Tag Archives: Neuroscience

The science behind brain and nervous system

Among all human organs, the brain is the most important and complex. The brain is the organ that regulates the function of the body and is the material basis for advanced neurological activities such as consciousness, spirit, language, learning, memory, and intelligence. The brain needs a nervous system to perform these neural activities.

In short, the nervous system is an intermediary that can transmit messages from the brain to various parts of the body. Neurons are the basic unit in the nervous system and they communicate through synapses. Synapse is like a bridge between nerve cells, and there are more than 100 trillion synapses in a typical brain. The formation of synapses is essential to ensure a nervous system can function smoothly since the number of synapses is very large.

Synapse Illustration

(One synapse in the nervous system. Source:Flickr.)

In 2018, Chen and his research team did a study about how the nerve cell formation of a worm, which is called C. elegans, is affected by one protein called Plexin. In this study, they found that two genes (Rap2 and TNIK) regulated by Plexin can affect synaptic tiling of C. elegans, and synaptic tiling is one kind of synapses formation. That is increased activity of Rap2 holds up synaptic tiling and TNIK is the opposite. The following video describes the story of their research.

Their findings are very helpful for other neuroscientists to understand the role of these genes in synapses formation. According to Ethan Fortes, one of Chen’s research team, “What we hope to do is to provide a deeper understanding of the function of the genes that might be disrupted in people who have neurological differences or disorders.” This study can be a very good inspiration for future study on other species whose nervous system is more advanced and more structurally related to humans.

The podcast below involves a conversational dialogue with the researcher and he answered some general questions from the perspective of researchers.

Studying the brain and nervous system is of great significance to humans. Brain and nervous system problems are quite common and more difficult to prevent. Beyond that, problems with the nervous system were found to be the cause of some mental illness such as Autism.

Group 2

Nathan Yan, Fareez Sanif, Zijie Lin, Serena Yu

 

What is sleepwalking?

One night, my high school roommate suddenly said: “Let’s go for a barbeque.” I was surprised and I said to him” Are you mad?” He replied to me” No, I am not.” However, I found that he was actually sleeping, but he could reply to me! This was the first time I saw a sleepwalker.

Image result for sleepwalking

Credit: Bret S. Stetka

What is sleepwalking?  

Sleepwalking refers to somnambulism or noctambulism, people in deep sleep will walk or perform other activities including eating, talking or cleaning. Some activities can be dangerous such as driving or even homicide.

How to explain sleepwalking?

There are 5 stages of sleep during a sleep cycle which lasts 90 minutes. During the first four stages, we have non-rapid eye movement (NREM) sleep, and rapid eye movement (REM) sleep occurs during the fifth stage. The sleepwalk usually occurs at stages 3&4. During this time, our brainwave is the slowest and we are in the deepest sleep. During REM sleep, our brain activity is much more active and our body muscles become temporarily paralyzed. Therefore most sleepwalking does not occur in REM sleep because we cannot walk when our muscles cannot move. People rise from their beds when their brain attempts to go straight from NREM sleep to being awake instead of completing the rest of the sleep cycle. Sleepwalking occurs mostly among children, some scientists think children are more likely to have sleepwalking because their brains are not fully developed. The growth hormones are the triggers causing the children to rise. It may also be related to inhibitory neurotransmitters. A neurotransmitter is called GABA which stifles the brains motor system. For adults, this neurotransmitter usually inhibits the body’s motion well. However, for kids, the neurons that release the neurotransmitter are not fully developed yet so their motor system may still be active and this will lead to sleepwalking.

Is it common?

  Dr. Plazzi and four colleagues did research about sleepwalking, their results showed:

  • Sleepwalking is most likely due to stress
  • Sleepwalking tends to run in families.
  • Sleepwalking occurs after 2-3 hours into sleep
  • Thirty percent of children between 5-12 experience at least one sleepwalking episode. Most children are between 4-6 years old.
  • Among 250 adults, one will have sleepwalks once a week.

As shown through this video, it talks about why we should not wake up a sleepwalker.

Video was taken from:https://www.youtube.com/watch?v=loCz8Rwaidk&t=104s

Image result for wake up a sleepwalker

Credit: Medifee

What should we do?

We have heard that waking up a sleepwalker will cause them to have a heart attack, brain damage. However, this is a misconception since there is no evidence that waking up a sleepwalker will cause them any harm. In fact, the one who tries to wake up a sleepwalker may be in danger because the sleepwalkers may react in unpredictable ways including attacking the one who tries to wake up them. Instead of waking up the sleepwalkers, what we are supposed to do is to gently lead them by the arm to guide them back to bed.

— ZIJIE(JERRY) LIN