.; Lin, K. S. Novel 68Ga-Labeled Pyridine-Based Fibroblast Activation Protein-Targeted Tracers with High Tumor-to-Background Contrast. Pharmaceuticals 2023, 16 (3), 449. https://doi.org/10.3390/PH16030449.
7. Verena, A.; Zhang, Z.; Kuo, H. T.; Merkens, H.; Zeisler, J.; Wilson, R.; Bendre, S.; Wong, A. A. W. L.; Bénard, F.; Lin, K. S. Synthesis and Preclinical Evaluation of Three Novel 68Ga-Labeled Bispecific PSMA/FAP-Targeting Tracers for Prostate Cancer Imaging. Molecules 2023, 28 (3), 1088. https://doi.org/10.3390/MOLECULES28031088.
2022
6. [Cover Feature] Todorovic, M.; Rivollier, P.; Wong, A. A. W. L.; Wang, Z.; Pryyma, A.; Nguyen, T. T.; Newell, K. C.; Froelich, J.; Perrin, D. M. Rationally Designed Amanitins Achieve Enhanced Cytotoxicity. J Med Chem 2022, 65 (15), 10357–10376. https://doi.org/10.1021/ACS.JMEDCHEM.1C02226.
5. Paul, S.; Wong, A. A. W. L.; Liu, L. T.; Perrin, D. M. Selection of M2+-Independent RNA-Cleaving DNAzymes with Side-Chains Mimicking Arginine and Lysine. ChemBioChem 2022, 23 (5), e202100600. https://doi.org/10.1002/CBIC.202100600.
2021
4. Matinkhoo, K.; Pryyma, A.; Wong, A. A. W. L.; Perrin, D. M. Synthesis and Evaluation of “Ama-Flash”, a Photocaged Amatoxin Prodrug for Light-Activated RNA Pol II Inhibition and Cell Death. Chemical Communications 2021, 57 (75), 9558–9561. https://doi.org/10.1039/D1CC03279H.
3. [Cover Feature] Matinkhoo, K.; Wong, A. A. W. L.; Hambira, C. M.; Kato, B.; Wei, C.; Müller, C.; Hechler, T.; Braun, A.; Gallo, F.; Pahl, A.; Perrin, D. M. Design, Synthesis, and Biochemical Evaluation of Alpha-Amanitin Derivatives Containing Analogs of the Trans-Hydroxyproline Residue for Potential Use in Antibody-Drug Conjugates. Chemistry – A European Journal 2021, 27 (40), 10282–10292. https://doi.org/10.1002/CHEM.202101373.
2020
2. Pryyma, A.; Matinkhoo, K.; Wong, A. A. W. L.; Perrin, D. M. Meeting Key Synthetic Challenges in Amanitin Synthesis with a New Cytotoxic Analog: 5’-Hydroxy-6’-Deoxy-Amanitin. Chem Sci 2020, 11 (43), 11927–11935. https://doi.org/10.1039/D0SC04150E.
1. Wong, A. A. W. L.; Lozada, J.; Lepage, M. L.; Zhang, C.; Merkens, H.; Zeisler, J.; Lin, K.-S.; Bénard, F.; Perrin, D. M. Synthesis and 18F-Radiolabeling of Thymidine AMBF3 RSC Med Chem 2020, 11 (5), 569–576. https://doi.org/10.1039/D0MD00054J.
