Author Archives: connie17

Burning Fats In The Winter With Chili Peppers

When you wake up in the dark at 7:00 am in the morning, you know that winter is here. For me, this is the time of the year when I crave for hot spicy stews every meal. But like most girls, I am afraid of gaining weight from eating so much and constantly find myself on the dilemma of whether to dig in or not. If you find yourself in the same situation as me, here is the good news! Research has found that low temperatures and chili peppers could help burn our body fat!

Chili peppers help to fight fats in body. Credit: iStock

Researchers from the Hokkaido University of Japan recently found that spending time in cold weather and consuming chili peppers allow a person to burn more energy because low temperature and the chemicals in chili peppers seem to stimulate and increase the activity of brown fat cells.

Brown and White Fat Cells. Credit: Susan Ardizzoni.

There are two types of fat in our body, namely the brown adipose tissue and the white adipose tissue. While brown fat cells burn off energy, white fat cells store energy and are responsible for making some people fat. Brown fat cells appear red-brown because they contain many mitochondria, which produce a large amount of energy in the form of ATP. And white fat cells appear white, or pale, under the microscope. Below is a clip which I found very clear on explaining the differences between the two different fats.
YouTube Preview Image

In the Japanese study, eight subjects with little brown fat tissue were recruited and exposed to a low temperature of 17 °C for two hours daily for six weeks. Comparing with the control participants who went about their normal lives during the experiment, the study found that the eight subjects who were exposed to low temperature had an average of 5% less body fat and less white fat cells. They also burned on average more energy than those in the control group.

In addition, the researchers studied people who ate chili peppers, which contain capsinoids, or substances that give chili peppers the hot taste. It was also found the participants burned more energy than the control group when exposed to cold. This result was consistent with a previous study which found that Ingesting capsinoids increased the levels of fat breakdown in our body, showing that capsinoid plays a pivotal role in fat reduction in mildly obese individuals.

Even though the reduction of white adipose tissue from cold exposure was somewhat expected, it was not expected that capsinoid in chili pepper would have an impact on energy and fat metabolism. The researchers concluded the study by stating that “capsinoids appear to [simulate] brown fat in the same way as cold, by ‘capturing’ the same cellular system that the body’s nervous system uses to increase heat production.”

While chemicals like capsinoids, which stimulate brown fat cells, demonstrate potential application in obesity treatments in the future, it is comforting to know that eating a bit more hot spicy stew than normal will not have a significant impact weight for now!

– By Connie (Kangchi) Lee

References:

Cold temperatures and chili peppers could help burn fat

Capsinoids and related food ingredients activating brown fat thermogenesis and reducing body fat in humans

Brushing and Flossing Diseases Away

Brushing teeth. Credit: Richmond Smile Centre, (http://www.richmondsmilecenter.com/blog/2012/09/13/your-richmond-dentist-discusses-bad-brushing-habits/)

How often do you brush your teeth thoroughly and floss? Do you pay enough attention to oral hygiene? If you don’t, you might want to consider taking oral hygiene more seriously because research has found that bad oral hygiene could potentially lead to detrimental diseases.

We know that the oral cavity is one of the places of your body that harbors the most bacteria. These bacteria often do not cause any significant harm to our body, given that we brush our teeth and floss regularly to get rid of these bacteria in our mouth. But when we do not clean our teeth regularly and thoroughly, these bacteria easily build up around our teeth and often cause inflammation of the gums. And in cases when the individuals who suffer from periodontal disease are not taking actions to improve their practice of oral hygiene, infections exacerbate and results in chronic conditions.

Usually, when we think of heart disease, we tend to associate it with obesity, hypertension, smoking, congenital conditions, and other genetic-related problems. But now we might want to add oral problems to our list of factors that contribute to cardiovascular disease. According to numerous studies, chronic bacterial infections in the gums from poor oral hygiene and serious periodontal disease increase an individual’s chance of developing heart attack and stroke.

Plaque in heart artery. Credit: Rudy Pospisil (http://blogs.theprovince.com/2012/03/22/heart-attack-warning-test/)

If you have poor oral hygiene practice, it is likely that you will often accidentally scrape or damage the epithelial oral tissue in the mouth, especially the gums. When the oral tissue is damaged, pathogens can easily enter into the tissues and eventually penetrate into the bloodstream, which then carries these pathogens to other parts of the body, affecting other tissues and body systems and causing multiple inflammations in the body. For instance, a 2005 study conducted by the University of Florida even found oral bacteria inside artery plaque.

Other than heart attack and stroke, the myriads of oral bacteria may also play a role in knee arthritis. In a 2012 study which sought to examine the link between oral bacteria and knee osteoarthritis, the researchers found that out of the 36 patients with knee arthritis, five of them had gum microbes in the synovial fluid in their joints. Although the association between oral bacteria and knee arthritis is still not fully understood, these bacterial certainly worsens arthritis.

Therefore, it is important to brush your teeth regularly and thoroughly since oral hygiene is related to the health of the rest of your body. However, this is not to say that bad oral health has a direct impact on heart disease, since there are other confounding factors such as smoking and type of lifestyle.

                                                                                                 – By Connie (Kangchi Lee)

Reference:

How Oral Hygiene Affects the Rest of You

Periodontal Disease Linked to Other Disease?

 

Aging Is Evitable?

Dramatic amount of aging. Credit to Mary Jo Fohey (http://www.godsebook.org/political_leaders.html)

What popped into your mind when you first saw the picture to the left? Besides the amusement, I’m sure many of you thought about the horrors aging can do to people. But why exactly in terms of molecular cell biology are we all in the process of developing those depressing lines on our foreheads?

Normally, when a unicellular organism undergoes cell division, it divides in such a way that one of its two daughter cells receives mostly the old and damaged cellular material such as DNA, while the other daughter cell gets the majority of the newly synthesized cellular content.
YouTube Preview Image

Because of this uneven distribution of old and new cellular material, one of the  daughter cells is always older than the other. According to previous studies, the cells that acquire the majority of old cellular material become slower in proliferating and carrying out metabolic activities, resulting in the phenomena of aging seen in research models such as E. coli bacteria. Because essentially all of the cells for most organisms divide in such way, aging is inevitable in our lives despite all the “anti-aging” products that we use!

Cell division of a single cell with replicated cell material. Credit to Roberto Piras from Shutterstock. (http://www.shutterstock.com/pic-141329944/stock-photo-two-cells-divide-by-osmosis-in-the-background-other-cells.html?src=tofjyodeYvtJcAapke2fzA-1-0)

 

However, one microbe seems to have managed to evade this depressing fate of aging. A recent study of the Max Planck Institute of Molecular Cell Biology and Genetics in Germany has identified a simple unicellular microbe, Schizosaccharomyces pombe, a yeast species, to be able to avoid aging. The researchers discovered that when growing under favorable conditions, S. pombe divides in a different way from other organisms. When S. pombe divides, both of its two daughter cells receive equal amount of the old and new cellular content. Thanks to this even distribution of damaged and newly synthesized cellular material, both of the two daughter cells are “younger than before,” as Iva Tolic-Norrelykke, one of the researchers of the new study said. In the study, the researchers found that since the daughter cells were younger than before cell division, S. pombe cells did not slow down in its proliferation and metabolic activities after dividing.

The new study did not, however, argue that S. pombe cells are immortal. Instead, it stated that if a S. pombe cell is followed for a long enough time, the cell will ultimately die, although “the probability of this death will [remain] constant” rather than increasing over time. The study also stated that if being put under stressful conditions, S. pombe cells tend to divide faster and consequently distribute old cellular material unevenly. And the daughter cells with more old material will ultimately die in the same way other types of cells age.

Aging is certainly an issue that is constantly on our mind. But instead of stressing about aging and perhaps therefore making our cells divide the old material even more unevenly, it is best that we be content with the way of life.

                                                                                                  -By Connie (Kang Chi) Lee

References:

Why one microbe seemingly doesn’t age at all.