Congratulations to Jessica K. Josephson and colleagues for their newly published paper, “Microbiome‑driven alterations in tryptophan metabolism contribute to behavioural comorbidities in the Muc2 knockout mouse model of chronic colitis,” in Taylor and Francis – Gut Microbes.
This study tackles a growing challenge in inflammatory bowel disease (IBD): the rise of neurobehavioral comorbidities such as anxiety, depression, and cognitive dysfunction. Using the Muc2⁻/⁻ mouse model of chronic colitis, the authors investigated how gut inflammation and microbial dysbiosis reshape tryptophan metabolism and how these metabolic shifts relate to changes in behaviour. These findings show a clear connection between microbiome‑driven metabolic changes and the behavioural symptoms that accompany chronic colitis.
Check out the full paper here!
