Category Archives: Science Communication

Getting a Grip on Hydrogen Fuel: Metal-Organic Frameworks

Hydrogen is  considered as one of the most volatile elements known to man. Yet, if this explosive hydrogen gas can be safely stored it can instead be used as a new fuel source, which would benefit the world at large. Recent advances in chemical engineering have produced a family of materials,  with the ability to efficiently adsorb (store) hydrogen gas. These materials, known as Metal-organic frameworks (MOFs), are a molecular structure that allows us the opportunity to take advantage of hydrogen as a fuel source. There are several benefits to using hydrogen as an energy source, one being that it can be readily produced for domestic use. For example, hydrogen can be generated from natural gas and biogas sources, as well as through the electrolysis (splitting) of water. This is favourable because the sources required to produce hydrogen are renewable, thus there is no need to worry about production shortages. Another advantage is that hydrogen is eco-friendly, in that using it in a fuel cell does not produce any greenhouse gases or air pollutants, and is not contributing to the effects of global warming.

In the following video, the basis of metal-organic frameworks in hydrogen gas storage is discussed, along with the associate research published by UBC graduate student Angela Crane:

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With so many potential benefits, you may wonder why MOF technology is not currently being utilized in hydrogen-fueled vehicles, to provide a viable green alternative. The problem lies with the MOF’s mechanism of hydrogen adsorption and desorption (release), where the flow of hydrogen in and out of the structure is, for the most part, only through methods involving extreme cooling and heating. This system of temperature-regulated gas delivery enables precise control over hydrogen flow and greater storage capacities, however it is an impractical system to adopt in vehicles.

Triptycene
Source: Animated

To remove the need of temperature for driving gas regulation and improving overall storage in the MOF structure, scientists are actively searching to optimize the material. They do this by increasing the available hydrogen binding sites and encouraging optimal pore-size, meaning hydrogen is better able to enter and remain in the MOF. In her research, Angela Crane investigats triptycene and pentiptycene, two large organic linkers with the potential for optimal pore size and orientation, thus being favourable in adsorbing hydrogen. When the MOF’s were tested for gas adsorption, however, she discovered that the complexity of the structure led to blockage of the pore-openings. This finding illustrates how the mechanics behind metal-organic frameworks are more complex than what one would expect from its relatively simple molecular structure.

Source Wikipedia: http://commons.wikimedia.org/wiki/File:IRMOF-1_wiki.png

Hydrogen fuel cells have the potential to revolutionize how we power the world. These devices lack all the liabilities associated with more conventional fossil fuels; most importantly pollution, and even other, less recognized concerns such as global conflict and of the depletion natural resources.  The current state of hydrogen fuel cell research has some significant drawbacks that will have to be addressed in order for this technology to become a viable alternative energy source. Currently, conventional methods for producing hydrogen gas relies on the use of methane, a fossil fuel, making this process inherently unsustainable. There is hope, however, in the way of MOFs, which may one day provide an effective storage medium for hydrogen gas, if a sustainable method of hydrogen synthesis can be found.

Information on the drawbacks of hydrogen fuel is available below:

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While the focus of metal-organic frameworks has been primarily based on hydrogen storage,  MOFs have shown potential in various other applications as well. MOFs are currently being implemented for a variety of uses; acting as filtration systems, drug delivery components, fluorescent-imaging vectors and catalytic systems, to name a few. Due to the relatively simple production process, MOFs have now become commercially mass-produced. With their basic structure and efficient manufacture, the future for metal-organic frameworks is not limited to hydrogen gas storage, and its broad spectrum of use gives these frameworks unprecedented potential.

-Natasha Smyrnis, Sungbin Choi, Gurneet Kalra

Group2

References:

The New Chemistry of MOFs, Metal Organic Frameworks

Plants – A Better Way to Fuel

Long line-up at the US Costco gas station for cheaper gas. Credit: Paul Sakuma

It is that time of the year again, when your neighbours brag about all the cheap items that they bring back from the south. But believe it or not, the one common thing that all these Canadian shoppers who pass the border for the US Black Friday sale come back with is neither discounted clothing nor electronics. Rather, it is gas.

The price of fuel has been skyrocketing over the past few years, compelling the Canadian industry to seek alternatives to fossil fuels. One of the most popular alternatives lies in the area of biofuels, a renewable and economical energy source derived from the products of living organisms such as the sugar secretions of plants. However, the problems with production efficiency and environment sustainability affiliated with biofuels have hindered their general adaptation in the industries.

Arabidopsis Thaliana secretes sugars which can be processed for biofuels. Credit: Thomas Meyer

Last year, an attempt to resolve the problem was done when Gabriel Levesque-Tremblay and his colleagues at the University of British Columbia conducted a research on the role of vesicle transport of sugars from the Golgi Apparatus to the cell wall of a small flowering Arabidopsis plant.

With prior knowledge of the functions of a particular plant gene, which encodes proteins that play a significant role in cellular secretion, Gabriel’s research team inhibited the expression of this gene, namely the ECHIDNA gene, in plant seeds to study the changes in the activity of secretory vesicles containing the polysaccharides, or sugars.

Granule accumulation inside the cell. Credit:http://pcp.oxfordjournals.org/ content/early/2013/09/20/pcp.pct129. full.pdf+html

They found that without the expression of the ECHIDNA gene, the cells are still able to transport sugars across the Golgi apparatus. However, the secretory vesicles are unable to fuse with the cell wall of the plant, resulting in clusters of vesicles accumulating near the cell membrane. In other words, without the proper functioning of this ECHIDNA gene, the plant is unable to secrete the sugar products that the industry needs to extract to use as biofuels.

The following podcast introduces the two novel techniques that Gabriel’s study used to knock off the gene of interest in order to study the genetic effect of proteins on the plant’s vesicular transport and subsequently the secretion of sugars.

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Gabriel’s study suggests that the ECHIDNA gene, as well as perhaps other unidentified genes in plants, plays a critical role in controlling the vesicular fusion with the cell wall. Consequently, the ECHIDNA gene also regulates the efficiency of plant secretion. This opens window into increasing the secretion yield of plants. Engineers may be able to modify the genes to improve the fusion of cellular vesicles with cell walls and enhance the efficiency of cellular secretion. Ultimately, this could allow more sugar extractions from the plants to be used as biofuels and potentially lower gas prices

For more details about the experiment and more examples of the industrial applications of biofuel, check out the following video:

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Ziharrphil Magnaye, Connie Lee, Nick Hsieh (Group 3)

References:

 

More Than Meets the Eye

      Everyday we are constantly surrounded by different types of screens. For example: our computer screens, our TV screens, and our cell phone screens. However, the images we see are not comparable to what we see in reality. Being aware of such a difference can be dissatisfying, especially when we look at pictures of: the sunset, the mountains, and the beach. Jakob Emmel, a Ph.D Candidate from the Physics Department at the University of British Columbia, was not an exception.

Jakob Emmel. Image source: still shot of raw footage

      The first time he saw high dynamic range (HDR) displays that can show huge contrast, he described it as an “eye-opening experience.” HDR refers to the ratio of the maximum darkness to the maximum brightness that a screen can show. The higher the ratio, the better we can distinguish the “black” parts of the screen compared to the “white” parts. For comparison, a common non-HDR display may show a contrast ratio of 1000:1 while average human eyes can see a contrast of 100,000:1. HDR displays can show a contrast in the range of the human eyes or even higher.

      Nonetheless, there are still drawbacks with these awesome displays. In the video below, Jakob describes how current displays can be improved in projecting more uniform brightness across the screen as well as the contrast:

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      Although Jakob’s research was successful, the first prototype he made was not as effective. To control the light coming from each light-emitting diodes (LEDs) for better contrast and uniformity, he had used black filters on top of each LEDs. However, due to the nature of these filters, they absorbed some of the light rather than allowing the light to brighten the screen.

First Prototype with Black Filters. Image source: still shot of raw footage

      In his second prototype, Jakob made white filters with special reflective coatings. This allowed the spreading light from each LEDs to be reflected back to its source rather than be absorbed, preserving the light more efficiently. This way, dark areas can be dark and bright areas can be bright in the displays.

Second Prototype with White Filters. Image source: still shot of raw footage

      This technology can be applied in many areas. The most prominent source for its effective use is in medicine. With a better display, doctors can see images more clearly and be able to differentiate them more effectively since even the smallest irregularity can be a sign of a deadly tumor.

      Specified in the podcast is the technology’s application in movie post editing. As doctors could examine x-ray or MRI images better, movie editors can take advantage of this as well for spotting inequalities in the raw footage.

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      It is adequate to say that Jakob Emmel’s technological innovation is a step forward in grasping reality into the pocket screens of our phones and more. Contribution in the fields of medicine and movie production may only be the tip of an iceberg of vast technological advances to be uncovered.

Group 1
Jina Choi, Matthew Hong, and Angelica Reyes

Burning Fats In The Winter With Chili Peppers

When you wake up in the dark at 7:00 am in the morning, you know that winter is here. For me, this is the time of the year when I crave for hot spicy stews every meal. But like most girls, I am afraid of gaining weight from eating so much and constantly find myself on the dilemma of whether to dig in or not. If you find yourself in the same situation as me, here is the good news! Research has found that low temperatures and chili peppers could help burn our body fat!

Chili peppers help to fight fats in body. Credit: iStock

Researchers from the Hokkaido University of Japan recently found that spending time in cold weather and consuming chili peppers allow a person to burn more energy because low temperature and the chemicals in chili peppers seem to stimulate and increase the activity of brown fat cells.

Brown and White Fat Cells. Credit: Susan Ardizzoni.

There are two types of fat in our body, namely the brown adipose tissue and the white adipose tissue. While brown fat cells burn off energy, white fat cells store energy and are responsible for making some people fat. Brown fat cells appear red-brown because they contain many mitochondria, which produce a large amount of energy in the form of ATP. And white fat cells appear white, or pale, under the microscope. Below is a clip which I found very clear on explaining the differences between the two different fats.
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In the Japanese study, eight subjects with little brown fat tissue were recruited and exposed to a low temperature of 17 °C for two hours daily for six weeks. Comparing with the control participants who went about their normal lives during the experiment, the study found that the eight subjects who were exposed to low temperature had an average of 5% less body fat and less white fat cells. They also burned on average more energy than those in the control group.

In addition, the researchers studied people who ate chili peppers, which contain capsinoids, or substances that give chili peppers the hot taste. It was also found the participants burned more energy than the control group when exposed to cold. This result was consistent with a previous study which found that Ingesting capsinoids increased the levels of fat breakdown in our body, showing that capsinoid plays a pivotal role in fat reduction in mildly obese individuals.

Even though the reduction of white adipose tissue from cold exposure was somewhat expected, it was not expected that capsinoid in chili pepper would have an impact on energy and fat metabolism. The researchers concluded the study by stating that “capsinoids appear to [simulate] brown fat in the same way as cold, by ‘capturing’ the same cellular system that the body’s nervous system uses to increase heat production.”

While chemicals like capsinoids, which stimulate brown fat cells, demonstrate potential application in obesity treatments in the future, it is comforting to know that eating a bit more hot spicy stew than normal will not have a significant impact weight for now!

– By Connie (Kangchi) Lee

References:

Cold temperatures and chili peppers could help burn fat

Capsinoids and related food ingredients activating brown fat thermogenesis and reducing body fat in humans

“Junk DNA” has a use after all!

Unique face. Image taken from India Times.

Every human has a unique face and our genetics play a major role in determining the shape of our face. But we all have the same genes that control the development of our heads.  How do these genes get turned on and off? However, until now scientists have not known exactly how DNA achieves this task.

A new study has found that “junk DNA” may be responsible for unique appearances. Junk DNA or non-coding DNA is the part of the genome that does not encode for proteins. The work was published on October 25, 2013 on Science.

Axel Visel and Catia Attanasio have found around 4,000 enhancers in the human genome. Picture taken from Huff Post Science.

The researchers have found over 4,000 enhancers in the mouse genome that influence the way facial features develop. According to Axel Visel, a geneticist at Lawrence Berkeley National Laboratory, “Enhancers are part of the 98 per cent of the human genome that is non-coding DNA – long thought of as junk DNA”.  He also added, ” The expressions of these genes makes all the difference and all the countless variation all around us.”

Growth of experiment mice. Image retrieved from Live Science

How did they test whether enhancers were responsible for shaping our face? Visel’s team deleted three of the enhancers in mice and compared them with an unmodified mice at 8 weeks of age. The results of this experiment showed that the deletion of each enhancer caused subtle changes in the shape of the face.

Earlier, enhancers had no directly visible role of shaping an organism, but now we know that these genetic sequence can add a layer of complexity.

This research could help us understand how things can go wrong as embryos develop in the womb. However, Professor Visel said it was very unlikely in the near future that DNA could be used to predict someone’s exact appearance.

References:
‘Junk’ DNA could determine face shape, scientists sayNew Research Finds How Genes Shape FacesFine Tuning of Craniofacial Morphology by Distant-Acting Enhancers

– Amna Awan

Is exercising with a cold harmful?

As the seasons change from summer to fall, the first thing that usually happens is the decrease in temperature which then leads to people getting the common cold. The common cold is usually just a neck cold, which in other words is a runny nose, clogged sinuses and a mild headache. People with the common cold are told that the best cure for it is rest so that the immune system is at its best, but what about those people that cannot rest and feel they need to be in the gym? I can help with that.

 

image source: flickr

Some of the best exercises to do when you have a cold are walking, jogging, Qi gong, yoga and dance. Walking and jogging are considered to be good exercises because they are fairly low intensity, which means that it will not put much stress on your body, allowing your immune system to function at a high rate, and it clears your head while breaking a sweat. Qigong is an exercise that is a cross between martial arts and yoga that enhances the blood flow in your body and permits the immune system to be working at a high standard. Dance is also low impact and it lowers the cortisol levels in the body, which then will let the immune system to work at a greater level.

 

image source: flickr

The worst exercises to do when you have a cold are endurance running, lifting weights, using machines at the gym, and team sports. Endurance running and lifting weights are bad because they are high intensity exercises and require a lot of your body’s resources to do these exercises, which leads to the decrease in energy put towards the immune system. Using machines at the gym and team sport are not good because these just influence the spread of the cold.

 

Having a cold is not a good enough excuse for sitting on the couch and watching the TV, so get out of bed and go for a walk or a jog to clear your head, but avoid going to the gym so that you are not the reason that everyone in the gym is sick. Here are a couple of simple yoga poses to help with your cold.

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Source: http://www.cnn.com/2013/10/10/health/exercising-with-cold-flu/index.html?hpt=he_t3

 

Brushing and Flossing Diseases Away

Brushing teeth. Credit: Richmond Smile Centre, (http://www.richmondsmilecenter.com/blog/2012/09/13/your-richmond-dentist-discusses-bad-brushing-habits/)

How often do you brush your teeth thoroughly and floss? Do you pay enough attention to oral hygiene? If you don’t, you might want to consider taking oral hygiene more seriously because research has found that bad oral hygiene could potentially lead to detrimental diseases.

We know that the oral cavity is one of the places of your body that harbors the most bacteria. These bacteria often do not cause any significant harm to our body, given that we brush our teeth and floss regularly to get rid of these bacteria in our mouth. But when we do not clean our teeth regularly and thoroughly, these bacteria easily build up around our teeth and often cause inflammation of the gums. And in cases when the individuals who suffer from periodontal disease are not taking actions to improve their practice of oral hygiene, infections exacerbate and results in chronic conditions.

Usually, when we think of heart disease, we tend to associate it with obesity, hypertension, smoking, congenital conditions, and other genetic-related problems. But now we might want to add oral problems to our list of factors that contribute to cardiovascular disease. According to numerous studies, chronic bacterial infections in the gums from poor oral hygiene and serious periodontal disease increase an individual’s chance of developing heart attack and stroke.

Plaque in heart artery. Credit: Rudy Pospisil (http://blogs.theprovince.com/2012/03/22/heart-attack-warning-test/)

If you have poor oral hygiene practice, it is likely that you will often accidentally scrape or damage the epithelial oral tissue in the mouth, especially the gums. When the oral tissue is damaged, pathogens can easily enter into the tissues and eventually penetrate into the bloodstream, which then carries these pathogens to other parts of the body, affecting other tissues and body systems and causing multiple inflammations in the body. For instance, a 2005 study conducted by the University of Florida even found oral bacteria inside artery plaque.

Other than heart attack and stroke, the myriads of oral bacteria may also play a role in knee arthritis. In a 2012 study which sought to examine the link between oral bacteria and knee osteoarthritis, the researchers found that out of the 36 patients with knee arthritis, five of them had gum microbes in the synovial fluid in their joints. Although the association between oral bacteria and knee arthritis is still not fully understood, these bacterial certainly worsens arthritis.

Therefore, it is important to brush your teeth regularly and thoroughly since oral hygiene is related to the health of the rest of your body. However, this is not to say that bad oral health has a direct impact on heart disease, since there are other confounding factors such as smoking and type of lifestyle.

                                                                                                 – By Connie (Kangchi Lee)

Reference:

How Oral Hygiene Affects the Rest of You

Periodontal Disease Linked to Other Disease?