THC-O vs THC-P: How Do These Potent Cannabinoids Compare?

As the cannabis industry continues to grow, new and exciting cannabinoids are being discovered and created. Two of the latest to gain significant popularity are THC-O and THC-P – both known for being extremely potent. But what exactly sets these two apart?

In this post, we’ll compare and contrast key aspects of THC-O and THC-P to help you understand the key differences and determine which may be better for your needs.

What is THC-O?

THC-O, also known as THC-O-acetate, is a synthetic cannabinoid created in a lab by adding acetic anhydride to CBD or Delta 8 THC extracted from hemp.

The addition of acetic anhydride boosts THC-O’s potency to about 3 times that of traditional THC. It also changes how THC-O interacts with CB1 receptors, producing effects that some claim have more psychedelic qualities resembling mescaline.

What is THC-P?

Unlike THC-O, THC-P (Tetrahydrocannabiphorol) is a naturally occurring cannabinoid that can be extracted from certain cannabis strains, albeit in very small concentrations (less than 0.1%).

Early research indicates THC-P binds to CB1 receptors up to 33 times more effectively than THC, making it significantly more potent in small doses. The differences in its molecular structure compared to THC are believed to facilitate stronger bonding.

Key Differences

Source Synthetically produced in a lab Naturally occurring but in low concentrations
Potency vs. THC ~3x more potent than ∆9 THC Up to 33x more potent than ∆9 THC
Effects Delayed onset, intense euphoria, possible psychedelic effects Rapid euphoria and relaxation, strongly intoxicating
Consumption Not recommended to vaporize or smoke due to toxicity risks. Best consumed orally in edibles, tinctures, etc. Can be vaped, smoked or taken orally much like traditional THC products
Legality Federally legal if derived from hemp, but banned in some states Federally legal from hemp, not banned specifically in any states yet

As you can see, while THC-O and THC-P are both highly potent cannabinoids, they differ quite a bit in terms of their sourcing, potency, effects and recommended usage.

Which is Better: THC-O or THC-P?

When it comes to choosing between the two, there are a few key factors to consider:

  • Potency – THC-P is the clear winner here, with exceptionally higher bonding affinity and psychoactive effects at lower doses.
  • Effects – For a more energetic, stimulating high, THC-O may be preferred. But for deeply intoxicating relaxation, THC-P is superior.
  • Safety – THC-P consumption aligns more closely with traditional THC, whereas THC-O can produce toxic ketene gas if combusted.

So while THC-P takes the lead in most areas, THC-O can still deliver unique effects some users may gravitate to. It comes down personal preference and responsibly matching potency levels to your tolerance.

The Takeaway

THC-O and THC-P represent exciting innovations when it comes to intensifying and transforming the traditional cannabis experience. However, their ultra-high potency also demands extra caution, especially for beginners.

Start low, go slow, and be sure to source from reputable vendors that provide detailed test results – this applies doubly when handling novel cannabinoids.

Hopefully this guide has helped demystify these two potent newcomers! We always recommend consulting a budtender or medical professional to find the best THC product to suit your wellness needs.


Is THCP stronger than THC-O?

Yes, THCP is significantly more potent than THC-O. According to anecdotal reports, THCP can be over 2 times stronger than THC-O in psychoactive effects and 33 times more potent than delta-9 THC. The differences lie in THCP’s molecular structure which allows it to bind more readily with cannabinoid receptors.

Which is stronger THCP or THCA?

THCP is stronger than THCA (tetrahydrocannabinolic acid). THCA is a precursor to THC found in raw cannabis plants that has not been decarboxylated yet. Once heated, THCA loses a carbon dioxide group and converts to THC which then causes a high when consumed. So while THCA has therapeutic properties, it is not psychoactive like THCP which binds strongly to CB1 receptors.

What is the difference between THCP and HHC?

HHC (hexahydrocannabinol) is a hydrogenated form of THC made by adding hydrogen molecules. This results in an effect described as similar to THC but more sedative and relaxing. In contrast, THCP (tetrahydrocannabiphorol) is a naturally occurring analog of THC estimated to be 30-33 times more potent due its chemical structure allowing greater receptor binding.

What is the difference between THCA and THC-O?

The main difference lies in their sources. THCA (Tetrahydrocannabinolic acid) is a non-psychoactive compound found naturally in raw, unheated cannabis plants. THC-O (Tetrahydrocannabinol acetate) is a lab-synthesized analog of THC created by adding an acetate group to increase potency, which results in psychedelic-like effects roughly 3 times stronger than THC itself.

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