Come join us for a student seminar led by Eden Dubchak discussing the involvement of impaired glutamate signalling in the excitotoxic phenotype of Huntington’s Disease. Huntington’s Disease is a progressive neurodegenerative disorder that produces cognitive, motor and psychiatric symptoms. Excitotoxicity, which is the damage or death of neurons caused by excessive overstimulation by an excitatory neurotransmitter, has been identified as a major pathway by which Huntington’s Disease induces neurodegeneration. The seminar will provide a brief overview of Huntington’s Disease, the evidence for excitoxicity as a pathogenic mechanism, the possible mechanisms behind impaired glutamate signaling, and how our understanding of the excitotoxic phenotype may still be incomplete.