Conference Presentations
Wenzel, T.J., Ranger, A., Klegeris, A. Extracellular cardiolipin (CL) modulates microglial phagocytosis and cytokine secretion in a toll-like receptor (TLR) 4-dependent manner. 9th International DAMPs and Alarmins Symposium (9th iDEAs), Okayama, Japan, November 2019.
Alford, M., Tian, Z., Menard, F, Klegeris, A. Characterization of novel kainic acid analogs as inhibitors of select microglial functions. The International Society for Neurochemistry (ISN) and the American Society for Neurochemistry (ASN) Meeting, Montreal, QC, Canada. J. Neurochem. (2019) 150 (Suppl. 1) 225.
Wenzel, T.J., Bajwa, E., Rheault, M.R., Klegeris, A. Extracellular cytochrome C modulates astrocyte functions in a toll-like receptor (TLR) 4-dependent manner. World Alzheimer Disease/Parkinson Disease Congress, Lisbon, Portugal, March 2019.
Gates, E.J., Klegeris, A. Signaling between gut microbiota and immune cells of the brain. Interdisciplinary Health Conference, Kelowna, BC., Canada, March 2019.
Alford, M., Tian, Z., Menard, F., Klegeris, A. Novel kainoid analogs as inhibitors of neuroinflammation. 18th World Congress of Basic and Clinical Pharmacology, Kyoto, Japan, July 2018.
Hashioka, S., Suzuki, H., Nakajima, D., Miyaoka, T., Wake, R., Hayashida, M., Horiguchi, J., Klegeris, A. Metabolomics analysis indicates noninvolvement of the kynurenine pathway neurotoxins in the interferon-γ-induced neurotoxicity of adult human astrocytes. 18th World Congress of Basic and Clinical Pharmacology, Kyoto, Japan, July 2018.
Lowry, J.R., Klegeris A. Dietary Fats Modulate Select Immune Functions of Microglia. 12th Annual Canadian Neuroscience Meeting, Vancouver, BC, May 2018.
Wenzel, T.J., Pointer, C.B., Klegeris A. Extracellular cardiolipin promotes microglial phagocytosis, and modulates their cytokine secretion in a toll-like receptor (TLR) 4-dependent manner. 12th Annual Canadian Neuroscience Meeting, Vancouver, BC, May 2018.
Lowry, J.R., Klegeris, A. The Effects of Fatty Acids on Brain Microglia Immune Responses. Experimental Biology Conference, San Diego, CA, USA, April 2018.
Alford, M., Zhenlin T., Menard, F. Klegeris, A. Novel derivatives of kainic acid inhibit select microglial functions. The Multidisciplinary Undergraduate Research Conference (MURC), UBC, Vancouver, March 2018.
Alford, M., Menard, F. Klegeris, A. Novel derivatives of kainic acid as inhibitors of microglia-mediated neuroinflammation. National Collegiate Research Conference (NCRC), Harvard University, Cambridge, MA, USA, January 2018.
Alford, M., Mendard, F., Klegeris, A. Novel derivatives of kainic acid as inhibitors of neuroinflammation. 13th Annual Canadian Undergraduate Conference on Healthcare: Medicine in the Modern World, Kingston, ON. November 2017. Abstract: URNCST(2017). 1(3), 24.
Spielman, L.J., Gibson, D.L.Klegeris, A. Incretin hormones regulate microglial oxidative stress, survival and expression of trophic factors. The XIII European Meeting on Glial Cells in Health and Disease, Edinburgh, UK, July 2017. Abstract: Glia (2017) 65 (Suppl. 1) E179-E180.
Pointer, C.B., Klegeris A. The effect of cardiolipin on microglial activation and microglia-mediated neuronal death. Experimental Biology Conference, Chicago, IL, USA, April 2017. FASEB J. 2017. 31 (Suppl.1) 659.11.
Lowry, J.R., Klegeris, A. The effects of fatty acids on brain microglial immune responses. Interdisciplinary Health Conference, Kelowna General Hospital, March 2017.
Pointer, C.B., Klegeris, A. The effect of extracellular cardiolipin on microglia-mediated cytotoxicity and neuronal survival. Interdisciplinary Health Conference, Kelowna General Hospital, March 2017.
McKenzie, J., Klegeris, A. Doramapimod and methyl jasmonate as inhibitors of neuroinflammation. The Multidisciplinary Undergraduate Research Conference (MURC), UBC, Vancouver, March 2017.
Klegeris, A., Spielman, L.J., Estaki, M., Ghosh, S., Gibson, D.L. Voluntary physical activity modifies neuroinflammatory status in a Monocyte chemoattractant protein-1 (MCP-1) dependent manner. 10th Federation of European Neuroscience Societies (FENS) Forum. Copenhagen, Denmark, July 2016.
Spielman, L.J., Estaki, M., Ghosh, S., Gibson, D.L., Klegeris, A. Voluntary wheel running modifies neuroinflammatory status: The role of monocyte chemoattractant protein-1. International Union of Biochemistry and Molecular Biology Conference, Vancouver, BC, Canada, July 2016.
Spielman, L.J., Klegeris, A. Incretin hormones as potential treatment options for brain disorders characterized by inflammation and microglial death. Interdisciplinary Health Conference, Kelowna General Hospital, March 2016.
Pointer, C., Klegeris, A. Cardiolipin as a novel intercellular signaling molecule in neuron-microglia communication. Interdisciplinary Health Conference, Kelowna General Hospital, March 2016.
Spielman, L.J., Pointer, C.B., Estaki, M., Ghosh, S., Gibson, D.L., Klegeris A. The effects of voluntary exercise on neuroinflammatory status: role of monocyte chemoattractant protein 1. Society for Neuroscience Meeting, Chicago, IL, USA, March 2016.
Klegeris, A., Bahniwal, M., Little, J.P. Elevated glucose levels enhance pro-inflammatory responses of astrocytes and increase vulnerability of neurons to toxic insults. 25th Meeting of the International Society for Neurochemistry, Cairns, Australia, August 2015.
Spielman, L.J., Schindler, S.M., Walker, D.G. Klegeris, A. Modulation of microglia-mediated neuroinflammation as a novel aspect of insulin activity in the central nervous system. Neuroimmunology and Therapeutics, San Francisco, CA, USA, July 2015.
Schindler, S.M., Spielman, L.J., Simtchouk, S., Little, J.P., Wolthers, K.R., Klegeris, A. Glial receptors for extracellular mitochondrial transcription factor A (TFAM): Potential new therapeutic targets in the treatment of neurodegenerative diseases. Neuroimmunology and Therapeutics, San Francisco, CA, USA, July 2015.
Rayevsky, A., Pinchuk, V., Fetyukhin, V., Kostyuk, O., Klegeris, A. Inhibition of cathepsin B by Au (I) complexes. Proteinase 2015; 9th RSC/SCI symposium on Proteinase Inhibitor Design, Basel, Switzerland, April 2015.
Bajwa, E., Klegeris, A. Cytochrome c: neurotoxic signaling molecule. The Multidisciplinary Undergraduate Research Conference (MURC), UBC, Vancouver, March 2015.
Schindler, S.M., Spielman, L.J., Little, J.P., Klegeris, A.Glial cell receptors engaged by extracellular mitochondrial transcription factor A (TFAM) as potential new therapeutic targets in the treatment of Alzheimer’s disease. Interdisciplinary Health Conference, Kelowna General Hospital, February 2015.
Spielman, L.J., Klegeris, A. Insulin modulates microglia secretions and impacts neuronal survival during inflammation: A model of the action of insulin in the central nervous system. Interdisciplinary Health Conference, Kelowna General Hospital, February 2015.
Klegeris, A., Madeira, J.M., D’Ovidio, A.R., Stuart, M.J., Renschler, C.J., Gill, N.E., Fetyukhin, V., Pinchuk, V., Kostyuk, O., Hashioka, S. Gold-containing drug auranofin and its derivatives could be beneficial in Alzheimer’s disease due to inhibition of cathepsin B and neuroprotection. 9th Federation of European Neuroscience Societies (FENS) Forum, Milan, Italy, July 2014.
Schindler, S.M., Klegeris, A. Mitochondrial Transcription Factor A (TFAM): Novel Intercellular Signaling Molecule Activating Microglia in Neuroinflammation. UBC Okanagan Interdisciplinary Research Conference, Kelowna, BC, Canada, March 2014.
Patinote, C., Roscoe, W., Karlik, S., Nirdé, P., Schall, N., Muller, S., Klegeris, A., Contino-Pépin, C. In-vitro and in-vivo evaluations of a mannosylated thalidomide derivative. Drug Discovery and Selection International Conference (RICT), Nice, France, July 3-5, 2013. Abstract of poster presentation.
Bahniwal, M., Little, J.P., Klegeris, A. High glucose induces pro-inflammatory phenotype in human astrocytes and enhances neurotoxicity. Experimental Biology Conference, Boston, MA, USA, April 2013. FASEB J. 2013;27:691.8. Abstract of poster presentation.
Little, J.P., Madeira, J.M., Bahniwal, M., Villanueva, E.B., Wolthers, K.R., Klegeris, A. Extracellular mitochondrial transcription factor A (Tfam) as a potential signal that promotes inflammation and induces microglia-mediated neurotoxicity. Alzheimer’s Association International Conference, Vancouver, BC, Canada, July 2012.
Madeira, J.M., Renschler, C.J., Gill, N.E., Klegeris, A. The anti-rheumatic gold drug auranofin could be beneficial in Alzheimer’s disease by inhibiting astrocyte-mediated neuroinflammation. Alzheimer’s. Association International Conference, Vancouver, BC, Canada, July 2012.
Klegeris, A., Bahniwal, M., Hurren H. Lack of correlation between distinct university student skill sets identified by using a panel of assessments: a two year study. International Journal of Arts & Sciences (IJAS) conference in Prague, Czech Republic, June 2012.
Bahniwal, M., Klegeris A, Hurren, H. Use of Diverse Instructional and Assessment Techniques Reveals Distinct Student Skill Sets. UBC Okanagan 8th Annual Learning Conference; Scholarly Approaches: Evidence-Informed Teaching and Learning, May 2012.
Little, J.P., Madeira, J.M., Klegeris, A. Palmitate and ceramide induce human monocytic cell toxicity towards neuronal cells. Federation of American Societies for Experimental Biology Meeting, San Diego, CA, USA, April 2012.
Renschler, C. Priming of the phagocyte respiratory burst: mechanisms, disease-specific involvement, and potential therapeutic targets. UBC Okanagan Undergraduate Research Conference, April 2012.
Bahniwal, M. Sweet tooth, dead brain: Role of elevated glucose in promoting neuron damage. Biochemistry and Molecular Biology Seminar Series, UBC Okanagan, February 2012.
Gurley, L., Beloukhina, N., Renschler, C., McNeil, W.S., Klegeris, A. Cobalt(II) β-ketoaminato complexes as novel anti-cancer drugs and imaging agents. Canadian Cancer Research Conference, November 2011, Toronto, ON, Canada
Klegeris, A. Tutorless Problem-Based Learning (PBL) in a Large Classroom Setting: Assessing Student Progress. Seminar at University of Calgary Teaching and Learning Centre, November 2011
Renschler, C. Detection of Co and Au compounds in brain tissues by LA-ICP-MS: A novel application of an analytical chemistry method. UBCO Undergraduate Research Symposion, November 2011.
Klegeris, A. Search for compounds with anti-inflammatory and neuroprotective properties. UBCO Department of Biology Seminar Series, September 2011.
Klegeris, A. Tutorless Problem-Based Courses: Assessing Student Progress. Seminar at UBC Centre for Teaching, Learning and Technology, September 2011, Vancouver BC.
Madeira, J.M., Villanueva, E.B., Beloukhina, N., Boudreau, K., Boettcher, T.A., Gurley, L., Rajendiran, E., Gibson, D.L., McNeil, W.S., Klegeris, A. Neurotoxicity caused by neuroinflammation could be mediated by glial cell-secreted phospholipase A2 and is inhibited by novel cobalt-containing compounds. 10th World Congress on Inflammation, June 2011, Paris, France.
Klegeris, A., Hurren H. (2011) Problem-based learning in a large classroom setting: Methodology, student perception and problem-solving skills. July 2011, Barcelona, Spain, Proceedings of EDULEARN11 Conference (ISBN:978-84-615-0441-1) pp. 2532-2541
Villanueva, E.B., Madeira, J.M., Klegeris, A. Secretory group IIA phospholipase A2 is a glial neurotoxin that acts non-enzymatically. Cell Biology Retreat, May 2011, Maple Ridge, BC, Canada.
Hashioka, S., Klegeris, A., McGeer, P.L. Inhibitory effects of proton pump inhibitors on astrocytic neurotoxicity: potentials of proton pump inhibitors for treatment of Alzheimer disease. 26th International Conference of Alzheimer’s Disease International, March 2011, Toronto, ON
Hashioka, S., Klegeris, A., McGeer, P.L. STAT3 inhibitors reduce human astrocytic neurotoxicity. The Society for Neuroscience Meeting, November 2010, San Diego, CA, USA
Gurley, L., Beloukhina, N., Boudreau, K., Villanueva, E.B., Klegeris, A., McNeil, W.S. The synthesis and characterization of a series of cobalt (II) beta-ketoaminato complexes and their cytotoxicity towards human tumor cell lines. BC Preclinical Research Consortium (BCPRC) Inaugural Symposium, October 2010, Vancouver, BC
Klegeris, A. Developing undergraduate student research skills in a large class setting through problem-based learning exercises. 35th International Conference on Improving University Teaching; Washington, DC, USA, July 2010
Villanueva, E.B. and Klegeris, A. Characterizing the role of secretory phospholipase A2 group IIA in glial cell-mediated neurotoxicity. 3rd Annual European Workshop on Lipid Mediators; Paris, France, June 2010 Abstract of a poster presentation by Villanueva, E.B.
Klegeris, A. Developing Undergraduate Research Skills through Problem Based Learning. UBCO Learning Conference “Learning through Research”, May, 2010, Kelowna, BC.
White M.S. and Klegeris A. Modeling inflammatory reactions relevant to neurodegenerative diseases. Multidisciplinary Undergraduate Research Conference (MURC), UBC, Vancouver, March 2010. Abstract of an oral presentation by White, M.S.
Boon, J., and Klegeris, A. Problem-oriented learning put into practice in biochemistry courses at UBCO. UBCO teaching conference “Looking for Success in Learning”, May, 2009, Kelowna, BC.
Gurley, L. Klegeris, A. and McNeil, S. Cobalt complexes that inhibit formation of Amyloid plaques. 92nd Canadian Chemistry Conference, May 30 – June 3, 2009, Hamilton, ON.
Bahniwal M. and Klegeris A. Moderate increase in body temperature may exacerbate neuroinflammatory processes in the brain. Rising Stars of Research undergraduate research conference, UBC, Vancouver, August 2009. Abstract of a poster presentation by Bahniwal, M.
Youssef, A.M., White, M.S., Villanueva, E.B., El-Ashmawy I.M., Klegeris, A. Neuroprotective and anti-inflammatory properties of novel pyrazolyl-2,4-thiazolidinediones. World Federation of Neurology XVIII World Congress on Parkinson’s Disease and Related Disorders, December 13-16, 2009, Miami Beach, Florida, USA.
Gurley, L., Klegeris, A., McNeil, S. Cobalt complexes that inhibit formation of Amyloid plaques. 92nd Canadian Chemistry Conference, May 30 – June 3, 2009, Hamilton, ON.
Abd-El-Aziz, A.S., Youssef. A.M., Neeland, E., Villanueva, E., White, S., and Klegeris, A. Neuroprotective and anti-inflammatory properties of novel dipyrazole ethandiamide, diimides and pyrazolo[3,4-d]pyrimidine 4(5H)-ones. Canadian Association for Neuroscience Meeting, May 24-27, 2009, Vancouver, BC.
Abd-El-Aziz, A.S., Youssef. A.M., Neeland, E., Villanueva, E., White, S., and Klegeris, A. Synthesis and biological evaluation of novel pyrazolo[3,4-d]pyrimidines as anti-inflammatory agents. 2nd World Conference on Magic Bullets (Ehrlich II), October, 2008, Nürnberg, Germany.
Hashioka, S., Klegeris, A., Schwab, C., McGeer, P.L. Human astrocytes and human U373 MG astrocytoma cells become neurotoxic when stimulated by interferon-γ. Alzheimer’s Association International Conference on Alzheimer’s Disease, July 2008, Chicago, IL, USA.
Hashioka, S., Klegeris, A., McGeer, P.L. Proton pump inhibitors reduce human microglia and THP-1 cell neurotoxicity. Society for Neuroscience Annual Meeting, November 2008, Washington, DC, USA.
Klegeris, A., J. Lee, T.K. Bammler, J. Jin, D. Zhu, D.T. Kashima, S. Pan, P.L. McGeer and J. Zhang. “Identification of prolyl endopeptidase as a mediator of monocytic cell toxicity using quantitative proteomics”. Society for Neuroscience annual meeting. San Diego, California, United States. Nov, 2007.
Hashioka, S., Miklossy, J., Klegeris A., and McGeer, P.L. “Human microglia-like THP-1 cells adhere to AD amyloid plaques”. Society for Neuroscience annual meeting. San Diego, California, United States. Nov, 2007.