Category Archives: Daily Science

Science in your day-to-day life, not science published every day! News from recent published journal articles, and cool science facts and tricks!

Telling the difference between major and minor chords – maybe not so easy?

Many people are of the “major-minor” distinction in Western classical music. The building blocks of Western classical music include major and minor chords, which are conventionally thought of a set of notes of certain frequency ratios in relation to the base note (see footnote for more information). Put simply, a major chord (like C major, C E G) has a root, a perfect fifth, an a major third; while a minor chord (like C minor, C E♭ G) has a root, a perfect fifth, and a minor third. This is one of the most important distinctions in Western tonal music, and virtually all popular music makes use of this schema.

So what if, even though this major-minor dichotomy is ingrained in our culture, some of us have trouble telling the difference?

In a paper by Chubb et al., (2013), researchers tested undergraduate students on whether they could describe randomized tone rows (containing notes in either major or minor chords) as either “happy” (major) or “sad” (minor). They found two groups in their sample population: ~30% that could tell the difference with virtually perfect accuracy, and ~70% that did no better than chance. Taken at face value, this would suggest that most of their population was unable to hear the difference between the major or minor tone rows.  There was, however, a correlation between having music education and being able to distinguish the two.

An interesting and more convincing study that followed performed a similar experiment in infants, conducted by Adler et al. (2020). Here, the auditory stimulus (a major or minor tone row) was associated with a visual target that would appear in a given location. Infants who learned to associate the stimulus with the location would anticipate where the visual target would appear. In this study, infants performed similarly to undergraduates: ~30% could anticipate the target location with near perfect accuracy, whereas ~70% could do no better than chance. The design of this study allowed for several variables present in the original study to be accounted for.

Although preliminary, these results could be surprising to a lot of musicians. If you are a musician, what do you think? Could there be other factors influencing it?

References:
1. Chubb C, Dickson CA, Dean T, et al. Bimodal distribution of performance in discriminating major/minor modes. J Acoust Soc Am. 2013;134(4):3067-3078. doi:10.1121/1.4816546
2. Adler SA, Comishen KJ, Wong-Kee-You AMB, Chubb C. Sensitivity to major versus minor musical modes is bimodally distributed in young infants. J Acoust Soc Am. 2020;147(6):3758-3764. doi:10.1121/10.0001349

Footnote:
The 12-tone equal temperament (12-TET) tuning system is most commonly used in western music, although intervals can also be thought of in other tuning systems, such as in “just intonation” which uses simple ratios. A major chord has a perfect fifth (12-TET 12√128:1, Just 3:2) and a major third (12-TET  3√2:1, Just 5:4) on top of a root, whereas a minor chord has a perfect fifth and minor third (12-TET 4√2:1, Just 6:5) on top of a root.

Embracing randomness to solve problems

It’s easy to think of problem-solving as a process where we follow a defined algorithm step-by-step to get the same answer each time. While this works for many cases, it often doesn’t work for more complex problems – how would you know what variables to use, and how would you manipulate them to get the answers you want? Questions like these are present all throughout computer science, mathematics, physics, biology, chemistry, engineering, psychology, economics, sociology… In many cases, it is easier and less computationally intensive to allow for some degree of randomness. This post is not meant to teach these concepts, but only to serve as a little taste of them so you can explore more about them if you’re interested!

For example, in finance, there can be many variables that influence a certain outcome, such as evaluating how well a portfolio does. Many outcomes under different values for different parameters can be simulated in order to evaluate how the portfolio will perform in the future, which could inform decisions about changes that could be made to improve its performance. This is known as a Monte Carlo simulation [1].

Another use of random sampling is in numeric integration, especially for multiple integrals. This is known as Monte Carlo integration [2]. These integrals have many uses in the physical sciences, computer science, and other domains. Many integrals are difficult to compute analytically, but in some scenarios, an exact answer is not needed – only one with enough precision for the current application. This can be accomplished by sampling random points within the given bounds, and with enough samples, the answer from the random sampling will approach the true answer. A simplified example would be to estimate the integral of some function over an interval, \int_{a}^{b}f(x)dx. Knowing that the average value of the function is related to the integral and the interval with f_{avg} = \frac{\int_{a}^{b}f(x)dx}{T}, you could find the average value of the function by taking multiple samples and rearranging to find the integral.

Yet even more problems that include randomness include optimization problems, which have a whole variety of applications across different fields. One such method is simulated annealing [3]. Imagine a function with lots of peaks and valleys that represents a value from a problem, and you want to find the minimum (or the maximum) value within the domain. Depending on the problem, many exact algorithms will actually fail to find the best/lowest (global) minimum within the search space, and will instead only find local minima. This can happen with search algorithms that only keep a result if it’s better than the previous one, such as hill-climbing algorithms. With simulated annealing algorithms, you can randomly search around neighbouring points and allow for a worse result at first, and then gradually “cool” down the tolerance for worse results until it gets to the best peak.

Other algorithms that use randomness include evolutionary algorithms [4]. These operate by varying different parameters in the “individuals” that it first generates, then selecting the individuals that perform the best at the problem in question. The characteristics of these “fittest” individuals can be “bred”, using genetically-inspired events such as “crossing over” and “mutation” to change the parameters in the “offspring”. This continues for many generations in order to find optimal solutions to a problem. These algorithms can be applied to artificial neural networks as part of the training and learning process. These algorithms have many applications, including facial identification, cybersecurity, diagnosing illnesses, machine translation, and even playing video games.

This was just a tiny overview of the enormous role randomness has in computing – some of the details were left out to make it more digestible. If you’re interested, you can read more on any of the topics!

Sources:
1. McLeish DL. Monte Carlo Simulation and Finance. John Wiley & Sons; 2011.
2. Weinzierl S. Introduction to Monte Carlo methods. arXiv:hep-ph/0006269. Published online June 23, 2000. Accessed November 10, 2021. http://arxiv.org/abs/hep-ph/0006269
3. Nikolaev AG, Jacobson SH. Simulated Annealing. In: Gendreau M, Potvin JY, eds. Handbook of Metaheuristics. International Series in Operations Research & Management Science. Springer US; 2010:1-39. doi:10.1007/978-1-4419-1665-5_1
4. Bäck T, Schwefel HP. An Overview of Evolutionary Algorithms for Parameter Optimization. Evolutionary Computation. 1993;1(1):1-23. doi:10.1162/evco.1993.1.1.1

 

Luminescence – phosphorescence, fluorescence… What’s the difference?

Glow in the dark toys. Glow sticks. They both glow, but not in the same way… So what’s the difference? Luminescence, phosphorescence, fluorescence… what does all of this mean?

Luminescence refers to the process where light is emitted from an object that is not due to the object’s temperature. This contrasts with incandescence – the process by which hot metal or a fire glows. With incandescent objects, the colour of the light is related to the temperature of the object.

Colour of radiation from a black body with increasing temperature (in Kelvin). Credits: Wikimedia

There are many forms of luminescence as well. For instance, glow sticks exhibit chemiluminescence: chemical energy is converted into visible light through the excitation and subsequent relaxation of electrons in a molecule – more on that here. Another form of luminescence is triboluminescence, which is a form of mechanoluminescence – mechanical energy is converted to light. You may be familiar with this from demonstrations of crushing sugar cubes, putting on bandages, or peeling off tape in the dark.

Glow sticks. Credits: Wikimedia

Triboluminescence of nicotine salicylate. Credits: Wikimedia

There is also photoluminescence, where higher energy photons are absorbed and lower energy photons are emitted. Fluorescence and phosphorescence are in this category. In fluorescence, the light is absorbed and re-emitted almost immediately – this would include fluorescent molecules such as those in fluorescent markers, luminol, quinine in tonic water, and riboflavin or vitamin B2. These are often viewed under UV light, which contains high energy photons that excite molecules, emitting lower energy photons. In phosphorescence, the photons are emitted over a longer period of time. This is the form of luminescence found in glow-in-the-dark dinosaur toys.

Fluorescence of quinine in tonic water. Credits: Wikimedia

Glow-in-the-dark figure. Credits: Wikimedia

The difference between fluorescence and luminescence can be visualized in a Jablonski diagram.

Jablonski diagram comparing fluorescence and phosphorescence. Credits: Wikimedia

This shows a molecule in its ground singlet state (1A), which is at its lowest energy level and has no unpaired electrons. With an input of energy, it goes into an excited singlet state (1A*). From here, there is vibrational relaxation down to a lower energy state (not pictured). If the energy is emitted from this state, it is called fluorescence. However, it is also possible (although less likely) for the molecule to transition into a triplet state with unpaired electrons through intersystem crossing. The triplet state (3A) lasts longer than the excited singlet state, and so the relaxation and emission of energy as light takes longer, resulting in the lasting glow.

How many types of ice are there?

When we think of water, we usually think of it having three states: solid, liquid, and gaseous. Water is a liquid between 0°C and 100°C (32°F and 212°F) under our standard atmospheric pressure of 1 atmosphere (760 Torr, 14.7 psi, 1.013 bar). Above 100°C, water becomes a gas (vapour), and below 0°C, water becomes a solid (ice). The pressure also affects the temperature at which the phase change occurs: in a pressure cooker, the temperature can reach 121°C with an additional 1 bar of pressure (0.987 atm, 750 Torr, 14.5 psi) before boiling. In a freeze dryer, the vacuum reduces the pressure as low as 0.1 mbar (9.87 x 10^-5 atm, 75 mTorr, 0.00145 psi), where water can boil at almost -40°C. This information can be displayed in a graph called a phase diagram, displaying the phase of the substance at a given pressure and temperature.

Phase diagram of water. Credit: Wikimedia

However, there are multiple possible crystal structures the water molecules can arrange themselves into, with different forms being favoured at different temperatures and pressures, and with different stabilities and ordering. This can be shown in a more complex phase diagram.

Phase diagram of water, with multiple phases of ice included. Credit: Wikimedia

Most of the ice on earth is in the ice I phase, specifically ice Ih, which is the hexagonal form of ice that we encounter in everyday life. As of 2021, there are now twenty known crystalline forms of ice (Hansen, 2021) with scientists still attempting to discover more. This results in a very complicated phase diagram of different phases of ice (Fig 1 in link).

In addition to crystalline ice, there is also amorphous ice. Amorphous solids do not have a defined crystal structure – one example in daily life is glass. Hence, amorphous ice is often described as being “glassy” or “vitreous”. So far, three forms of amorphous ice have been identified (Martoňáka et al., 2005). All these forms of ice have distinct properties, as well.

Even though water may seem simple, there is still plenty of ongoing research on the peculiarities of water and its properties. Scientists speculate that there may be further forms of ice that have yet to be discovered… perhaps you will join the search?

Protein Showcase: Chaperon(ins) to the Rescue

The process of protein synthesis has probably been ingrained in your brain if you have taken any introductory biology or cell biology courses. It is so important that it is often referred to as the central dogma of molecular biology: DNA is transcribed to RNA, which is then translated to proteins.

Proteins essentially carry out the functions needed for the cells to remain alive. Need something made or broken down? Enzymes. Need something transported or moved? Carrier and intramembrane proteins. When it comes to proteins, shape equals function.

With their vast variety in function, the way a protein folds as it is made is closely monitored. Protein folding is faster than translation, thus the moment the N-terminal is exposed to the aqueous environment of the cytosol, the chain begins to fold due to intramolecular forces. As the chain continues to elongate, the protein can become kinetically trapped because the native state of a protein is only partially stable. Partially folded or misfolded states are problematic because they tend to aggregate due to their exposed hydrophobic surfaces (Hartl, F., et al. 2011).

Figure 1: Competing reactions of protein folding and aggregation (Hartl, F., et al. 2011)

So, what to do with a misfolded protein? Chaperones and chaperonins are in charge or re-folding them. Also known as heat-shock proteins (hsp’s). These proteins seek and bind to exposed hydrophobic surfaces in newly translated proteins (Campbell, M., & Farrel, S. 2012).

Chaperones (Hsp70) bind and stabilize misfolded or partially folded proteins and prevent their aggregation as they are translated. ATP binding causes the chaperone to release the completed chain into the cytosol, allowing the protein to fold properly (Albert, B. 2015).

Figure 2: The hsp70 family of molecular chaperones (Albert, B. 2015)

Sometimes, even the chaperones are unsuccessful in helping the protein re-fold into its native state. In this case, additional chaperones or the more complex chaperonins (hsp60 and hsp10) provide additional help.

Chaperonins create a chamber for the proteins to re-fold post-translationally. First, the protein is captured though hydrophobic interactions with the entrance of the chamber (hsp60). The protein is then released into the interior of the chamber, which is lined with hydrophilic amino acids, and then it is sealed with a lid (hsp10). Here, the substrate can fold into its final conformation in isolation, where there are no other proteins that may aggregate. Finally, when ATP is hydrolyzed, the lid pops off, and the substrate protein is released from the chamber (Albert, B. 2015).

The best characterized chaperonin is the GroEL/GroES system in E. coli

Figure 3: Visualization of the GroEL/GroES chaperonins in E. coli (Rachel Davidovitz, 2014)

If the protein is still improperly folded, it is then targeted for degradation (ubiquitination, we’ll talk about it next time!)

References:

Albert, B, et al. (2015). Molecular Biology of the Cell (6th Edition). Garland Science, Taylor & Francis Group, LLC.

Campbell, M., & Farrel, S. (2012). Biochemistry (7th Edition). Brooks/Cole Cengage Learning.

Hartl, F. U., Bracher, A., & Hayer-Hartl, M. (2011). Molecular chaperones in protein folding and proteostasis. Nature, 475(7356), 324-332.doi:10.1038/nature10317

Rachel Davidovitz (2014, October 6). Active Cage Mechanism of Chaperonin-Assisted Protein Folding Demonstrated at Single-Molecule Level [Video]. https://www.youtube.com/watch?v=–NcNeLc1mo&ab_channel=RachelDavidowitz

Music and Math – Frequencies, ratios, and tuning

Beneath the beauty of music lies some interesting mathematics, from Fourier transforms of waveforms to ratios of frequencies. In this blog post, we’ll be discussing frequency ratios and tuning in particular!

The most simple ratio is the 1:1 ratio (perfect unison); that is, two sounds with the same frequency will sound at the same pitch. There is also the 2:1 ratio (perfect octave), the most consonant interval. Multiplying the frequency by 2 will always give a pitch an octave above, so the 4:1 ratio will be a perfect fifteenth (2 octaves above) and so forth. This means that if you play one tone at 100 Hz and another at 400 Hz, you will hear two tones separated by an interval of 2 octaves.

The just intonation (or pure intonation) tuning system utilizes similarly simple ratios for other common intervals. For example, the 3:2 ratio is the perfect fifth (the interval from C going up to G). The 4:3 ratio is the perfect fourth, and the 5:4 ratio is the major third.

However, our current twelve-tone musical system does not function very well when using these simple ratios. There are many intricacies with this tuning system that can result in some “out of tune” sounds and the music drifting away from the original pitch. One example is in a comma, which is the interval between a note being tuned in two different ways. For example, the syntonic comma is the 81:80 ratio.

In modern music, equal temperament is used. In our twelve-tone system, that means the difference in frequencies in a semitone is the twelfth root of 2.  A perfect fifth is 7 semitones up, thus the frequency difference is 7 times the twelfth root of 2, which roughly approximates 3/2. This system allows us to play in any key equally by having all intervals slightly out of tune from their just counterparts.

Arachidonic acid: a very important fatty acid

Arachidonic acid is a fatty acid (a carboxylic acid with a long carbon tail) with 20 carbons and 4 double bonds. Counting from the end without the carboxylic acid group, the first double bond appears at the 6th position from the end, making this an omega-6 fatty acid.

Chemical structure of arachidonic acid. Credits: Wikimedia (Public domain) https://commons.wikimedia.org/wiki/File:AAnumbering.png

Arachidonic acid is incorporated into phospholipids in cell membranes. In the process of some cell signalling events such as the inflammatory cascade, it is cleaved from phospholipids by phospholipase A2 (PLA2), after which it can be modified into many signalling molecules including the prostaglandins (PGs), thromboxanes (TXs), and leukotrienes (LTs). These are the most well-known and well-studied of the metabolites derived from arachidonic acid; however, there are also many other compounds including the endocannabinoids (ECs), and several less understood groups such as the eoxins (EXs)lipoxins (LXs), epoxyeicosatrienoic acids (EETs), hepoxilins (HXs), isoprostanes (IsoPs), and isofurans (IsoFs). Some of these compounds are quite recent discoveries and thus have little information available about them. Nevertheless, many of these compounds have biological activity associated with the inflammatory response, either with anti-inflammatory or pro-inflammatory effects. The latter molecules are still under active investigation in order to better understand the way they mediate actions in the body. [1]

The actions of all these molecules are too numerous to explain here. Some of the most well-known actions are those of the prostaglandins. If you have ever taken NSAIDs such as ibuprofen or naproxen, you will have affected this system. These drugs inhibit the cyclooxygenase enzyme, a critical enzyme in prostaglandin synthesis. Prostaglandins have diverse effects such as acting as pro-inflammatory mediators and regulating smooth muscle contraction and relaxation (such as PGE2), or causing vasodilation and preventing platelet aggregation (such as PGI2, also known as prostacyclin). Other molecules in the cyclooxygenase pathway, such as thromboxane, promote clotting and causing blood vessels to contract (such as TXA2). [2] The leukotrienes, synthesized from the lipooxygenase pathway, are inflammatory mediators. Some asthma medications, such as montelukast and zafirlukast, block the actions of the leukotriene LTD4 which can help with the bronchospasms in asthma. [3]

The endocannabinoid system is also a growing area of interest. The compound N-arachidonoylethanolamine, also known as anandamide, is probably the most well-known compound. The effects of this compound include pain sensation modulation, reward processes in the brain, and immune system modulation. [4]

This is only a small peek at the world of arachidonic acid metabolites: there remains much to be explained outside of this blog post, and much to be discovered!

Sources:

[1] Wang, B., Wu, L., Chen, J., Dong, L., Chen, C., Wen, Z., Hu, J., Fleming, I., & Wang, D. W. (2021). Metabolism pathways of arachidonic acids: Mechanisms and potential therapeutic targets. Signal Transduction and Targeted Therapy, 6(1), 1–30. https://doi.org/10.1038/s41392-020-00443-w
[2] Ricciotti, E., & FitzGerald, G. A. (2011). Prostaglandins and inflammation. Arteriosclerosis, Thrombosis, and Vascular Biology, 31(5), 986–1000. https://doi.org/10.1161/ATVBAHA.110.207449
[3] Dempsey, O. J. (2000). Leukotriene receptor antagonist therapy. Postgraduate Medical Journal, 76(902), 767–773. https://doi.org/10.1136/pmj.76.902.767
[4] Lu, H.-C., & Mackie, K. (2016). An Introduction to the Endogenous Cannabinoid System. Biological Psychiatry, 79(7), 516–525. https://doi.org/10.1016/j.biopsych.2015.07.028

Hydrogels as an Ophthalmic Drug Delivery System

If you’ve ever had some sort of eye surgery, you might have been prescribed an assortment of eyedrops with their own frequent dosing schedules. The reason for the frequent dosing is that topical drug delivery to the eye is quite difficult, and upon further evaluation this should make sense! The eye is a delicate structure that has many barriers to prevent the entry of foreign particles. Hydrogel technology has been heavily investigated as a sustained drug release vehicle, obviating the need for such frequent dosing.

barriers of the eye

Drug residence time delivered via eye drops can be cut short due to pre-corneal factors: tears, blinking, and drainage through the nasolacrimal duct. Some of you might have been told to pinch the bridge of your nose after administering eye drops, this is to block off the drug from draining through this duct into the nose. In addition, drug that does remain on the eye must penetrate through the thick multi-layered cornea to get to the deeper tissues of the eye. The conjunctiva at the surface of the eye is also highly vascularized, meaning the drug will also be absorbed into the bloodstream before penetrating through the eye.

Anatomy of the eye. Credits: American Academy of Ophthalmology

Drainage through the nasolacrimal duct and absorption through the highly vascularized conjunctiva may cause unwanted side effects, as the drug is being distributed to off-target tissues through the circulatory system. Ironically, drugs cannot be delivered via consumption or systemic injection as there are blood-ocular barriers (analogous to the blood-brain barrier) that prevent systemic distribution of drugs to ocular tissue.

hydrogels to the rescue!

Hydrogels are basically polymers (long chemical chains) composed 95% of water. The advantage of hydrogels is that they are viscous, meaning that they can stick onto the eye longer before being removed. They can also encapsulate drug molecules, and can release the desired drug at a certain rate, based on their initial preparation conditions. Currently, there are many types of hydrogels being investigated for there use in drug delivery. These can be broken down into synthetic polymers, which have the advantage of being easily tunable in mechanical properties and natural polymers, which have the advantage of being biocompatible to the eye. In-situ forming hydrogels have been an area of focus, as they can be administered as a liquid, but gels in response to a stimulus. For example a gel could be liquid at room temperature but turn into a gel at body temperature.

Despite being a potential solve to a long-standing problem, there is currently no FDA-approved hydrogel used in drug delivery. A lot more research in terms of in vitro, in vivo, and clinical studies are needed to evaluate the long-term efficacy and biocompatibility of these options. However, hydrogels have made their way into clinical use in other ophthalmic departments! An immediate one that comes to mind is the use of contact lenses which are practically just hydrogels. A lesser known use is in cataract surgery, where hydrogels have been used as ocular adhesives to seal any surgery-induced wounds.

References

Lynch, C.R.; Kondiah, P.P.D.; Choonara, Y.E.; du Toit, L.C.; Ally, N.; Pillay, V. Hydrogel Biomaterials for Application in Ocular Drug Delivery. Front. Bioeng. Biotechnol. 2020, 8, 228, doi:10.3389/fbioe.2020.00228.

Embarrassed of Asian Glow? Don’t Worry, The Future is Promising

Ever find yourself beet red after one small drink? You’re not alone! Over one-third of East Asians and eight percent of the world population experience this awkward phenomenon; however, a solution is in the works. Just last month, researchers from Weill Cornell Medical College have solved this problem by experimenting with targeted gene therapy on mice.

What does asian glow look like? A before and after comparison. (Credits: Wikimedia Commons)

The Dangers of Asian Glow

Apart from causing embarrassment, asian glow comes with more serious consequences than just flushing red. The red glow is caused by a deficiency in the ALDH2 enzyme, a key component in detoxifying alcohol. When you drink alcohol, your body converts the alcohol into acetaldehyde. Normally, acetaldehyde is further converted to a safer compound by ALDH2; however in individuals with asian glow, ALDH2 does not function, causing acetaldehyde to build up. Since acetaldehyde is a cancer-causing agent, its accumulation drastically increases the risk of developing esophageal cancer by six to ten folds.

Conversion of alcohol to acetate is stopped in people with asian glow. This leads to toxic buildup of acetaldehyde. (Credits: Me – created with Notability)

A Glowing Solution…

Matsumura’s team reasoned if a lack of ALDH2 enzyme was the problem, maybe they could simply add it back in.

“We hypothesized that a one-time administration of a […] virus […] expressing the human ALDH2 coding sequence […] would correct the deficiency”

They tested their idea on three strains of mice: mice with functional ALDH2, mice lacking ALDH2, and mice with a non-functional version of ALDH2. The latter two simulated the asian flush syndrome seen in humans. After introducing all the mice with the ALDH2 gene and feeding them alcohol, the researchers carefully monitored acetaldehyde levels in the blood.

Their hard-work paid off! In the two strains deficient for ALDH2 function, acetaldehyde levels and abnormal behavior associated with alcohol consumption were back to near-normal levels. Furthermore, they found that one dose was enough to confer persistent and long-term protection.

From Mice to Humans: A Complicated Decision

Matsumura’s team emphasize that a long-lasting treatment for ALDH2 deficiency currently does not exist. Although making the jump from mice to humans will be challenging, they assure that virus-mediated gene therapy shows the most promise in becoming an effective therapy. The million-dollar question is whether the risks of the glow outweigh the benefits of reduced alcohol consumption seen in affected individuals. To this Matsumura’s team say:

“the overall burden […] on human health, particularly […] cancer, supports […] gene therapy.”

What do you think?

The COSMIC Bubble Helmet: A Revolutionary Ventilation System

As the COVID-19 virus evolves into different strains so to has the methods of dealing with the consequences of this virus. In patients with severe COVID-19, they are plagued with acute respiratory distress disorder (ARDS). This is a condition where fluid fills the lungs and prevents air from reaching the necessary gas exchange compartments, similar to what occurs in drowning. These patients are subjected to invasive mechanical ventilation, where a tube is uncomfortably shoved down the patients throat to facilitate breathing.

a potential alternative?

To avoid ventilator-induced lung injury, non-invasive ventilation methods have shown to be well tolerated by patients. Instead of a tube, a tight-fitting nasal or facial mask is used and uses positive pressure to facilitate ventilation. In the context of COVID-19, the use of current non-invasive ventilation methods is not recommended due to virus aerosolization risks which puts healthcare staff in danger of contracting the virus.

Example of a non-invasive ventilation face mask.

A cunning solution

COSMIC Medical, a Vancouver-based organization has designed a “Bubble Helmet” that remains noninvasive but also reduces the aerosolization risks mentioned previously! Additionally, the materials needed to make the helmet are low cost and can be easily be retooled or adjusted by manufacturers due to its simplistic design.

Owing to its flexible design, patients freedom of mobility will not be hindered as they can lie face up or down comfortably. Furthermore, the helmet is made of transparent material, thus a patient’s vision will be unobstructed, further enhancing comfortability.

the next steps

There are still many hoops to jump through before this helmet can be offered to patients. These steps include obtaining regulatory approval and completing clinical trials. So far results have been obtained in an experimental setting, thus the effectiveness of the helmet must be measured in clinical settings as well. Currently the Bubble Helmet design is open source and available to all to peruse. Check out the open source paper!