Exposure to Blue Light Leading to a Shortened Lifespan

Nowadays, lightbulbs are not the only reason our sleeping schedules are affected but the blue light emitting from our screens also plays a huge role in keeping us up once it becomes dark outside. With the amount of technology used daily, whether it involves completing an assignment on our laptops or checking social media multiple times throughout the day could be the leading cause to accelerated aging.

Blue Light Affecting Eyes via Screens in Dark Room
Image Source: Allure | Getty Images

A Bright Idea

Before lightbulbs were invented life was simple, and people would go to bed as soon as the sun went down. The effect light has on our health is often disregarded when in fact it’s critical to understand. Who thought such a small artifact present all around us could lead to detrimental effects? However, light is necessary for life and is an aspect which changed the world. Therefore, understanding the history behind the lightbulb is important as the following video produced by Neha Barjatya describes.

Out of Our Sight

In particular to light, humans are exposed to an increasing amount of blue-light produced through light emitting diodes (LED) every day. Recent research conducted at Oregon State University suggests that even though light may not be reaching our eyes directly, blue wavelengths have the ability to reach our brains and retinas that further damage cells.

In the specific study conducted by researcher Jaga Giebultowicz and colleagues, flies exposed to 12 hours of light and 12 hours of darkness exhibited having shorter lifespans when compared to flies that stayed in complete darkness throughout a 24-hour period. The Drosophila melanogaster are common fruit flies and useful model organisms as their cellular and developmental mechanisms are similar to humans and other animals. When exposed to blue-light their retinal cells and neurons had impaired locomotion as they were not able to partake in common behaviour of being able to climb the enclosures walls. When mutant flies without eyes were looked at, they seemed to display the same impairments, suggesting that the simple presence of blue light wavelengths are harmful.

Further analysis on light spectrums showed that without the blue, lifespan only shortened slightly; it was only once blue light was added that there were drastic shortages.  Although, Giebultowicz whom specializes in analyzing the bodies biological clock claims that natural light is critical for the bodies circadian rhythm as it allows for physiological processes such as brain wave activity, hormone production and cell regeneration to occur. She continues to state, “if given a choice, avoid blue light”.

A Future Without Blue-Light?

With many cures found for diseases within the past century, human lifespan has already increased significantly even though we continue to use increased amounts of artificial light. Humans in general are often driven to focus on ways to increase lifespan through acting healthier. And with advanced science always proving to provide methods that design better health spectrums for the population, there is no doubt eliminating blue light may become a solution for the future. As of now though, researchers recommend setting device screens to block blue emissions for longer living!

Written By: Sana Furqan

Video

Fancy Edible Chemicals

Fancy Edible Chemicals

Clear pasta, exploding fruit caviar, flavoured air; things that only one could find in Willy Wonka’s chocolate factory are no longer just teasers that only exist in our imaginations. These otherworldly creations come from molecular gastronomy, the creation of Hungarian physicist, Nicholas Kurti and French chemist, Hervé This. Molecular gastronomy is a blend of manipulating the physical and chemical processes of cooking to create playful interpretations of traditional recipes. For example, the classic lemon meringue pie, a favourite for those that enjoy the sweet and sour combination can now be enjoyed transparently

Molecular gastronomy takes traditional recipes and breaks down each step of the preparation and through specific analysis, recipe development of producing new techniques in food preparation and even new textures. As described in Roisin Burke et al.’s journal “Molecular Gastronomy: An Introduction” one of the main techniques for specific analysis used is the Dispersed Food Formalism (DSF) which allows for chefs to look at how the chemical composition of certain ingredients in food will react with each other in different phases: gas, liquid, solid, oil. For example, the exploding fruit caviar that have become extremely popular in frozen yogurt/ bubble tea shops use the molecular gastronomy technique of spherification. Spherification looks at the interactions between the surface of two chemicals (sodium alginate and calcium carbonate) that bind together to form a flexible casing surrounding a flavourful liquid. 

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This highly scientific, technical and innovative branch of culinary has managed to allow the general public to enter a world where advanced chemistry and physics play a major role. This new age of culinary has become extremely popular that restaurants such as Alinea, have become centralized to only producing molecular gastronomy creations. As we continue to understand the complex sciences integrated in our lives, the divide between the science world where words like chemicals and food usually would not exist in a sentence will cease to exist and we can broaden our minds to a more innovative future.

Monica Lee

How we recycle isn’t helping the environment

(Credit: Vasiliy Ptitsyn/Shutterstock)

The effects of recycling seems to be over exaggerated due to the fact that not many are aware that improper recycling harms the environment than it does good. Tragically, improper recycling is done by many, whether intentionally due to situational circumstances or because they are unaware of proper practices. For your understanding, improper recycling is defined to be recycling strategies that makes it harder for recyclable materials to be recycled, or harms the environment more than intended. This article will go over some of the major improper recycling methods that we need to be aware of, so that we can assure that we take full responsibility for our future – a responsibility that everyone must hold.

 

One thing that we do that represents improper recycling the most is how we dispose of our plastic bags. Interestingly, it has been found that many people put plastic bags in the plastic section, or one of the recycle bins. However, these plastic bags, even if they are stated to be biodegradable, cannot be recycled in this manner. This is because, firstly, biodegradable plastic bags need to be in a condition where they can be broken down by bacteria – hence “bio”-degradable. This condition is only met if the plastic bags are in landfill, but the bags will never be able to reach landfill if it is put in the ‘plastic’ section.

 

Ironically even if they are thrown away properly, green consumer advocate Debra Lynn Dadd states that contemporary landfill cannot degrade materials “because they are compacted so tightly, [they] do not let much air in”.  The severity of the issue can be further implied as she was able to find “25-year old hotdogs”, as well as “50-year-old newspapers” in the landfill that were still readable. This is what we define as situational improper recycling, where we are not able to recycle efficiently even when putting in our efforts to do so, because the circumstances does not support it. This calls for attention by the government, or any other institutes to devise a new method into reinforcing biodegradation in landfills. However, the general public is not demanding, or aware of this fact because they are negligent towards it.

 

Furthermore, Items that are in the plastic section is moved to a recycling center, where workers sort items accordingly. One would assume that machinery would be involved, as the daily trash production globally is immensely high – and yes, machinery are involved. However, when plastic bags are in the recycle bin, the “soft plastics clog up the machinery”, meaning that you could break the recycling center. When plastic bags enter the recycling center, Mike Tunney, area recycling director for Waste Management states that it “contaminates their recycling streams, [slows down] their systems, drives up [the] cost [of the process], and hurts the quality of the materials”. Specifically, Tunney informs us that the plastic would plug the gaps of the machine, and that more than five hours are spent removing these materials from the machine. Plastic bags, therefore, should either be “reused”, returned to retailers, and most importantly, thrown into “regular trash”.

  • Figure 1. News that outlines how improper recycling practices of plastic bags do more harm than good to the environment

 

Another issue that needs to be outlined is that people are simply, not recycling properly. Mark Badger, the executive vice-president of Canada Fibers state that “almost one in three pounds of what goes in a blue box shouldn’t be there”. This, contaminates the existing recyclable materials from being recyclable to non-recyclable, as it is stated that even a few spoonful of peanut butter can contaminate a tonne of paper. Furthermore, China, the world’s biggest importer of recyclable material, started banning imports of paper with more than 0.5 percent contamination, making contamination an even more significant problem. This meant that these paper, had to be in almost perfect condition. Any small deformities, such as a stain on paper has now made it become utter trash. To add insult to injury, it has been found that “North American cities are struggling to meet” the standard of the 0.5 percent contamination, serving as a further implication of how poorly we are recycling.

  • Figure 2. This outlines the contamination rate of recyclable material that is caused by improper recycling practices all across Canada. Statistics are shown to be from April 2018. Further implies, that most of North America isn’t passing the threshold to pass paper material over to China.

 

So, what can we do? First, it is clearly evident that we must be careful of how we dispose of our plastic bags, or any other items. Never assume that something should go in a blue bin, even if it has the recycling symbol. This is because depending on your region, it may not be recyclable, like how a “coffee cup lid [is] not recyclable in Toronto”. Search up what is recyclable to be able to identify what materials go in what, and plastic bags should go into the regular trashcan. There are many more things that you can do to properly recycle – and there are many more improper recycling practices that are continued today, that you may not have known. There are simply too much to cover in one article. So, do the research – bear the responsibilities that we must take in order to protect our world, for today – and for tomorrow.

 

Written by – Isaiah Youm

Air Pollution in New Delhi

Air quality in New Delhi has worsened in the last decade. According to a WHO survey, Delhi has the worst air quality as compared to other major cities around the world. The poisonous particulate matter of air in New Delhi is 440 pm which is 12 times worse than the recommended level of 35 pm. Air pollution is responsible for killing millions of people across India, from lung cancer, ischaemic heart disease, chronic obstructive pulmonary disease, acute lower respiratory infections, and diabetes. Air pollution in New Delhi is expected to reduce the life expectancy of its residents by 20 months and responsible for irreversible damage to the lungs of 50% of all children in the state. 

Reason for Pollution 

  •  Air quality worsens in the capital around this time of the year due to stubble burning when crops are being harvested. 
  • Around 60% of the population in India still use fossil and solid fuels to cook food, thus increasing the carbon dioxide level in the air. 
  • Firecrackers burnt on Diwali, known as the festival of lights also add to the increasing smog levels. 
  • New Delhi has a population of around 20 million people and carbon dioxide emissions from 8.8 million registered motor vehicles.  

Current Situation    

On 3rd Nov 2019, the air quality level climbed to a hazardous level and 37 flights were diverted from the New Delhi Airport due to poor visibility. New Delhi’s Chief Minister had to shut down schools due to the current hazardous air quality and announced that 5 million masks would be distributed to schoolchildren across the state. The government has given out temporary bans on construction activities and industrial plants to control the pollution level. Further, the government has implemented an odd-even scheme for cars under which vehicles with an odd number will not be allowed to drive on even dates of the month.

Next Steps to reduce air pollution

  • Burning waste – Heavy fines should be imposed on people who burn garbage, tires, leaves and other wastes.
  • Solar energy – Installation of solar panels at home should be encouraged and subsidies should be provided to residents.
  • Carpooling- Congestion free lanes can be made for cars with three or four people to encourage people to carpool to work.
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Group A- Simarbir Singh Dhaliwal

Random math

Consider the direction of a leaf floats as it falls from the tree, is the direction random? Is a coin flip random? Is the following sequence random?

5359408128 4811174502 8410270193 8521105559 6446229489 5493038196

What is randomness

Before revealing the answer to those questions, I want to introduce what is randomness. It is very hard to define randomness. Take a minute and try to think of a way to define randomness in your own words. You might think of flip a coin, roll a die, or draw a card from a deck of cards. There are many definitions of randomness in different branches of mathematics. However the basic intuition of randomness is the same; randomness is events happen by equal chance, and there isn’t a pattern can help people to recreate the sequence, like 10101010… just “10” repeats itself.

Randomness and Chaos

Is there a difference between randomness and chaos? Let’s first consider a dice. Is dice rolling random? In a paper in 2012, researchers from the University of Lodz developed a three-dimensional model of the dice throwing to predict the outcome of the result. With some initial conditions like the viscosity of the air, the friction of the table and so on, the model can provide an accurate prediction. This means starting from 2012, at least for scientists, throwing dices is no longer random. Chaos system, in mathematical terms, is a system that has extreme sensitivity to initial conditions, but with precise initial conditions, the results can be calculated.  A good example of the chaos system is the weather system. With the perfect knowledge of the weather, like the real temperature, humidity, cloud and etc. in every unit square of the earth, with support of a good model, we can calculate the exact weather data for any location. However, for a random system, by definition, the output is independent with the input, which means even with the complete information,  people still cannot predict the output.

So the answers to the questions at the start of the blog are all false. With perfect initial condition and a proper model, the direction of a leaf floats as it falls from the tree can be calculated. And this is true for the coin toss as well. And in fact, there are many studies about coin tossing, and I linked a few interesting ones in the further readings section of the blog. The sequence of the numbers is from 141th to 200th digits behind the decimal point of the famous irrational number pi. With this information, we can easily reconstruct the sequences.

Application to randomness

Randomness seems like a very theoretical concept, however, it has many applications. Randomness is used in computer science, information theory, physics, statistics, gaming, music, art, and so many other areas. I will quickly go through a few important ones.

In computer science, pseudo-random number generators (PRNGs) are used very often. The idea of a PRNG is using a seed(integer), and a set of rules to generate more integers with a given range with the probability of each number within the range to be the same. True random number generators (TRNGs) is another random number generator used in computer science. A TRNG generates the random number from a physical process and directly measure it with an external device. By comparing the two pictures below, the first picture has no clear pattern; however, the second picture has strip patterns.

Generated by a true random number generator,from https://www.random.org/analysis/

Generated by a true random number generator, from https://www.random.org/analysis/

Generated by a pseudo-random number generator, from https://www.random.org/analysis/

Generated by a pseudo-random number generator, from https://www.random.org/analysis/

 

In many scientific fields, computer simulation is an important tool. Computer simulation relies on a predetermined model and either pseudo-random number generators or true random number generators.

An online pseudo-random number generators:

https://www.mathgoodies.com/calculators/random_no_custom

A true online random number generators:

https://www.random.org/

Further readings/watching material

An interesting video about pseudo-random number generators and more

 

the butterfly effect in chaos system:

https://en.wikipedia.org/wiki/Butterfly_effect

Comparison between real random number generators and pseudorandom number generators:

https://www.random.org/randomness/

Research paper of the three-dimensional model of dice throwing: https://aip.scitation.org/doi/10.1063/1.4746038

Research paper of coin tossing:

https://arxiv.org/pdf/1008.4559.pdf

-(Sylvester) Shunkai Li

Why You Should Care About Multiple Sclerosis

Multiple Sclerosis, also known as MS, is a chronic and progressive disease. The symptoms can range from tremors, double vision, blindness, inability to speak, and in some severe cases, paralysis and death. One’s symptoms depend on where MS has targeted, and there is no cure as of today. 

MS gets its name from the plaques, or “sclera”, that form in the brain where cells have been destroyed. The word “sclera” is Greek, meaning “skleros” = hard. These sclera may occur anywhere in our brain. Typically, the location of the sclera is the reason for a certain symptom. For example if sclera form near or on the optic nerve, which is responsible for sight, then symptoms of blindness or double vision may arise. 

To better understand the full force of the disease, we need to discuss how it occurs in the first place.

Our central nervous system (CNS) consists of our brain and spine, and in the CNS we have helpful messengers that transmit signals between each other to tell our body to move, breathe, and basically survive. These helpful messengers are called Neurons. Neurons have a “head”, “body”, and “tail” end. Messages are received at the head, which is composed of dendrites and the cell body, and transmitted down the body (axons) to the tail (axon terminal), which finally sends the signal over to the soma of the adjacent neuron. 

The axon has a protective blanket around them called myelin, and myelin is created by a special type of cell called an oligodendrocyte. MS is a disease that is caused by one’s own immune system targeting their own oligodendrocytes and myelin, resulting in the neuron losing its armour. Without it, it can no longer send signals down to its neighbours! 

MS itself does not target the oligodendrocytes, but rather our own immune system does. Our immune system is our bodies form of protection against harmful substances (known as antigens) that may have entered our body. The antigens are recognized by our immune system and eliminated to protect us. For an unknown reason, our immune system causes an autoimmune reaction against the oligodendrocytes. An autoimmune reaction occurs when one’s body mistakes it’s own healthy cells for antigens.

So, why should we care about all this? 

The problem is that scientists are still unsure what actually causes MS. We know the “where” and the “how”, but not the “why”. There are speculations in the field with convincing evidence pointing to autoimmune reactions that target the oligodendrocytes being the “cause” of MS. However, without knowing 100% why MS occurs, scientist cannot formulate a cure! Doctors have been prescribing medication to improve quality of life by treating individual symptoms, but this is only a short-term solution and varies from patient-to-patient. 

MS can be a very frustrating experience for patients because the symptoms can be so diverse, and their doctors may not be able to give them a proper diagnosis for years! Because of this, many afflicted individuals are told that their symptoms are “in their heads” or given an improper diagnosis. 

There is a dire need for more funding and research on MS. 

For more information, please take a look at a crash course video posted on youtube by “Osmosis”.

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Written by Taranom Behzadi

Video

Animal testing: Where do we stand?

A sketch depicting mutual dependency in human-animal relationships. Source: The Telegraph UK

Human dependency on animals has a long history spanning over a million years. Historically humans have partnered with animals for a variety of purposes required for their mutual consumption and existence. From domesticating animals for meat, agricultural practices, hunting activities, transport etc.., to  employing them for developing and testing therapeutics, it would not be completely wrong if I were to say that we humans became a little selfish along the way. For more than a decade there has been an increase in this awareness but there is still an ongoing debate with the pros and cons of employing animals for research. But how far have we come along in developing effective medications at the expense of animal welfare? Read more to find out! (P.S Some images have graphic content!)

Rodents are most commonly used laboratory organisms. Source: Flikr

First of all, if we look at the historical origin of using animal models for  research, the idea was born 2400 years ago when researchers realized the functional and anatomical similarities between humans and animals. Prominent thinkers such as Aristotle documented their findings based on observational and experimental studies conducted on animals and this was further spread across Europe and other parts of the world. With technological advancement in the previous decade such as sequencing of mouse and rat genomes and the development of the first knockout mice/rat , animal models have become an indispensable tool in biological research. Advantages such as the ability to recapitulate life processes, understand mechanisms under normal and diseased conditions and manipulate these mechanisms to develop novel effective therapies have favored their increased use in research. Significant breakthroughs have been made using animal models in the past decade in fields such as aging, neurodegenerative disorders, different types of cancers, gene editing etc…

Bovine fetuses are subjected to cardiac puncture during FBS extraction.Source: Trancend.org

One could argue that animals models promote animal welfare by developing therapeutics for animal diseases however majority of experimentation conducted on animals are extremely inhumane. To give you an image of how badly animals are exploited, let me state an example. Foetal bovine serum (FBS) is a constituent derived from young calves that is used for culturing human/animal cells outside the body. It is widely used by labs across the world but not many researchers are aware of its ethical concerns. FBS is harvested from bovine fetuses by puncturing the heart using a syringe and drawing blood. All this is done without anesthesia! And the reason this is being done in live organisms is because blood drawn from dead fetuses have the tendency to clot which is unfavorable for research purposes.

 

Source: Flikr

For experimental purposes animals are subjected to various activities that involves restraining, collection of  blood samples from various parts of the body, performing surgeries with or without anesthesia, overdosing, behavioral tests, inoculation of tumor producing cells, sacrificing and harvesting body organs for analysis etc.. which causes severe discomfort to animals. Even though its extremely difficult to eliminate animals from being used in research, steps can still be taken to reduce suffering as much as possible.

So where do we currently stand and what can we do to promote animal safety ?There has been a major debate in the past decade and  a lot of steps have been adopted in hope to promote animal welfare. Recently, 3D cell culture systems, micro arrays, artificial organs, organs on an electronic chip, computer based simulations have been developed, it is better to reduce animal experimentation as much as possible or replace them completely using these or other alternative strategies. Adaptation of the 3 R’s that aims to replace, reduce and refine the use of animal experiments needs to be strictly employed by research investigators to ensure animal welfare. Scientific personnel must be well trained in animal handling and certified prior to conducting experiments. Furthermore, the concept of ethical applications have been adopted by various countries that evaluates project plans prior to conducting experiments. These evaluation committees are composed of panelists from various backgrounds that assess  and approve whether a certain study ensures animal safety or not. Most cosmetic industries are also adopting to cruelty free methods of testing their products, which are increasingly popular among their consumers, this should be encouraged further.

Source: Flikr

In conclusion, it is possible to adopt alternative strategies but currently it is not feasible to completely abandon the use of animals in research. Some would argue that this is still beneficial for  a mass population when compared to the sacrifice of a small percentage of animals. That small percentage could grow rapidly and possibly lead to ecological imbalances and suffering in the future so this issue still needs to be taken seriously. With rising technological advancements and inventions such as organ on a chip  (video by Wyss institute included below) there is a small ray of hope that animals will be completely spared from being used in scientific experiments.

Written by Harshitha Nagesh

 

 

A Novel Treatment for Benign Bone Tumours

A new Canadian study has described a novel way to effectively treat a benign bone tumour, specifically Osteoblastoma, using an antibody called Denosumab.

The study, which took place over the span of 46 months detailed using Denosumab to treat a young  18-year-old man who described symptoms of pain and swelling in his hand. The man was diagnosed with Osteoblastoma in his right thumb. However, this was a complex case because he was a concert pianist! This made traditional treatments such as surgery unappealing, since the patient would risk ending his career due to surgeries being too invasive and his ability to move his thumb and play the piano could’ve been greatly reduced post operation.

An x-ray of the patients hand pre-surgery (Kooner and Ferguson 2019).

The patient was given a variety of options in treatment and ultimately decided on trying Denosumab as it would pose the least risk to his mobility, as many other traditional methods had high risk of long-lasting pain even past recovery.

Denosumab is an anitbody that works by blocking the signalling pathway between two types of bone cells, called Osteoblasts, which make bone and Osteoclasts, which eat bone.  These cells allow calcium to be recycled and old bone to be replaced with new bone. In Osteoblastoma, the uncontrolled increase of Osteoblasts causes a lump of immature bone to form, which can be extremely painful due to the physical location of the tumour and the pressure it causes on joints and muscles. By preventing the ability for the Osteoblasts to communicate with Osteoclasts, Denosumab prevents the further growth of bone, and also reduces the size of the benign tumour due to the immature cells eventually dying and not being replaced.

A diagram showing the way that Osteoblasts and Osteoclasts work together to form new bone, Retrieved from https://www.news-medical.net/health/What-are-Osteoblasts.aspx

The treatment was injected six times within three months along with oral calcium and vitamin D pills, which served to promote regular bone growth. Initially it was successful, as the patient reported no pain and full ability to move his thumb and tests showed that the tumour was gone, but the pain came back again 22 months post treatment. Testing showed a recurrence of the disease and a second treatment regiment was undergone. After the second treatment, the patient has since been entirely pain free and has even been able to continue playing piano full time, something that would’ve been unthinkable with other surgical methods that are most commonly used as treatment in cases of Osteoblastoma. Tests once again showed that the tumour was gone, but that the original bone was now slightly denser than normal, though this had lesser adverse effects on health and dexterity than other treatments used to treat the disease.

Although this case study shows extreme promise, and was a great fit for this particular individual , there is still much more research to do on the effectiveness of Denosumab as a drug for all cases of Osteoblastoma, which can occur in many other parts of the body including the spine and feet.

There are also adverse side effects to using Denosumab, which include muscle pain, electrolyte imbalance and dense bones. This trade-off, however, was more than worth it for this particular patient, whose career could’ve been completely ended by surgery. Ultimately, this case study shows the great value in multiple treatment methods being available to those who need them, in order to maximize their quality of life.

-Gurkaran Bhandal

Are Cats a Man’s Best Friend?

We’ve often heard of the saying,  “A dog is a man’s best friend,” but that doesn’t mean that cats can’t be as well! A recent study from the journal Current Biology found that humans and cats can share an attachment bond with each other, and that this is not just limited to dogs.

In this study, they conducted a test where an adult cat or kitten was left in a room with their owner for two minutes, followed by two more minutes alone. They were then reunited with their owner for another two minutes. The frequency of “meow” vocalizations were recorded in the alone phase as a measure of separation distress. They noticed that during the time the cat was left alone, the number of vocalizations was much greater than in the company of their owner, signifying distress in the cat. Consequently, they discovered cats share a very similar attachment to their owner as do infants. This sign of human attachment persisted through the cat’s adulthood. Therefore, this shows that cat-owner relationships are closely related to parent-child relationships.

Image from SkitterPhoto

They’re not Kitten around!

Humans find companionship with their pets and thus being one of the reasons we feel so close to them. Another study in the journal Applied Animal Behaviour Science found that most owners regarded cats as family members with developed socio-cognitive skills. For example, the cats noticed visual and audio cues of humans such as the pointing of an arm and recognizing their owners’ voice. The researchers noted that there were certain traits in cats that were similar for dogs. For instance, both cats and dogs were seen as more emotionally matching with their owners, meaning they feel emotionally closer with them. This shows that there are strong attachment and emotional bonds between cats and their owners.

Image from Pixabay

Paws for a moment.

So what is the cat-ch? You may have heard people treating their pets as if they were their own children, and there is a lot of meaning to that. These studies enforce the idea that cats are just as capable of forming strong bonds with their owners as with dogs, especially if you put in the effort to do so.  The ability to share a close relationship with your pet is what makes them so special to us, and more so the reason we should consider every one of them, even cats, our best friend.

Edmund Kwan

Sep 30, 2019

Revised Oct. 21, 2019